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Impulsive Behavior and Recurrent Major Depression Associated with Dandy-Walker Variant

Kim JH, Kim TH, Choi YC, Chung SC, Moon SW

  • Psychiatry Investig.
  • 2013 Sep;10(3):303-305.
Reported herein is a case of recurrent major depression with impulse control difficulty in a 33-year-old man with Dandy-Walker variant. He was diagnosed as having major depressive disorder a year...
Myasthenia Gravis, Schizophrenia, and Colorectal Cancer in A Patient: Long-Term Follow-Up with Medication Complexity

Kim H, Hong M, Bahn GH

  • Psychiatry Investig.
  • 2013 Sep;10(3):300-302.
In a case of 46-year-old woman suffering from schizophrenia for over 20 years, she experienced frequent episodes of dyspnea and confirmed as superimposed with myasthenia gravis (MG). Throughout the seven-year...
Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder

Kim JW, Kim YK, Hwang JA, Yoon HK, Ko YH, Han C, Lee HJ, Ham BJ, Lee HS

  • Psychiatry Investig.
  • 2013 Sep;10(3):294-299.
OBJECTIVE: Cytokines are believed to have a role in the pathophysiology of major depression. The alteration in levels of pro-inflammatory cytokines [interleukin 1beta (IL-1beta), IL-2, IL-6, IL-12, interferon gamma, and...
CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression

Han KM, Chang HS, Choi IK, Ham BJ, Lee MS

  • Psychiatry Investig.
  • 2013 Sep;10(3):286-293.
OBJECTIVE: Cytochrome P450 (CYP) enzymatic activity, which is influenced by CYP genetic polymorphism, is known to affect the inter-individual variation in the efficacy and tolerability of antidepressants in major depressive...
Decreased Serum Sulphydryl Levels as a Sign of Increased Oxidative Stress in Generalized Anxiety Disorder

Kaya MC, Bez Y, Karababa I, Emhan A, Aksoy N, Bulut M, Gunes M, Atli A, Selek S

  • Psychiatry Investig.
  • 2013 Sep;10(3):281-285.
OBJECTIVE: In recent years, many published studies have focused on the relationship between oxidative stress and psychiatric disorders. However, studies in generalized anxiety disorder (GAD) are few despite relatively high...
Anti-Intrusion Effect of Lorazepam: An Experimental Study

Lee HS, Lee HP, Lee SK, Kim YK, Choi YK

  • Psychiatry Investig.
  • 2013 Sep;10(3):273-280.
OBJECTIVE: Easy triggering of trauma-related episodic memory fragments caused by perceptual cues is tied to strong perceptual priming in the implicit memory system. And among benzodiazepines, only lorazepam has been...
Disruption of Orbitofronto-Striatal Functional Connectivity Underlies Maladaptive Persistent Behaviors in Alcohol-Dependent Patients

Lee S, Lee E, Ku J, Yoon KJ, Namkoong K, Jung YC

  • Psychiatry Investig.
  • 2013 Sep;10(3):266-272.
OBJECTIVE: Alcohol dependence is characterized by persistent alcohol-seeking despite negative consequences. Previous studies suggest that maladaptive persistent behaviors reflect alcohol-induced brain changes that cause alterations in the cortico-striatal-limbic circuit. METHODS: Twenty...
The Impact of Personality Traits on Ratings of Obsessive-Compulsive Symptoms

Huh MJ, Shim G, Byun MS, Kim SN, Kim E, Jang JH, Shin MS, Kwon JS

  • Psychiatry Investig.
  • 2013 Sep;10(3):259-265.
OBJECTIVE: The goal of this study was to evaluate consistencies and discrepancies between clinician-administered and self-report versions of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and to examine relationships between these...
Nocturnal Enuresis Is Associated with Attention Deficit Hyperactivity Disorder and Conduct Problems

Park S, Kim BN, Kim JW, Hong SB, Shin MS, Yoo HJ, Cho SC

  • Psychiatry Investig.
  • 2013 Sep;10(3):253-258.
OBJECTIVE: There are no published prevalence estimates of elimination disorders and their association with disruptive-behavior disorders among children in the Asian region using standardized diagnostic interviews. This study was conducted...
The Relationship between Impulsivity and Quality of Life in Euthymic Patients with Bipolar Disorder

Kim YS, Cha B, Lee D, Kim SM, Moon E, Park CS, Kim BJ, Lee CS, Lee S

  • Psychiatry Investig.
  • 2013 Sep;10(3):246-252.
OBJECTIVE: Bipolar disorder (BD) is characterized by elevated impulsivity, even during periods of remission. Many recovered BD patients have functional impairments, which can lead to poor quality of life (QoL)....
Validation of the Dementia Care Assessment Packet-Instrumental Activities of Daily Living

Lee SB, Park JR, Yoo JH, Park JH, Lee JJ, Yoon JC, Jhoo JH, Lee DY, Woo JI, Han JW, Huh Y, Kim TH, Kim KW

  • Psychiatry Investig.
  • 2013 Sep;10(3):238-245.
OBJECTIVE: We aimed to evaluate the psychometric properties of the IADL measure included in the Dementia Care Assessment Packet (DCAP-IADL) in dementia patients. METHODS: The study involved 112 dementia patients and...
Clinical Usefulness of Loudness Dependence of Auditory Evoked Potentials (LDAEP) in Patients with Bipolar Disorder

Park YM, Lee SH

  • Psychiatry Investig.
  • 2013 Sep;10(3):233-237.
While it has been reported previously that the loudness dependence of auditory evoked potentials (LDAEP) is a putative biological marker or a predictor of treatment response, there have been few...
Circadian Rhythm Hypotheses of Mixed Features, Antidepressant Treatment Resistance, and Manic Switching in Bipolar Disorder

Lee HJ, Son GH, Geum D

  • Psychiatry Investig.
  • 2013 Sep;10(3):225-232.
Numerous hypotheses have been put forth over the years to explain the development of bipolar disorder. Of these, circadian rhythm hypotheses have gained much importance of late. While the hypothalamus-pituitary-adrenal...
Bipolar Spectrum: A Review of the Concept and a Vision for the Future

Ghaemi SN

  • Psychiatry Investig.
  • 2013 Sep;10(3):218-224.
This paper reviews the bipolar spectrum concept historically and empirically. It describes how the concept derives from Kraepelin, but was lost with DSM-III, which divided the broad manic-depressive illness concept,...
Is Psychiatry Scientific? A Letter to a 21st Century Psychiatry Resident

de Leon J

  • Psychiatry Investig.
  • 2013 Sep;10(3):205-217.
During the development of the DSM-5, even the lay press questioned psychiatr's scientific validity. This review provides 21st century psychiatry residents with ways of answering these attacks by defining the...

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