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Bioactive Sphingolipids as Major Regulators of Coronary Artery Disease

Song JH, Kim GT, Park KH, Park WJ, Park TS

  • KMID: 2517155
  • Biomol Ther.
  • 2021 Jul;29(4):373-383.
Atherosclerosis is the deposition of plaque in the main arteries. It is an inflammatory condition involving the accumulation of macrophages and various lipids (low-density lipoprotein [LDL] cholesterol, ceramide, S1P). Moreover,...
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Therapeutic potential of stem cell-derived extracellular vesicles in osteoarthritis: preclinical study findings

Kim KH, Jo JH, Cho HJ, Park TS, Kim TM

Extracellular vesicles (EVs) are nano-sized particles secreted by almost all cell types, and they mediate various biological processes via cell-to-cell communication. Compared with parental cells for therapeutic purposes, stem cell-derived...
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Hepatic Expression of the Serine Palmitoyltransferase Subunit Sptlc2 Reduces Lipid Droplets in the Liver by Activating VLDL Secretion

Kim GT, Kim SJ, Park SH, Lee D, Park TS

Objective: Ceramide is a signaling molecule that contributes to insulin resistance and hepatosteatosis. In the present study, we activated de novo ceramide synthesis by inducing the hepatic expression of Sptlc2...
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Gradual Increase in Hematologic Malignancy in Korea from 2005 to 2015 Based on the National Health Insurance Service Data

Han Y, Kim YJ, Kim MJ, Byun JM, Youk T, Yoon HS, Lee JH, Lee WI, Park TS, Yoo J

Background Hematologic malignancies have a relatively lower prevalence than major solid cancers, although the incidence of hematologic malignancies has significantly increased in recent years. However, understanding the current status of hematologic...
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Attachment distribution of pectoral muscle origins identified in dual-plane breast implant insertion

Nam SB, Song KH, Seo JY, Choi JS, Park TS, Lee JW, Kim JH, Kim MW, Kim HY, Jung YJ, Kim C

Background Implant-based dual-plane augmentation mammoplasty requires accurate separation of the pectoralis major muscle (PMM) at its origins. The authors identified the PMM origins during breast reconstruction surgery with the goal...
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Volumetric change of the latissimus dorsi muscle after postoperative radiotherapy in immediate breast reconstruction with an extended latissimus dorsi musculocutaneous flap

Park TS, Seo JY, Razzokov A, Choi JS, Kim MW, Lee JW, Kim HY, Jung YJ, Choo KS, Song KH, Nam SB

Background This study aimed to determine the magnitude of volume reduction of the latissimus dorsi (LD) muscle after treatment using only postoperative radiotherapy (PORTx) in patients who underwent immediate breast...
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Epidemiology of Congenital Bleeding Disorders: a Nationwide Populationbased Korean Study

Yoon HS, Han Y, Kim YJ, Kim MJ, Byun JM, Youk T, Lee JH, Park TS, Yoo J

Background: Except for data in the Korea Hemophilia Foundation Registry, little is known of the epidemiology of congenital bleeding disorders in Korea. Methods: Data were obtained from the Korean Health Insurance...
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Effectiveness and Safety of Adding Basal Insulin Glargine in Patients with Type 2 Diabetes Mellitus Exhibiting Inadequate Response to Metformin and DPP-4 Inhibitors with or without Sulfonylurea

Kang YM, Jung CH, Lee SH, Kim SW, Song KH, Kim SG, Kim JH, Cho YM, Park TS, Ku BJ, Koh G, Kim DM, Lee BW, Park JY

BACKGROUND: We aimed to investigate the effectiveness and safety of adding basal insulin to initiating dipeptidyl peptidase-4 (DPP-4) inhibitor and metformin and/or sulfonylurea (SU) in achieving the target glycosylated hemoglobin...
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Partial Thickness Rotator Cuff Tears of the Shoulder Related to the Sports

Park TS

A painful shoulder is common among athletes, particularly those involved in overhead throwing. Professional and recreational athletes in throwing activities have an increased risk of partial thickness tears of the...
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Clinical Utility of Quantitative CT Analysis for Fissure Completeness in Bronchoscopic Lung Volume Reduction: Comparison between CT and Chartisâ„¢

Lee SW, Shin SY, Park TS, Choi YY, Park JC, Park J, Oh SY, Kim N, Lee SH, Lee JS, Seo JB, Oh YM, Lee SD, Lee SM

