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Reconstruction of the sciatic nerve using bilateral vascularized sural nerve grafts: a case report

Roh SG, Chun JY, Lee NH, Shin JY, Kim JL

An injury of a peripheral nerve may require reconstruction for motor and sensory function recovery. However, if the nerve defect is long, especially in the lower extremities, reconstruction with successful...
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Quantification of Nerve Viscosity Using Shear Wave Dispersion Imaging in Diabetic Rats: A Novel Technique for Evaluating Diabetic Neuropathy

Liu F, Li D, Xin Y, Liu F, Li W, Zhu J

Objective: Viscoelasticity is an essential feature of nerves, although little is known about their viscous properties. The discovery of shear wave dispersion (SWD) imaging has presented a new approach for...
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Effects of cyanocobalamin and its combination with morphine on neuropathic rats and the relationship between these effects and thrombospondin-4 expression

Düzenli N, Ülker S, Şengül G, Kayhan B, Önal A

Background: Thrombospondin-4 (TSP4) upregulates in the spinal cord following peripheral nerve injury and contributes to the development of neuropathic pain (NP). We investigated the effects of cyanocobalamin alone or in combination...
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Complex Variations in the Course of the Sciatic Nerve and Origin of the Inferior Gluteal Nerve: A Case Report

Park KR, Kim MS, Lee YS, Lee JH

The sciatic nerve (SN) and the inferior gluteal nerve (IGN) exit through the greater sciatic foramen below the piriformis muscle (PM). Its variation is extremely frequent and it may induce...
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The Restorative Effect of Gallic Acid on the Experimental Sciatic Nerve Damage Model

Gurkan G, Erdogan MA, Yigitturk G, Erbas O

Objective : Peripheral nerve injuries occur mostly as a result of mechanical trauma. Due to the microvascular deterioration in peripheral nerve damage, it becomes challenging to remove free oxygen radicals....
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Effect of intravenous dexamethasone on the duration of postoperative analgesia for popliteal sciatic nerve block: a randomized, double-blind, placebo-controlled study

Kim BG, Lee W, Song JH, Yang C, Heo GA, Kim H

Background Intravenous (IV) dexamethasone prolongs the duration of a peripheral nerve block; however, there is little available information about its optimal effective dose. This study aimed to evaluate the effects of...
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Sciatic nerve neurolymphomatosis as the initial presentation of primary diffuse large B-cell lymphoma: a rare cause of leg weakness

Kim KT, Kim SI, Do YR, Jung HR, Cho JH

Neurolymphomatosis (NL) is defined as the involvement of the peripheral nervous system in lymphocytic invasion. It is a very rare form of lymphoma that may occur as an initial presentation...
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Intrapelvic Nerve Entrapment Syndrome Caused by a Variation of the Intrapelvic Piriformis Muscle and Abnormal Varicose Vessels: A Case Report

Kale A, Basol G, Topcu AC, Gundogdu EC, Usta T, Demirhan R

Entrapment neuropathy of the sciatic nerve and pudendal nerve are painful syndromes that are often overlooked by physicians. Laparoscopic surgical interventions for nerve entrapment syndromes of the posterior pelvis focus...
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Does subepineural injection damage the nerve integrity? A technical report from four amputated limbs

Diwan S, Nair A, Sancheti P, Zundert AV

Local anesthetic (LA) injection outside the sheath in epineural or paraneural connective tissue is considered safe practice among regional anesthesiologists. There is limited evidence as to whether neurological complications occur...
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Functional and electron-microscopic changes after differential traction injury in the sciatic nerve of a rat

Byun SH, Ahn KM

Background: During maxillofacial trauma or oral cancer surgery, peripheral nerve might be damaged by traction injury. The purpose of this study was to evaluate functional and histomorphometric changes after traction...
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Extra-spinal sciatica and sciatica mimics: a scoping review

