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Clinical Aspects of the Differential Diagnosis of Parkinson’s Disease and Parkinsonism

Shin HW, Hong SW, Youn YC

Parkinsonism is a clinical syndrome presenting with bradykinesia, tremor, rigidity, and postural instability. Nonmotor symptoms have recently been included in the parkinsonian syndrome, which was traditionally associated with motor symptoms...
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Reliability and Validity of the Subjective Cognitive Complaints Questionnaire for Parkinson’s Disease (SCCQ-PD)

Ko J, Ha J, Lee JJ, Jin S, Lee J, Baek MS, Hong JY

Background and Purpose Subjective cognitive complaints (SCCs) are gaining attention as a self-perceived symptom for cognitive impairment in patients with Parkinson’s disease (PD), but there are few suitable tools for...
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Conformation-specific Antibodies Targeting Aggregated Forms of α-synuclein Block the Propagation of Synucleinopathy

Choi M, Kim Tk, Ahn J, Lee JS, Jung BC, An S, Kim D, Lee MJ, Mook-Jung I, Lee SH, Lee SJ

Abnormal aggregation of α-synuclein is a key element in the pathogenesis of several neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy. α-synuclein aggregation spreads...
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Current Status of Telemedicine for Parkinson’s Disease in Japan: A Single-Center Cross-Sectional Questionnaire Survey

Ogawa M, Oyama G, Sekimoto S, Hatano T, Hattori N

Objective Using telemedicine is a way to improve the accessibility of specialists for patients with Parkinson’s disease (PD); however, it is not widely used in Japan. We investigated the efficacy...
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The Supplementary Motor Complex in Parkinson’s Disease

Rahimpour S, Rajkumar S, Hallett M

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by both motor and nonmotor symptoms. Although the basal ganglia is traditionally the primary brain region implicated in this disease process, this...
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Constipation is Associated With Mild Cognitive Impairment in Patients With de novo Parkinson’s Disease

Kang SH, Lee J, Koh SB

Objective The association between gastrointestinal (GI) symptoms and cognitive profile in patients with Parkinson’s disease (PD) at diagnosis remains unclear, although GI symptoms and cognitive impairment are highly prevalent in...
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Association of AXIN1 With Parkinson’s Disease in a Taiwanese Population

Fang HS, Chao CY, Wang CC, Fan WL, Huang PJ, Fung HC, Wu YR

Objective A meta-analysis of locus-based genome-wide association studies recently identified a relationship between AXIN1 and Parkinson’s disease (PD). Few studies of Asian populations, however, have reported such a genetic association....
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Dance Intervention Using the Feldenkrais Method Improves Motor, and Non-Motor Symptoms and Gait in Parkinson’s Disease: A 12-Month Study

Kang SH, Kim J, Kim I, Moon YA, Park S, Koh SB

Objective The aim of this study was to assess the effects of dancing (using the Feldenkrais method) on motor and non-motor symptoms, quality of life (QoL), and objective parameters of...
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Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy

Lai TT, Kim YJ, Ma Hi, Kim YE

Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark of Parkinson’s disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved in the pathogenesis...
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Botulinum Toxin A Ameliorates Neuroinflammation in the MPTP and 6-OHDA-Induced Parkinson’s Disease Models

Ham HJ, Yeo IJ, Jeon SH, Lim JH, Yoo SS, Son DJ, Jang SS, Lee H, Shin SJ, Han SB, Yun JS, Hong JT

Recently, increasing evidence suggests that neuroinflammation may be a critical factor in the development of Parkinson’s disease (PD) in addition to the ratio of acetylcholine/dopamine because dopaminergic neurons are particularly...
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The Association Between Cancer and Neurodegenerative Diseases: A Retrospective Cohort Study Using the National Health Insurance Service-National Health Information Database

