- Screening Moringa species focused on development of locally available sustainable nutritional supplements
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Kim YJ, Kim HS
- KMID: 2464132
- Nutr Res Pract.
- 2019 Dec;13(6):529-534.
- doi: 10.4162/nrp.2019.13.6.529
BACKGROUND/OBJECTIVES: The leaves of Moringa oleifera (MO) and Moringa stenopetala (MS) commonly grown in Ethiopia possess potential nutritional and medicinal value. The aim of this study was to evaluate the... -
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- The Clinical Value of PELP1 for Breast Cancer: A Comparison with Multiple Cancers and Analysis in Breast Cancer Subtypes
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Wang X, Tsang JY, Lee MA, Ni YB, Tong JH, Chan SK, Cheung SY, To KF, Tse GM
- KMID: 2464416
- Cancer Res Treat.
- 2019 Apr;51(2):706-717.
- doi: 10.4143/crt.2018.316
PURPOSE: Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a novel nuclear receptor (NR) co-regulator, is highly expressed in breast cancer. We investigated its expression in breast cancer subtypes, in... -
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- Biomarker for Ischemic Stroke Using Metabolome: A Clinician Perspective
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Sidorov E, Sanghera D, Vanamala J
- KMID: 2438648
- J Stroke.
- 2019 Jan;21(1):31-41.
- doi: 10.5853/jos.2018.03454
Finding ischemic stroke biomarker is highly desirable because it can improve diagnosis even before a patient arrives to the hospital. Metabolome is one of new technologies that help to find... -
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- Vaccination of goats with a combination Salmonella vector expressing four Brucella antigens (BLS, PrpA, Omp19, and SOD) confers protection against Brucella abortus infection
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Leya M, Kim WK, Cho JS, Yu EC, Kim YJ, Yeo Y, Lyoo KS, Yang MS, Han SS, Lee JH, Tark D, Hur J, Kim B
- KMID: 2420933
- J Vet Sci.
- 2018 Sep;19(5):643-652.
- doi: 10.4142/jvs.2018.19.5.643
Salmonella is an intracellular pathogen with a cellular infection mechanism similar to that of Brucella, making it a suitable choice for use in an anti-Brucella immune boost system. This study... -
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- Effect of immunization routes and protective efficacy of Brucella antigens delivered via Salmonella vector vaccine
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Lalsiamthara J, Won G, Lee JH
- KMID: 2412132
- J Vet Sci.
- 2018 May;19(3):416-425.
- doi: 10.4142/jvs.2018.19.3.416
An anti-Brucella vaccine candidate comprised of purified Brucella lipopolysaccharide (LPS) and a cocktail of four Salmonella Typhimurium (ST)-Brucella vectors was reported previously. Each vector constitutively expressed highly conserved Brucella antigens... -
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- Correlation Between Gastric Emptying and Gastric Adaptive Relaxation Influenced by Amino Acids
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Uchida M, Kobayashi , Saito C
- KMID: 2387831
- J Neurogastroenterol Motil.
- 2017 Jul;23(3):400-408.
- doi: 10.5056/jnm16153
BACKGROUND/AIMS: Amino acids have many physiological activities. We report the correlation between gastric emptying and gastric adaptive relaxation using tryptophan and amino acids with a straight alkyl chain, hydroxylated chain,... -
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- Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder
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Demir S, Bulut M, Atli A, Kaplan I, Kaya MC, Bez Y, Özdemir P, Sır A
- KMID: 2344740
- Psychiatry Investig.
- 2016 Jul;13(4):420-426.
- doi: 10.4306/pi.2016.13.4.420
OBJECTIVE: Many neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl... -
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- Possible Role of a Missense Mutation of p.P167S on NOTCH3 Gene Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
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Choi BW, Park S, Kim HJ
- KMID: 2442856
- Dement Neurocogn Disord.
- 2016 Jun;15(2):52-54.
- doi: 10.12779/dnd.2016.15.2.52
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a single-gene disorder caused by mutations in the NOTCH3 gene, located on chromosome 19p13. NOTCH3 encodes a transmembrane... -
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- Polymorphisms of SLC22A9 (hOAT7) in Korean Females with Osteoporosis
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Ahn SK, Suh CK, Cha SH
- KMID: 2285574
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):319-325.
- doi: 10.4196/kjpp.2015.19.4.319
Among solute carrier proteins, the organic anion transporters (OATs) play an important role for the elimination or reabsorption of endogenous and exogenous negatively charged anionic compounds. Among OATs, SLC22A9 (hOAT7)... -
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- Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases
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Kant R, Bali A, Singh N, Jaggi AS
- KMID: 1429381
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):111-120.
- doi: 10.4196/kjpp.2013.17.2.111
Prolyl 4 hydroxylases (P4H) are iron- and 2-oxoglutamate-dependent dioxygenase enzymes and hypoxia-inducible transcription factor (HIF)-P4Hs play a critical role in the regulating oxygen homeostasis in the local tissues as well... -
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- Treatment of chronic hepatitis C
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Jun DW
- KMID: 2342151
- J Korean Med Assoc.
