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Reconsidering Clinical Staging Model: A Case of Genetic High Risk for Schizophrenia

Lee TY, Kim M, Kim SN, Kwon JS

  • Psychiatry Investig.
  • 2017 Jan;14(1):107-109.
  • doi: 10.4306/pi.2017.14.1.107
The clinical staging model is considered a useful and practical method not only in dealing with the early stage of psychosis overcoming the debate about diagnostic boundaries but also in...
Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

Cho CH, Ahn YM, Kim SJ, Ha TH, Jeon HJ, Cha B, Moon E, Park DY, Baek JH, Kang HJ, Ryu V, An H, Lee HJ

  • Psychiatry Investig.
  • 2017 Jan;14(1):100-106.
  • doi: 10.4306/pi.2017.14.1.100
The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2)...
Design and Methodology of the Korean Early Psychosis Cohort Study

Kim SW, Lee BJ, Kim JJ, Yu JC, Lee KY, Won SH, Lee SH, Kim SH, Kang SH, Chung YC

  • Psychiatry Investig.
  • 2017 Jan;14(1):93-99.
  • doi: 10.4306/pi.2017.14.1.93
The present study details the rationale and methodology of the Korean Early Psychosis Cohort Study (KEPS), which is a clinical cohort investigation of first episode psychosis patients from a Korean...
Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder

Watanabe T, Ishiguro S, Aoki A, Ueda M, Hayashi Y, Akiyama K, Kato K, Shimoda K

  • Psychiatry Investig.
  • 2017 Jan;14(1):86-92.
  • doi: 10.4306/pi.2017.14.1.86
OBJECTIVE: Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for...
Association between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimer's Disease in the Korean Population

Kim YJ, Park JK, Kang WS, Kim SK, Han C, Na HR, Park HJ, Kim JW, Kim YY, Park MH, Paik JW

  • Psychiatry Investig.
  • 2017 Jan;14(1):81-85.
  • doi: 10.4306/pi.2017.14.1.81
OBJECTIVE: Mitochondrial dysfunction is a prominent and early feature of Alzheimer's disease (AD). The morphologic changes observed in the AD brain could be caused by a failure of mitochondrial fusion...
Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical, Bacopa Monnieri

Hazra S, Kumar S, Saha GK, Mondal AC

  • Psychiatry Investig.
  • 2017 Jan;14(1):74-80.
  • doi: 10.4306/pi.2017.14.1.74
OBJECTIVE: The aims of the present study were to explore the behavioural effects and to understand the possible mode of action of Bacopa monnieri extract (BME) on chronic unpredictable stress...
Efficacy and Safety of Bitopertin in Patients with Schizophrenia and Predominant Negative Symptoms: Subgroup Analysis of Japanese Patients from the Global Randomized Phase 2 Trial

Hirayasu Y, Sato SI, Shuto N, Nakano M, Higuchi T

  • Psychiatry Investig.
  • 2017 Jan;14(1):63-73.
  • doi: 10.4306/pi.2017.14.1.63
OBJECTIVE: The aim of the present study was to perform a subgroup analysis of data from a phase II global, multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and...
Effectiveness of Electroconvulsive Therapy Augmentation on Clozapine-Resistant Schizophrenia

Kim HS, Kim SH, Lee NY, Youn T, Lee JH, Chung S, Kim YS, Chung IW

  • Psychiatry Investig.
  • 2017 Jan;14(1):58-62.
  • doi: 10.4306/pi.2017.14.1.58
OBJECTIVE: This retrospective case series study of the effectiveness of electroconvulsive therapy (ECT) augmentation on clozapine-resistant schizophrenia was conducted by EMR review. METHODS: Clozapine-resistance was defined as persistent psychotic symptoms despite...
Sensory Processing Disorders are Associated with Duration of Current Episode and Severity of Side Effects

Serafini G, Engel-Yeger B, Vazquez GH, Pompili M, Amore M

  • Psychiatry Investig.
  • 2017 Jan;14(1):51-57.
  • doi: 10.4306/pi.2017.14.1.51
OBJECTIVE: Longer duration of untreated illness, longer duration of current episode, and the severity of medication side effects may negatively impact on the perceived disability and psychosocial impairment of patients...
Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study

