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Cefepime-induced neurotoxicity after flap surgery: a rare case report

Song WJ, Lee CY, Ryu HR, Byeon JY, Choi HJ

Cefepime is a fourth-generation cephalosporin that covers gram-positive bacteria and gram-negative bacteria, such as Pseudomonas. A 48-year-old male patient underwent a posterior tibial artery perforator-based fasciocutaneous turnover flap and was...
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Incidence and Economic Burden of Adverse Drug Reactions in Hospitalization: A Prospective Study in Korea

Seo B, Yang MS, Park SY, Park BY, Kim JH, Song WJ, Kwon HS, Chang YS, Cho YS, Kim SH, Kim TB

Background: Adverse drug reactions (ADRs) are escalating, and their socioeconomic burden is increasing. However, large-scale prospective studies investigating ADRs during hospitalization are rare in Korea. We prospectively investigated the incidence,...
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Sugammadex administration in patients with end-stage renal disease: a narrative review with recommendations

Oh SK, Lim BG

Due to unknown safety concerns, sugammadex should not be administered to patients withend-stage renal disease (ESRD). However, because the supply of benzylisoquinolinium-typeneuromuscular blocking agents (NMBAs) has been discontinued, rocuronium is...
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Old Age, Female Sex, and Psychotropic Medications Predict Hyposalivation But Not Heart Rate Variability

Lee SY, Jung KI, Park MH, Lee CU

Objective To explore risk factors for dry mouth and examine the clinical utility of the heart rate variability (HRV) test in the prediction of dry mouth. Methods Every outpatient, who underwent...
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A case of esophageal perforation caused by suicidal caffeine poisoning in a teenager

Kim SJ, Choi Yj, Lee KS, Jang HJ, Moon JH, Kim YJ, Yang S

Spontaneous esophageal perforation (also known as Boerhaave syndrome) is associated with sudden increase in intra-esophageal pressure by vomiting, coughing or straining at stool. This case describes a 13-year-old girl who...
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Immune Checkpoint Inhibitors and Endocrine Disorders: A Position Statement from the Korean Endocrine Society

Kwon H, Roh E, Ahn CH, Kim HK, Ku CR, Jung KY, Lee JH, Kim EH, Suh S, Hong S, Ha J, Moon JS, Kim JH, Kim Mk, The Committee of Clinical Practice Guideline of the Korean Endocrine Society

Immune checkpoint inhibitors (ICIs) including an anti-cytotoxic T-lymphocyte-associated antigen 4 inhibitor, anti-programmed cell death protein 1 (PD-1) inhibitors, and anti-PD-ligand 1 inhibitors are representative therapeutics for various malignancies. In oncology,...
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A Case of A typical Fixed Drug Eruption Induced by Erdosteine

Choi JW, Kim HJ, Yoon J, Seo JH, Lee JY, Kang HR

Erdosteine is a mucolytic agent used in acute and chronic respiratory disease and it is known to be well tolerated. Adverse drug reactions related with erdosteine are mostly mild gastrointestinal...
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Pharmacovigilance and Its Importance for Primary Health Care Professionals

Hamid AAA, Rahim R, Teo SP

Pharmacovigilance is used to detect, assess, understand, and prevent the adverse effects of medications. The need for safety monitoring has evolved around unfortunate incidents in history, with deaths caused by...
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Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review

Park JY, Kim JH, Park S, Hwang YI, Kim HI, Jang SH, Jung KS, Kim YK, Kim HA, Lee IJ

Background/Aims: Pulmonary toxicities of coronavirus disease 2019 (COVID-19) vaccination are exceedingly rare. However, there are a few reported cases after mRNA vaccination, especially from Asian countries. The purpose of this...
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Discrimination between Benign and Malignant Post-SARS-CoV-2 Vaccination Lymphadenopathy is Feasible

Finsterer J

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Factors Associated with Adverse Events Following the First Dose of COVID-19 Immunization in Indonesia

Fadlilah S, Setiawan DI, Muflih M, Amigo TAE, Susanto R, Pujianto A

Purpose: This study investigated the factors associated with Adverse Event Following Immunization (AEFI) for Coronavirus Disease 2019 (COVID-19) in selected areas in Indonesia. Methods: We used a cross-sectional approach with...
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Antispasmodics

Song KH

Antispasmodics are effective in reducing abdominal pain associated with visceral organs, bloating, and bowel habit changes and are commonly used as “on-demand therapy.” A relatively regular intake of antispasmodics may...
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Drug-Induced Vitamin Deficiency

Jung JW, Park SY, Kim H

Drug-induced vitamin depletion can occur in hospitalized patients due to the administration of specific medications, which could potentially adversely affect patient outcomes. Signs and symptoms related to vitamin deficiency while...
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Vortioxetine Induced Hypomania: A Case Presentation and Review of the Literature

Tunc EB, Tunc S

Antidepressant-induced hypomania/mania is a complex issue that can be seen in mood disorders but is not clarified. There are case reports in the literature regarding vortioxetine-induced mania and hypomania;...
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The Willingness of Enduring Drug Side Effects in the Patients of Depressive Disorders: From the Results of Korean Nationwide Patients’ Perspectives Survey Study

Ko M, Song HR, Kim SY, Jung YE, Kim W, Seo JS, Sohn I, Lee K, Lee JH, Chung SK, Lee SY, Hong JW, Yoon BH, Woo YS, Bahk WM

Objectives There has been increased use of medications in treating depressive disorders. Nowadays, patient value is an important part of prescribing medications. This study examines depressive patients’ perspectives on the side...
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Pharmacotherapy for Insomnia of the Elderly

Kang SG

Insomnia is a common disease in the elderly. It is caused by various etiologies and their combinations. Therefore, treatment should be tailored to the individual. Cognitive-behavioral therapy for insomnia (CBT-I)...
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Analysis of Fluoroquinolone Adverse Drug Reaction Reported in a Single Center

Kim HJ, Hwang S, Kim HH, Jang JY, Suh JH, Kang DY, Lee JY, Kang HR

Objective: With the increased use of fluoroquinolone in the clinical setting, adverse drug reactions (ADR) to fluoroquinolones are also on the rise. The purpose of this study was to analyze...
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Risk Factors for Clostridium difficile Infection in Antibiotic Use Inpatients Based on Common Data Model

Moon SH, Kim HH, Nam DH, Moon Y, Kang MG, Choi IY, Byeon Sj, Yang HJ, Kim SH, Kim K, Kang DY

Objective: Clostridium difficile infection (CDI) is affected by various factors. The association between CDI and antibiotic use is well known, and proton pump inhibitors (PPI) and histamine H2 receptor antagonist...
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Diagnosis and Management of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) Syndrome

Lee SY

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe cutaneous adverse reaction characterized by fever, lymphadenopathy and multiorgan involvement. The delayed onset of symptoms makes diagnosis difficult,...
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Safe use of opioids

Go SI, Won YW, Kang JH

Background: Opioids are effective analgesics for cancer pain and refractory non-cancer pain. Although they are essential medication, problematic issues on aberrant behavior and adverse events have rapidly emerged as social...
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