- Guidelines for Cancer Care during the COVID-19 Pandemic in South Korea
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Lee JB, Jung M, Kim JH, Kim BH, Kim Y, Kim YS, Kim BC, Kim J, Moon SH, Park KU, Park M, Park HJ, Sim SH, Yoon HM, Lee SJ, Lee E, Chun JY, Chung YK, Jung SY, Chung J, Lee ES, Chung HC, Yun T, Rha SY
- KMID: 2514915
- Cancer Res Treat.
- 2021 Apr;53(2):323-329.
- doi: 10.4143/crt.2020.1256
At the end of 2019, the cause of pneumonia outbreaks in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In February 2020, the World Health... -
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- Transcriptome analysis of iBET-151, a BET inhibitor alone and in combination with paclitaxel in gastric cancer cells
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Kang SK, Bae HJ, Kwon WS, Che J, Kim TS, Chung HC, Rha SY
- KMID: 2510352
- Genomics Inform.
- 2020 Dec;18(4):e37.
- doi: 10.5808/GI.2020.18.4.e37
BET inhibitor, as an epigenetic regulator inhibitor, reduces the expression of oncogenes such as Myc and Bcl-2, which affects cancer growth and development. However, it has modest activity because of... -
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- Synergistic Antitumor Effects of Combined Treatment with HSP90 Inhibitor and PI3K/mTOR Dual Inhibitor in Cisplatin-Resistant Human Bladder Cancer Cells
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Kim HJ, Gong MK, Yoon CY, Kang J, Yun M, Cho NH, Rha SY, Choi YD
- KMID: 2503353
- Yonsei Med J.
- 2020 Jul;61(7):587-596.
- doi: 10.3349/ymj.2020.61.7.587
Purpose: The current study aimed to investigate the synergistic antitumor effect of combined treatment with 17-DMAG (HSP90 inhibitor) and NVP-BEZ235 (PI3K/mTOR dual inhibitor) on cisplatin-resistant human bladder cancer cells. Materials and... -
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- Temsirolimus in Asian Metastatic/Recurrent Non-clear Cell Renal Carcinoma
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Lee JB, Park HS, Park S, Lee HJ, Kwon KA, Choi YJ, Kim YJ, Nam CM, Cho NH, Kang B, Chung HC, Rha SY
- KMID: 2460606
- Cancer Res Treat.
- 2019 Oct;51(4):1578-1588.
- doi: 10.4143/crt.2018.671
PURPOSE: Temsirolimus is effective in the treatment for metastatic non-clear cell renal cell carcinoma (nccRCC) with poor prognosis. We aim to investigate the efficacy and tolerability of temsirolimus in treatment... -
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- Characteristics and Treatment Patterns of Patients with Advanced Soft Tissue Sarcoma in Korea
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Kim HS, Nam CM, Jang SY, Choi SK, Han M, Kim S, Moneta MV, Lee SY, Cho JM, Novick D, Rha SY
- KMID: 2460587
- Cancer Res Treat.
- 2019 Oct;51(4):1380-1391.
- doi: 10.4143/crt.2018.476
PURPOSE: A soft tissue sarcoma (STS) is a rare type of cancer, accounting for 1% of adult solid cancers. The aim of the present study is to determine the incidence... -
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- Behaviors and Attitudes toward the Use of Complementary and Alternative Medicine among Korean Cancer Patients
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Kwon JH, Lee SC, Lee MA, Kim YJ, Kang JH, Kim JY, Lee HJ, Bae WK, Kim MJ, Chie EK, Kim J, Kim YH, Chung HC, Rha SY
- KMID: 2454278
- Cancer Res Treat.
- 2019 Jul;51(3):851-860.
- doi: 10.4143/crt.2019.137
PURPOSE: A cross-sectional survey was conducted to explore the current awareness and use of complementary and alternative medicine (CAM), as well as attitudes toward CAM, in patients with cancer and... -
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- Significance of Metabolic Tumor Volume and Total Lesion Glycolysis Measured Using ¹â¸F-FDG PET/CT in Locally Advanced and Metastatic Gallbladder Carcinoma
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Chun YJ, Jeung HC, Park HS, Park JS, Rha SY, Choi HJ, Lee JH, Jeon TJ
- KMID: 2450399
- Yonsei Med J.
- 2019 Jul;60(7):604-610.
