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Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats

Kang JB, Park DJ, Koh PO

Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral...
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The Role of Peroxiredoxin Family in Cancer Signaling

Kim Y, Jang HH

Peroxiredoxins (Prxs) are antioxidant enzymes that protect cells from oxidative stress by reducing intracellular accumulation of reactive oxygen species (ROS). In mammalian cells, the six Prx isoforms are ubiquitously expressed...
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Silencing of peroxiredoxin II by promoter methylation is necessary for the survival and migration of gastric cancer cells

Hong SH, Min C, Jun Y, Lee DJ, Kim SH, Park JH, Cheong JH, Park YJ, Kim SY, Lee S, Kang SW

Peroxiredoxin (Prx), a family of ubiquitous thiol peroxidases, functions as a redox signaling regulator that controls cellular Hâ‚‚Oâ‚‚ in mammalian cells and has recently received attention for being overexpressed in...
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An important role for peroxiredoxin II in survival of A549 lung cancer cells resistant to gefitinib

Kwon T, Rho JK, Lee JC, Park YH, Shin HJ, Cho S, Kang YK, Kim BY, Yoon DY, Yu DY

Redox adaptation is an important concept that explains the mechanisms by which cancer cells survive under persistent endogenous oxidative stress and become resistant to certain anticancer agents. To investigate this...
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Elevated Prx1 Provides Resistance to Docetaxel, But Is Not Associated with Predictive Significance in Lung Cancer

Hwang KE, Park C, Seol CH, Hwang YR, Hwang JS, Jung JW, Choi KH, Jeong ET, Kim HR

  • KMID: 2320440
  • Tuberc Respir Dis.
  • 2013 Aug;75(2):59-66.
BACKGROUND: This study was conducted in order to elucidate the effects of docetaxel on the growth of peroxiredoxin 1 (Prx1) knockdown A549 xenograft tumors and further tested the role of...
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Studies on In Vivo Function of Peroxiredoxins in Knockout Mice

Yu DY

Peroxiredoxins (Prxs) are a family of antioxidant proteins that reduce peroxide levels by using reducing agents such as thioredoxin. These proteins were characterized to have a number of cellular functions,...
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Oxidative stress and the antioxidant enzyme system in the developing brain

Shim SY, Kim HS

Preterm infants are vulnerable to the oxidative stress due to the production of large amounts of free radicals, antioxidant system insufficiency, and immature oligodendroglial cells. Reactive oxygen species (ROS) play...
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Targeting Cellular Antioxidant Enzymes for Treating Atherosclerotic Vascular Disease

Kang DH, Kang SW

  • KMID: 1502509
  • Biomol Ther.
  • 2013 Mar;21(2):89-96.
Atherosclerotic vascular dysfunction is a chronic inflammatory process that spreads from the fatty streak and foam cells through lesion progression. Therefore, its early diagnosis and prevention is unfeasible. Reactive oxygen...
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Effect of PRX-1 Downregulation in the Type 1 Diabetes Microenvironment

Yoo JS, Lee YJ, Hyung KE, Yoon JW, Lee IH, Park SY, Hwang KW

Type 1 diabetes (T1D) is caused by dysregulation of the immune system in the pancreatic islets, which eventually leads to insulin-producing pancreatic beta-cell death and destabilization of glucose homeostasis. One...
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Thyroid and Hydrogen Peroxide

Park DJ

The thyroid gland produces high concentrations of hydrogen peroxide (H2O2) which is used for the biosynthesis of the thyroid hormones, triiodothyronine and thyroxine. The most important step in thyroid hormone...
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Protective Effects of Peroxiredoxin on Hydrogen Peroxide Induced Oxidative Stress and Apoptosis in Cardiomyocytes

Park KJ, Kim YJ, Kim J, Kim SM, Lee SY, Bae JW, Hwang KK, Kim DW, Cho MC

BACKGROUND AND OBJECTIVES: The redox system is an important anti-oxidative system composed of thioredoxin, thioredoxin reductase, and peroxiredoxin (PRx). The fine details of PRx expression and its protective effects in...
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Peroxiredoxin I regulates the component expression of gamma-secretase complex causing the Alzheimer's disease

