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Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats

Yang HJ, Kim MJ, Kim SS, Cho YW

The sleep-wake cycle is regulated by the alternating activity of sleep- and wake-promoting neurons. The dorsal raphe nucleus (DRN) secretes 5-hydroxytryptamine (5-HT, serotonin), promoting wakefulness. Melatonin secreted from the pineal...
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Evaluations of Gastric Acid Pocket Using Novel Vertical 8-Channel pH Monitoring System and Effects of Acid Secretion Inhibitors

Sumi S, Ishimura N, Mikami H, Okimoto E, Tamagawa Y, Mishiro T, Kinoshita Y, Ishihara S

  • KMID: 2517531
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):370-376.
  • doi: 10.5056/jnm20115
Background/Aims The gastric acid pocket has an important role in gastroesophageal reflux disease development. In this study, we utilized a novel 8-channel pH monitoring system with sensor intervals of 1 cm...
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Clinical Manifestations and Prognostic Factors of Fungal Keratitis: Analysis in Patients Over a 20-year Period

Cho SI, Park YM, Ahn M, Cho NC, You IC

Purpose: To describe the clinical manifestations, causative organisms, treatment, and prognostic factors of fungal keratitis based on analysis of patients over the past 20 years. Methods: A total of 177...
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Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes Mellitus

Rattanatham R, Settasatian N, Komanasin N, Kukongviriyapan U, Sawanyawisuth K, Intharaphet P, Senthong V, Settasatian C

Background: Vascular complications are the major morbid consequences of type 2 diabetes mellitus (T2DM). The transcription factor 7-like 2 (TCF7L2), potassium voltage-gated channel subfamily Q member 1 (KCNQ1), and inwardly-rectifying...
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Carbon monoxide activates large-conductance calcium-activated potassium channels of human cardiac fibroblasts through various mechanisms

Bae H, Kim T, Lim I

Carbon monoxide (CO) is a cardioprotectant and potential cardiovascular therapeutic agent. Human cardiac fibroblasts (HCFs) are important determinants of myocardial structure and function. Large-conductance Ca 2+ -activated K+ (BK) channel...
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Different Seasonal Variations of Potassium in Hemodialysis Patients with High Longitudinal Potassium Levels: A Multicenter Cohort Study Using DialysisNet

Kim Y, Yun SH, Koo H, Hwang S, Kim HJ, Lee S, Baek H, Kim HH, Lee KH, Kim JH, Park JI, Yoo KD

Purpose: To determine seasonal variations in serum potassium levels among hemodialysis patients. Materials and Methods: This was a multicenter cohort study of patients whounderwent hemodialysis and were registered in DialysisNet at...
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Formulation, validation and evaluation studies on metaxalone and diclofenac potassium topical gel

Tiwari A, Bag P, Sarkar M, Chawla V, Chawla PA

Twenty different batches of gels containing metaxalone and diclofenac potassium were prepared for topical application. These drugs act synergistically in the management of pain and inflammation. Gels were prepared by...
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Efficacy of Tegoprazan for Improving the Susceptibility of Antimicrobial Agents against Antibiotic-Resistant Helicobacter pylori

Lee JW, Kim N, Nam RH, Yu JE, Son JH, Lee SM, Lee DH

Background/Aims: Favorable outcomes of potassium-competitive acid blocker (PCAB)-containing eradication therapy have been reported. In fact, tegoprazan, a recently developed PCAB, was presumed to show good eradication efficacy even for resistant...
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The Relationship between Dietary Sodium-to-Potassium Ratio and Metabolic Syndrome in Korean Adults: Using Data from the Korean National Health and Nutrition Examination Survey 2013-2015

Lee YS, Lee SY

Background: The dietary sodium-to-potassium ratio (Na:K) is known to have a stronger association with cardiovascular disease compared with a single intake of sodium or potassium. Accordingly, this study sought to...
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Role of potassium channels in female reproductive system

Kim JM, Song KS, Xu B, Wang T

Potassium channels are widely expressed in most types of cells in living organisms and regulate the functions of a variety of organs, including kidneys, neurons, cardiovascular organs, and pancreas among...
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Loss of MicroRNA-137 Impairs the Homeostasis of Potassium in Neurons via KCC2

Mi TW, Sun XW, Wang ZM, Wang YY, He XC, Liu C, Zhang SF, Du HZ, Liu CM, Teng ZQ

  • KMID: 2500525
  • Exp Neurobiol.
  • 2020 Apr;29(2):138-149.
  • doi: 10.5607/en19072
Neuropsychiatric disorders are the leading cause of mental and intellectual disabilities worldwide. Current therapies against neuropsychiatric disorders are very limited, and very little is known about the onset and development...
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Renal Potassium Excretion Visualized on 82Rubidium PET/CT

Jochumsen M, Tolbod LP, Borre M, Frøkiær J, Bouchelouche K, Sörensen J

The positron emission tomography (PET) flow tracer 82Rubidium is a known potassium analogue. During our studies of tumor blood flow in prostate cancer, we found that approximately 10% of the patients...
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Nutrients and Diabetes Mellitus: Potassium

Kang JH

Potassium (K) is an essential mineral that plays major roles in intracellular osmolality and acid-base balance. In addition, potassium affects endothelial and vascular smooth muscle functions and has been shown...
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Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects

Lee WY, Oh E, Cui M, Kim CO, Lim Y, Kim H, Park H, Yoon S, Park MS, Hong T

YH4808 is a novel potassium-competitive acid blocker that was developed as a therapeutic agent for gastric acid-related diseases; it may replace proton pump inhibitors, which are widely used in combination...
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Perioperative Management of a Patient with Hypokalemic Periodic Paralysis: A Case Report

Bae SI, Hwang Y, Kim J, Tak S, Sohn JT

Potassium imbalances can be life-threatening and must be identified and corrected prior to surgery. Patients with hypokalemic periodic paralysis (hypoKPP) experience recurrent muscle weakness or paralysis due to hypokalemia. We...
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Dual regulatory effects of PI(4,5)P2 on TREK-2 K+ channel through antagonizing interaction between the alkaline residues (K330. and R355-357 ) in the cytosolic C-terminal helix

Kim SE, Kim MH, Woo J, Kim SJ

TWIK-related two-pore domain K+ channel-2 (TREK-2) has voltageindependent activity and shows additional activation by acidic intracellular pH (pH i ) via neutralizing the E332 in the cytoplasmic C terminal (Ct)....
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Effect of nutrition education in reducing sodium intake and increasing potassium intake in hypertensive adults

Lee YS, Rhee MY, Lee SY

BACKGROUND/OBJECTIVES: Hypertension is the major risk factor for cardiovascular disease, a leading cause of deaths in Korea. The objective of this study was to evaluate the effect of a nutrition...
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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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Registered dietitian nutritionists and perceptions of liberalizing the hemodialysis diet

Welte AL, Harpel T, Schumacher J, Barnes JL

BACKGROUND/OBJECTIVES: The objective of this study was to assess the level of awareness, comfort, and likelihood of liberalizing the hemodialysis diet in practicing renal registered dietitian nutritionists (RDN). SUBJECTS/METHODS: An original,...
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Pharmacologic Treatment of Chronic Hyperkalemia in Patients with Chronic Kidney Disease

Kim GH

Hyperkalemia is frequently complicated in patients with advanced chronic kidney disease (CKD) because kidney is the major route of potassium excretion. Urinary potassium excretion is reduced according to the decline...
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