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Recent Advances in the Diagnosis and Management of Pneumocystis Pneumonia

Tasaka S

In human immunodeficiency virus (HIV)-infected patients, Pneumocystis jirovecii pneumonia (PCP) is a wellk-nown opportunistic infection and its management has been established. However, PCP is an emerging threat to immunocompromised patients...
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A Case of Severe Pneumocystis Pneumonia in a Thyroid Cancer Patient Receiving Lenvatinib

Jin MH, Kim WG, Kim TY, Kim WB, Shong YK, Jeon MJ

Lenvatinib is a multitargeted tyrosine kinase inhibitor approved for use in patients with iodine-131–refractory thyroid cancer. The common adverse events of lenvatinib include hypertension, proteinuria, fatigue, and diarrhea. To date,...
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A Stepwise Diagnostic Approach to Cystic Lung Diseases for Radiologists

Lee KC, Kang EY, Yong HS, Kim C, Lee KY, Hwang SH, Oh YW

Lung cysts are commonly seen on computed tomography (CT), and cystic lung diseases show a wide disease spectrum. Thus, correct diagnosis of cystic lung diseases is a challenge for radiologists....
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Comparative Evaluation Between the RealStar Pneumocystis jirovecii PCR Kit and the AmpliSens Pneumocystis jirovecii (carinii)-FRT PCR Kit for Detecting P. jirovecii in Non-HIV Immunocompromised Patients

Huh HJ, Lim KR, Ki CS, Huh K, Shim HJ, Song DJ, Kim YJ, Chung DR, Lee NY

BACKGROUND: Real-time PCR is more sensitive than microscopic examination for detecting Pneumocystis jirovecii. We compared the performance of two assays for detecting P. jirovecii DNA: the RealStar Pneumocystis jirovecii PCR...
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Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study

Choi Y, Choi BY, Kim SM, Kim SI, Kim J, Choi JY, Kim SW, Song JY, Kim YJ, Park DW, Kim HY, Choi HJ, Kee MK, Shin YH, Yoo M

OBJECTIVES: To manage evidence-based diseases, it is important to identify the characteristics of patients in each country. METHODS: The Korea HIV/AIDS Cohort Study seeks to identify the epidemiological characteristics of 1,442...
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Pneumocystis Pneumonia Developing during Treatment of Recurrent Renal Cell Cancer with Nivolumab

Kim HR, Keam B, Park YS, Kim M, Kim TM, Kim DW, Heo DS

Nivolumab is an immune checkpoint inhibitor approved for the treatment of metastatic cancers. Here, we report the case of a 65-year-old male with recurrent renal cell carcinoma. After six cycles...
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Mycobacterium avium Complex Infection-Related Immune Reconstitution Inflammatory Syndrome Mimicking Lymphoma in an Human Immunodeficiency Virus-Infected Patient

Sohn S, Shi HJ, Wang SH, Lee SK, Park SY, Lee JS, Eom JS

In acquired immunodeficiency syndrome (AIDS) patients, immune reconstitution inflammatory syndrome (IRIS) due to Mycobacterium avium complex (MAC) infection is one of the most difficult IRIS types to manage. We report...
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Characteristic Features of Pneumocystis Pneumonia in Pediatric Acute Lymphoblastic Leukemia

Kim H, Jang H, Kim YK, Kim D, Kim JY

BACKGROUND: Pneumocystis is difficult to culture or detect in laboratory environments. Its ecology including the timing and method of transmission as well as environmental sources and communicability remain unclear. METHODS: We...
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Therapeutic effect of ascorbic acid on dapsone-induced methemoglobinemia in rats

Kang C, Kim DH, Kim T, Lee SH, Jeong JH, Lee SB, Kim JH, Jung MH, Lee KW, Park IS

OBJECTIVE: Dapsone (diaminodiphenyl sulfone, DDS) is currently used to treat leprosy, malaria, dermatitis herpetiformis, and other diseases. It is also used to treat pneumocystis pneumonia and Toxoplasma gondii infection in...
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Clinical significance of positive Pneumocystis jirovecii polymerase chain reaction in non-human immunodeficiency virus immunocompromised patients in a real practice

Lee HY, Kang HS, Lee HY, Rhee CK, Lee SY, Kim SC, Kim SJ, Park YJ, Kim YK, Kang JY

