- B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages
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Kim MY, Kim DH, Do MS
- KMID: 2154223
- Exp Mol Med.
- 2013 Jan;45(1):e4.
3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-alpha and rosiglitazone. Here we... -
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- Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme
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Song MS, Jeong JS, Cho KS, Lee SW
- KMID: 1091067
- Exp Mol Med.
- 2007 Dec;39(6):722-732.
A trans-splicing ribozyme which can specifically reprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in... -
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- Characterization of aberrant FHIT transcripts in gastric adenocarcinomas
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Lee SH, Kim CJ, Park HK, Koh JW, Cho MH, Baek MJ, Lee MS
- KMID: 938875
- Exp Mol Med.
- 2001 Sep;33(3):124-130.
Aberrant transcripts of FHIT (fragile histidine triad) have been reported in several types of primary tumors and cell lines, including gastric carcinoma. The role of these aberrant transcripts in tumorigenesis... -
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- A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis
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Park SM, Park SJ, Kim HJ, Kwon OH, Kang TW, Sohn HA, Kim SK, Moo Noh S, Song KS, Jang SJ, Sung Kim Y, Kim SY
- KMID: 2154250
- Exp Mol Med.
- 2013 Jul;45(7):e31.
Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput... -
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- Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos
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Cho J, Kang S, Lee BC
- KMID: 1784643
- J Vet Sci.
- 2014 Jun;15(2):225-231.
- doi: 10.4142/jvs.2014.15.2.225
This study was conducted to investigate the expression of three genes related to early embryonic development in bovine transgenic cloned embryos. To accomplish this, development of bovine transgenic somatic cell... -
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- Expression of Angiopoietin 1, 2 and Their Common Receptor Tie2 in Human Gastric Carcinoma: Implication for Angiogenesis
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Moon WS, Park HS, Yu KH, Jang KY, Kang MJ, Park H, Tarnawski
- KMID: 1781834
- J Korean Med Sci.
- 2006 Apr;21(2):272-278.
- doi: 10.3346/jkms.2006.21.2.272
Angiogenesis, formation of new microvessels providing oxygen and nutrient supply, is essential for tumor growth. It is dependent on the production of angiogenic growth factors by tumor cells. Angiopoietin 1... -
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- Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability
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Lee W, Choi HI, Kim MJ, Park SY
- KMID: 1103594
- Exp Mol Med.
- 2008 Feb;40(1):109-117.
- doi: 10.3858/emm.2008.40.1.109
The mutation and reduction of mitochondrial DNA (mtDNA) have been suggested as factors in the carcinogenesis. However, whether the depletion of mtDNA induces multidrug resistance in cancer cells has not... -
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- Cloning, expression and functional analysis of the duck Toll-like receptor 5 (TLR5) gene
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Cheng Y, Sun Y, Wang H, Shi S, Yan Y, Li J, Ding C, Sun J
- KMID: 2160819
- J Vet Sci.
- 2015 Mar;16(1):37-46.
- doi: 10.4142/jvs.2015.16.1.37
Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In the present study, the first TLR5 gene in duck was cloned. The open reading frame... -
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- miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
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Tak H, Kim J, Jayabalan , Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK
- KMID: 2155388
- Exp Mol Med.
- 2014 Nov;46(11):e123.
- doi: 10.1038/emm.2014.73
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial... -
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- Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer
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Yan C, Kim YH, Kang HW, Seo SP, Jeong P, Lee IS, Kim D, Kim JM, Choi YH, Moon SK, Yun SJ, Kim WJ
- KMID: 2359962
- J Korean Med Sci.
- 2015 Dec;30(12):1784-1792.
- doi: 10.3346/jkms.2015.30.12.1784
The potential use of urinary nucleic acids as diagnostic markers in prostate cancer (PCa) was evaluated. Ninety-five urine samples and 234 prostate tissue samples from patients with PCa and benign... -
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- Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage
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Wu LM, Guo R, Hui L, Ye YG, Xiang JM, Wan CY, Zou M, Ma R, Sun XZ, Yang SJ, Guo DZ
- KMID: 2070233
- J Vet Sci.
- 2014 Dec;15(4):475-483.
