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Diagnostic Performance of the GENEDIA MTB/NTM Detection Kit for Detecting Mycobacterium tuberculosis and Nontuberculous Mycobacteria With Sputum Specimens

Shin S, Yoo IY, Shim HJ, Kang OK, Jhun BW, Koh WJ, Huh HJ, Lee NY

The GENEDIA MTB/NTM Detection Kit (GENEDIA MTB/NTM; Green Cross Medical Science Corp., Chungbuk, Korea) is a multiplex real-time PCR assay used for differential identification of Mycobacterium tuberculosis complex (MTBC) and...
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Quality of Same-Day Sputum Smears Microscopy and Presumptive Tuberculosis Patients Drop-out at Health Facilities of Addis Ababa, Ethiopia

Taddese BD, Misganaw A

BACKGROUND: Same-day sputum microcopy is recommended in areas where sputum smear microscopy external quality assessment (EQA) is effectively implemented and sturdy. In Addis Ababa, the status of EQA and drop-out...
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Sputum Autoantibodies Are More Relevant in Autoimmune Responses in Asthma than Are Serum Autoantibodies

Qin R, Long F, Xiao X, Xiao J, Zheng Z, Feng M, Huang R, Peng T, Li J

PURPOSE: The data on the differences between sputum autoantibodies (Sp-Abs) and serum autoantibodies (Se-Abs) in reflection of autoimmune responses to lungs is still lacking. METHODS: Ten types of Abs were investigated...
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Different Biological Pathways Are Up-regulated in the Elderly With Asthma: Sputum Transcriptomic Analysis

Kim BK, Lee HS, Sohn KH, Lee SY, Cho SH, Park HW

BACKGROUND: Elderly asthma (EA) is increasing, but the pathogenesis is unclear. This study aimed to identify EA-related biological pathways by analyzing genome-wide gene expression profiles in sputum cells. METHODS: A total...
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Factors Associated with Persistent Sputum Positivity at the End of the Second Month of Tuberculosis Treatment in Lithuania

Diktanas S, Vasiliauskiene E, Polubenko , Danila E, Celedinaite I, Boreikaite E, Misiunas K

BACKGROUND: Non-conversion of sputum smear and culture prolongs the infectivity of the patient and has been associated with unfavorable outcomes. We aimed to evaluate factors associated with persistent sputum positivity...
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KAAACI Standardization Committee report on the procedure and application of induced sputum examination

Kim MH, Kim MY, Lim KH, Yang MS, Song WJ, Lee J, Suh DI, Shin YS, Kwon JW, Kim SH, Kim SH, Lee BJ, Cho SH, Jung JW, Korean Academy of Asthma, Allergy and Clinical Immunology Standardization Committee

Induced sputum and sputum cell count analysis is a test for the diagnosis of various respiratory diseases. In particular, it has long been used as an important biomarker in the...
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Usefulness of flexible bronchoscopy in children with suspected pulmonary tuberculosis who have difficulty in sputum expectoration

Lee HJ, Park Y, Yang EA, Kim HS, Chun YH, Yoon JS, Kim HH, Kim JT

PURPOSE: To assess the usefulness of flexible bronchoscopy in patients with suspected pulmonary tuberculosis (PTB) who have difficulty in sputum expectoration. METHODS: The subjects of this study were patients who were...
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Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics

Ghebre MA, Desai D, Singapuri , Woods J, Rapley L, Cohen S, Herath A, Wardlaw AJ, Pashley CH, May R, Brightling CE

Aspergillus fumigatus sensitization and culture in asthma are associated with disease severity and lung function impairment, but their relationship with airway inflammation is poorly understood. We investigated the profile of...
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The transition of sputum inflammatory cell profiles is variable in stable asthma patients

Shin B, Kwon HS, Park SY, Kim TB, Moon HB, Cho YS

BACKGROUND: The sputum inflammatory cell profile is an important indicator for classifying asthma phenotypes. OBJECTIVE: To investigate if sputum inflammatory cell profile remains stable and there are different characteristics between groups...
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Duration of Pulmonary Tuberculosis Infectiousness under Adequate Therapy, as Assessed Using Induced Sputum Samples

Ko Y, Shin JH, Lee HK, Lee YS, Lee SY, Park SY, Mo EK, Kim C, Park YB

BACKGROUND: A sputum culture is the most reliable indicator of the infectiousness of pulmonary tuberculosis (PTB); however, a spontaneous sputum specimen may not be suitable. The aim of this study...
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Association between Body Mass Index and Sputum Culture Conversion among South Korean Patients with Multidrug Resistant Tuberculosis in a Tuberculosis Referral Hospital

