- Novel ABCD1 Gene Mutation in a Korean Patient with X-Linked Adrenoleukodystrophy Presenting with Addison's Disease
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Cho YK, Lee SY, Kim SW
- KMID: 2471735
- Endocrinol Metab.
- 2020 Mar;35(1):188-191.
- doi: 10.3803/EnM.2020.35.1.188
X-linked adrenoleukodystrophy (X-ALD) occurs due to mutations in the ABCD1 gene that encodes the peroxisomal membrane protein peroxisomal transporter ATP-binding cassette sub-family D member 1 (ABCD1). Degradation of very long-chain... -
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- Cryptotanshinone Inhibits Lipid Accumulation in Differentiating 3T3-L1 Preadipocytes by Down-regulating C/EBP-α, PPAR-γ, FAS, Perilipin A, and STAT-3
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Park YK, Jang BC
- KMID: 2469571
- Keimyung Med J.
- 2019 Dec;38(1,2):1-10.
- doi: 10.0000/kmj.2019.38.1.1
Differentiation of preadipocyte, also named adipogenesis, leads to the phenotype of mature adipocyte that is filled with many lipid droplets. Excessive lipid accumulation in adipocytes leads to the development of... -
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- Cryptotanshinone Inhibits Lipid Accumulation in Differentiating 3T3-L1 Preadipocytes by Down-regulating C/EBP-α, PPAR-γ, FAS, Perilipin A, and STAT-3
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Park YK, Jang BC
- KMID: 2469552
- Keimyung Med J.
- 2019 Dec;38(1-2):1-10.
- doi: 10.0000/kmj.2019.38.1.1
Differentiation of preadipocyte, also named adipogenesis, leads to the phenotype of mature adipocyte that is filled with many lipid droplets. Excessive lipid accumulation in adipocytes leads to the development of... -
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- Cryptotanshinone Inhibits Lipid Accumulation in Differentiating 3T3-L1 Preadipocytes by Down-regulating C/EBP-α, PPAR-γ, FAS, Perilipin A, and STAT-3
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Park YK, Jang BC
- KMID: 2469544
- Keimyung Med J.
- 2019 Dec;38(1):1-10.
- doi: 10.0000/kmj.2019.38.1.1
Differentiation of preadipocyte, also named adipogenesis, leads to the phenotype of mature adipocyte that is filled with many lipid droplets. Excessive lipid accumulation in adipocytes leads to the development of... -
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- The Activation of PPAR-α and Wnt/β-catenin by Luffa cylindrica Supercritical Carbon Dioxide Extract
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Kim B
- KMID: 2468068
- Nat Prod Sci.
- 2019 Dec;25(4):341-347.
- doi: 10.20307/nps.2019.25.4.341
Luffa cylindrica (LC) is a very fast-growing climber and its fruit have been considered as agricultural wastes. We conducted to check the comparative qualities of ethanol solvent extraction (LCE) and... -
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- Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser¹¹â·â¹ Dephosphorylation
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Cho DH
- KMID: 2461172
- J Korean Med Sci.
- 2019 Nov;34(42):e266.
- doi: 10.3346/jkms.2019.34.e266
BACKGROUND: Apart from its blood pressure-lowering effect by blocking the renin-angiotensin-aldosterone system, telmisartan, an angiotensin II type 1 receptor blocker (ARB), exhibits various ancillary effects including cardiovascular protective effects in... -
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- 15-Deoxy-Δ(12,14)-prostaglandin J₂ Upregulates the Expression of 15-Hydroxyprostaglandin Dehydrogenase by Inducing AP-1 Activation and Heme Oxygenase-1 Expression in Human Colon Cancer Cells
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Park JM, Na HK
- KMID: 2468800
- J Cancer Prev.
- 2019 Sep;24(3):183-191.
- doi: 10.15430/JCP.2019.24.3.183
BACKGROUND: Abnormal upregulation of prostaglandin Eâ‚‚ (PGEâ‚‚) is considered to be a key oncogenic event in the development and progression of inflammation-associated human colon cancer. It has been reported that... -
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- Deficiency or activation of peroxisome proliferator-activated receptor α reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J mice
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Hsiao WT, Su HM, Su KP, Chen SH, Wu HP, You YL, Fu RH, Chao PM
- KMID: 2453106
- Nutr Res Pract.
- 2019 Aug;13(4):286-294.
- doi: 10.4162/nrp.2019.13.4.286
BACKGROUND/OBJECTIVES: Docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid (LCPUFA), is acquired by dietary intake or the in vivo conversion of α-linolenic acid. Many enzymes participating in LCPUFA... -
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- Fumigaclavine C attenuates adipogenesis in 3T3-L1 adipocytes and ameliorates lipid accumulation in high-fat diet-induced obese mice
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Yu WG, He Y, Chen YF, Gao XY, Ning WE, Liu CY, Tang TF, Liu Q, Huang XC
- KMID: 2443604
- Korean J Physiol Pharmacol.
- 2019 May;23(3):161-169.
