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Knockdown of CPEB1 and CPEB4 Inhibits Scar Formation via Modulation of TAK1 and SMAD Signaling

Cui HS, Lee YR, Ro YM, Joo SY, Cho YS, Kim JB, Kim DH, Seo CH

Background: Cytoplasmic polyadenylation element binding (CPEB) proteins are sequencespecific RNA-binding proteins that control translation via cytoplasmic polyadenylation. We previously reported that CPEB1 or CPEB4 knockdown suppresses TAK1 and SMAD signaling...
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A case of papillary fibroelastoma in the left ventricle

Hyun JY, Jung IH, Lee HJ, Lee SJ, Kim JS, Na CY, Ro YM

Cardiac papillary fibroelastoma (CPF) is a rare and benign primary cardiac neoplasm of unknown prevalence. The incidence of CPF in the left ventricle is lower than that in other parts...
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A Case of a Pulmonary Arteriovenous Malformation With Ebstein's Anomaly

Park K, Kim C, Lim DS, Ro YM, Park J, Chun S, Lim S, Cho H, Lee S, Kim SE

A pulmonary arteriovenous malformation (PAVM) is a rare pulmonary vascular anomaly presenting as dyspnea or recurrent epistaxis. Ebstein's anomaly (EA), a congenital cardiac malformation, is also a rare condition. There...
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Effects of Granulocyte-Colony Stimulating Factor and Bone Marrow Mononuclear Cells on Cardiac Function and Remodeling in the Porcine Reperfused Myocardial Infarction Model

Park MY, Lim DS, Choi SC, Fang YH, Kim JH, Hong SJ, Shin SH, Ro YM, Shim WJ

BACKGROUND: Granulocyte stimulating factor (G-CSF) and bone marrow mononuclear cells (BM-MNC) were reported to improve cardiac function after myocardial infarction (MI). This study was to examine their combined beneficial effects...
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A Case of Hepatopulmonary Syndrome in a Patient with Child-Pugh Class A Liver Cirrhosis

Kim JS, Kim C, Kim GS, Lim DS, Hwang HK, Ro YM

  • KMID: 2319149
  • Tuberc Respir Dis.
  • 2009 Jan;66(1):47-51.
Hepatopulmonary syndrome (HPS) is characterized by a defect in arterial oxygenation that's induced by pulmonary vascular dilatation in the setting of liver disease. Some studies have shown the relationship between...
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Deep Vein Thrombosis and Pulmonary Embolism in the 8th Week of Pregnancy

Ha SH, Choi RK, Jang JW, Lim DS, Hwang HK, Ro YM

A 29-year-old woman in her 8th week of pregnancy was referred to our hospital for swelling in the lower extremities, rapid onset of dyspnea (1 hr) and pre-syncope. Severe right...
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Efficacy of the Computer Program to Compensate Color Vision Deficiency using Seohan Computerized 85-Hue Test

Shin YJ, Wee WR, Lee JH, Yang SJ, Ro YM

  • KMID: 2337428
  • J Korean Ophthalmol Soc.
  • 2006 Oct;47(10):1638-1646.
PURPOSE: to study the utility of a program which diagnoses and compensates for color defects on computer monitors according to the severity and type of color vision deficiency (CVD). METHODS: Twenty-eight...
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Decrease in Plasma Adiponectin Concentrations in Patients with Vasospastic Angina

Hong SJ, Park CG, Seo HS, Rha SW, Kim JW, Oh DJ, Kwon JA, Lee KN, Jang YS, Ro YM

BACKGROUND AND OBJECTIVES: Plasma adiponectin, which decreases the progression of atherosclerosis and insulin resistance, as well as suppressing lipid accumulation in macrophages, is decreased in patients with acute myocardial infarction...
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Effect of Human Bcl-2 Gene Expression on the Peripheral Atherosclerotic Lesions of Apolipoprotein E-Deficient Mouse

Park SW, Seo HS, Kim JW, Hong SJ, Shin SH, Rha SW, Ahn JC, Song WH, Park CG, Shim WJ, Oh DJ, Ro YM

BACKGROUND AND OBJECTIVES: Bcl-2 protein is related to the inhibition of apoptosis via the mitochondrial pathway and Bcl-2's anti-oxidant effect. During the development of atherosclerosis, apoptosis is known to play...
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Plasma Renin Activity and Clinical Implication in Korean Hypertensive Patients

Suh SY, Park CG, Chwe UR, Kim JW, Rha SW, Seo HS, Oh DJ, Ro YM

BACKGROUND AND OBJECTIVES: Angiotension II, the active component in the renin angiotensin system, modulates blood pressure via vasoconstriction and sodium retention. In normal subjects, the active level of the RAS...
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Antifibrillatory and Proarrhythmic Effects of d,l-Sotalol Mediated by the Action Potential Duration Restitution Kinetics

