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The Amniotic Fluid Proteome Differs Significantly between Donor and Recipient Fetuses in Pregnancies Complicated by Twin-to-Twin Transfusion Syndrome

Kim SM, Cho BK, Kim BJ, Lee HY, Norwitz ER, Kang MJ, Lee SM, Park CW, Jun JK, Yi EC, Park JS

BACKGROUND: Twin-to-twin transfusion syndrome (TTTS) is a serious complication of monochorionic twin pregnancies. It results from disproportionate blood supply to each fetus caused by abnormal vascular anastomosis within the placenta....
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The role of antibiotic prophylaxis in mild to moderate isolated hydronephrosis detected in antenatal screening

Rianthavorn P, Phithaklimnuwong S

PURPOSE: To determine whether continuous antibiotic prophylaxis (CAP) could prevent urinary tract infection (UTI) in mild to moderate antenatal isolated hydronephrosis (IH), characterized by hydronephrosis without ureter and bladder abnormalities,...
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Prenatal diagnosis of harlequin ichthyosis: a case report

Vijayakumari M, Reddy DK, Routhu M, Vuchuru M, Reddy NS

Harlequin ichthyosis (HI) is a rare and severe form of ichthyosis and is characterized by thickened, hard, armor-like plates of skin that cover the entire body. This disease is caused...
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Pseudo-Single Umbilical Artery by Spontaneous Intrauterine Umbilical Artery Thrombosis

Baik M, Im SY, Lee G

Umbilical artery thrombosis is rare event and few prenatally diagnosed cases have been reported. Antenatal diagnosis is very critical, as it is associated with high risk of perinatal motility and...
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The Management and Outcomes of Placental Adhesion

Kim SY, Kong SK, Lee YJ

Placenta adhesion, often involving placenta accreta, placenta increta, and placenta percreta, is a clinical term used to describe placenta that does not separate spontaneously and cannot be removed without causing...
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Clinical Validation of Non-Invasive Prenatal Testing for Fetal Common Aneuploidies in 1,055 Korean Pregnant Women: a Single Center Experience

Lee DE, Kim H, Park J, Yun T, Park DY, Kim M, Ryu HM

BACKGROUND: Non-invasive prenatal testing (NIPT) using cell-free fetal DNA from maternal plasma for fetal aneuploidy identification is expanding worldwide. The objective of this study was to evaluate the clinical utility...
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The Effect of Multidisciplinary Approach on the Birth Rate of Fetuses with Prenatally Diagnosed Congenital Heart Disease

Kim ST, Song J, Huh J, Kang IS, Yang JH, Jun TG, Oh SY, Choi SJ, Roh CR

BACKGROUND: This study aimed to determine the effect of a multidisciplinary approach on the birth rate of fetuses with prenatally diagnosed congenital heart diseases (CHDs). METHODS: Among the fetuses of 724...
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Multiple Congenital Pancreatic Cysts in a Neonate

Kwon EM, Shin J, Jeon GW

Congenital pancreatic cysts are rare in newborn babies, and this makes prenatal diagnosis difficult. Diagnosis can be delayed for a few months after birth until the infant presents with an...
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Recent progress in laboratory diagnosis of thalassemia and hemoglobinopathy: a study by the Korean Red Blood Cell Disorder Working Party of the Korean Society of Hematology

Lee YK, Kim HJ, Lee K, Park SH, Song SH, Seong MW, Kim M, Han JY

Genetic hemoglobin disorders are caused by mutations and/or deletions in the α-globin or β-globin genes. Thalassemia is caused by quantitative defects and hemoglobinopathies by structural defect of hemoglobin. The incidence...
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The Clinical Importance of the Prenatal Diagnosis of Fetal Scalp Hemangioma

Hwang HS, Koo JH, Kim SY, Kim RY, Wie JH, Ko HS, Park IY, Shin JC

Scalp hemangioma is a rare disease of the extracranial mass in the fetus. Here, we demonstrate a case of fetal scalp hemangioma as evaluated by prenatal ultrasonography and magnetic resonance...
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Diagnosis of Tuberous Sclerosis Complex and Epilepsy Outcomes in Children with Fetal Cardiac Rhabdomyoma: A Long Term Follow-up Study

