- The Rescue on Reperfusion Damage in Cerebral Infarction by Nelonemdaz (RODIN) Trial: Protocol for a Double-Blinded Clinical Trial of Nelonemdaz in Patients with Hyperacute Ischemic Stroke and Endovascular Thrombectomy
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Lee JS, Lee JS, Gwag BJ, Choi DW, An CS, Kang HG, Song TJ, Ahn SH, Kim CH, Shin DI, Kwon SU
- KMID: 2539069
- J Stroke.
- 2023 Jan;25(1):160-168.
- doi: 10.5853/jos.2022.02453
Background and Purpose Nelonemdaz (Neu2000) has both selective antagonism against 2B subunit of N-methyl-D-aspartate receptor and antioxidant activity. This drug provides sufficient evidence of neuroprotection in acute cerebral ischemia/reperfusion models.... -
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- Contralateral Cortical Subarachnoid Hemorrhage as a Manifestation of Hyperperfusion Syndrome after Carotid Artery Stenting
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Kim SM, Kang S, Shin DH, Ahn SH
- KMID: 2535878
- J Korean Neurol Assoc.
- 2022 Oct;40(4):343-348.
- doi: 10.17340/jkna.2022.4.12
Cerebral hyperperfusion syndrome is a rare but serious complication of carotid revascularization, and characterized by ipsilateral headache, hypertension, seizures, and focal neurological deficits. Therefore, treatment strategies are directed towards regulation... -
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- Didymin Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the PPAR Signaling Pathway
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Li Q, Zhang H, Liu X
- KMID: 2533398
- Yonsei Med J.
- 2022 Oct;63(10):956-965.
- doi: 10.3349/ymj.2022.0040
Purpose: Cerebral ischemia-reperfusion (IR) injury is a severe secondary injury induced by reperfusion after stroke. Didymin has been reported to have a protective effect on intracerebral hemorrhage. However, the underlying... -
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- White Cord Syndrome: A Reperfusion Injury Following Spinal Decompression Surgery
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So JS, Kim YJ, Chung J
- KMID: 2538477
- Korean J Neurotrauma.
- 2022 Oct;18(2):380-386.
- doi: 10.13004/kjnt.2022.18.e36
Reperfusion injury of the spinal cord has been scarcely reported. Herein, we present a case of white cord syndrome after spinal decompression. A 61-year-old male, who initially had ossification of... -
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- Multiple Cerebral Hemorrhages Caused by Paradoxical Reperfusion Injury After Cranioplasty
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Oh HJ, Shim JJ, Ahn JM, Oh JS, Yoon SM
- KMID: 2538469
- Korean J Neurotrauma.
- 2022 Oct;18(2):335-340.
- doi: 10.13004/kjnt.2022.18.e28
Cranioplasty-related reperfusion injury has rarely been reported. Although there are several hypotheses, particularly regarding the mechanisms of the event, clear evidence is lacking. Here, we report the case of an... -
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- Beneficial Effects of Insulin on Ischemia Reperfusion Injury in Human Skeletal Muscle
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Gooneratne TD, Homer-Vanniasinkam S, Wijeyaratne SM
- KMID: 2534031
- Vasc Spec Int.
- 2022 Sep;38(3):28.
- doi: 10.5758/vsi.220018
Purpose: Exaggerated leucocyte activity is a crucial step in the pathophysiology of skeletal muscle ischemia-reperfusion injury (IRI). We tested the hypothesis that insulin, via its’ anti-leukocyte activity, attenuates skeletal muscle... -
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- CircZNF609 Aggravated Myocardial Ischemia Reperfusion Injury via Mediation of miR-214-3p/PTGS2 Axis
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Tang WQ, Yang FR, Chen KM, Yang H, Liu Y, Dou B
- KMID: 2532933
- Korean Circ J.
- 2022 Sep;52(9):680-696.
- doi: 10.4070/kcj.2021.0252
Background and Objectives: Circular RNAs were known to play vital role in myocardial ischemia reperfusion injury (MIRI), while the role of CircZNF609 in MIRI remains unclear. This study was aimed to... -
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- Therapeutic hypothermia for acute myocardial infarction: a narrative review of evidence from animal and clinical studies
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Jung KT, Bapat A, Kim YK, Hucker WJ, Lee K
- KMID: 2530010
- Korean J Anesthesiol.
- 2022 Jun;75(3):216-230.
- doi: 10.4097/kja.22156
Myocardial infarction (MI) is the leading cause of death from coronary heart disease and requires immediate reperfusion therapy with thrombolysis, primary percutaneous coronary intervention, or coronary artery bypass grafting. However,... -
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- Role of T cells in ischemic acute kidney injury and repair
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Lee K, Jang HR
- KMID: 2529651
- Korean J Intern Med.
- 2022 May;37(3):534-550.
- doi: 10.3904/kjim.2021.526
Ischemic acute kidney injury (AKI) is a common medical problem with significant mortality and morbidity, affecting a large number of patients globally. Ischemic AKI is associated with intrarenal inflammation as... -
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- Cold but not too cold: advances in hypothermic and normothermic organ perfusion
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Kirste G
- KMID: 2527893
- Korean J Transplant.
- 2022 Mar;36(1):2-14.