Park HO, Kim SH, Moon SH, Byun JH, Kim JW, Lee CE, Kim JD, Jang IS, Yang JH

BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is an important global health problem. Furthermore, the time to identify a positive sputum culture is an important risk factor for the spread of tuberculosis, and...
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Lung Microbiome Analysis in Steroid-NaÑ—ve Asthma Patients by Using Whole Sputum

Jung JW, Choi JC, Shin JW, Kim JY, Park IW, Choi BW, Park HW, Cho SH, Kim K, Kang HR

BACKGROUND: Although recent metagenomic approaches have characterized the distinguished microbial compositions in airways of asthmatics, these results did not reach a consensus due to the small sample size, non-standardization of...
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Efficacy of Induced Sputum for the Diagnosis of Pulmonary Tuberculosis in Adults Unable to Expectorate Sputum

Park JS

BACKGROUND: Induced sputum (IS) has been used to collect airway secretions in subjects who have inadequate sputum production. The aim of this study was to investigate the efficacy of IS...
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Fractional Exhaled Nitric Oxide: Comparison Between Portable Devices and Correlation With Sputum Eosinophils

Yune S, Lee JY, Choi DC, Lee BJ

This study was performed to compare the 2 different portable devices measuring fractional exhaled nitric oxide (FeNO) and to see the correlation between FeNO and induced sputum eosinophil count (ISE)....
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Expression of the Brother of the Regulator of Imprinted Sites Gene in the Sputum of Patients with Lung Cancer

Lee HY, Kim JI, Cho SH, Ko TY, Kim HS, Park SD, Cho SR, Chang HK, Hwang GJ, Jung SB

  • KMID: 2382172
  • Korean J Thorac Cardiovasc Surg.
  • 2014 Aug;47(4):378-383.
BACKGROUND: Brother of the regulator of imprinted sites (BORIS) is a putative new oncogene that is classified as a cancer germline gene; however, its role in the development of cancer...
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Reference ranges for induced sputum eosinophil counts in Korean adult population

Kim MY, Jo EJ, Lee SE, Lee SY, Song WJ, Kim TW, Hur GY, Lee JH, Kim TB, Park HW, Chang YS, Park HS, Min KU, Cho SH

BACKGROUND: Induced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults. OBJECTIVE: The purpose of this study is to...
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Usefulness of Sputum Induction with Hypertonic Saline in a Real Clinical Practice for Bacteriological Yields of Active Pulmonary Tuberculosis

Seong GM, Lee J, Lee JH, Kim JH, Kim M

  • KMID: 2320500
  • Tuberc Respir Dis.
  • 2014 Apr;76(4):163-168.
BACKGROUND: Mycobacterial identification in active pulmonary tuberculosis (APTB) is confirmative, even though successful rates using self-expectorated sputum are limited. Sputum specimens collected by hypertonic saline nebulization showed higher bacteriologic diagnostic...
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Total Unilateral Obstruction by Sputum Immediately after Tracheal Bougienage

Kim K, Jun J, Jeong M, Choi S, Lee Y

A 25-year-old man developed tracheal stenosis due to prolonged intubation for five days. Immediately after bougienage, his left lung was not possible to ventilate and emergency tracheostomy was performed to...
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Clinical characteristics and long-term outcomes related to sputum eosinophilia in Korean asthmatics

Jung JW, Kim SH, Kwon JW, Kim TW, Kang HR, Park HW, Kim SS, Chang YS, Cho SH, Min KU, COREA (Cohort for Reality and Evolution of adult Asthma) Research Group

BACKGROUND: Bronchial asthma is usually associated with high sputum eosinophil levels. However, recent reports have suggested the importance of noneosinophilic asthma (NEA) as a distinct phenotype of asthma. OBJECTIVE: The aim...
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Clinical Manifestations of Persistent Smear Positive and Culture Negative Sputum Tests 5 Months after First-line Anti-Tuberculous Chemotherapy

Kim DH, Hwang SH, Cheon DS, Min JH, Kang HS, Park SG

BACKGROUND: It is not known with certainty whether patients with persistently positive sputum smear results who have also had negative sputum culture results require prolongation of treatment for tuberculosis in...
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