- 2012 Nov;55(11):1113-1120.
In the past 10 years, the standard treatment for chronic hepatitis C has been pegylated interferon and ribavirin for 24 to 48 weeks, based on genotype. Until now, fixed schedule... -
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- pncA Mutations in the Specimens from Extrapulmonary Tuberculosis
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Lee J, Yun YJ, Kqueen CY, Lee JH, Kim HY, Kim YR, Kook YH, Lee KH
- KMID: 2319847
- Tuberc Respir Dis.
- 2012 Jun;72(6):475-480.
BACKGROUND: Pyrazinamide (PZA) is an effective antitubercular drug that becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase), encoded by mycobacterial pncA. A strong association was... -
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- The Therapeutic Approaches for Hepatitis C Virus: Protease Inhibitors and Polymerase Inhibitors
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Kwo PY, Vinayek R
- KMID: 2284229
- Gut Liver.
- 2011 Dec;5(4):406-417.
The current standard of care for hepatitis C infection is peginterferon/ribavirin (PegIFN/RBV). We are entering the era where direct-acting antiviral agents (DAAs) will be added to PegIFN/RBV, leading to higher... -
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- Inhibition of NF-kappaB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
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Jeong IK, Oh DH, Park SJ, Kang JH, Kim S, Lee MS, Kim MJ, Hwang YC, Ahn KJ, Chung HY, Chae MK, Yoo HJ
- KMID: 1058706
- Exp Mol Med.
- 2011 Dec;43(12):684-692.
- doi: 10.3858/emm.2011.43.12.079
Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads... -
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- Therapeutic Difficulties in Poorly Differentiated and Undifferentiated Thyroid Cancer
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Lee J, Soh EY
- KMID: 2198456
- J Korean Thyroid Assoc.
- 2011 Nov;4(2):87-93.
Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) have poor prognosis and rare incidence compared to well differentiate thyroid cancer. Since the original description of PDTC in 1983,... -
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- Relationship Between Depression Anxiety Stress Scale (DASS) and Urinary Hydroxyproline and Proline Concentrations in Hospital Workers
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Lee KW, Kim SJ, Park JB, Lee KJ
- KMID: 1003034
- J Prev Med Public Health.
- 2011 Jan;44(1):9-13.
- doi: 10.3961/jpmph.2011.44.1.9
OBJECTIVES: Although increased reactive oxygen species (ROS) is caused by stress accelerates collagen degradation, there was no data on the relationship between stress and urinary hydroxyproline (Hyp) and proline (Pro),... -
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- Preconditioning of isoflurane on spinal cord ischemia can increase the number of inducible nitric oxide synthase-expressing motor neurons in rat
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Sung YH, Lee SH, Sung JK, Han JH, Kim H, Kim CJ, Kang JM
- KMID: 2031783
- Korean J Anesthesiol.
- 2010 Jan;58(1):70-75.
- doi: 10.4097/kjae.2010.58.1.70
BACKGROUND: Spinal cord ischemia with resulting paraplegia remains one of the most common complications after repair of thoracoabdominal aortic aneurysms or dissection. Inducible nitric oxide synthase (iNOS) is known to... -
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- Effect of Vitamin C, Silicon and Iron on Collagen Synthesis and Break-Down Enzyme Expression in the Human Dermal Fibroblast Cell (HS27)
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Kim JE, Lee J, Kim H, Kim J, Cho Y
- KMID: 2267331
- Korean J Nutr.
- 2009 Sep;42(6):505-515.
- doi: 10.4163/kjn.2009.42.6.505
Collagen is the major matrix protein in dermis and consists of proline and lysine, which are hydroxylated by prolyl hydroxylase (PH) and lysyl hydroxylase (LH) with cofactors such as vitamin... -
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- Zinc Inhibits Amyloid beta Production from Alzheimer's Amyloid Precursor Protein in SH-SY5Y Cells
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Lee J, Kim CH, Kim DG, Ahn YS
- KMID: 2071671
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):195-200.
- doi: 10.4196/kjpp.2009.13.3.195
Zinc released from excited glutamatergic neurons accelerates amyloid beta (A beta) aggregation, underscoring the therapeutic potential of zinc chelation for the treatment of Alzheimer's disease (AD). Zinc can also alter... -
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- The role of group III metabotropic receptors on opioid tolerance
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Yoon MH, Lee HK, Kim WM, Cho SY, Kim YO, Cui JH
- KMID: 1970958
- Anesth Pain Med.
- 2009 Apr;4(2):138-141.
BACKGROUND: Prolonged exposure to morphine causes tolerance to morphine-induced antinociception, yet the mechanisms of such tolerance are not fully understood. Although group I and II metabolic glutamate receptors (mGluRs) are... -
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