- Microarray Analysis in Spontaneously Hypertensive Rat Heart after Losartan Treatment
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Lee SW, Kim Y, Kim KC, Sohn S, Hong YM
- KMID: 2171364
- Ewha Med J.
- 2016 Apr;39(2):45-50.
- doi: 10.12771/emj.2016.39.2.45
OBJECTIVES: Spontaneously hypertensive rats (SHR) are frequently used as rat models of essential hypertension. The mechanism for the development of hypertension is complicated and it is unknown. The renin-angiotensin system... -
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- The Effects of CCl4 on the Expressions of Aquaporin and Superoxide Dismutase in the Kidney of the Spontaneously Hypertensive Rat
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Kim KT, Lee D, Seo YK, Kim SY
- KMID: 2283757
- Korean J Phys Anthropol.
- 2015 Jun;28(2):87-101.
- doi: 10.11637/kjpa.2015.28.2.87
Carbon tetrachloride (CCl4) induces hepatocellular damage, resulting in liver cirrhosis by generating reactive oxygen species (ROS). At the stage of decompensated liver cirrhosis, many patients suffer from the abnormal regulation... -
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- Effects of kimchi supplementation on blood pressure and cardiac hypertrophy with varying sodium content in spontaneously hypertensive rats
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Lee SM, Cho Y, Chung HK, Shin DH, Ha WK, Lee SC, Shin MJ
- KMID: 2313610
- Nutr Res Pract.
- 2012 Aug;6(4):315-321.
We tested the effects of dietary intake of freeze-dried Korean traditional fermented cabbage (generally known as kimchi) with varying amounts of sodium on blood pressure and cardiac hypertrophy in spontaneously... -
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- Development and Changes with Age of Detrusor Overactivity in Spontaneous Hypertensive Rats as Observed by Simultaneous Registrations of Intravesical and Intraabdominal Pressures
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Jin LH, Lee HJ, Shin HY, Choi BH, Yoon SM, Park CS, Lee T
- KMID: 2232819
- Int Neurourol J.
- 2011 Dec;15(4):192-198.
PURPOSE: Overactive bladder is especially common in the elderly, although it is not regarded as a normal part of aging. Thus, we investigated how aging alters the cystometric and detrusor... -
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- Imatinib Mesylate Attenuates Cardiac Fibrosis in Spontaneously Hypertensive Rats
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Choo EH, Ihm SH, Kim OR, Jang SW, Park CS, Kim HY, Chang K, Youn HJ, Chung WS, Seung KB, Kim JH
- KMID: 2196454
- J Korean Soc Hypertens.
- 2011 Jun;17(2):48-56.
- doi: 10.5646/jksh.2011.17.2.48
BACKGROUND: Hypertensive myocardial fibrosis promotes abnormalities of cardiac function that may adversely affect the clinical outcome of hypertensive patients. Imatinib mesylate blocks receptor tyrosine kinase and is clinically used to... -
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- Comparison of ANG II-mediated [Ca2+i, IP3 Production and [ATP]i in Isolated Renal Proximal Convoluted Tubules of Adult SHR and WKY
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Kwak JO, Kim HW, Cha SH
- KMID: 2254877
- Korean J Nephrol.
- 2004 Nov;23(6):848-858.
BACKGROUND: The renin angiotensin syaimstem plays an important role in hypertension. Therefore, the purpose of this study was to investigate the comparison of responsiveness to angiotensin II (ANG II) in... -
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- Supplementary Effect of Lentinus Edodes on Serum and Hepatic Lipid Levels in Spontaneously Hypertensive Rat
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Lee SH, Park HJ, Cho SY, Jeong HJ
- KMID: 2269791
- Korean J Nutr.
- 2004 Sep;37(7):509-514.
This study was conducted to investigate the supplementary effects of Lentinus edodes on blood pressure and blood lipid levels in the Hypertensive Rat. We supplied 3 kinds of experimental diets... -
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- Age-Related Changes of Catalase Immunoreactivity in the Main Olfactory Bulbs of Wistar and Spontaneously Hypertensive Rats
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Kim DS, Yoo KY, An SJ, Park SK, Hwang IK, Jung JY, Lee KW, Cho JH, Kang TC, Won MH
- KMID: 2092804
- Korean J Anat.
- 2003 Oct;36(5):353-361.