- doi: 10.3349/ymj.2019.60.7.604
PURPOSE: This study aimed to determine the prognostic value of new quantitative parameters of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), including metabolic tumor volume (MTV), in patients with locally... -
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- Immunohistochemistry Biomarkers Predict Survival in Stage II/III Gastric Cancer Patients: From a Prospective Clinical Trial
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Kim MH, Zhang X, Jung M, Jung I, Park HS, Beom SH, Kim HS, Rha SY, Kim H, Choi YY, Son T, Kim HI, Cheong JH, Hyung WJ, Noh SH, Chung HC
- KMID: 2464427
- Cancer Res Treat.
- 2019 Apr;51(2):819-831.
- doi: 10.4143/crt.2018.331
PURPOSE: Identification of biomarkers to predict recurrence risk is essential to improve adjuvant treatment strategies in stage II/III gastric cancer patients. This study evaluated biomarkers for predicting survival after surgical... -
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- Landscape of Actionable Genetic Alterations Profiled from 1,071 Tumor Samples in Korean Cancer Patients
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Lee SH, Lee B, Shim JH, Lee KW, Yun JW, Kim SY, Kim TY, Kim YH, Ko YH, Chung HC, Yu CS, Lee J, Rha SY, Kim TW, Jung KH, Im SA, Moon HG, Cho S, Kang JH, Kim J, Kim SK, Ryu HS, Ha SY, Kim JI, Chung YJ, Kim C, Kim HL, Park WY, Noh DY, Park K
- KMID: 2437614
- Cancer Res Treat.
- 2019 Jan;51(1):211-222.
- doi: 10.4143/crt.2018.132
PURPOSE: With the emergence of next-generation sequencing (NGS) technology, profiling a wide range of genomic alterations has become a possibility resulting in improved implementation of targeted cancer therapy. In Asian... -
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- S-1 Based Doublet as an Adjuvant Chemotherapy for Curatively Resected Stage III Gastric Cancer: Results from the Randomized Phase III POST Trial
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Lee CK, Jung M, Kim HS, Jung I, Shin DB, Kang SY, Zang DY, Kim KH, Lee MH, Kim BS, Lee KH, Cheong JH, Hyung WJ, Noh SH, Chung HC, Rha SY
- KMID: 2437593
- Cancer Res Treat.
- 2019 Jan;51(1):1-11.
- doi: 10.4143/crt.2018.028
PURPOSE: We conducted a randomized, multicenter, phase III trial to compare S-1 plus docetaxel (DS) with S-1 plus cisplatin (SP) as adjuvant chemotherapy for stage III gastric cancer patients. MATERIALS AND... -
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- Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions
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Lee SH, Kim JE, Jang HS, Park KH, Oh BH, Shin SJ, Chung KY, Roh MR, Rha SY
- KMID: 2424809
- Cancer Res Treat.
- 2018 Oct;50(4):1378-1387.
- doi: 10.4143/crt.2017.535
PURPOSE: Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between... -
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- CpG Island Methylator Phenotype and Methylation of Wnt Pathway Genes Together Predict Survival in Patients with Colorectal Cancer
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Kim SH, Park KH, Shin SJ, Lee KY, Kim TI, Kim NK, Rha SY, Ahn JB
- KMID: 2412649
- Yonsei Med J.
- 2018 Jul;59(5):588-594.
- doi: 10.3349/ymj.2018.59.5.588
PURPOSE: Dysregulation of the Wnt pathway is a crucial step in the tumorigenesis of colorectal cancer (CRC). This study aimed to determine whether DNA methylation of Wnt pathway genes helps... -
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- Pazopanib for the Treatment of Non-clear Cell Renal Cell Carcinoma: A Single-Arm, Open-Label, Multicenter, Phase II Study
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Jung KS, Lee SJ, Park SH, Lee JL, Lee SH, Lim JY, Kang JH, Lee S, Rha SY, Lee KH, Kim HY, Lim HY
- KMID: 2411137
- Cancer Res Treat.
- 2018 Apr;50(2):488-494.
- doi: 10.4143/crt.2016.584
PURPOSE: The optimal treatment strategy for patients with metastatic non-clear cell type renal cell carcinoma (nccRCC) remains unclear. Although several inhibitors of vascular endothelial growth factor have recently shown efficacy... -
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- Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee
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Kim MJ, Kim YS, Oh SY, Lee S, Choi YJ, Seol YM, Park MJ, Kim KH, Park LC, Kang JH, Hwang IG, Lee SI, Lim ST, Kim HS, Lim HY, Rha SY, Kim HJ
- KMID: 2411550
- Korean J Intern Med.
