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Metformin-loaded Citric Acid Cross-linked Agarose Films in the Prevention of Postoperative Abdominal Adhesion

Moon JH, Park JH, Jeong JH, Sung NS, Jeong YG, Song KC, Ahn JP, Lee NS, Han SY

Postoperative abdominal adhesion (PAA) causes significant long-term postoperative morbidity. Although numerous physical anti-adhesion barriers (AAB) are used as therapeutical interventions, none of them has achieved sustained success. As a potential...
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Preparation of Compact Agarose Cell Blocks from the Residues of Liquid-Based Cytology Samples

Choi SJ, Choi YI, Kim L, Park IS, Han JY, Kim JM, Chu YC

BACKGROUND: Inevitable loss of diagnostic material should be minimized during cell block preparation. We introduce a modified agarose cell block technique that enables the synthesis of compact cell blocks by...
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In-house Manual Construction of High-Density and High-Quality Tissue Microarrays by Using Homemade Recipient Agarose-Paraffin Blocks

Kim KH, Choi SJ, Choi YI, Kim L, Park IS, Han JY, Kim JM, Chu YC

  • KMID: 2277440
  • Korean J Pathol.
  • 2013 Jun;47(3):238-244.
BACKGROUND: Self-made tissue punches can be effectively used to punch holes in blank recipient paraffin blocks and extract tissue cores from the donor paraffin blocks for the low-cost construction of...
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Comparison of Superparamagnetic Iron Oxide Labeling Efficiency between Poly-L-Lysine and Protamine Sulfate for Human Mesenchymal Stem Cells: Quantitative Analysis Using Multi-Echo T2* Magnetic Resonance Imaging

Suh JY, Lee JH, Lee CK, Shin JH, Choi CG, Kim JK

PURPOSE: To quantify in vitro labeling efficiency of protamine sulfate (PS) and poly-L-lysine (PLL) for labeling of human mesenchymal stem cells (hMSCs) with superparamagnetic iron oxide (SPIO) using multi-echo T2*...
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Association of Alanine-Valine Manganese Superoxide Dismutase Gene Polymorphism and Microheterogeneity Manganese Superoxide Dismutase Activity in Breast Cancer and Benign Breast Tissue

Atoum M, Abdel-Fattah M, Nimer N, Abdel-Rahman S, Abdeldayem SA

PURPOSE: Although the etiology of breast cancer is multifactorial, oxidative stress plays an important role in carcinogenesis. In this study, manganese superoxide dismutase (MnSOD) gene polymorphism and activity were evaluated...
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Simple and Novel Three Dimensional Neuronal Cell Culture Using a Micro Mesh Scaffold

Yoo SJ, Kim J, Lee CS, Nam Y

Conventional method of cell culture studies has been performed on two-dimensional substrates. Recently, three-dimensional (3D) cell culture platforms have been a subject of interest as cells in 3D has significant...
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Measurements of T1- and T2-relaxation Time Changes According to the Morphological Characteristics of Gold Nanoparticles (GNPs)

Jang MY, Han YH, Mun CW

PURPOSE: The aim of this study is to measure the typical MR variables such as T1- and T2-relaxation times according to morphological characteristics of gold nanoparticles as a preliminary study...
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Fractionation of DNases Specific to Haemonchus contortus Intestine by Phenyl Sepharose Column

Seo MG, Kim TH, Kwon OD, Jeong KS, Lee YJ, Kim SJ, Park SJ, Kwon YS, Kwak DM

  • KMID: 2312059
  • Lab Anim Res.
  • 2010 Jun;26(2):139-144.
Multiple DNases were identified from Haemonchus contortus intestine based on previous studies. The DNases detected at 34, 36 and 38.5 kDa had diverse characteristics. Some of them had characteristics similar...
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Magnolol Inhibits LPS-induced NF-kappaB/Rel Activation by Blocking p38 Kinase in Murine Macrophages

Li MH, Kothandan , Cho SJ, Huong PT, Nan YH, Lee KY, Shin SY, Yea SS, Jeon YJ

This study demonstrates the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to inhibit LPS-induced expression of iNOS gene and activation of NF-kappaB/Rel in RAW 264.7 cells....
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Water Extract of Samultang Reduces Apoptotic Cell Death by H2O2-Induced Oxidative Injury in SK-N-MC Cells

Lee GW, Kim MS

The purpose of this study was to evaluate the effects of the water extract of Samultang (SMT), a Chinese herb, on apoptotic cell death by H2O2-induced oxidative stress in SK-N-MC...
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Time Resolution Improvement of MRI Temperature Monitoring Using Keyhole Method

