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Treatment outcomes of imported Plasmodium falciparum malaria with intravenous artesunate

Lee S, Park T, Jung SK, Cho W, Lee K, Ko JI

  • KMID: 2527387
  • J Korean Soc Emerg Med.
  • 2022 Feb;33(1):121-129.
Objective: There has been a consistent import of Plasmodium falciparum malaria into South Korea. As artesunate has been shown to reduce malaria related mortality in other countries, we sought to...
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A LAMP-SNP Assay Detecting C580Y Mutation in Pfkelch13 Gene from Clinically Dried Blood Spot Samples

Khammanee T, Sawangjaroen N, Buncherd H, Tun AW, Thanapongpichat S

Artemisinin resistance (ART) has been confirmed in Greater Mekong Sub-region countries. Currently, C580Y mutation on Pfkelch13 gene is known as the molecular marker for the detection of ART. Rapid and...
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Mixed Infection with Plasmodium falciparum and Plasmodium ovale in a Returned Traveller: the First Case in Korea

Kim G, Hong HL, Kim SY, Lee HR, Kim DG, Park S, Shin HS, Chin BS, Kim Y

Mixed-species malaria infections are often unrecognized or underestimated. We hereby report the first described case of mixed infection with Plasmodium falciparum and Plasmodium ovale malaria in a returned traveller in...
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An Evaluation of Active Case Detection in Malaria Control Program in Kiyuni Parish of Kyankwanzi District, Uganda

Bahk YY, Cho PY, Ahn SK, Lee WJ, Kim TS, Working Groups in ChildFund Korea, Uganda

Malaria remains one of the leading health burdens in the developing world, especially in several sub-Saharan Africa countries; and Uganda has some of the highest recorded measures of malaria transmission...
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Unraveling Haplotype Diversity of the Apical Membrane Antigen-1 Gene in Plasmodium falciparum Populations in Thailand

Lumkul L, Sawaswong , Simpalipan P, Kaewthamasorn M, Harnyuttanakorn P, Pattaradilokrat S

Development of an effective vaccine is critically needed for the prevention of malaria. One of the key antigens for malaria vaccines is the apical membrane antigen 1 (AMA-1) of the...
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An Alternative Method for Extracting Plasmodium DNA from EDTA Whole Blood for Malaria Diagnosis

Seesui K, Imtawil K, Chanetmahun P, Laummaunwai P, Boonmars T

Molecular techniques have been introduced for malaria diagnosis because they offer greater sensitivity and specificity than microscopic examinations. Therefore, DNA isolation methods have been developed for easy preparation and cost...
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Delayed Diagnosis of Falciparum Malaria with Acute Kidney Injury

Choi IH, Hwang PH, Choi SI, Lee DY, Kim MS

Prompt malaria diagnosis is crucial so antimalarial drugs and supportive care can then be rapidly initiated. A 15-year-old boy who had traveled to Africa (South Africa, Kenya, and Nigeria between...
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Antiplasmodial and Cytotoxic Activities of Toad Venoms from Southern Amazon, Brazil

Banfi FF, Guedes KD, Andrighetti CR, Aguiar AC, Debiasi BW, Noronha JD, Rodrigues , Júnior GM, Sanchez BA

The drug-resistance of malaria parasites is the main problem in the disease control. The huge Brazilian biodiversity promotes the search for new compounds, where the animal kingdom is proving to...
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Characteristics of Imported Malaria and Species of Plasmodium Involved in Shandong Province, China (2012-2014)

Xu C, Wei QK, Li J, Xiao T, Yin K, Zhao CL, Wang YB, Kong XL, Zhao GH, Sun H, Liu X, Huang BC

Malaria remains a serious public health problem in Shandong Province, China; therefore, it is important to explore the characteristics of the current malaria prevalence situation in the province. In this...
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Impact of Irrigation Extension on Malaria Transmission in Simret, Tigray, Ethiopia

Chung B

Poor subsistence farmers who live in a semi-arid area of northern Ethiopia build irrigation systems to overcome water shortages. However, there is a high risk of malaria transmission when increased...
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Hemozoin Pigment: An Important Tool for Low Parasitemic Malarial Diagnosis

