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Effects of Hydrogen Sulfide and Nitric Oxide on the Permeability of Cultured Trabecular Meshwork Cells

Son MS, Baek MJ, Kim JW

PURPOSE: To investigate the effects of hydrogen sulfide (Hâ‚‚S) on the permeability of a cultured human trabecular meshwork cells (HTMC) monolayer and its interaction with nitric oxide (NO). METHODS: After exposing...
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Bowel Wall Thickness, Elasticity, Intestinal Permeability, and Inflammatory Cytokines in Patients with Cirrhosis and Ascites

Lee SH, Kwon HJ, Kim NH, Kim HJ, Cho YK, Jeon WK, Park EH, Kim BI

BACKGROUND/AIMS: Previous studies have reported that endotoxemia is associated with pathogenesis and complications in cirrhosis. Endotoxin stimulates the secretion of inflammatory cytokines, which contributes to the development of complications. In...
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Arg-Leu-Tyr-Glu Suppresses Retinal Endothelial Permeability and Choroidal Neovascularization by Inhibiting the VEGF Receptor 2 Signaling Pathway

Park W, Baek YY, Kim J, Jo DH, Choi S, Kim JH, Kim T, Kim S, Park M, Kim JY, Won MH, Ha KS, Kim JH, Kwon YG, Kim YM

Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the...
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Circulating Permeability Factors in Idiopathic Nephrotic Syndrome

Ha TS

Nephrotic syndrome (NS) is a common chronic glomerular disease in children characterized by significant proteinuria with resulting hypoalbuminemia, edema, and hyperlipidemia. Renal biopsy findings of diffuse foot processes effacement on...
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Ethanol changes atpB gene expression and proton permeability in Streptococcus mutans

Cho CM, Park YJ, Lee SA, Kim JB, Kang JS

OBJECTIVES: As a first step to study the anticaries effect of ethanol alone, we investigated the effects of ethanol on the expression levels of the atpB gene and proton permeability...
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Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model

Song CH, Kim N, Sohn SH, Lee SM, Nam RH, Na HY, Lee DH, Surh YJ

BACKGROUND/AIMS: Intestinal barrier dysfunction is a hallmark of inflammatory bowel diseases (IBDs) such as ulcerative colitis. This dysfunction is caused by increased permeability and the loss of tight junctions in...
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Effects of High Glucose and Dexamethasone on the Permeability in Trabecular Meshwork Cells

Kang SH, Kim JW

PURPOSE: To investigate the effects of high glucose (HG) and dexamethasone (DEX) on the survival and permeability of trabecular meshwork cells (HTMC), and associated changes in tight junctions. METHODS: Primary cultured...
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chelakkot , Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH

The gut microbiota has an important role in the gut barrier, inflammation and metabolic functions. Studies have identified a close association between the intestinal barrier and metabolic diseases, including obesity...
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Inflammation, Impaired Motility, and Permeability in a Guinea Pig Model of Postoperative Ileus

Lee YJ, Hussain Z, Huh CW, Lee YJ, Park H

  • KMID: 2417282
  • J Neurogastroenterol Motil.
  • 2018 Jan;24(1):147-158.
  • doi: 10.5056/jnm17012
BACKGROUND/AIMS: Postoperative ileus (POI) is characterized by impaired propulsive function of the gastrointestinal tract after surgery. Although inflammation is considered to be an important pathogenesis of POI, significant data are...
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The Effect of Anti-inflammatory Agents on the Permeability of Trabecular Meshwork Cell Monolayers

Kang HR, Lee JH, Kim JW

PURPOSE: To compare the effects of anti-inflammatory agents, specifically bromfenac, loteprednol, and prednisolone, on the permeability of cultured human trabecular meshwork cell (HTMC) monolayers. METHODS: HTMCs were cultured until confluency in...
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Comparative Study of the Effects of Trabecular Meshwork Outflow Drugs on the Permeability and Nitric Oxide Production in Trabecular Meshwork Cells

Kim JW

PURPOSE: To compare the effects of the barrier function in human trabecular meshwork (TM) cells monolayer and the production of nitric oxide (NO) between trabecular outflow drugs, Rho-associated kinase (ROCK)...
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Calcium permeability of transient receptor potential canonical (TRPC) 4 channels measured by TRPC4-GCaMP6s

Ko J, Myeong J, Yang D, So I

Conflicting evidence has been obtained regarding whether transient receptor potential cation channels (TRPC) are store-operated channels (SOCs) or receptor-operated channels (ROCs). Moreover, the Ca/Na permeability ratio differs depending on whether...
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Effect of Tetrahydrozoline on the Permeability of Trabecular Meshwork Cell Monolayer

Hwang SJ, Kim JW

PURPOSE: To investigate the effects of tetrahydrozoline (THZ) on the survival of cultured human trabecular meshwork cells (HTMC) and the permeability of HTMC monolayer. METHODS: Primary cultured HTMC were exposed to...
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Chronic Early-life Stress in Rat Pups Alters Basal Corticosterone, Intestinal Permeability, and Fecal Microbiota at Weaning: Influence of Sex

Moussaoui , Jacobs JP, Larauche M, Biraud M, Million M, Mayer E, Taché Y

  • KMID: 2367465
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):135-143.
  • doi: 10.5056/jnm16105
BACKGROUND/AIMS: Wistar rat dams exposed to limited nesting stress (LNS) from post-natal days (PND) 2 to 10 display erratic maternal behavior, and their pups show delayed maturation of the hypothalamic-pituitary-adrenal...
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The pH-dependent effects of combining ethanol with fluoride on proton permeability in Streptococcus mutans

Lee SA, Jung SI, Kim JB, Kang JS

OBJECTIVES: The aim of this research was to determine the pH-dependent changes in F-ATPase activity and proton fluxes in Streptococcus mutans (S. mutans) as induced by varying the concentration of...
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Involvement of Protein Kinase C-delta in Vascular Permeability in Acute Lung Injury

Ahn JJ, Jung JP, Park SE, Lee M, Kwon B, Cho HR

Pulmonary edema is a major cause of mortality due to acute lung injury (ALI). The involvement of protein kinase C-delta (PKC-delta) in ALI has been a controversial topic. Here we...
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Effect of Nitric Oxide on the Permeability of Trabecular Meshwork Cell Monolayer

Kim HY, Kim JW

PURPOSE: To investigate the effects of nitric oxide (NO) on the permeability of cultured human trabecular meshwork cell (HTMC) monolayer. METHODS: HTMCs were cultured until confluency in the Transwell inner chamber...
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Effect of Bimatoprost on the Permeability of Trabecular Meshwork Cell Monolayer

Chang B, Kim JW

PURPOSE: To investigate the effects of bimatoprost on the permeability of cultured human trabecular meshwork cells (HTMC) monolayer. METHODS: HTMCs were cultured until confluency in the inner Transwell chamber and then...
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Role of Corticotropin-releasing Factor in Gastrointestinal Permeability

Rodino-Janeiro BK, Alonso-Cotoner C, Pigrau M, Lobo B, Vicario M, Santos J

  • KMID: 2381230
  • J Neurogastroenterol Motil.
  • 2015 Jan;21(1):33-50.
  • doi: 10.5056/jnm14084
The interface between the intestinal lumen and the mucosa is the location where the majority of ingested immunogenic particles face the scrutiny of the vast gastrointestinal immune system. Upon regular...
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Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases

Lee SH

Epithelial tight junctions (TJs) are the key structures regulating paracellular trafficking of macromolecules. The TJ is multi-protein complex that forms a selective permeable seal between adjacent epithelial cells and demarcates...
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