- Clinicopathological Significance of SMAD4 Expression in Breast Cancer
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Woo JS, Chung MS, Paik SS
- KMID: 2470603
- J Breast Dis.
- 2019 Dec;7(2):52-58.
- doi: 10.14449/jbd.2019.7.2.52
PURPOSE: SMAD4 is a member of the SMAD family and acts as a central mediator of transforming growth factor beta signaling. Little is known about SMAD4 expression and its prognostic... -
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- Pokemon Inhibits Transforming Growth Factor β-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1
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Chen L, Zhong J, Liu JH, Liao DF, Shen YY, Zhong XL, Xiao X, Ding WJ, Peng XD, Xiong W, Zu XY
- KMID: 2441848
- J Breast Cancer.
- 2019 Mar;22(1):15-28.
- doi: 10.4048/jbc.2019.22.e11
PURPOSE: Pokemon, also known as ZBTB7A, belongs to the POZ and Krüppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study... -
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- The effect of melatonin on cardio fibrosis in juvenile rats with pressure overload and deregulation of HDACs
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Wu Y, Si F, Luo L, Jing F, Jiang K, Zhou J, Yi Q
- KMID: 2430083
- Korean J Physiol Pharmacol.
- 2018 Nov;22(6):607-616.
- doi: 10.4196/kjpp.2018.22.6.607
The effect of melatonin on juveniles with cardio fibrosis is poorly understood. We investigated whether HDACs participate in the anti-fibrotic processes regulated by melatonin during hypertrophic remodeling. Abdominal aortic constriction... -
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- A Novel Germline Mutation in Exon 10 of the SMAD4 Gene in a Familial Juvenile Polyposis
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Jee MJ, Yoon SM, Kim EJ, Choi HJ, Kim JW, Sung RH, Han JH, Chae HB, Park SM, Youn SJ
- KMID: 1712337
- Gut Liver.
- 2013 Nov;7(6):747-751.
Familial juvenile polyposis (FJP) is a rare autosomal dominant hereditary disorder that is characterized by the development of multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk... -
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- Mesenchymal Smad4 mediated signaling is essential for palate development
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Yoon CY, Baek JA, Cho ES, Ko SO
- KMID: 2328582
- J Korean Assoc Oral Maxillofac Surg.
- 2010 Dec;36(6):460-465.
INTRODUCTION: A cleft palate is a common birth defect in humans with an incidence of 1/500 to 1/1,000 births. It appears to be caused by multiple genetic and environmental factors... -
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- TGF-beta1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions
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Nam EH, Park SR, Kim PH
- KMID: 983953
- Exp Mol Med.
- 2010 Sep;42(9):606-613.
- doi: 10.3858/emm.2010.42.9.059
Angiogenesis is a multi-step process that involves the activation, proliferation, and migration of endothelial cells. We have recently shown that TGF-beta1 can induce mouse macrophages to produce VEGF, a potent... -
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- Clinical Features and Mutations in the ENG, ACVRL1, and SMAD4 genes in Korean Patients with Hereditary Hemorrhagic Telangiectasia
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Lee ST, Kim JA, Jang SY, Kim DK, Do YS, Suh GY, Kim JW, Ki CS
- KMID: 1794409
- J Korean Med Sci.
- 2009 Feb;24(1):69-76.
- doi: 10.3346/jkms.2009.24.1.69
Hereditary hemorrhagic telangiectasia (HHT) is an inherited disorder that is characterized by abnormal communication between the arteries and veins in the skin, mucosa, and various organs. HHT has been reported... -
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- The Prognostic Significance of Chromosome 18 Monosomy in the Colon Cancer: Correlations with the Expressions of Smad4 and TGF-beta Receptor II Proteins
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Choi YS, Lim HM, Kim BG, Lee TJ
- KMID: 2211101
- J Korean Surg Soc.
- 2007 Sep;73(3):227-234.
PURPOSE: Chromosomal instability of chromosome 18 and inhibition of the transforming growth factor beta (TGF-beta) signaling pathway, which is mediated through Smad4, play important roles in the tumorigenesis of colon... -
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- Smad4 Expression in Gastric Adenocarcinoma
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Kim HO, Park DY, Suh KS
- KMID: 1921703
- Korean J Pathol.
- 2003 Apr;37(2):93-99.
BACKGROUND: The role of Smad4 in carcinogenesis is important, because of its function as a central mediator of TGF-beta signaling. In the present study we analyzed the expressions of Smad4... -
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