- 2018 Mar;33(2):383-390.
- doi: 10.3904/kjim.2015.162
BACKGROUND/AIMS: Because of rarity, role of chemotherapy of bladder adenocarcinoma are still unidentified. Therefore, we performed a retrospective analysis of the clinical features and chemotherapy outcomes of bladder adenocarcinoma. METHODS: Eligible... -
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- Rab25 augments cancer cell invasiveness through a β1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin
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Jeong BY, Cho KH, Jeong KJ, Park YY, Kim JM, Rha SY, Park CG, Mills GB, Cheong JH, Lee HY
- KMID: 2438365
- Exp Mol Med.
- 2018 Jan;50(1):e435.
- doi: 10.1038/emm.2017.248
The small GTP-binding protein Rab25 is associated with tumor formation and progression. However, recent studies have shown discordant effects of Rab25 on cancer cell progression depending on cell lineage. In... -
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- Deep vein thrombosis caused by malignant afferent loop obstruction
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Kang EG, Kim C, Lee J, Cha MU, Kim JH, Park SH, Kim MD, Lee DY, Rha SY
- KMID: 2366134
- Yeungnam Univ J Med.
- 2016 Dec;33(2):166-169.
- doi: 10.12701/yujm.2016.33.2.166
Afferent loop obstruction following gastrectomy is a rare but fatal complication. Clinical features of afferent loop obstruction are mainly gastrointestinal symptoms. A 56-year-old female underwent radical total gastrectomy with Roux-en-Y... -
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- Efficacy and Toxicity of Mammalian Target Rapamycin Inhibitors in Patients with Metastatic Renal Cell Carcinoma with Renal Insufficiency: The Korean Cancer Study Group GU 14-08
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Kim KH, Kim JH, Lee JY, Kim HS, Heo SJ, Kim JH, Kim HY, Rha SY
- KMID: 2356230
- Cancer Res Treat.
- 2016 Oct;48(4):1286-1292.
- doi: 10.4143/crt.2016.018
PURPOSE: We evaluated the efficacy and toxicity of mammalian target rapamycin inhibitors in Korean patients with metastatic renal cell carcinoma (mRCC) with chronic renal insufficiency not requiring dialysis. MATERIALS AND METHODS:... -
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- Fibroblast Growth Factor Receptor 1 Overexpression Is Associated with Poor Survival in Patients with Resected Muscle Invasive Urothelial Carcinoma
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Lim S, Koh MJ, Jeong HJ, Cho NH, Choi YD, Cho DY, Lee HY, Rha SY
- KMID: 2374112
- Yonsei Med J.
- 2016 Jul;57(4):831-839.
- doi: 10.3349/ymj.2016.57.4.831
PURPOSE: To examine the usefulness of various receptor tyrosine kinase expressions as prognostic markers and therapeutic targets in muscle invasive urothelial cancer (UC) patients. MATERIALS AND METHODS: We retrospectively analyzed the... -
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- PTEN Methylation Dependent Sinonasal Mucosal Melanoma
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Lee SH, Roh MR, Kang B, Park KH, Kim SH, Lee SE, Rha SY
- KMID: 2454366
- Cancer Res Treat.
- 2016 Apr;48(2):853-858.
- doi: 10.4143/crt.2014.356
Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations... -
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- A Retrospective Analysis for Patients with HER2-Positive Gastric Cancer Who Were Treated with Trastuzumab-Based Chemotherapy: In the Perspectives of Ethnicity and Histology
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Yi JH, Kang JH, Hwang IG, Ahn HK, Baek HJ, Lee SI, Lim DH, Won YW, Ji JH, Kim HS, Rha SY, Oh SY, Lee KE, Lim T, Maeng CH, Kim MJ, Kim ST, Lee J, Park JO, Park YS, Lim HY, Kang WK, Park SH
- KMID: 2454332
- Cancer Res Treat.
- 2016 Apr;48(2):553-560.
- doi: 10.4143/crt.2015.155
PURPOSE: While the Trastuzumab for Gastric Cancer (ToGA) trial demonstrated the efficacy and safety of trastuzumab-based chemotherapy in HER2-positive metastatic gastric cancer, the overall survival (OS) benefit was not found... -
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