Lee YJ, Goo JS, Kim JE, Nam SH, Hwang IS, Choi SI, Lee HR, Lee EP, Choi HW, Kim HS, Lee JH, Jung YJ, Kim HJ, Hwang DY

Peroxiredoxin I (Prx I) is a member of the peroxiredoxins (Prxs) family, which are antioxidant enzymes that regulate various cellular process via intracellular oxidative signal pathways. In order to investigate...
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Nuclear factor E2-related factor 2 Dependent Overexpression of Sulfiredoxin and Peroxiredoxin III in Human Lung Cancer

Kim YS, Lee HL, Lee KB, Park JH, Chung WY, Lee KS, Sheen SS, Park KJ, Hwang SC

BACKGROUND/AIMS: Oxidative stress results in protein oxidation and is implicated in carcinogenesis. Sulfiredoxin (Srx) is responsible for the enzymatic reversal of inactivated peroxiredoxin (Prx). Nuclear factor E2-related factor 2 (Nrf2)...
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Expression of peroxiredoxin I regulated by gonadotropins in the rat ovary

Lee YI, Kang WD, Kim MY, Cho MK, Chun SY

OBJECTIVE: Peroxiredoxins (Prxs) play an important role in regulating cellular differentiation and proliferation in several types of mammalian cells. This report examined the expression of Prx isotype I in the...
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The Role of Oxidative Stress in the Pathogenesis of Asthma

Cho YS, Moon HB

Oxidative stress plays a critical role in the pathogenesis of asthma. To effectively control oxidative stress in asthmatics, it is important to investigate the precise intracellular mechanism by which the...
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Proteomic Changes in the Female Rat Bladder Tissue following Bilateral Oophorectomy

Lee HC, Kim HJ

  • KMID: 2331554
  • J Korean Continence Soc.
  • 2009 Dec;13(2):134-141.
PURPOSE: To explore the effect of bilateral oophorectomy on the several proteins of female rat bladder via a proteomic approach. MATERIALS AND METHODS: A total of 20 female Sprague-Dawley rats were...
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Reduced Mitochondrial Properties in Putative Progenitor/Stem Cells of Human Keratinocytes

Chang SE, Pak YK, Lee HW, Choi JH, Jeong EJ, Choi SH, Chang HW, Chung YS, Kim SY

BACKGROUND: The characterization of progenitor/keratinocyte stem cells (KSC) remains an unachieved goal. A previous study showed that rapid adhering cells to collagen IV had the characteristics of putative progenitor/KSCs. OBJECTIVE: The...
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Selectively Decreased Expression of Peroxiredoxins Induced by Silica in Pulmonary Epithelial Cells

Lee HL, Kim YS, Park JH, Chung WY, Lee KS, Oh YJ, Sheen SS, Park KJ, Hwang SC

BACKGROUND/AIMS: Peroxiredoxin (Prx) belongs to a ubiquitous family of antioxidant enzymes that regulates many cellular processes through intracellular oxidative signal transduction pathways. Silica-induced lung damage involves reactive oxygen species (ROS)...
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Expression of Peroxiredoxin I in the Epidermis of Vitiligo

Quan G, Piao MS, Choi JY, Chun JS, Lee JB, Lee SC

  • KMID: 2248128
  • Korean J Dermatol.
  • 2008 Jun;46(6):736-741.
BACKGROUND: Although the pathogenesis of vitiligo isn't fully understood, a recent study demonstrates that oxidative stress plays an important role to induce vitiligo. Peroxiredoxin (Prx) is a novel peroxidase family...
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Analysis of the Expression of Peroxiredoxin I in Human Bladder Cancer

Kim ET, Sagong H, Kim WJ

  • KMID: 2311995
  • Korean J Urol.
  • 2008 Apr;49(4):300-306.
PURPOSE: Peroxiredoxins(PRDXs) are antioxidant enzymes that play an important role on cell differentiation, proliferation and apoptosis. In this study, we investigated if the expression levels of PRDX I were related...
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