- Neuronal Functions of ESCRTs
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Lee JA, Gao FB
- KMID: 2165385
- Exp Neurobiol.
- 2012 Mar;21(1):9-15.
- doi: 10.5607/en.2012.21.1.9
The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission,... -
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- High-concentration Epigallocatechin Gallate Treatment Causes Endoplasmic Reticulum Stress-mediated Cell Death in HepG2 Cells
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Ahn JI, Jeong KJ, Ko MJ, Shin HJ, Chung HJ, Jeong HS
- KMID: 2053228
- Genomics Inform.
- 2009 Jun;7(2):97-106.
Epigallocatechin gallate (EGCG), a well-known antioxidant molecule, has been reported to cause hepatotoxicity when used in excess. However, the mechanism underlying EGCG-induced hepatotoxicity is still unclear. To better understand the... -
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- Immunohistochemical Study on GTP-binding Rab6 Expression in the Hippocampal Cortices of the Alzheimer Brain
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Cheon YH, Kang YJ, Lee JH, Pyo JS, Baik TK
- KMID: 2092863
- Korean J Anat.
- 2005 Oct;38(5):451-459.
The ras-related GTP binding protein, rab6, is located in late Golgi compartment. Modulation of beta-and gamma-secretase activity may lead to production of beta-amyloid fragments that are ultimately deposited in senile... -
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- On Changes of fine Structures of the Sertoli Cells in the Human Male Sterility
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Cho SR
- KMID: 1677653
- Korean J Urol.
- 1975 Jun;16(2):81-88.
Electron microscopic observation of fine structural changes of Sertoli cells in the male sterility patients was made on 10 histologically proved cases. They were histologically classified to 3 groups by... -
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- Membrane Trafficking of Collecting Duct Water Channel Protein AQP2 Regulated by Akt/AS160
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Jung HJ, Kwon TH
- KMID: 2406195
- Electrolyte Blood Press.
- 2010 Dec;8(2):59-65.
Akt (protein kinase B (PKB)) is a serine/threonine kinase that acts in the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. The PI3K/Akt signaling pathway, triggered by growth factors and hormones including vasopressin,... -
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- Kinesin Superfamily KIF1A Protein Binds to Synaptotagmin XI
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Park HY, Yea SS, Jang WH, Chung JY, Lee SK, Kim SJ, Yang YI, Kim JY, Park YH, Seog DH
- KMID: 2092858
- Korean J Anat.
- 2005 Oct;38(5):403-411.
The kinesin proteins (KIFs) make up a large superfamily of molecular motors that transport cargo such as vesicles, protein complexes, and organelles. KIF1A is a monomeric motor that conveys synaptic vesicle... -
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- The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus
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Jang YH, Min DS
- KMID: 1506220
- Exp Mol Med.
- 2012 Oct;44(10):571-577.
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different... -
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- Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
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Park MH, Lee DH
- KMID: 1103592
- Exp Mol Med.
- 2008 Feb;40(1):92-97.
- doi: 10.3858/emm.2008.40.1.92
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and... -
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- Gephyrin: a central GABAergic synapse organizer
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Choii G, Ko J
- KMID: 2070277
- Exp Mol Med.
- 2015 Apr;47(4):e158.
- doi: 10.1038/emm.2015.5
Gephyrin is a central element that anchors, clusters and stabilizes glycine and gamma-aminobutyric acid type A receptors at inhibitory synapses of the mammalian brain. It self-assembles into a hexagonal lattice... -
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- Translocational changes of localization of synapsin in axonal sprouts of regenerating rat sciatic nerves after ligation crush injury
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Kwon KB, Kim JS, Chang BJ
- KMID: 1103468
- J Vet Sci.
- 2000 Jun;1(1):1-9.
Time-dependent translocational changes of Synapsin I (SyI), a synaptic vesicle-associated phosphoprotein and its involvement in the axonal transport were investigated in the regenerating axonal sprouts. A weak SyI immunoreactivity (IR)... -
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- Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes
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Choi YO, Ryu HJ, Kim HR, Song YS, Kim C, Lee W, Choe H, Leem CH, Jang YJ
- KMID: 1111411
- Exp Mol Med.
- 2006 Apr;38(2):180-189.