Han YH, Kim TH, Chun SI, Kim DH, Lee KS, Eun CK, Jun JR, Mun CW

  • KMID: 1471616
  • J Korean Soc Magn Reson Med.
  • 2009 Jun;13(1):31-39.
PURPOSE: This study proposes the keyhole method in order to improve the time resolution of the proton resonance frequency(PRF) MR temperature monitoring technique. The values of Root Mean Square (RMS)...
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The Binding Properties of Glycosylated and Non-Glycosylated Tim-3 Molecules on CD4+CD25+ T Cells

Lee MJ, Heo YM, Hong SH, Kim K, Park S

BACKGROUND: T cell immunoglobulin and mucin domain containing 3 protein (Tim-3) expressed on terminally differentiated Th1 cells plays a suppressive role in Th1-mediated immune responses. Recently, it has been shown...
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The Clinical Significance of Nasopharyngeal Carriages in Immunocompromised Children as Assessed

Kim KH, Shin JH, Kim SY

BACKGROUND: The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in immunocompromized children by using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. METHODS:...
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Detection of nasopharyngeal carriages in children by multiplex reverse transcriptase-polymerase chain reaction

Shin JH, Han HY, Kim SY

PURPOSE: The aim of this study was to determine the prevalence of asymptomatic nasopharyngeal carriages in children using a multiplex reverse transcriptase-polymerase chain reaction (mRT-PCR) assay kit. METHODS: We obtained...
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Apolipoprotein E polymorphisms in the development of hypertensive diseases of pregnancy in Korean women

Nam H, Kang JH, Jun JK

  • KMID: 2077888
  • Korean J Obstet Gynecol.
  • 2008 Jul;51(7):716-724.
OBJECTIVE: Hypertensive disorder in pregnancy is one of the most serious obstetrical complications. Apolipoprotein E (Apo E) genotype is polymorphic and recently it was reported to be associated with preeclampsia....
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Molecular diagnosis of fragile X syndrome in a female child

Jeong SY, Yang JA, Kim HJ

  • KMID: 2184446
  • J Genet Med.
  • 2008 Jun;5(1):41-46.
PURPOSE: Fragile X syndrome (FXS) is the most common heritable cause of cognitive impairment. FXS is caused by hyperexpansion and hypermethylation of a polymorphic CGG trinucleotide repeat in the 5'...
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Development of Ultrasound Phantom for Volume Calibration

Kim HY, Lee JH, Lee KJ, Suh H, Lee R

  • KMID: 2243963
  • Korean J Med Phys.
  • 2008 Dec;19(4):227-230.
The purpose of this study was to design and construct an ultrasound phantom for volume calibration and evaluate the volume measurement accuracy of a 2 dimensional ultrasonic system. Ultrasound phantom...
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Preliminary Study on the MR Temperature Mapping using Center Array-Sequencing Phase Unwrapping Algorithm

Tan KC, Kim TH, Chun SI, Han YH, Choi KS, Lee KS, Jun JR, Eun CK, Mun CW

  • KMID: 2144316
  • J Korean Soc Magn Reson Med.
  • 2008 Dec;12(2):131-141.
PURPOSE: To investigate the feasibility and accuracy of Proton Resonance Frequency (PRF) shift based magnetic resonance (MR) temperature mapping utilizing the selfdeveloped center array-sequencing phase unwrapping (PU) method for non-invasive...
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Transcription Factor Profile by Degenerate RT-PCR/SSCP: Application in 3T3-L1 Adipocyte Treated with TNF-alpha

Kim YL, Lee SH, Choi YK, Chang SY, Kim YS, Kim SK, Park SW, Park WK, Cho YW, Lee SJ

  • KMID: 2331803
  • J Korean Diabetes Assoc.
  • 2007 Sep;31(5):410-420.
BACKGROUND: Several high-throughput gene analysis techniques - differential display PCR, suppression subtraction hybridization (SSH), serial analysis of gene expression (SAGE), and DNA microarray - have permitted transcriptome profiling to understand...
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Effect of antitumor agents on the survival of human hepatocellular carcinoma cells under hypoxic conditions

Lee JY, Lim SH, Park SH, Ahn KS, Suh HS, Lee J

  • KMID: 1962201
  • Korean J Med.
  • 2007 Apr;72(4):384-392.
BACKGROUND: In a previous study, we have shown that quinolones, antibiotics inhibiting topoisomerases, improve survival of tumor cells under hypoxic conditions. In this study, we tested whether antitumor agents such...
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