- doi: 10.4142/jvs.2014.15.4.475
Chronic enteritis can produce an excess of reactive oxygen species resulting in cellular damage. Stanniocalcin-1(STC-1) reportedly possesses anti-oxidative activity, the aim of this study was to define more clearly the... -
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- Upregulation of Proinflammatory Cytokines in the Fetal Brain of the Gaucher Mouse
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Hong YB, Kim EY, Jung SC
- KMID: 2157830
- J Korean Med Sci.
- 2006 Aug;21(4):733-738.
- doi: 10.3346/jkms.2006.21.4.733
Gaucher disease is caused by a deficiency of glucocerebrosidase. Patients with Gaucher disease are divided into three major phenotypes: chronic nonneuronopathic, acute neuronopathic, and chronic neuronopathic, based on symptoms of... -
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- Down syndrome critical region 1 enhances the proteolytic cleavage of calcineurin
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Lee JE, Jang H, Cho EJ, Youn HD
- KMID: 1058021
- Exp Mol Med.
- 2009 Jul;41(7):471-477.
- doi: 10.3858/emm.2009.41.7.052
Down syndrome critical region 1 (DSCR1), an oxidative stress-response gene, interacts with calcineurin and represses its phosphatase activity. Recently it was shown that hydrogen peroxide inactivates calcineurin by proteolytic cleavage.... -
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- Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform
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Han H, Wang YH, Qu GJ, Sun TT, Li FQ, Jiang W, Luo SS
- KMID: 2154232
- Exp Mol Med.
- 2013 Mar;45(3):e13.
The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary... -
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- Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae
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He Y, Mei H, Yu H, Sun S, Ni W, Li H
- KMID: 2155359
- Exp Mol Med.
- 2014 May;46(5):e94.
- doi: 10.1038/emm.2014.18
Histone deacetylases are involved in many biological processes and have roles in regulating cell behaviors such as cell cycle entry, cell proliferation and apoptosis. However, the effect of histone deacetylases... -
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- Quantitative expression and localization of cysteine and aspartic proteases in human abdominal aortic aneurysms
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Lohoefer F, Reeps C, Lipp C, Rudelius M, Haertl F, Matevossian E, Zernecke A, Eckstein H, Pelisek J
- KMID: 2155360
- Exp Mol Med.
- 2014 May;46(5):e95.
- doi: 10.1038/emm.2014.20
Cysteine and aspartic proteases possess high elastolytic activity and might contribute to the degradation of the abdominal aortic aneurysm (AAA) wall. The aim of this study was to analyze, in... -
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- Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma
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Xu H, Choe C, Shin SH, Park SW, Kim HS, Jung SH, Yim SH, Kim TM, Chung YJ
- KMID: 2155362
- Exp Mol Med.
- 2014 May;46(5):e97.
- doi: 10.1038/emm.2014.23
Although it has been suggested that kinesin family member 14 (KIF14) has oncogenic potential in various cancers, including hepatocellular carcinoma (HCC), the molecular mechanism of this potential remains unknown. We... -
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- Biologic Response of Degenerative Living Human Nucleus Pulposus Cells to Treatment with Cytokines
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Kim SH, Kuh SU, Kim KN, Park JY, Cho KH, Chin DK, Kim KS, Cho YE
- KMID: 2352817
- Yonsei Med J.
- 2015 Jan;56(1):277-286.
- doi: 10.3349/ymj.2015.56.1.277
PURPOSE: To investigate the molecular responses of various genes and proteins related to disc degeneration upon treatment with cytokines that affect disc-cell proliferation and phenotype in living human intervertebral discs... -
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- Acute UV Irradiation Increases Heparan Sulfate Proteoglycan Levels in Human Skin
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Jung JY, Oh JH, Kim YK, Shin MH, Lee D, Chung JH
- KMID: 1793002
- J Korean Med Sci.
- 2012 Mar;27(3):300-306.
- doi: 10.3346/jkms.2012.27.3.300
Glycosaminoglycans are important structural components in the skin and exist as various proteoglycan forms, except hyaluronic acid. Heparan sulfate (HS), one of the glycosaminoglycans, is composed of repeated disaccharide units,... -
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- Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis
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Zhang L, Yu M, Deng J, Lv X, Liu J, Xiao Y, Yang W, Zhang Y, Li C
- KMID: 2366358
- Yonsei Med J.
- 2015 Jul;56(4):1134-1142.
- doi: 10.3349/ymj.2015.56.4.1134
PURPOSE: Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progression of which leads to the destruction of cartilage and bone. Chemokines are involved in RA pathogenesis. In this study,... -
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