- Altered remodeling of nucleolar machineries in cultured hepatocytes treated with thioacetamide
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Jeong JS, Han SY, Kim YH, Choi YC
- KMID: 1066498
- J Korean Med Sci.
- 2001 Feb;16(1):75-82.
- doi: 10.3346/jkms.2001.16.1.75
Thioacetamide (TA) is converted into a hyperacetylating agent which causes hepatic necrosis, regeneration, cirrhosis and cancerous transformation. One of the most characteristic toxicities of TA in rat is observed with... -
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- Microarray for Genes Associated with Signal Transduction in Diabetic OLETF Keratocytes
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Lee JE, Lee JS, Hwang SH
- KMID: 1101914
- Korean J Ophthalmol.
- 2007 Jun;21(2):111-119.
- doi: 10.3341/kjo.2007.21.2.111
PURPOSE: The purpose of this study was to identify differences in signal transduction gene expression between normal and diabetic keratocytes stimulated with interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha). ... -
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- Sphingosine 1-Phosphate Triggers Apoptotic Signal for B16 Melanoma Cells via ERK and Caspase Activation
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Shin JH, Choi GS, Kang WH, Myung KB
- KMID: 1713191
- J Korean Med Sci.
- 2007 Apr;22(2):298-304.
- doi: 10.3346/jkms.2007.22.2.298
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects. In... -
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- Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration
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Jeon S, Kim NH, Koo BS, Lee HJ, Lee AY
- KMID: 1090963
- Exp Mol Med.
- 2007 Oct;39(5):603-613.
Pigmentation may result from melanocyte proliferation, melanogenesis, migration or increases in dendricity. Recently, it has been reported that secreted phospholipase A2(sPLA2) known as a component of bee venom (BV), stimulates... -
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- Functional involvement of src and focal adhesion kinase in a CD99 splice variant-induced motility of human breast cancer cells.
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Lee HJ, Kim ES, Jee BE, Hahn JH, Han KH, Jung KC, Park SH, Lee HS
- KMID: 1380225
- Exp Mol Med.
- 2002 Jul;34(3):177-183.
Earlier report showed that expression of a splice variant of CD99 transmembrane protein increases invasive ability of human breast cancer cells. Cell motility was also significantly enhanced by the CD99... -
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- Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis
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Cha SW, Lee JW, Hwang YS, Chae JP, Park KM, Cho HJ, Kim DS, Bae YC, Park MJ
- KMID: 1104809
- Exp Mol Med.
- 2008 Oct;40(5):550-557.
- doi: 10.3858/emm.2008.40.5.550
We have previously shown that the inhibition of fibroblast growth factor (FGF) signaling induced endodermal gene expression in the animal cap and caused the expansion of the endodermal mass in... -
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- Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling
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Cucuzza LS, Motta M, Miretti S, Accornero , Baratta M
- KMID: 1072945
- Exp Mol Med.
- 2008 Dec;40(6):647-657.
- doi: 10.3858/emm.2008.40.6.647
Curcumin (from the rhizome of Curcuma longa) is well documented for its medicinal properties in Indian and Chinese systems of medicine where it is widely used for the treatment of... -
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- Modulation of Colon Cancer Cell Invasiveness Induced by Deoxycholic Acid
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Kim HS, Lee YK, Kim JW, Baik SK, Kwon SO, Jang HI
- KMID: 782732
- Korean J Gastroenterol.
- 2006 Jul;48(1):9-18.
BACKGROUND/AIMS: Deoxycholic acid (DCA), a secondary bile acid, has been implicated to promote colon cancer growth and progression. However, its molecular mechanisms are largely unknown. In this study, we investigated... -
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- The synthetic peptide, His-Phe-Tyr-Leu-Pro-Met, is a chemoattractant for Jukat T cells
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Kim YD, Bae YS, Park JC, Suh PG, Ryu SH
- KMID: 1457539
- Exp Mol Med.
- 2001 Dec;33(4):257-262.
His-Phe-Tyr-Leu-Pro-Met (HFYLPM) is a synthetic peptide that stimulates Jurkat T cells resulting in intracellular calcium ([Ca2+]i) increase in a pertussis toxin (PTX)-sensitive manner. We have examined the physiological role of... -
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- Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells
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Lee YJ, Lee SH
- KMID: 1123448
- J Korean Med Sci.
- 2011 Nov;26(11):1474-1482.
- doi: 10.3346/jkms.2011.26.11.1474
Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated. In... -
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- Counteracting the enzymatic activity of dipeptidylpeptidase 4 for potential therapeutic advantage, with an emphasis on cord blood transplantation
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Broxmeyer
- KMID: 1780121
- Korean J Intern Med.