- doi: 10.4196/kjpp.2019.23.3.161
Fumigaclavine C (FC), an active indole alkaloid, is obtained from endophytic Aspergillus terreus (strain No. FC118) by the root of Rhizophora stylosa (Rhizophoraceae). This study is designed to evaluate whether... -
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- Effects of Lonicera caerulea extract on adipocyte differentiation and adipogenesis in 3T3-L1 cells and mouse adipose-derived stem cells (MADSCs)
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Park M, Lee C, Lee HJ
- KMID: 2466679
- J Nutr Health.
- 2019 Feb;52(1):17-25.
- doi: 10.4163/jnh.2019.52.1.17
PURPOSE: Obesity is a major health problem of global significance because it is clearly associated with an increased risk of health problems, such as nonalcoholic fatty liver disease (NAFLD), diabetes,... -
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- Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes
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Lee HJ, Yang SJ
- KMID: 2434070
- Nutr Res Pract.
- 2019 Feb;13(1):3-10.
- doi: 10.4162/nrp.2019.13.1.3
BACKGROUND/OBJECTIVES: The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents... -
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- Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver
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Cho KW, Cho DH
- KMID: 2434096
- Yeungnam Univ J Med.
- 2019 Jan;36(1):26-35.
- doi: 10.12701/yujm.2019.00059
BACKGROUND: Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in... -
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- Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma
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Huang J, Su M, Lee BK, Kim MJ, Jung JH, Im DS
- KMID: 2427506
- Biomol Ther.
- 2018 Nov;26(6):539-545.
- doi: 10.4062/biomolther.2018.006
4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione (PD1) is a synthetic phthalimide derivative of a marine compound. PD1 has peroxisome proliferator-activated receptor (PPAR) γ agonistic and anti-inflammatory effects. This study aimed to investigate the effect of... -
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- The effects of Brassica juncea L. leaf extract on obesity and lipid profiles of rats fed a high-fat/high-cholesterol diet
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Lee JJ, Kim HA, Lee J
- KMID: 2420995
- Nutr Res Pract.
- 2018 Aug;12(4):298-306.
- doi: 10.4162/nrp.2018.12.4.298
BACKGROUND/OBJECTIVES: Obesity is a global health problem of significant importance which increases mortality. In place of anti-obesity drugs, natural products are being developed as alternative therapeutic materials. In this study,... -
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- Peroxisome proliferator-activated receptor gamma agonist as a novel treatment for interstitial cystitis: A rat model
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Mahal A, Young-Lin , Dobberfuhl A, Estes J, Comiter CV
- KMID: 2414759
- Investig Clin Urol.
- 2018 Jul;59(4):257-262.
- doi: 10.4111/icu.2018.59.4.257
PURPOSE: To understand the therapeutic potential of pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist with a propensity to cause bladder mucosal proliferation, on interstitial cystitis (IC) in a rat... -
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- Leucrose, a Sucrose Isomer, Suppresses Hepatic Fat Accumulation by Regulating Hepatic Lipogenesis and Fat Oxidation in High-fat Diet-induced Obese Mice
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Lee J, Kim E, Kim Y, Yoo SH
- KMID: 2417374
- J Cancer Prev.
- 2018 Jun;23(2):99-106.
- doi: 10.15430/JCP.2018.23.2.99
Obesity is currently one of the most serious public health problems and it can lead to numerous metabolic diseases. Leucrose, d-glucopyranosyl-α-(1-5)-d-fructopyranose, is an isoform of sucrose and it is naturally... -
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- Troglitazone Inhibits Matrix Metalloproteinase-9 Expression and Invasion of Breast Cancer Cell through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism
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Hong OY, Youn HJ, Jang HY, Jung SH, Noh EM, Chae HS, Jeong YJ, Kim W, Kim CH, Kim JS
- KMID: 2441865
- J Breast Cancer.
- 2018 Mar;21(1):28-36.
- doi: 10.4048/jbc.2018.21.1.28
PURPOSE: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling... -
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- Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats
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Hwang YC, Oh DH, Choi MC, Lee SY, Ahn KJ, Chung HY, Lim SJ, Chung SH, Jeong IK
- KMID: 2411547
- Korean J Intern Med.
- 2018 Mar;33(2):347-355.
- doi: 10.3904/kjim.2015.208
BACKGROUND/AIMS: Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the... -
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- Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells
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Hong SW, Lee J, Cho JH, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY
- KMID: 2407127
- Endocrinol Metab.
- 2018 Mar;33(1):105-113.
- doi: 10.3803/EnM.2018.33.1.105
BACKGROUND: The nuclear receptor peroxisome proliferator-activator gamma (PPARγ) is a useful therapeutic target for obesity and diabetes, but its role in protecting β-cell function and viability is unclear. METHODS: To identify... -
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- Galangin Suppresses Pro-Inflammatory Gene Expression in Polyinosinic-Polycytidylic Acid-Stimulated Microglial Cells
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Choi MJ, Park JS, Park JE, Kim HS, Kim HS
- KMID: 2395814
- Biomol Ther.
- 2017 Nov;25(6):641-647.
- doi: 10.4062/biomolther.2017.173
Galangin (3,5,7-trihydroxyflavone) is a polyphenolic compound abundant in honey and medicinal herbs, such as Alpinia officinarum. In this study, we investigated the anti-inflammatory effects of galangin under in vitro and... -
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