Kim JH, Kim YT, Lee HJ, Kim HC

Objectives According to previous studies, cancer risk has decreased among patients with neurodegenerative disease (ND). However, some types of cancer are positively associated with ND. ND and cancer share common mechanisms...
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The Reliability and Validity of the Korean Version of Hospital Anxiety and Depression Scale Using Rasch Measurement Theory in Patients with Parkinson’s Disease

Choi JH, Jeon S, Hong S, Kim A, Park JY, Yang HJ

Background: Depression and anxiety are prevalent and can cause suffering in patients with Parkinson’s disease (PD). The Korean version of the Hospital Anxiety and Depression Scale (K-HADS) has been widely...
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Biomarker in Parkinson’s Disease: Clinical and Biochemical Biomarker

Lee JY, Ma Hi, Kim YE

Parkinson’s disease is a neurodegenerative disease compromising progressive motor and non-motor features for a long disease course. Although many drugs controlling parkinsonian symptoms were discovered, treatment with disease-modifying or halting...
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Quantitative Evaluation of Gastrocnemius Medialis Stiffness During Passive Stretching Using Shear Wave Elastography in Patients with Parkinson’s Disease: A Prospective Preliminary Study

Yin L, Du L, Li Y, Xiao Y, Zhang S, Ma H, He W

Objective: To prospectively investigate the feasibility of shear wave elastography (SWE) as a new quantitative and objective method for evaluating the stiffness of the gastrocnemius medialis (GM) muscle during passive...
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Neuroprotective Effect of Astersaponin I against Parkinson’s Disease through Autophagy Induction

Zhang L, Park JY, Zhao D, Kwon HC, Yang HO

An active compound, triterpene saponin, astersaponin I (AKNS-2) was isolated from Aster koraiensis Nakai (AKNS) and the autophagy activation and neuroprotective effect was investigated on in vitro and in vivo...
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Diffusion Measure Changes of Substantia Nigra Subregions and the Ventral Tegmental Area in Newly Diagnosed Parkinson’s Disease

Shim JH, Baek HM

  • KMID: 2522149
  • Exp Neurobiol.
  • 2021 Oct;30(5):365-373.
  • doi: 10.5607/en21025
Historically, studies have extensively examined the basal ganglia in Parkinson’s disease for specific characteristics that can be observed with medical imaging. One particular methodology used for detecting changes that occur...
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Convolutional Neural Network-Based Automatic Segmentation of Substantia Nigra on Nigrosome and Neuromelanin Sensitive MR Images

Kang J, Kim H, Kim E, Kim E, Lee H, Shin Ny, Nam Y

Recently, neuromelanin and nigrosome imaging techniques have been developed to evaluate the substantia nigra in Parkinson’s disease. Previous studies have shown potential benefits of quantitative analysis of neuromelanin and nigrosome...
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Association of Parkinson’s disease with ischemic stroke in Korea: A nationwide longitudinal cohort study in Korea

Kim WY, Kim H, Hong JB, Sheen SH, Han Ib, Sohn S

Objective: The aim of this nationwide age- and sex- matched longitudinal follow up study is to determine the risk of Parkinson’s disease (PD) associated with ischemic stroke in Korea. Methods: Patient...
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Focused Vibrotactile Stimulation with Cueing Effect on Freezing of Gait in Parkinson’s Disease: Two Case Reports

Tan XS, Pierres F, Dallman-Porter A, Hardie-Brown W, Kwon KY

Freezing of gait (FOG) is a common occurrence in patients with Parkinson’s disease (PD) that leads to significant limitations in mobility and increases risk of falls. Focused vibrotactile stimulation and...
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Emerging Nondopaminergic Medications for Parkinson’s Disease: Focusing on A2A Receptor Antagonists and GLP1 Receptor Agonists

Shang P, Baker M, Banks S, Hong SI, Choi DS

Parkinson’s disease (PD) is a severe neurodegenerative disease characterized by classic motor features associated with the loss of dopaminergic neurons and appearance of Lewy bodies in the substantia nigra. Due...
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