BACKGROUND/AIMS: Pneumocystis jirovecii polymerase chain reaction (PCR) can be helpful in diagnosing Pneumocystis pneumonia (PCP); however it has limitations. We evaluated the prevalence of positive P. jirovecii PCR from non-human...
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A Case of Methemoglobinemia Caused by Primaquine

Lee JY, Kim SH, An S, Oh HS, Yi SY, Lee HH, Han DJ

Primaquine is often administered for the hypnozoite stage of Plasmodium vivax and Plasmodium ovale. Primaquine (with clindamycin) is also an alternative drug for treatment of pneumocystis pneumonia when trimethoprim/sulfamethoxazole cannot...
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Pneumocystis jirovecii Pneumonia with Granulomatous Reaction in the Lung and the Liver Discovered at Autopsy

Kim MY, Bak S, Park S, Choi M, Lee SD

We report the case of a 42-year-old woman who died in hospital from severe respiratory failure, 10 days after the onset of symptoms. Autopsy and microscopic examination identified features of...
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The 2015 Clinical Guidelines for the Treatment and Prevention of Opportunistic Infections in HIV-Infected Koreans: Guidelines for Opportunistic Infections

The Korean Society for AIDS

The Committee for Clinical Guidelines for the Treatment and Prevention of Opportunistic Infections of the Korean Society for AIDS was founded in 2011. The first edition of the Korean guidelines...
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Tacrolimus for the Treatment of Ulcerative Colitis

Matsuoka K, Saito E, Fujii T, Takenaka K, Kimura M, Nagahori M, Ohtsuka K, Watanabe M

Tacrolimus is a calcineurin inhibitor used for the treatment of corticosteroid-refractory ulcerative colitis (UC). Two randomized controlled trials and a number of retrospective studies have assessed the therapeutic effect of...
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Single Nodular Opacity of Granulomatous Pneumocystis Jirovecii Pneumonia in an Asymptomatic Lymphoma Patient

Kim HS, Shin KE, Lee JH

The radiologic findings of a single nodule from Pneumocystis jirovecii pneumonia (PJP) have been rarely reported. We described a case of granulomatous PJP manifesting as a solitary pulmonary nodule with...
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Successful rapid desensitization to trimethoprim-sulfamethoxazole-induced delayed hypersensitivity

Yoon D, Ahn H, Kim SY, Hwang SJ, Park HK, Kang HR

Trimethoprim-sulfamethoxazole (TMP-SMX) is an antibiotic used for the treatment or prophylaxis of Pneumocystis pneumonia and other infectious conditions. Sulfonamide derivatives have been reported to cause delayed hypersensitivity reactions, resulting in...
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Ultra-Low-Dose Chest CT in Patients with Neutropenic Fever and Hematologic Malignancy: Image Quality and Its Diagnostic Performance

Kim HJ, Park SY, Lee HY, Lee KS, Shin KE, Moon JW

PURPOSE: The aim of this study was to evaluate the image quality of ultra-low-dose computed tomography (ULDCT) and its diagnostic performance in making a specific diagnosis of pneumonia in febrile...
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Common Infectious Diseases in HIV Infected Persons

Choi JY

  • KMID: 2267875
  • Korean J Med.
  • 2013 Feb;84(2):179-185.
Opportunistic infections (OIs) are defined as infections that are more frequent or more severe because of immunosuppression in HIV-infected persons. Before the widespread use of combination antiretroviral therapy (ART), OIs...
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Infection Prevention in Transplant Recipients

Ha YE, Peck KR

  • KMID: 2267874
  • Korean J Med.
  • 2013 Feb;84(2):168-178.
Opportunistic infections are major causes of morbidity and mortality in hematopoietic stem-cell transplant and solid organ transplant recipients. The epidemiology and incidence of opportunistic infections in those patients have been...
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Trends of Mortality and Cause of Death among HIV-Infected Patients in Korea, 1990-2011

Lee SH, Kim KH, Lee SG, Chen DH, Jung DS, Moon CS, Park JY, Chung JS, Kwak IS, Cho GJ

Although a decrease in acquired immunodeficiency syndrome (AIDS)-related mortality has been documented in highly active antiretroviral therapy (HAART) era, there are no published data comparing specific causes of death between...
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