OBJECTIVE: The absence of collateral ventilation (CV) is crucial for effective bronchoscopic lung volume reduction (BLVR) with an endobronchial valve. Here, we assessed whether CT can predict the Chartisâ„¢ results. MATERIALS...
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Current Status of Noninvasive Ventilation Use in Korean Intensive Care Units: A Prospective Multicenter Observational Study

Nam H, Cho JH, Choi EY, Chang Y, Choi WI, Hwang JJ, Moon JY, Lee K, Kim SW, Kang HK, Sim YS, Park TS, Park SY, Park S, on behalf of Korean NIV Study Group

BACKGROUND: Data on noninvasive ventilation (NIV) use in intensive care units (ICUs) are very limited in South Korea. METHODS: A prospective observational study was performed in 20 ICUs of university-affiliated hospitals...
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A Case of Catabacter hongkongensis and Alistipes indistinctus Isolated from Blood Cultures of a Patient with Acute Appendicitis

Ryu J, Kim Y, Lee J, Cho SY, Park TS, Lee HJ

Catabacter hongkongensis is an anaerobic gram-positive coccobacillus that was first isolated in Hong Kong. It is infectious and causes high mortality in patients with rare but underlying diseases. Alistipes indistinctus...
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Efficacy and Safety of Voglibose Plus Metformin in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial

Oh TJ, Yu JM, Min KW, Son HS, Lee MK, Yoon KH, Song YD, Park JY, Jeong IK, Cha BS, Kim YS, Baik SH, Kim IJ, Kim DM, Kim SR, Lee KW, Park JH, Lee IK, Park TS, Choi SH, Park SW

BACKGROUND: Combination of metformin to reduce the fasting plasma glucose level and an α-glucosidase inhibitor to decrease the postprandial glucose level is expected to generate a complementary effect. We compared...
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Predictive Factors for Efficacy of AST-120 Treatment in Diabetic Nephropathy: a Prospective Single-Arm, Open-Label, Multi-Center Study

Hwang YC, Kim SW, Hur KY, Cha BS, Kim IJ, Park TS, Baik SH, Yoon KH, Lee KW, Lee IK, Lee MK

BACKGROUND: Removal of uremic toxins such as indoxyl sulfate by AST-120 is known to improve renal function and delay the initiation of dialysis in patients with advanced chronic kidney disease....
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Performance Evaluation of Two Immunochromatographic Assays for Rotavirus Detection in Stool Specimens

Kim S, Kim YJ, Cho SY, Park TS, Lee HJ

BACKGROUND: Rotavirus is a major pathogen causing enteritis worldwide in children under five years of age. In recent years, immunochromatographic assay (ICA) has been widely used as a diagnostic test...
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Incidence Rate of Lumbosacral Transitional Vertebrae and Measurement of their Cross-sectional Areas of Vertebral Canal and Dural Sac Using Magnetic Resonance Imaging

Park TS, Lim YS, Baek SY, Yoon S

Human lumbar spines usually consist of five vertebrae; however, some individuals have vertebral anomalies with four or six lumbar vertebrae because of the lumbarized first sacral vertebra (lumbarization) or the...
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Investigation of the dorsolateral branch of the posterior intercostal artery for use as the pedicle of a free flap: A cadaveric study and case series

Nam SB, Seo JY, Park TS, Sung JY, Kim JH, Lee JW, Kim MW, Oh HC

BACKGROUND: The dorsolateral branch of the posterior intercostal artery (DLBPI) can be easily found while harvesting a latissimus dorsi (LD) musculocutaneous flap for breast reconstruction. However, it remains unknown whether...
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Clinical Importance of Diabetic Neuropathy

Park TS

Diabetic neuropathy is a complex and common disorder with multiple etiologies and affects about 43.1% of the Korean diabetes population. Good glycemic control slows progression of diabetic neuropathy in subjects...
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Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats

Lee KA, Jin HY, Lee NY, Kim YJ, Park TS

The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic...
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The efficacy of elongated axillary incision on extended latissimus dorsi flap for immediate breast reconstruction

Park TS, Nam SB, Choi JY, Bae SH, Lee JW, Kim HY

BACKGROUND: In performing extended latissimus dorsi (ELD) flap procedures, a skin paddle design on the bra line helps reduce visible scarring. This improves the patient’s satisfaction with the outcome. However,...
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