- doi: 10.4285/kjt.22.0008
Transplantation is the method of choice and, in many cases, the only method of treatment for patients with end-stage organ disease. Excellent results have been achieved, and the main focus... -
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- Alleviation of renal ischemia/reperfusion injury by exosomes from induced pluripotent stem cell-derived mesenchymal stem cells
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Lim SW, Kim KW, Kim BM, Shin YJ, Luo K, Quan Y, Cui S, Ko EJ, Chung BH, Yang CW
- KMID: 2527304
- Korean J Intern Med.
- 2022 Mar;37(2):411-424.
- doi: 10.3904/kjim.2020.438
Background/Aims: Renal ischemia followed by reperfusion (I/R) is a leading cause of acute kidney injury (AKI), which is closely associated with high morbidity and mortality. Studies have shown that induced... -
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- Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits
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Michino T, Tanabe K, Takenaka M, Akamatsu S, Uchida M, Iida M, Iida H
- KMID: 2522641
- Korean J Anesthesiol.
- 2021 Dec;74(6):531-540.
- doi: 10.4097/kja.21155
Background: Cerebral blood flow (CBF) has direct effects on neuronal function and neurocognitive disorders. Oxidative stress from abdominal aortic surgery is important in the pathophysiology of CBF impairment.... -
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- Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation
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Yang L, Chen X, Bi Z, Liao J, Zhao W, Huang W
- KMID: 2519404
- Korean J Physiol Pharmacol.
- 2021 Sep;25(5):413-423.
- doi: 10.4196/kjpp.2021.25.5.413
Apoptosis is proved responsible for renal damage during ischemia/reperfusion. The regulation for renal apoptosis induced by ischemia/reperfusion injury (IRI) has still been unclearly characterized to date. In the present study,... -
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- Risk Factors and Clinical Outcomes of Brain Reperfusion Injury after Mechanical Thrombectomy for Ischemic Stroke
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Moon JH, Choi HR
- KMID: 2519509
- J Korean Biol Nurs Sci.
- 2021 Aug;23(3):217-226.
- doi: 10.7586/jkbns.2021.23.3.217
Purpose: The aim of this study was to investigate the risk factors for brain reperfusion injury in ischemic stroke patients and to analyze the clinical outcomes. Methods: A retrospective study... -
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- Factors Contributing to an Efficacious Endovascular Treatment for Acute Ischemic Stroke in Asian Population
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Lee JS, Hwang YH, Sohn SI
- KMID: 2517734
- Neurointervention.
- 2021 Jul;16(2):91-110.
- doi: 10.5469/neuroint.2020.00339
Although randomized control trials about endovascular treatment (EVT) of emergent large vessel occlusion (LVO) have demonstrated the success of mechanical thrombectomy as the choice of treatment, a wide range of... -
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- Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1α/Nrf2 signaling pathway
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Wang H, Shi X, Cheng L, Han J, Mu J
- KMID: 2514949
- Korean J Physiol Pharmacol.
- 2021 May;25(3):239-249.
- doi: 10.4196/kjpp.2021.25.3.239
The present study explored the therapeutic potential of hydrogen sulfide (H2 S) in restoring aging-induced loss of cardioprotective effect of remote ischemic preconditioning (RIPC) along with the involvement of signaling... -
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- Radiomics of Non-Contrast-Enhanced T1 Mapping: Diagnostic and Predictive Performance for Myocardial Injury in Acute ST-Segment-Elevation Myocardial Infarction
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Ma Q, Ma Y, Yu T, Sun Z, Hou Y
- KMID: 2514619
- Korean J Radiol.
- 2021 Apr;22(4):535-546.
- doi: 10.3348/kjr.2019.0969
Objective: To evaluate the feasibility of texture analysis on non-contrast-enhanced T1 maps of cardiac magnetic resonance (CMR) imaging for the diagnosis of myocardial injury in acute myocardial infarction (MI). Materials and... -
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- Role of Ischemic Preconditioning in the Cardioprotective Mechanisms of Monomeric C-Reactive Protein-Deposited Myocardium in a Rat Model
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Kim EN, Choi JS, Kim CJ, Kim SR, Oh SJ
- KMID: 2512652
- J Chest Surg.
- 2021 Feb;54(1):9-16.
- doi: 10.5090/kjtcs.20.096
Background: The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. Methods: We... -
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- Liver graft from donation after circulatory death donor: Real practice to improve graft viability
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Hashimoto K
- KMID: 2507959
- Clin Mol Hepatol.
- 2020 Oct;26(4):401-410.
- doi: 10.3350/cmh.2020.0072
Donation after circulatory death (DCD) is an increasing source of liver grafts for transplantation, yet outcomes have been inferior compared to donation after brain death liver transplantation. These worse outcomes... -
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- Human Recombinant Apyrase Therapy Protects Against Myocardial Ischemia/Reperfusion Injury and Preserves Left Ventricular Systolic Function in Rats, as Evaluated by 7T Cardiovascular Magnetic Resonance Imaging
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Xu Z, Chen W, Zhang R, Wang L, Chen R, Zheng J, Gao F
- KMID: 2502466
- Korean J Radiol.
- 2020 Jun;21(6):647-659.
- doi: 10.3348/kjr.2019.0853
Objective: The occurrence of intramyocardial hemorrhage (IMH) and microvascular obstruction (MVO) in myocardial infarction (MI), known as severe ischemia/reperfusion injury (IRI), has been associated with adverse remodeling. APT102, a soluble... -
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