The reactive oxygen species (ROS) is well-known for the causative factors inducing ischemia, Parkinson's disease, Alzheimer, amylotrophic lateral sclerosis, hypertension and aging. Catalase (CAT) is an important endogenous antioxidant enzyme... -
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- Changes in Myogenic Tone in Spontaneously Hypertensive Rat: Role of RhoA and Protein Kinase C
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Seo JP, Ryu SK, Kang NY, Ahn DS, Lee YH
- KMID: 1938907
- Korean Circ J.
- 2002 Mar;32(3):257-267.
- doi: 10.4070/kcj.2002.32.3.257
BACKGROUND AND OBJECTIVES: The myogenic response was originally described as a contraction of a blood vessel that occurred following an increase in intravascular distending pressure. Conversely, a reduction in intravascular... -
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- Apoptosis in Kidney and the Heart of the Spontaneously Hypertensive Rats
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Yoon SC, Kim YK, Kim YJ
- KMID: 2254929
- Korean J Nephrol.
- 2000 May;19(3):383-391.
BACKGROUND: The terminal features of hypertensive target organ damage include decrease in the kidney size and increase in the heart size and wall thickness. Increased apoptosis has been known in... -
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- Cholinergic activity related to cardiovascular regulation in rostral ventrolateral medulla of spontaneously hypertensive rats
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Lee SY, Lee SB
- KMID: 1917067
- Korean J Physiol Pharmacol.
- 1999 Feb;3(1):29-34.
The hyperactivity of cholinergic system in the RVLM of spontaneously hypertensive rats (SHR) may contribute to the sustained elevation of blood pressure. However, the hyperactivity mechanisms of cholinergic system are controversial. Thus, to... -
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- Altered renal expression of nitric oxide synthase isozymes in spontaneously hypertensive rats
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Kim SW, Moon KH, Lee SC, Kim NH, Kang DG, Lee JU, Choi KC, Kang YJ
- KMID: 759080
- Korean J Intern Med.
- 1999 Jan;14(1):21-26.
OBJECTIVES: The present study was aimed at exploring whether the pathogenesis of hypertension is related with an altered expression of nitric oxide synthase (NOS) isozymes, i.e., bNOS, iNOS... -
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- Distribution of the Dopamine D1 and D2 Receptor Protein Using Immunohistochemistry in Wistar-Kyoto Rat (WKY) and Spontaneously Hypertensive Rat (SHR) Kidneys
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Chang SH, Lee JD, Cho GJ, Koh PO, Choi WS, Chung SI
- KMID: 1990093
- Korean J Nephrol.
- 1998 Nov;17(6):841-852.
The kidney and balances of fluid and volume are the basic components of bloocl pressure control, and the kidney is the primary site that initiates the hypertensive process and is... -
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- Morphologic studies of the retina in a new diabetic model; SHR/N:Mcc-cp rat
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Kim SH, Chu YK, Kwon OW, McCune SA, Davidorf F
- KMID: 711583
- Yonsei Med J.
- 1998 Oct;39(5):453-462.
- doi: 10.3349/ymj.1998.39.5.453
The pathogenesis of diabetic retinopathy has not been fully explained. The earliest histological lesion is the loss of intramural pericytes and thickening of the basement membrane. Increased activity of the... -
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- Distributional patterns of phospholipase C isozymes in heart and brain of spontaneously hypertensive and normotensive rats
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Choi JW, Cho YJ, Cha SH, Lee KH, Lee SB
- KMID: 2071510
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):385-392.
The phospholipase C (PLC)-mediated intracellular signal transduction pathway is considered to be involved in the regulation of blood pressure. However, little information is available concerning the distributional and functional significance of PLC in... -
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- Studies on the structural changes of aortic media and its repairing effect by enalapril in spontaneously hypertensive rats
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Hong SP, Chung CH
- KMID: 2229234
- Korean Circ J.
- 1993 Jun;23(3):426-439.
- doi: 10.4070/kcj.1993.23.3.426
BACKGROUND: It has been known that arteries of hypertensive animals and patients are generally thicker and more rigid than those of normal subjects, resulting from the morphological changes induced by... -
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- Influence of Enalapril on Blood Pressure in Spontaneously Hypertensive Rats
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Huh HH, Son UD, Kim CY, Bae JD
- KMID: 2229139
- Korean Circ J.
- 1991 Jun;21(3):539-545.
- doi: 10.4070/kcj.1991.21.3.539
We aimed to evaluate the long term trantment of enalapril on the vascular response in the isolated aorta, and in anesthetized or pithed spontaneously hypertensive rats(SHR). In the isolated aorta,... -
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