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Derivation of endothelial cells from porcine induced pluripotent stem cells by optimized single layer culture system

Wei R, Lv J, Li X, Li Y, Xu Q, Jin J, Zhang Y, Liu Z

Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most...
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Maintenance of hPSCs under Xeno-Free and Chemically Defined Culture Conditions

Lim JJ, Kim HJ, Rhie BH, Lee MR, Choi MJ, Hong SH, Kim KS

Previously, the majority of human embryonic stem cells and human induced pluripotent stem cells have been derived on feeder layers and chemically undefined medium. Those media components related to feeder...
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Direct Reprogramming to Human Induced Neuronal Progenitors from Fibroblasts of Familial and Sporadic Parkinson’s Disease Patients

Lee M, Sim H, Ahn H, Ha J, Baek A, Jeon YJ, Son MY, Kim J

In Parkinson’s disease (PD) research, human neuroblastoma and immortalized neural cell lines have been widely used as in vitro models. The advancement in the field of reprogramming technology has provided...
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Reprogramming of Cancer Cells into Induced Pluripotent Stem Cells Questioned

Bang JS, Choi NY, Lee M, Ko K, Park YS, Ko K

BACKGROUND AND OBJECTIVES: Several recent studies have claimed that cancer cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, in most cases, cancer cells seem to be resistant...
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Stem cell therapy in pain medicine

Han YH, Kim KH, Abdi S, Kim TK

Stem cells are attracting attention as a key element in future medicine, satisfying the desire to live a healthier life with the possibility that they can regenerate tissue damaged or...
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Human Induced Pluripotent Stem Cells: Clinical Significance and Applications in Neurologic Diseases

Chang EA, Jin SW, Nam MH, Kim SD

The generation of human induced pluripotent stem cells (iPSCs) from somatic cells using gene transfer opens new areas for precision medicine with personalized cell therapy and encourages the discovery of...
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Comparative Evaluation of Hormones and Hormone-Like Molecule in Lineage Specification of Human Induced Pluripotent Stem Cells

Choi SA, An JH, Lee SH, Lee GH, Yang HJ, Jeong PS, Cha JJ, Lee S, Park YH, Song BS, Sim BW, Kim YH, Kim JS, Jin YB, Huh JW, Lee SR, Lee JH, Kim SU

BACKGROUND AND OBJECTIVES: Proficient differentiation of human pluripotent stem cells (hPSCs) into specific lineages is required for applications in regenerative medicine. A growing amount of evidences had implicated hormones and...
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Regenerative Medicine of the Bile Duct: Beyond the Myth

Buisson EM, Jeong J, Kim HJ, Choi D

Cholangiopathies are rare diseases of the bile duct with high mortality rates. The current treatment for cholangiopathies is liver transplantation, but there are significant obstacles including a shortage of donors...
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Clinical and genetic aspects of Charcot-Marie-Tooth disease subtypes

Nam SH, Choi BO

Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neuropathies and is both genetically and clinically heterogeneous, with variable inheritance modes. With regard to clinical and genetic aspects, CMT...
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The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction

Li L, Roh JH, Kim HJ, Park HJ, Kim M, Koh W, Heo H, Chang JW, Nakanishi , Yoon T, Na DL, Song J

Alzheimer's Disease (AD) is a progressive neurodegenerative disease, which is pathologically defined by the accumulation of amyloid plaques and hyper-phosphorylated tau aggregates in the brain. Mitochondrial dysfunction is also a...
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Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and Radiotherapy

Okada K, Fujisawa M

The survival rates of boys and men with cancer have increased due to advances in cancer treatments; however, maintenance of quality of life, including fertility preservation, remains a major issue....
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Conditioned Medium Enhances Osteogenic Differentiation of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

Zhong S, He X, Li Y, Lou X

BACKGROUND: Recent studies have shown that induced pluripotent stem cells (iPSCs) could be differentiated into mesenchymal stem cells (MSCs) with notable advantages over iPSCs per se. In order to promote...
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Stem Cell-Based Therapies for Liver Diseases: An Overview and Update

Wang J, Sun M, Liu W, Li Y, Li M

BACKGROUND: Liver disease is one of the top causes of death globally. Although liver transplantation is a very effective treatment strategy, the shortage of available donor organs, waiting list mortality,...
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Current Stem Cell Therapy for Osteoarthritis

Nam Y, Rim YA, Ju JH

Osteoarthritis is a musculoskeletal disease representative of an aging society. As medical conditions are usually complicated in an aging population, osteoarthritis becomes more frequently encountered in the physician's office. There...
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Alteration of Genomic Imprinting Status of Human Parthenogenetic Induced Pluripotent Stem Cells during Neural Lineage Differentiation

Lee HJ, Choi NY, Lee SW, Lee Y, Ko K, Kim GJ, Hwang HS, Ko K

BACKGROUND AND OBJECTIVES: Genomic imprinting modulates growth and development in mammals and is associated with genetic disorders. Although uniparental embryonic stem cells have been used to study genomic imprinting, there...
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Regulation of Neural Stem Cell Fate by Natural Products

Kim HJ

Neural stem cells (NSCs) can proliferate and differentiate into multiple cell types that constitute the nervous system. NSCs can be derived from developing fetuses, embryonic stem cells, or induced pluripotent...
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Determining Osteogenic Differentiation Efficacy of Pluripotent Stem Cells by Telomerase Activity

Zhang S, Sun Y, Sui Y, Li Y, Luo Z, Xiao X, Zhou P, Wei S

BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the...
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Mbd3 Promotes Reprogramming of Primary Human Fibroblasts

Jaffer S, Goh P, Abbasian M, Nathwani A

Mbd3 (Methyl-CpG binding domain protein), a core member of NuRD (nucleosome remodelling and deacetylation) is essential for embryogenesis. However, its role in reprogramming of somatic cells into induced pluripotent stem...
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Cardiac Regeneration with Human Pluripotent Stem Cell-Derived Cardiomyocytes

Park M, Yoon YS

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), which are collectively called pluripotent stem cells (PSCs), have emerged as a promising source for regenerative medicine. Particularly, human pluripotent...
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iPSC Modeling of Presenilin1 Mutation in Alzheimer's Disease with Cerebellar Ataxia

Li L, Roh JH, Chang EH, Lee Y, Lee S, Kim M, Koh W, Chang JW, Kim HJ, Nakanishi , Barker RA, Na DL, Song J

Disease modeling of Alzheimer's disease (AD) has been hampered by the lack of suitable cellular models while animal models are mainly based on the overexpression of AD-related genes which often...
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