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Screening Moringa species focused on development of locally available sustainable nutritional supplements

Kim YJ, Kim HS

BACKGROUND/OBJECTIVES: The leaves of Moringa oleifera (MO) and Moringa stenopetala (MS) commonly grown in Ethiopia possess potential nutritional and medicinal value. The aim of this study was to evaluate the...
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The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes

Wang X, Tsang JY, Lee MA, Ni YB, Tong JH, Chan SK, Cheung SY, To KF, Tse GM

PURPOSE: Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel nuclear receptor (NR) co-regulator, is highly expressed in breast cancer. We investigated its expression in breast cancer subtypes, in...
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Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective

Sidorov E, Sanghera D, Vanamala J

Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find...
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Vaccination of goats with a combination Salmonella vector expressing four Brucella antigens (BLS, PrpA, Omp19, and SOD) confers protection against Brucella abortus infection

Leya M, Kim WK, Cho JS, Yu EC, Kim YJ, Yeo Y, Lyoo KS, Yang MS, Han SS, Lee JH, Tark D, Hur J, Kim B

Salmonella is an intracellular pathogen with a cellular infection mechanism similar to that of Brucella, making it a suitable choice for use in an anti-Brucella immune boost system. This study...
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Effect of immunization routes and protective efficacy of Brucella antigens delivered via Salmonella vector vaccine

Lalsiamthara J, Won G, Lee JH

An anti-Brucella vaccine candidate comprised of purified Brucella lipopolysaccharide (LPS) and a cocktail of four Salmonella Typhimurium (ST)-Brucella vectors was reported previously. Each vector constitutively expressed highly conserved Brucella antigens...
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Correlation Between Gastric Emptying and Gastric Adaptive Relaxation Influenced by Amino Acids

Uchida M, Kobayashi , Saito C

  • KMID: 2387831
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):400-408.
  • doi: 10.5056/jnm16153
BACKGROUND/AIMS: Amino acids have many physiological activities. We report the correlation between gastric emptying and gastric adaptive relaxation using tryptophan and amino acids with a straight alkyl chain, hydroxylated chain,...
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Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder

Demir S, Bulut M, Atli A, Kaplan I, Kaya MC, Bez Y, Özdemir P, Sır A

OBJECTIVE: Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl...
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Possible Role of a Missense Mutation of p.P167S on NOTCH3 Gene Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Choi BW, Park S, Kim HJ

BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a single-gene disorder caused by mutations in the NOTCH3 gene, located on chromosome 19p13. NOTCH3 encodes a transmembrane...
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Polymorphisms of SLC22A9 (hOAT7) in Korean Females with Osteoporosis

Ahn SK, Suh CK, Cha SH

Among solute carrier proteins, the organic anion transporters (OATs) play an important role for the elimination or reabsorption of endogenous and exogenous negatively charged anionic compounds. Among OATs, SLC22A9 (hOAT7)...
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Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases

Kant R, Bali A, Singh N, Jaggi AS

Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well...
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Treatment of chronic hepatitis C

Jun DW

  • KMID: 2342151
  • J Korean Med Assoc.
  • 2012 Nov;55(11):1113-1120.
In the past 10 years, the standard treatment for chronic hepatitis C has been pegylated interferon and ribavirin for 24 to 48 weeks, based on genotype. Until now, fixed schedule...
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pncA Mutations in the Specimens from Extrapulmonary Tuberculosis

Lee J, Yun YJ, Kqueen CY, Lee JH, Kim HY, Kim YR, Kook YH, Lee KH

  • KMID: 2319847
  • Tuberc Respir Dis.
  • 2012 Jun;72(6):475-480.
BACKGROUND: Pyrazinamide (PZA) is an effective antitubercular drug that becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase), encoded by mycobacterial pncA. A strong association was...
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The Therapeutic Approaches for Hepatitis C Virus: Protease Inhibitors and Polymerase Inhibitors

Kwo PY, Vinayek R

  • KMID: 2284229
  • Gut Liver.
  • 2011 Dec;5(4):406-417.
The current standard of care for hepatitis C infection is peginterferon/ribavirin (PegIFN/RBV). We are entering the era where direct-acting antiviral agents (DAAs) will be added to PegIFN/RBV, leading to higher...
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Inhibition of NF-kappaB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells

Jeong IK, Oh DH, Park SJ, Kang JH, Kim S, Lee MS, Kim MJ, Hwang YC, Ahn KJ, Chung HY, Chae MK, Yoo HJ

Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads...
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Therapeutic Difficulties in Poorly Differentiated and Undifferentiated Thyroid Cancer

Lee J, Soh EY

  • KMID: 2198456
  • J Korean Thyroid Assoc.
  • 2011 Nov;4(2):87-93.
Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) have poor prognosis and rare incidence compared to well differentiate thyroid cancer. Since the original description of PDTC in 1983,...
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Relationship Between Depression Anxiety Stress Scale (DASS) and Urinary Hydroxyproline and Proline Concentrations in Hospital Workers

Lee KW, Kim SJ, Park JB, Lee KJ

OBJECTIVES: Although increased reactive oxygen species (ROS) is caused by stress accelerates collagen degradation, there was no data on the relationship between stress and urinary hydroxyproline (Hyp) and proline (Pro),...
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Preconditioning of isoflurane on spinal cord ischemia can increase the number of inducible nitric oxide synthase-expressing motor neurons in rat

Sung YH, Lee SH, Sung JK, Han JH, Kim H, Kim CJ, Kang JM

BACKGROUND: Spinal cord ischemia with resulting paraplegia remains one of the most common complications after repair of thoracoabdominal aortic aneurysms or dissection. Inducible nitric oxide synthase (iNOS) is known to...
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Effect of Vitamin C, Silicon and Iron on Collagen Synthesis and Break-Down Enzyme Expression in the Human Dermal Fibroblast Cell (HS27)

Kim JE, Lee J, Kim H, Kim J, Cho Y

Collagen is the major matrix protein in dermis and consists of proline and lysine, which are hydroxylated by prolyl hydroxylase (PH) and lysyl hydroxylase (LH) with cofactors such as vitamin...
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Zinc Inhibits Amyloid beta Production from Alzheimer's Amyloid Precursor Protein in SH-SY5Y Cells

Lee J, Kim CH, Kim DG, Ahn YS

Zinc released from excited glutamatergic neurons accelerates amyloid beta (A beta) aggregation, underscoring the therapeutic potential of zinc chelation for the treatment of Alzheimer's disease (AD). Zinc can also alter...
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The role of group III metabotropic receptors on opioid tolerance

Yoon MH, Lee HK, Kim WM, Cho SY, Kim YO, Cui JH

  • KMID: 1970958
  • Anesth Pain Med.
  • 2009 Apr;4(2):138-141.
BACKGROUND: Prolonged exposure to morphine causes tolerance to morphine-induced antinociception, yet the mechanisms of such tolerance are not fully understood. Although group I and II metabolic glutamate receptors (mGluRs) are...
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