- 2013 Nov;28(6):639-645.
- doi: 10.3904/kjim.2013.28.6.639
Dipeptidylpeptidase (DPP) 4, also known as CD26, is an enzyme present on the surface of a number of different cell types. It is also found within cells and as a... -
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- Altered Gene Expression Profile After Exposure to Transforming Growth Factor beta1 in the 253J Human Bladder Cancer Cell Line
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Lee C, Lee SH, Kim DS, Jeon YS, Lee NK, Lee SE
- KMID: 1794590
- Korean J Urol.
- 2014 Aug;55(8):542-550.
- doi: 10.4111/kju.2014.55.8.542
PURPOSE: Transforming growth factor beta1 (TGF-beta1) inhibits the growth of bladder cancer cells and this effect is prominent and constant in 253J bladder cancer cells. We performed a microarray analysis... -
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- Emodin prevents intima thickness via Wnt4/Dvl-1/beta-catenin signaling pathway mediated by miR-126 in balloon-injured carotid artery rats
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Hua JY, He YZ, Xu Y, Jiang XH, Ye W, Pan ZM
- KMID: 2155424
- Exp Mol Med.
- 2015 Jun;47(6):e170.
- doi: 10.1038/emm.2015.36
Neointimal proliferation after vascular injury is a key mechanism of restenosis, a major cause of percutaneous transluminal angioplasty failure and artery bypass occlusion. Emodin, an anthraquinone with multiple physiological activities,... -
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- Arsenic trioxide-induced apoptosis is independent of stress-responsive signaling pathways but sensitive to inhibition of inducible nitric oxide synthase in HepG2 cells
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Kang SH, Song JH, Kang HK, Kang JH, Kim SJ, Kang HW, Lee YK, Park DB
- KMID: 1097255
- Exp Mol Med.
- 2003 Apr;35(2):83-90.
Arsenic trioxide (As2O3) has been found to be remarkably effective in the treatment of patients with acute promyelocytic leukemia (APL). Although evidences for the proapoptotic activity of As2O3 have been... -
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- Induction of Macrophage Migration Inhibitory Factor in ConA-Stimulated Rheumatoid Arthritis Synovial Fibroblasts through the P38 MAP Kinase-Dependent Signaling Pathway
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Kim HR, Park MK, Cho ML, Kim KW, Oh HJ, Park JS, Heo YM, Lee SH, Kim HY, Park SH
- KMID: 1776614
- Korean J Intern Med.
- 2010 Sep;25(3):317-326.
- doi: 10.3904/kjim.2010.25.3.317
BACKGROUND/AIMS: This study was undertaken to identify the intracellular signaling pathway involved in induction of macrophage migration inhibitory factor (MIF) in human rheumatoid arthritis (RA) synovial fibroblasts. METHODS: Human RA... -
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- SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor
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Rhee MH, Kim SK
- KMID: 1095119
- J Vet Sci.
- 2002 Sep;3(3):179-184.
It is now well established that several G protein- coupled receptors can signal without agonist stimulation (constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive... -
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- Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C
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Kim J, Min G, Bae YS, Min DS
- KMID: 1380203
- Exp Mol Med.
- 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in... -
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- Effect of short-term ethanol on the proliferative response of Swiss 3T3 cells to mitogenic growth factors
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Yeo EJ, Lim HK, Park SC
- KMID: 755081
- Exp Mol Med.
- 2000 Sep;32(3):161-169.
Both adaptive and deleterious responses of cells to ethanol are likely triggered by short-term interactions of the cells with ethanol. Many studies have demonstrated the direct effect of ethanol... -
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- Gap junction blockage promotes cadmium-induced apoptosis in BRL 3A derived from Buffalo rat liver cells
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Hu D, Zou H, Han T, Xie J, Dai N, Zhuo L, Gu J, Bian J, Yuan Y, Liu X, Liu Z
- KMID: 2363336
- J Vet Sci.
- 2016 Mar;17(1):63-70.
- doi: 10.4142/jvs.2016.17.1.63
Gap junctions mediate direct communication between cells; however, toxicological cascade triggered by nonessential metals can abrogate cellular signaling mediated by gap junctions. Although cadmium (Cd) is known to induce apoptosis... -
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- Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells
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Kim YS, Jhon DY, Lee KY
- KMID: 1380210
- Exp Mol Med.
- 2004 Apr;36(2):157-164.
Selenium is a dietary essential trace nutrient with important biological roles. Selenocompounds were reported to induce apoptosis in many types of tumor cells. In this study, we investigated the signaling... -
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