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Relative Risk and Clinical Severity Assessment in Patients with Non-Oral Route Organophosphate Poisoning Compared with Oral Route Poisoning

Jung WJ, Yu MH, Lee Y, Kim H, Cha YS, Park KH

PURPOSE: Organophosphates, commonly used in agricultural pesticides, pose high risks and incidences of poisoning. In the present study, we investigated the relative risk and clinical severity, including laboratory results, of...
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Delayed recovery from paralysis by succinylcholine in patient with preoperatively unrecognized and inherited pseudocholinesterase deficiency

Ok SH, Woo MK, Kim CG, Hwang I, Sohn JT

No abstract available.
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A Case of Amitraz Poisoning Initially Misdiagnosed as Acute Organophosphate Insecticide Poisoning

Cho Y, Kim JW

  • KMID: 2317669
  • Soonchunhyang Med Sci.
  • 2012 Dec;18(2):151-154.
Amitraz is acaricidal and insecticidal pesticide used worldwide to control ticks and mites in plants and animals. Amitraz poisoning is characterized by clinical toxidrome such as central nervous system, respiratory...
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Basal Level of Cholinesterase in a Population of Residents Over 60 Years Old in Jeju

Park KH, Kim WJ, Kang YJ, Park JH, Park JO, Kim H

  • KMID: 2192128
  • J Korean Soc Emerg Med.
  • 2012 Jun;23(3):383-388.
PURPOSE: Measurement of pseudocholinesterase (PChE) is a simple test for evaluation of the severity of intoxication with organophosphate and carbamate insecticides, because they inhibit PChE; however, as demonstrated in several...
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A Study on Organophosphate Poisoning Patients: Comparison of the Survivor Group and Dead Group

Choi YG, Lee DH, Kim WH, Lee GW, Kim SP, Kim SJ, Cho SH, Cho NS

  • KMID: 2204091
  • J Korean Soc Clin Toxicol.
  • 2010 Jun;8(1):16-23.
PURPOSE: Organophosphate insecticide poisoning is common in Korea, but there is no definitive guideline for determining the severity of the poisoning and the predictive factors. Therefore, we evaluated the organophosphate...
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Neuromuscular Pharmacodynamics of Mivacurium in Patients with Major Burns

Chung MH, Jung JK, Lee JY, Kwak IS, Choi YR, Won RS, Han TH

BACKGROUND: Burned patients sometimes require rapid onset of neuromuscular paralysis to secure the airway in full stomach patients or to treat laryngospasm. Because of poor lung function and hypermetabolic state,...
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Pharmacodynamic Changes of Mivacurium in Liver Cirrhosis Model in Rabbits Using Carbon Tetrachloride Intoxication

Cha YD, Lee HS, Ki HY, Park HJ, Yang CW, Kim YH, Kim KS, Han JU

BACKGROUND: A reproducible animal model of liver cirrhosis by administering multiple doses of carbon tetrachloride (CCl4) is highly desirable for appropriate metabolic and therapeutic studies. The current study was undertaken...
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Effects of Edrophonium and/or Pseudocholinesterase for the Reversal of Mivacurium-Induced Paralysis in vitro

Park DH, Seong KW, Jeong WY, Kim HK, Yang HS

BACKGROUND: Mivacurium is a nondepolarizing neuromuscular blocking agent hydrolyzed by pseudocholinesterase. Anticholinesterase used in the reversal of mivacurium-induced muscle relaxation may also inhibit plasma pseudocholinesterase, and delay hydrolysis...
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Effects of Mivacurium in the Patients with Myasthenia Gravis

Kim DY, Park SH, Lim TH, Lee EJ, Yang HS

BACKGROUND: Myasthenia gravis is an autoimmune neuromuscular disorder that shows increased sensitivity to nondepolarizing muscle relaxants. Mivacurium chloride is a short acting nondepolarizing neuromuscular blocker and a benzylisoquinolin diester...
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Effects of Pseudocholinesterase and/or Neostigmine, Pyridostigmine, Edrophonium and Galanthamine for Reversal of Mivacurium- or Succinylcholine-induced Paralysis in Vitro