Siddiq MAB, Clegg D, Hasan SA, Rasker JJ

Not all sciatica-like manifestations are of lumbar spine origin. Some of them are caused at points along the extra-spinal course of the sciatic nerve, making diagnosis difficult for the treating...
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Reunification of a split sciatic nerve

Huang B, Decater T, Iwanaga J, Dumont AS, Tubbs RS

Sciatic nerve (SN) variaitons can result in interesting clinical presentations. We identified a SN variant that does not fit into preexisting classification schemes. In an adult male cadaver, the SN...
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Exploring the role and mechanisms of diallyl trisulfide and diallyl disulfide in chronic constriction-induced neuropathic pain in rats

Wang G, Yang Y, Wang C, Huang J, Wang X, Liu Y, Wang H

Background: Garlic oil is a rich source of organosulfur compounds including diallyl disulfide and diallyl trisulfide. There have been studies showing the neuroprotective actions of these organosulfur compounds. However, the...
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Cdk5 Phosphorylation of STAT3 in Dorsal Root Ganglion Neurons Is Involved in Promoting Axonal Regeneration After Peripheral Nerve Injury

Hwang J, Namgung U

Purpose: The goal of this study is to investigate the role of cyclin-dependent kinase 5 (Cdk5) in axonal regeneration in dorsal root ganglion (DRG) neurons after peripheral nerve injury. Methods: Crush...
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Dexmedetomidine Improves Locomotor Function and Alleviates Thermal Hyperalgesia Following Sciatic Nerve Crush Injury in Rats

Jang MS, Han JH, Kim DO, Woo G, Kwon JI, Chung JY, Lee BJ, Yi JW

Purpose: The effects of dexmedetomidine on locomotor function and thermal hyperalgesia in sciatic nerve crush injury (SNCI) were investigated using rats. Methods: After exposing the right sciatic nerve, the sciatic nerve...
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Neuroprotective Effects of Lacosamide in Experimental Peripheral Nerve Injury in Rats : A Prospective Randomized and Placebo-Controlled Trial

Demiroz S, Ur K, Bengu AS, Ulucan A, Atici Y, Erdogan S, Cirakli A, Erdem S

Objective : To evaluate the neuroprotective effects of lacosamide after experimental peripheral nerve injury in rats. Methods : A total of 28 male wistar albino rats weighing 300–350 g were divided...
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Protective Effect of Sphaerococcus coronopifolius Crude Extract in Combination with Bacillus Calmette-Guerin on Ligature-Induced Depression in Female Wistar Rats

Fellah F, Djenidi R, Chebout I

Objective Immunomodulation is a therapeutic technique that modulates the balance of cytokines in the body. In this regard, our experiment was conducted to investigate the potential effect of S. coronopifolius...
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Effective Parameters for Gait Analysis in Experimental Models for Evaluating Peripheral Nerve Injuries in Rats

Matias Júnior I, Medeiros P, de Freita , Vicente-César H, Ferreira Junior JR, Machado HR, Menezes-Reis R

OBJECTIVE: Chronic constriction injury (CCI) of the sciatic nerve is a peripheral nerve injury widely used to induce mononeuropathy. This study used machine learning methods to identify the best gait...
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Iatrogenic Injury to the Sciatic Nerve due to Intramuscular Injection: A Case Report

Park CW, Cho WC, Son BC

Iatrogenic injuries due to intramuscular (IM) injection, although less frequently reported than before, are still common. The sciatic nerve is the most commonly injured nerve because of an IM injection...
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Sciatic nerve leachate of cattle causes neuronal differentiation of PC12 cells via ERK1/2 signaling pathway

Zhang Z, Liu Y, Zhu X, Wei L, Zhu J, Shi K, Wang G, Pan L

Previous studies have shown that the sciatic nerve has neurotrophic activity, and nerve regeneration, differentiation, and axon outgrowth can be modulated by different sciatic nerve preparations. However, numerous animals may...
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