Pak HN, Kim YH, Hwang GS, Lee SJ, Lee HS, Lim HE, Ro YM

BACKGROUND AND OBJECTIVES: The action potential duration (APD) restitution kinetics has been known to play a crucial role in the initiation and maintenance of ventricular tachycardia (VT)/fibrillation (VF). We hypothesized...
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Changes of Coronary Blood Flow in Vasospastic Angina under Cold Stimulation by Transthoracic Doppler Echocardiography

Park SM, Shim WJ, Ahn JC, Lim DS, Kim YH, Ro YM

This study was done to evaluate changes of microvascular function under cold stimulation by measuring coronary flow velocities (CFVs) in vasospastic angina (VA) patients using transthoracic Doppler echocardiography (TTDE). 14...
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Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting for Diabetics with Multivessel Coronary Artery Disease: The Korean Multicenter Revascularization Registry (KORR)

Gwon HC, Choi SH, Choi BI, Cho SY, Ro YM, Lee WR, KORR Investigators

This study was designed to assess the relative merits of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in multivessel coronary artery disease (MVCAD), particularly for Korean diabetics....
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The Source of Inflammatory Response and Platelet Activation in Patients with Acute Myocardial Infarction

Shin SH, Oh DJ, Lim HE, Park SM, Kim EJ, Lee SJ, Ahn JC, Park CG, Seo HS, Ro YM

BACKGROUND AND OBJECTIVES: Studies on the stability of atheromatous plaques, as a determinant of the cause of complications, have been reported. Among the functional features of plaques related with vulnerability,...
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Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery in an Elderly Patient Visualized by Three-Dimensional Multidetector Computed Tomograph Coronary Angiography

Rha SW, Park CG, Yong HS, Suh SY, Moon SK, Hong SJ, Kim JW, Seo HS, Oh DJ, Ro YM

An anomalous origin of the left coronary artery (LCA )from the pulmonary artery (ALCAPA syndrome )or Bland-White-Garland syndrome is a rare congenital cardiac anomaly. We report a 65-year old female...
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Time-Related Alterations of Endogenous Ouabain in DOCA-Salt Hypertensive Rats

Park CG, Hong SJ, Suh SY, Lim HE, Kim JW, Seo HS, Oh DJ, Ro YM

BACKGROUND AND OBJECTIVES: Controversy exists regarding the role of endogenous ouabain in the pathogenesis of DOCA-salt induced hypertension. The purpose of this study was to investigate the role of endogenous...
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Early Assessment of Myocardial Contractility by Contrast-Enhanced Magnetic Resonance (ceMRI) Imaging after Revascularization in Acute Myocardial Infarction (AMI)

Lim HE, Yong HS, Shin SH, Ahn JC, Seo HS, Oh DJ, Ro YM, Park CG

  • KMID: 1109519
  • Korean J Intern Med.
  • 2004 Dec;19(4):213-219.
BACKGROUND: Recent studies have demonstrated that the size and shape of the hyperenhanced areas on contrast-enhanced magnetic resonance imaging (ceMRI) were nearly identical to areas of irreversible injury, as defined...
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5-azacytidine induces cardiac differentiation of P19 embryonic stem cells

Choi SC, Yoon JH, Shim WJ, Ro YM, Lim DS

  • KMID: 1103318
  • Exp Mol Med.
  • 2004 Dec;36(6):515-523.
The P19 embryonal carcinoma cell line is a useful model cells for studies on cardiac differentiation. However, its low efficacy of differentiation hampers its usefulness. We investigated the effect of...
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An Appraisal of the Electrocardiographic Criteria for Diagnosis of Left Ventricular Hypertrophy in Koreans: Comparison to Echocardiographic Measurement of Left Ventricular Mass

Park SM, Ro YM, Ahn JC, Lim DS, Park CG, Kim YH, Seo HS, Shim WJ, Oh DJ

BACKGROUND AND OBJECTIVES: Left ventricular hypertrophy (LVH) is associated with an increased risk of cardiovascular morbidity and mortality. Electrocardiography (ECG) is a widely available, simple and cost-effective screening method for...
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Gene Expression and Ultrastructural Remodeling in Persistent Atrial Fibrillation

Hwang GS, Kim YH, Kim MK, Lee JH, Rha SW, Lim DS, Ro YM, Park HL

BACKGROUND: Atrial fibrillation (AF) has a tendency to become persistent over time and is known to induce atrial electrical, mechanical and ionic remodeling. However, the underlying mechanisms by which AF...
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