Kim D, Kim HJ, You SJ, Yum MS, Ko TS

PURPOSE: Prenatal diagnosis of cardiac rhabdomyoma is suggestive of the presence of tuberous sclerosis complex (TSC), which is commonly associated with epilepsy. This study investigated the diagnostic rate of TSC,...
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Fetal Ultrasonography for Prenatal Detection of Tuberous Sclerosis Associated with Cardiac Rhabdomyoma

Kang MJ, Hong SY, Kwon BY, Jeong JE, Bae JY

Cardiac rhabdomyoma is common cardiac mass found during the fetal period. Cardiac rhabdomyoma and tuberous sclerosis have significant associations. Tuberous sclerosis in newborns can cause disability in nearly all organs....
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Evaluation of the Early Onset Neonatal Sepsis according to Two Antenatal Group B Streptococcus Screening Methods: Risk-Based versus Universal Screening

Hong JY, Kim SH, Kim SM, Yee CA, Choi SJ, Oh SY, Roh CR

OBJECTIVE: The standard antenatal screening method for Group B Streptococcus (GBS) has not been established yet. Therefore, many practitioners in South Korea offer GBS screening to all pregnant women without...
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Three Cases of Nasal Chondromesenchymal Hamartoma Occurred in Sinonasal Tract

Choi Y, Jang YJ, Cho KJ, Chung YS

Nasal chondromesenchymal hamartoma (NCMH) is a rare benign tumor of the sinonasal tract. Most NCMH has a benign nature and can be cured by complete resection. Only a few NCMH...
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Prenatal ultrasonography of craniofacial abnormalities

Mak AS, Leung KY

Craniofacial abnormalities are common. It is important to examine the fetal face and skull Epub ahead of print during prenatal ultrasound examinations because abnormalities of these structures may indicate the...
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Change in rates of prenatal tests for chromosomal abnormality over a 12-year period in women of advanced maternal age

Kim SM, Kim HH, Han YJ, Choi JS, Ryu HM, Yang S, Kim MH

OBJECTIVE: In 2007, the American College of Obstetricians and Gynecologists (ACOG) recommended that all pregnant women be offered screening or diagnostic tests for chromosomal abnormalities regardless of their age. Noninvasive...
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Trends in Treatment Outcome and Critical Predictors of Mortality for Congenital Diaphragmatic Hernia in a Single Center

Hwang JH, Kim CY, Park HW, Namgoong J, Kim DY, Kim SC, Lee MY, Won HS, Shim JY, Lee PR, Kim A, Jung E, Lee BS, Kim KS, Kim EA

OBJECTIVE: To review trends in treatment outcomes, to determine risk factors for mortality, and to present a cut-off values of observed/expected lung to head ratio (O/E LHR) predicting mortality in...
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Role of fetal ultrasound in prenatally diagnosed de novo balanced translocations

Seong ES, Youn HJ, Park MK, Boo HY, Lee BY, Ryu HM, Han YJ

PURPOSE: This study aimed to investigate fetal ultrasonographic findings in cases of prenatally diagnosed de novo balanced translocations and the role of fetal ultrasound in prenatal genetic counseling. MATERIALS AND METHODS:...
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Ex utero intrapartum treatment procedure in two fetuses with airway obstruction

Lee J, Lee MY, Kim Y, Shim JY, Won HS, Jeong E, Lee BS, Kim KS, Choi WJ, Lee YS

The ex utero intrapartum treatment (EXIT) procedure was introduced to reduce fetal hypoxic damage while establishing an airway in fetuses with upper and lower airway obstruction. Delivery of the fetal...
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The clinical usefulness of non-invasive prenatal testing in pregnancies with abnormal ultrasound findings

Boo H, Kim SY, Seoung ES, Kim MH, Kim MY, Ryu HM, Han YJ, Chung JH

PURPOSE: This study aimed to evaluate the clinical usefulness of non-invasive prenatal testing (NIPT) as an alternative testing of invasive diagnostic testing in pregnancies with ultrasound abnormalities. MATERIALS AND METHODS: This...
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