Cho SS, Yoon SN, Choi Y, Yang HS, Han SM, Kim SY, Suh BT

BACKGROUND: The hydrolysis of mivacurium and succinylcholine is impaired in the presence of defects of pseudocholinesterase. Clinical reports are conflicting as to the utility of anticholinesterases, in the reversal of...
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The Effects of Ethanol on Cholinesterase Inactivation by Organophosphorous

Choi HC, Kim JH, Ha JH, Lee KY, Kim WJ, Woo HJ, Huh CU, Son SM, Chun EJ

  • KMID: 2320290
  • Yeungnam Univ J Med.
  • 1999 Dec;16(2):326-332.
BACKGROUND: In korea the agricultural community widely uses organophosphorous, and organophosphorous poisonings are increasing every year. We compared change in activity of acetylcholinesterase and pseudocholinesterase by organophosphorous and by the interaction...
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Effects of Pseudocholinesterase, Anticholinesterase, and 4-Aminopyridine to the Mivacurium-induced Neuromuscular Block on Rat Diaphragm

Kim YI, Kang KS, Hwang KH, Yang HS, Kim SY, Song JE

BACKGROUND: Prolongation of the neuromuscular block of mivacurium can occur when there is a genetic deficiency of the enzyme or in the presence of anticholinesterase (AntiChE) which inhibit the activity...
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Comparison of Pseudocholinesterase Activity between Nonpregnant and Term-pregnant Women with the Genotypically Normal Enzyme

Park SJ, Baik HJ, Kim KS, Cho DS

BACKGROUND: Many reports on the change of pseudocholinesterase activity in pregnant women showed that it declines during pregnancy and in the immediate postpartum period. In Korea, there are two papers...
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The Infusion Rate of Mivacurium for Cesarean Section and its Spontaneous Recovery

Kim JH, Ahn EK, Shin YS, Byun H

BACKGROUND: Mivacurium is a nondepolarizing muscle relaxant and metabolized by pseudo-cholinesterase(pChe). Many reports show fall in pChe activity during pregnancy, so the metabolism of mivacurium may be delayed and muscle...
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Inhibition Numbers of Pseudocholinesterase in Korean Adults

Cho DS, Lee NK, Kim CG, Lee HL, Hong SI

Pseudocholinesterase is an essential enzyme for hydrolysis of succinylcholine and some people has low activity. The pseudocholinesterase from a normal individual has a greater apparent affinity for the cholinester substrate...
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Comparison of Pharmacokinetic Affinity of Various Non-depolarizing Neuromuscular Blocking Agents in the Isolated Foream

Lee SK, Jeon YS, Ahn JS, Hwang KH, Park W, Kim SY

It is well known that the plasma concentration is important in determining the rate of recovery from neuromuscular block. However, nondepolarizing neuromuscular blockade are retained at the neuromuscular junction and...
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The Effects of Hypothermic Hemodilutional Cardiopulmonary Bypass on the Pseudocholinesterase Level

Chae BK, Lee HW, Chang SH

Pseudocholinesterase is known to be involved in the metabolism of succinylcholine, mivacurium, procaine, chloroprocaine, tetracaine, cocaine, heroin, and other drugs, although the physiologic function has not been well established. Prolonged...
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Influence of age and sex on pseudocholinesterase activity of Korean adults

Cho DS, In CH

Serum pseudocholinesterase activities, using butyrylthiocholine as substrate, measured in 639 employees of Korea Cancer Center Hospital in 1993. Overall mean value of pseudocholinesterase was 9.38+/-2.10 U/ml, 10.6+/-2.10 U/ml in male,...
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The Pharmacokinetic Response of Succinylcholine from Blood Flow occlusion

Yoon SJ, Kim CS, Cha YD, Kim YI, Kang KS, Kim SY

There is a direct relationship between the plasma concentration of the drugs and the magnitude of neuromuscular blockade in non-depolarizing neuromuscular blocking agents. But the classical pharmacokinetic data of succinylcholine...
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Modification of Atracurium or Vecuronium Blockade and Their Reversal by Succinylcholine in the Cat

Shin YS, Yoo ES, Min SK, Kim JR, Park KW

The interaction between succinylcholine(SCC) and non-depolarizer; atracurium or vecuronium, was investigated in 36 cats of either sex using the sciatic nerve-anterior tibialis muscle preparation. And also, its relation to the...
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