In adipocytes, insulin stimulates glucose transport primarily by promoting the translocation of GLUT4 to the plasma membrane. Requirements for Ca2+/ calmodulin during insulin-stimulated GLUT4 translocation have been demonstrated; however, the... -
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- Calcium Signaling in Salivary Secretion
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Kim JM, Lee SW, Park K
- KMID: 2405561
- J Korean Dent Sci.
- 2017 Dec;10(2):45-52.
- doi: 10.5856/JKDS.2017.10.2.45
Calcium has versatile roles in diverse physiological functions. Among these functions, intracellular Ca²⺠plays a key role during the secretion of salivary glands. In this review, we introduce the diverse... -
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- Cell-free expression and functional reconstitution of CALM in clathrin assembly
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Kim JA, Kim HL
- KMID: 1085745
- Exp Mol Med.
- 2001 Jun;33(2):89-94.
Clathrin-mediated vesicle formation is an essential step in the intracellular trafficking of the protein and lipid. Binding of clathrin assembly protein to clathrin triskelia induces their assembly into clathrin-coated vesicles... -
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- Cyclophilin A: A Mediator of Cardiovascular Pathology
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Soe NN, Berk BC
- KMID: 1492131
- J Korean Soc Hypertens.
- 2011 Dec;17(4):133-147.
- doi: 10.5646/jksh.2011.17.4.133
Cyclophilin A (CyPA) is a 17 kDa, ubiquitously expressed multifunctional protein that possesses peptidylprolyl cis-trans isomerase activity and scaffold function. Its expression is increased in inflammatory conditions including rheumatoid arthritis,... -
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- Choline Acetyltrans ferase Immunoreactivity in the Rat Brainstem
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Kim ES, Han DH
- KMID: 2338343
- J Korean Geriatr Soc.
- 2004 Sep;8(3):170-176.
BACKGROUND: Cholinergic neurons in the forebrain of mamals are well elucidated, meanwhile, the distribution of these neurons in the brainstem is not conformed according to investigators. To identify cholinergic neurons... -
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- Modulation of the caveolin-3 and Akt status in caveolae by insulin resistance in H9c2 cardiomyoblasts
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Ha H, Pak Y
- KMID: 1056228
- Exp Mol Med.
- 2005 Jun;37(3):169-178.
We investigated glucose uptake and the translocation of Akt and caveolin-3 in response to insulin in H9c2 cardiomyoblasts exposed to an experimental insulin resistance condition of 100 nM insulin in... -
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- Distinct Patterns of Cleavage and Translocation of Cell Cycle Control Proteins in CD95-induced and p53-induced apoptosis
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Park WS, Jung KC, Chung DH, Nam WD, Choi WJ, Bae Y
- KMID: 648894
- J Korean Med Sci.
- 2003 Aug;18(4):467-472.
- doi: 10.3346/jkms.2003.18.4.467
Apoptotic cell death induced by p53 occurs at a late G1 cell cycle checkpoint termed the restriction(R)point, and it has been proposed that p53-induced apoptosis causes upregulation of CD95. However,... -
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- Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells
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Kim J, Choi BH, Jang KL, Min DS
- KMID: 1123766
- Exp Mol Med.
- 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast... -
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- The effect of Der p 2 antigen on the production of interferon gamma by CD3+T, CD56+NK and CD3+CD56+TNK cells from patients with mild persistent allergic asthma
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Maeng SH, Lee JS, Park CW, Cho YJ
- KMID: 2285850
- J Asthma Allergy Clin Immunol.
- 2003 Jun;23(2):341-348.
BACKGROUND: Asthma is a chronic inflammatory disease of the bronchial mucosa and is associated with excess production of Th2 cytokines (IL-4, IL-5) relative to Th1 cytokine (IFN-V). The NK cell... -
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- Glucose Lowering Effect of SGLT2 Inhibitors: A Review of Clinical Studies
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Kim HJ
- KMID: 2173886
- J Korean Diabetes.
- 2014 Sep;15(3):146-150.
- doi: 10.4093/jkd.2014.15.3.146
There are numerous glucose lowering agents in clinical use for type 2 diabetic patients, yet most do not achieve glycemic targets. Recently, inhibitors of the sodium glucose cotransporter 2 (SGLT2)... -
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