Lee JS, Kwon JS, Kim D, Kim SW, Kim JJ, Kim JH, Nam HJ, Ryu S, Park IH, An SK, Oh HS, Won S, Lee K, Lee KY, Lee SH, Lee YS, Yi JS, Hong KS, Joo YH

  • Psychiatry Investig.
  • 2017 Jan;14(1):44-50.
  • doi: 10.4306/pi.2017.14.1.44
OBJECTIVE: We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. METHODS: This multicenter, cross-sectional, and...
The Relationship between Childhood Trauma and Suicidal Ideation: Role of Maltreatment and Potential Mediators

Bahk YC, Jang SK, Choi KH, Lee SH

  • Psychiatry Investig.
  • 2017 Jan;14(1):37-43.
  • doi: 10.4306/pi.2017.14.1.37
OBJECTIVE: Childhood trauma is recognized as an important risk factor in suicidal ideation, however it is not fully understood how the different types of childhood maltreatment influence suicidal ideation nor...
Reliability and Validity of the Beck Depression Inventory-II among Korean Adolescents

Lee EH, Lee SJ, Hwang ST, Hong SH, Kim JH

  • Psychiatry Investig.
  • 2017 Jan;14(1):30-36.
  • doi: 10.4306/pi.2017.14.1.30
OBJECTIVE: The Beck Depression Inventory-II (BDI-II) is one of the most popular scales for evaluating the severity of depression in adolescents as well as adults. The prevalence of depression increases...
The Structured Clinical Interview for DSM-5 Internet Gaming Disorder: Development and Validation for Diagnosing IGD in Adolescents

Koo HJ, Han DH, Park SY, Kwon JH

  • Psychiatry Investig.
  • 2017 Jan;14(1):21-29.
  • doi: 10.4306/pi.2017.14.1.21
OBJECTIVE: This study aimed to develop and validate a Structured Clinical Interview for Internet Gaming Disorder (SCI-IGD) in adolescents. METHODS: First, we generated preliminary items of the SCI-IGD based on the...
The Economic Crisis in Greece and Its Impact on the Seasonality of Suicides in the Athens Greater Area

Christodoulou C, Efstathiou V, Michopoulos I, Gkerekou M, Paraschakis A, Koutsaftis F, Douzenis A

  • Psychiatry Investig.
  • 2017 Jan;14(1):16-20.
  • doi: 10.4306/pi.2017.14.1.16
OBJECTIVE: The economic crisis and the implementation of austerity measures in Greece lead to significant socioeconomic changes. The effects of the crisis were mainly felt by the Greek population during...
Short-Term Psychiatric Rehabilitation in Major Depressive and Bipolar Disorders: Neuropsychological-Psychosocial Outcomes

Perna G, Daccò S, Sacco F, Micieli W, Cavedini P, Caldirola

  • Psychiatry Investig.
  • 2017 Jan;14(1):8-15.
  • doi: 10.4306/pi.2017.14.1.8
OBJECTIVE: Our pilot study aims to investigate the efficacy of a Short-Term (4 weeks) Psychiatric Rehabilitation Program (S-T PsyRP), without specific cognitive remediation trainings, on the neuropsychological performance and psychosocial...
Comparisons of Subthreshold Versus Full Posttraumatic Stress Disorder Distinguished by Subjective Functional Impairment Among Train Drivers: A Population-Based Nationwide Study in South Korea

Baek JH, Kim JH, Kim BN, Park SJ, Fava M, Mischoulon D, Lee D, Jeon HJ

  • Psychiatry Investig.
  • 2017 Jan;14(1):1-7.
  • doi: 10.4306/pi.2017.14.1.1
OBJECTIVE: Subthreshold posttraumatic stress disorder (SPTSD), a condition that meets the full symptomatic criteria of posttraumatic stress disorder (PTSD) without subjective functional impairment, has yet to be fully investigated. In...

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