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Mouse models for hepatitis B virus research

Hwang JR, Park SG

Hepatitis B virus (HBV) infection remains a major global health problem; indeed, there are 250 million carriers worldwide. The host range of HBV is narrow; therefore, few primates are susceptible...
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miR-215 Enhances HCV Replication by Targeting TRIM22 and Inactivating NF-κB Signaling

Tian H, He Z

PURPOSE: Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associated with HCV infection. This study aimed to investigate the...
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Characterization of Extended-Spectrum β-Lactamase Genes of Shigella flexneri Isolates With Fosfomycin Resistance From Patients in China

Liu Y, Cheng Y, Yang H, Hu L, Cheng J, Ye Y, Li J

BACKGROUND: The emergence of fosfomycin resistance and extended-spectrum β-lactamase (ESBL) genes is a serious threat to public health and a new challenge in shigellosis treatment. The purpose of this study...
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Multidrug Resistance Mechanisms of Carbapenem Resistant Klebsiella pneumoniae Strains Isolated in Chongqing, China

Yan J, Pu S, Jia X, Xu X, Yang S, Shi J, Sun S, Zhang L

BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is considered a serious global threat. However, little is known regarding the multidrug resistance (MDR) mechanisms of CRKP. This study investigated the phenotypes and MDR...
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Profiling of antimicrobial resistance and plasmid replicon types in beta-lactamase producing Escherichia coli isolated from Korean beef cattle

Shin SW, Jung M, Shin MK, Yoo HS

In this study, 78 isolates of Escherichia coli isolated from Korean beef cattle farms were investigated for the production of extended-spectrum beta-lactamase (ESBL) and/or AmpC beta-lactamase. In the disc diffusion...
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Development of porcine respiratory and reproductive syndrome virus replicon vector for foot-and-mouth disease vaccine

Jeeva S, Lee JA, Park SY, Song CS, Choi IS, Lee JB

PURPOSE: Foot-and-mouth disease (FMD) is an economically important global animal disease. To control FMD virus (FMDV) outbreaks, a lot of different novel approaches have been attempted. In this study, we...
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HMG CoA Reductase Inhibitors Inhibit HCV RNA Replication of HCV Genotype 1b but Not 2a

Chang KS, Jo HJ

Replication of hepatitis C virus (HCV) is regulated by statin, one of 3-hydroxy-3-methylglutaryl CoA reducatase (HMG CoA reductase) inhibitors that block mevalonate pathway and cholesterol biosyntheis, which has been used...
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Dissemination of Plasmid-mediated qnr, aac(6')-Ib-cr, and qepA Genes Among 16S rRNA Methylase Producing Enterobacteriaceae in Korea

Kang HY, Tamang MD, Seol SY, Kim J

Plasmid-mediated quinolone resistance (PMQR) genes: qnr, aac(6')-Ib-cr, and qepA were investigated among 153 armA and 51 rmtB-positive transconjugants and their 204 clinical isolates of Enterobacteriaceae. Overall, qnrB4 and aac(6')-Ib-cr genes...
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Evidence for the Presence of a cis-acting Element in the Coding Region of the Japanese Encephalitis Virus Capsid Protein

Yun SI, Choi YJ, Song BH, Kim JM, Kang SY, Lee YM

Japanese encephalitis virus (JEV) is a member of mosquito-borne flaviviruses. To investigate whether there is a cis-acting genetic element in the coding region of the JEV C protein, which is...
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The Role of Integrons in the Spread of Multi-drug Resistance

Jang SJ

  • KMID: 2224686
  • Korean J Clin Microbiol.
  • 2005 Apr;8(1):1-9.
The liberal use of antibiotics in human medicine and animal husbandry has promoted the spread of multiple antibiotic resistance. Molecular mechanisms for the acquisition of resistance genes by integron-mediated recombination...
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Expression of Angiostatin Using DNA-Based Semliki Forest Virus Replicon

Choi YS, Lee JS, Choi YK, Shin KS, Kim HS, Kim CJ

  • KMID: 1101573
  • J Vet Sci.
  • 2002 Mar;3(1):41-45.
Angiogenesis is recognized as a critical factor in the growth of tumor cells and plays a key role in the tumor metastasis. Recent studies for antiangiogenic substances are getting popular....
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Construction of a Mycobacterium - Escherichia coli Shuttle Vector and Use in the Expression of Foreign Genes in Mycobacteria

Cho SN, Kim JD, Lee HY, Kim HJ

  • KMID: 1540524
  • J Korean Soc Microbiol.
  • 1997 Jun;32(3):293-300.
The ability to introduce recombinant DNA molecules back into mycobacteria would greatly increase the potential of molecular genetic approaches for the study of mycobacteria as well as for the use...
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