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Plasmapheresis for a Female with Cryptogenic New-Onset Refractory Status Epilepticus Not Benefiting from Monoclonal Antibody Therapy

Ha H, Kim YS, Kim DH, Yang TW, Chung B, Lee CH, Kim E, Kwon OY

Monoclonal antibodies are pure antibodies that react to a specific epitope. Plasmapheresis is a treatment that separates and eliminates disease-causing substances before replacing the blood with plasma. Plasmapheresis has insufficient...
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Garcinia Cambogia-Induced Refractory Status Epilepticus

Nam Hw, Kim KT, Song M, Kim H, Kim JB

Garcinia cambogia (G.cambogia) is a herbal dietary supplement for managing obesity. Several adverse effects of G.cambogia have been reported including serotonin syndrome and mania. We report a patient with refractory...
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An Autoimmune Encephalitis Case Associated with Pembrolizumab Use

Yum JY, Kim J, Kim T, Park WH, Chu MK

Immune checkpoint inhibitors may be associated with various adverse events, including encephalitis. Here, we report a case of encephalopathy associated with pembrolizumab therapy. A 60-year-old male diagnosed with cholangiocarcinoma with...
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Contrast-induced encephalopathy and nonconvulsive status epilepticus after diagnostic cerebral angiography in an end-stage renal disease patient

Kim HN, Park SY, Koh S, Kim TJ, Jung WS, Lee JS, Hong JM, Lee SJ

A 70-year-old man with a history of recurrent ischemic stroke and end-stage renal disease was admitted to the neurology department for a transient ischemic attack. The patient underwent transfemoral cerebral...
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Non-convulsive status epilepticus in the immediate postoperative period following spine surgery -a case report-

Kim KO, Lee T, Kim T

Background: Non-convulsive status epilepticus (NCSE), in which continuous epileptiform dis-charges occur without seizure-like movement, is rare and unfamiliar to anesthesiologists, both of which make this condition overlooked in patients with...
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Comeback of ketamine: resurfacing facts and dispelling myths

Kumar A, Kohli A

Initially known as CI-581, ketamine was first synthesized in 1962 as a replacement from phencyclidine. It has since been used as an anesthetic and analgesic. In addition, it has bronchodilating,...
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Low Doses of Baclofen Induced Nonconvulsive Status Epilepticus in a Patient with Chronic Kidney Disease

Kim SH, Kim S, Kim H, Kim HH, Yun JY, Lee JH, Kim GH

Baclofen, a gamma-aminobutyric acid B agonist, is frequently used in the treatment of various neurologic diseases including spasticity, dystonia and trigeminal neuralgia. This drug usually acts at the presynaptic motor...
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Intraoperative refractory status epilepticus caused by propofol -a case report-

Kumar A, Kumar A, Kumar N, Kumar A

Background: Status epilepticus, when continued despite the administration of two antiepileptic drugs, is called refractory status epilepticus (RSE). The seizure-like phenomenon due to propofol is widely reported in...
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Clinical Characteristics and Treatment Outcomes of De Novo Nonconvulsive Status Epilepticus: A Retrospective Study

Lee JJ, Park KI, Park JM, Kang K, Kwon O, Lee WW, Kim BK

Background and Purpose Nonconvulsive status epilepticus (NCSE) is challenging to diagnose. This study aimed to describe and classify the clinical features and electroencephalography (EEG) findings of patients with de novo...
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Treatments for Convulsive and Nonconvulsive Status Epilepticus in Adults: An Expert Opinion Survey in South Korea

Byun JI, Kim DW, Kim KT, Yang KI, Lee ST, Seo JG, No YJ, Kang KW, Kim D, Cho YW, Kim JM, , on behalf of the Drug Committee of Korean Epilepsy Society

Background and Purpose The aim of this study was to survey the expert opinions on treatments for convulsive status epilepticus (CSE) and nonconvulsive status epilepticus (NCSE) in adults. Methods Forty-two South...
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Antiepileptic Drug Therapy for Status Epilepticus

Kim D, Kim JM, Cho YW, Yang KI, Kim DW, Lee ST, No YJ, Seo JG, Byun JI, Kang KW, Kim KT, on behalf of the Drug Committee of Korean Epilepsy Society

Status epilepticus (SE) is one of the most serious neurologic emergencies. SE is a condition that encompasses a broad range of semiologic subtypes and heterogeneous etiologies. The treatment of SE...
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Neurosyphilis Presenting with Status Epilepticus

Ok T, Lee GY, Sung M, Choi BJ, Kim WJ

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Status Epilepticus as the Initial Manifestation of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome

Kim JG, Kang CH, Choi JC, Shin J, Kim MJ, Oh JH

Mitochondrial encephalomyopathy with lactic acid and stroke-like episodes (MELAS) is a multisystem mitochondrial disorder that is rarely observed in adulthood. We report a case of MELAS syndrome diagnosed in a...
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Trend of Status Epilepticus Statistics in Korea: An Epidemiologic Study Based on National Health Insurance Database

Kim HK, Kang S, Lee SY

Background: Status epilepticus is a severe neurologic emergency comprising significant morbidity and mortality. This study investigated the epidemiologic features of status epilepticus in Korea from 2010 to 2019. Methods: We used...
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Clinical Approach to Autoimmune Epilepsy

Jang Y, Kim DW, Yang KI, Byun JI, Seo JG, No YJ, Kang KW, Kim D, Kim KT, Cho YW, Lee ST, obotDCoKES

Autoimmune epilepsy is a newly emerging area of epilepsy. The concept of “autoimmune” as an etiology has recently been revisited thanks to advances in autoimmune encephalitis and precision medicine with...
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Nonconvulsive status epilepticus associated with leptomeningeal carcinomatosis and positive SOX1 antibodies

Kim JY, Kim GY, Jeong JH, Kim SH

Background: Nonconvulsive status epilepticus (NCSE) is a disorder with varying prognoses depending on the underlying etiology. It is increasingly recognized as a cause of altered mental status but is difficult...
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Favorable clinical course after early-intensive immunotherapy for new-onset refractory status epilepticus

Kim HS, Kim J, Hwang BJ, Woo KN, Park MG, Park KP, Ahn SH

Background: New-onset refractory status epilepticus (NORSE) refers to the newly established concept of a disease characterized by refractory status epilepticus without an identifiable etiology. Recent reports have indicated the importance...
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Febrile Infection-Related Epilepsy Syndrome: Refractory Status Epilepticus and Management Strategies

Lee YJ

Febrile infection-related epilepsy syndrome (FIRES) is a rare, catastrophic epileptic syndrome that strikes previously healthy children. Its pathogenesis is unknown, it has few treatments, and it is typically refractory. In...
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Spatiotemporal expression of RCAN1 and its isoform RCAN1-4 in the mouse hippocampus after pilocarpine-induced status epilepticus

Cho KO, Jeong KH, Cha JH, Kim SY

Regulator of calcineurin 1 (RCAN1) can be induced by an intracellular calcium increase and oxidative stress, which are characteristic features of temporal lobe epilepsy. Thus, we investigated the spatiotemporal expression...
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Cefepime-induced neurotoxicity

Lee SJ

Cefepime, a widely used fourth-generation cephalosporin, has been reported to cause neurotoxicity because it crosses the blood-brain barrier. Although cefepime-induced neurotoxicity (CIN) occurs in patients with renal dysfunction administered a...
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