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Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells

Cheon YH, Kim MS, Kim JY, Kim DH, Han SY, Lee JH

Chronic inflammatory airway diseases, such as chronic rhinosinusitis, chronic obstructive pulmonary disease, and asthma, are associated with excessive mucus production. Hence, the regulation of mucus production is important for the...
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G0/G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells

Cho E, Kwon YJ, Ye DJ, Baek HS, Kwon TU, Choi HK, Chun YJ

Human breast cancer cell line, MDA-MB-231, is highly invasive and aggressive, compared to less invasive cell line, MCF-7. To explore the genes that might influence the malignancy of MDA-MB-231, DNA...
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Insights into the signal transduction pathways of mouse lung type II cells revealed by transcription factor profiling in the transcriptome

Ramana CV

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells...
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Cellular Prion Protein Enhances Drug Resistance of Colorectal Cancer Cells via Regulation of a Survival Signal Pathway

Lee JH, Yun CW, Lee SH

Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive....
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Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway

Zhou W, Quan JH, Gao FF, Ismail HA, Lee YH, Cha GH

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little...
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A two-component signal transduction system contributes to the virulence of Riemerella anatipestifer

Wang Q, Chen M, Zhang W

Similar to other studies of bacterial pathogens, current studies of the pathogenesis of Riemerella anatipestifer (RA) are focused mainly on in vitro culture conditions. To elucidate further the pathogenesis of...
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Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway

Ko GA, Kim Cho S

Ethyl linoleate is an unsaturated fatty acid used in many cosmetics for its various attributes, such as antibacterial and anti-inflammatory properties and clinically proven to be an effective anti-acne agent....
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Chronic persistent post-surgical pain following staging laparotomy for carcinoma of ovary and its relationship to signal transduction genes

Saxena AK, Chilkoti G, Chopra AK, Banerjee B, Sharma T

BACKGROUND: The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and the role of signal transduction genes in patients undergoing staging laparotomy for carcinoma...
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The volatile anesthetic sevoflurane attenuates ventilator-induced lung injury through inhibition of ERK1/2 and Akt signal transduction

Kim SH, Li M, Pyeon TH, So KY, Kwak SH

BACKGROUND: Ventilator-induced lung injury (VILI) sustained during mechanical ventilator support is still a cause of a high rate of morbidity and mortality in intensive care units and in operating rooms....
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Tacrolimus (FK506) Induced Apoptotic Signal Transduction Pathway

Jung MR, Choi SJ, Chung SY

  • KMID: 2117082
  • J Korean Surg Soc.
  • 2007 Nov;73(5):359-365.
PURPOSE: This study examined the effects of Tacrolimus (FK506) on the expression of the apoptotic signal transduction proteins of Jurkat human T-lymphocytes. METHODS: The cell viability was examined by a...
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Cross-talk between Integrin and SMAD Signal Pathway in Articular Chondrocyte

Hahn SB, Park MS, Kim YH, Lee JW

  • KMID: 2199076
  • J Korean Orthop Res Soc.
  • 2007 Oct;10(2):65-75.
PURPOSE: Identifying the signal cross-talk between integrin signaling cascade and TGF-beta 1 signaling cascade in articular chondrocytes. MATERIALS AND METHODS: To analyze integrin or TGF-beta 1 mediated signaling pathways from extracellular...
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Signal Transduction Pathways as Novel Therapeutic Targets in Asthma

  • KMID: 2299608
  • Korean J Asthma Allergy Clin Immunol.
  • 2007 Sep;27(3):147-154.
No abstract available.
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Activation of ATM-dependent DNA Damage Signal Pathway by a Histone Deacetylase Inhibitor, Trichostatin A

Lee JS

  • KMID: 1522935
  • Cancer Res Treat.
  • 2007 Sep;39(3):125-130.
PURPOSE: Ataxia-telangiectasia mutated (ATM) kinase regulates diverse cellular DNA damage responses, including genome surveillance, cell growth, and gene expression. While the role of histone acetylation/deacetylation in gene expression is well...
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Regulation of Inflammatory Repertoires and NF-kappaB Signal Transduction by DDB, an Active Compound from Schizandra Chinensis Baillon

Joo SS, Yoo YM, Won TJ, Kim MJ, Lee SG, Hwang KW, Lee DI

BACKGROUND: Chronic inflammation in the brain has known to be associated with the development of a various neurological diseases including dementia. In general, the characteristic of neuro-inflammation is the activated...
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A Study for the Mechanism of Abnormal Proliferation in Vascular Endothelial Cells using Inhibitors to the Signal Transduction Pathway

Bae YC, Park SY, Nam SB, Herh JY, Kang YS

  • KMID: 2120052
  • J Korean Soc Plast Reconstr Surg.
  • 2006 Jan;33(1):5-12.
Protein tyrosine kinase(PTK), protein kinase C(PKC), oxidase, as a mediator, take a significant role in signal transduction pathway of angiogenesis. The authors utilized the inhibitors, targeting the formation of three...
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Signal Transduction Pathways in Colorectal Cancer Carcinogenesis and Metastasis

Baek MJ

  • KMID: 2334341
  • J Korean Soc Coloproctol.
  • 2005 Dec;21(6):433-444.
Cell proliferation and differentiation are regulated by a number of hormones, growth factors. These molecules interact with cellular receptors and communicate with the nucleus of the cell through a network...
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Bone/Vascular Calcification: Signal Transduction Pathway and Calcification Related Genes

Choi JY

No Abstract available.
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Wnt Signal Transduction and Its Involvement in Human Diseases

Jho EH

No Abstract available.
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Tamoxifen Resistance and Crosstalk of Signal Transduction in Breast Cancer

Park WC

In the hormonal therapy of breast cancer, tamoxifen is currently the standard treatment for estrogen receptor (ER)-positive patients. A response to tamoxifen has been reported in only 2/3 of patients...
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A Two Component Signal Transduction System Required for the Virulence of Vibrio vulnificus

Jin YS, Kim YR, Rhee JH

  • KMID: 1579123
  • J Bacteriol Virol.
  • 2004 Dec;34(4):291-301.
Vibrio vulnificus is an estuarine bacterium that opportunistically infects humans with underlying hepatic diseases, heavy alcohol drinking habits, and other immunocompromised conditions. A locus in the V. vulnificus genome was...
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