Mohapatra , Ghosh A, Singh R, Singh DP, Sharma B, Samantaray JC, Deb M, Gaind R

Low parasitemic condition in malaria remains a diagnostic challenge; as the available diagnostic methods failed to detect. Currently, hemozoin (Hz) pigment is gaining attention in the diagnosis of malaria. The...
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Imported Malaria over Fifteen Years in an Inner City Teaching Hospital of Washington DC

Yeruva SL, Sinha A, Sarraf-Yazdy M, Gajjala J

As endemic malaria is not commonly seen in the United States, most of the cases diagnosed and reported are associated with travel to and from the endemic places of malaria....
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Effective High-Throughput Blood Pooling Strategy before DNA Extraction for Detection of Malaria in Low-Transmission Settings

Nyunt MH, Kyaw MP, Thant KZ, Shein T, Han SS, Zaw NN, Han JH, Lee SK, Muh F, Kim JY, Cho SH, Lee SE, Yang EJ, Chang CL, Han ET

In the era of (pre) elimination setting, the prevalence of malaria has been decreasing in most of the previously endemic areas. Therefore, effective cost- and time-saving validated pooling strategy is...
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Potential Interaction of Plasmodium falciparum Hsp60 and Calpain

Yeo SJ, Liu DX, Park H

After invasion of red blood cells, malaria matures within the cell by degrading hemoglobin avidly. For enormous protein breakdown in trophozoite stage, many efficient and ordered proteolysis networks have been...
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High Malaria Prevalence among Schoolchildren on Kome Island, Tanzania

Kim MJ, Jung BK, Chai JY, Eom KS, Yong TS, Min DY, Siza JE, Kaatano GM, Kuboza J, Mnyeshi P, Changalucha JM, Ko Y, Chang SY, Rim HJ

In order to determine the status of malaria among schoolchildren on Kome Island (Lake Victoria), near Mwanza, Tanzania, a total of 244 schoolchildren in 10 primary schools were subjected to...
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Effect of Farnesyltransferase Inhibitor R115777 on Mitochondria of Plasmodium falciparum

Ha YR, Hwang BG, Hong Y, Yang HW, Lee SJ

The parasite Plasmodium falciparum causes severe malaria and is the most dangerous to humans. However, it exhibits resistance to their drugs. Farnesyltransferase has been identified in pathogenic protozoa of the...
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Allelic Diversity of MSP1 Gene in Plasmodium falciparum from Rural and Urban Areas of Gabon

Mawili-Mboumba DP, Mbondoukwe N, Adande E, Bouyou-Akotet MK

The present study determined and compared the genetic diversity of Plasmodium falciparum strains infecting children living in 2 areas from Gabon with different malaria endemicity. Blood samples were collected from...
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Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand

Kuesap J, Chaijaroenkul W, Rungsihirunrat K, Pongjantharasatien K, Na-Bangchang K

Hemoglobinopathy and malaria are commonly found worldwide particularly in malaria endemic areas. Thalassemia, the alteration of globin chain synthesis, has been reported to confer resistance against malaria. The prevalence of...
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Allelic Diversity and Geographical Distribution of the Gene Encoding Plasmodium falciparum Merozoite Surface Protein-3 in Thailand

Sawaswong , Simpalipan P, Siripoon N, Harnyuttanakorn P, Pattaradilokrat S

Merozoite surface proteins (MSPs) of malaria parasites play critical roles during the erythrocyte invasion and so are potential candidates for malaria vaccine development. However, because MSPs are often under strong...
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Sensitivity of Plasmodium falciparum to Antimalarial Drugs in Hainan Island, China

Wang SQ, Wang GZ, Li YC, Meng F, Lin SG, Zhu ZH, Sun DW, He CH, Hu XM, Du JW

Pyronaridine and artesunate have been shown to be effective in falciparum malaria treatment. However, pyronaridine is rarely used in Hainan Island clinically, and artesunate is not widely used as a...
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