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Antioxidant and hepatoprotective effects of Korean ginseng extract GS-KG9 in a D-galactosamine-induced liver damage animal model

Jo YH, Lee H, Oh MH, Lee GH, Lee YJ, Lee JS, Kim MJ, Kim WY, Kim JS, Yoo DS, Cho SW, Cha SW, Pyo MK

BACKGROUND/OBJECTIVES: This study was designed to investigate the improvement effect of white ginseng extract (GS-KG9) on D-galactosamine (Ga1N)-induced oxidative stress and liver injury. SUBJECTS/METHODS: Sixty Sprague-Dawley rats were divided into 6...
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Cognition enhancing effect of panax ginseng in Korean volunteers with mild cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial

Park KC, Jin H, Zheng R, Kim S, Lee SE, Kim BH, Yim SV

This study aimed to investigate the cognition-enhancing effect of Panax ginseng. A randomized, double-blind, placebo-controlled clinical trial was conducted to address the cognition-enhancing effects of Panax ginseng. A total of...
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The Comparison of Seasonal Ginsenoside Composition Contents in Korean Wild Simulated Ginseng (Panax ginseng) which were Cultivated in Different Areas and Various Ages

Yang BW, Lee JB, Lee JM, Jo MS, Byun JK, Kim HC, Ko SK

The ginsenoside content was compared with wild simulated ginseng (Panax ginseng) collected every season at 11 wild simulated ginseng plantations in Korea. As a result, the total saponin of 7...
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Which Types of Dietary Supplements Are Used in Korea? Data from the 2015 Korea National Health and Nutrition Examination Survey

Park HA

BACKGROUND: The consumption of dietary supplements is increasing in Korea. The aim of this study is to assess the prevalence, types, and trends of dietary supplement (DS) use in Korean...
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Effect of P. ginseng on the expression of c-Fos in the brain of Wistar rats with testosterone induced benign prostatic hyperplasia

Jang HM

The lower urinary tract symptoms (LUTS) show in benign prostatic hyperplasia (BPH). The three major micturition centers in brain are pontine micturition center (PMC), ventrolateral periaqueductal gray (vlPAG), and medial...
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Therapeutic Effects of Korean Red Ginseng Extract in a Murine Model of Atopic Dermatitis: Anti-pruritic and Anti-inflammatory Mechanism

Lee HJ, Cho SH

Korean red ginseng (KRG) and ginsenosides exhibit diverse biological effects, including anti-inflammatory and anti-allergic. We aimed to investigate the therapeutic effect of KRG in a murine model of atopic dermatitis...
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Compound K attenuates stromal cell-derived growth factor 1 (SDF-1)-induced migration of C6 glioma cells

Kim H, Roh HS, Kim JE, Park SD, Park WH, Moon JY

BACKGROUND/OBJECTIVES: Stromal cell-derived growth factor 1 (SDF-1), also known as chemokine ligand 12, and chemokine receptor type 4 are involved in cancer cell migration. Compound K (CK), a metabolite of...
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Identification of Dammarane-type Triterpenoid Saponins from the Root of Panax ginseng

Lee DG, Lee J, Yang S, Kim KT, Lee S

The root of Panax ginseng, is a Korea traditional medicine, which is used in both raw and processed forms due to their different pharmacological activities. As part of a continued...
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Mixed plant extract-dependent exercise-induced anaphylaxis

Choi JW, Lee JO, Choi J, Han Y, Kim J, Ahn K

Food-dependent exercise-induced anaphylaxis (FDEIA) is a potentially life-threatening clinical reaction in which anaphylaxis develops when physical activity occurs within a few hours after ingesting a specific food. An 18-year-old girl...
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Genetic Diversity and Pathogenicity of Cylindrocarpon destructans Isolates Obtained from Korean Panax ginseng

Song JY, Seo MW, Kim SI, Nam MH, Lim HS, Kim HG

  • KMID: 2312741
  • Mycobiology.
  • 2014 Jun;42(2):174-180.
We analyzed the genetic diversity of Cylindrocarpon destructans isolates obtained from Korean ginseng (i.e., Panax ginseng) roots by performing virulence tests and nuclear ribosomal gene internal transcribed spacer (ITS) and...
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Diversity of Endophytic Fungi Isolated from Korean Ginseng Leaves

Eo JK, Choi MS, Eom AH

  • KMID: 2312737
  • Mycobiology.
  • 2014 Jun;42(2):147-151.
We investigated the diversity of the foliar endophytes of Korean ginseng. Endophytic fungi were isolated from healthy leaves of mountain-cultivated ginseng (MCG) and field-cultivated ginseng (FCG) at 4 sites in...
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Inhibition of TNF-alpha-Mediated NF-kappaB Transcriptional Activity by Dammarane-Type Ginsenosides from Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells

Cho K, Song SB, Tung NH, Kim KE, Kim YH

  • KMID: 2048331
  • Biomol Ther.
  • 2014 Jan;22(1):55-61.
Panax ginseng is a medicinal herb that is used worldwide. Its medicinal effects are primarily attributable to ginsenosides located in the root, leaf, seed, and flower. The flower buds of...
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Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster

Kim MS

  • KMID: 1502494
  • Biomol Ther.
  • 2013 May;21(3):241-245.
Aging is the single most important risk factor that increases susceptibility to many forms of diseases. As such, much effort has been put forward to elucidate the mechanisms behind the...
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Inhibitory Effects of Ginsenoside Metabolites, Compound K and Protopanaxatriol, on GABAC Receptor-Mediated Ion Currents

Lee BH, Hwang SH, Choi SH, Kim HJ, Lee JH, Lee SM, Ahn YG, Nah SY

Ginsenosides, one of the active ingredients of Panax ginseng, show various pharmacological and physiological effects, and they are converted into compound K (CK) or protopanaxatriol (M4) by intestinal microorganisms. CK...
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Subacute Oral Toxicity Study of Korean Red Ginseng Extract in Sprague-Dawley Rats

Park SJ, Lim KH, Noh JH, Jeong EJ, Kim YS, Han BC, Lee SH, Moon KS

  • KMID: 2317847
  • Toxicol Res.
  • 2013 Dec;29(4):285-292.
Ginseng is a well-known traditional medicine used in Asian countries for several thousand years, and it is currently applied to medicine, cosmetics, and nutritional supplements due to its many healing...
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Effects of Korean Red Ginseng on Cardiovascular Risks in Subjects with Metabolic Syndrome: a Double-blind Randomized Controlled Study

Park BJ, Lee YJ, Lee HR, Jung DH, Na HY, Kim HB, Shim JY

BACKGROUND: This study investigated the effects of Korean red ginseng (KRG) supplementation on metabolic parameters, inflammatory markers, and arterial stiffness in subjects with metabolic syndrome. METHODS: We performed a randomized, double-blind,...
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Ginsan Enhances Humoral Antibody Response to Orally Delivered Antigen

Na HS, Lim YJ, Yun YS, Kweon MN, Lee HC

BACKGROUND: There have been several reports describing the capability of ginseng extracts as an adjuvant. In this study, we tested if ginsan, a polysaccharide extracted from Panax ginseng, was effective...
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Hypolipidemic and Antioxidant Effects to Ginseng Extract (PD:PT = 1) in Apo E Null Mice

Jang S, Kim SS, Lee M

  • KMID: 2263025
  • Korean J Nutr.
  • 2008 Oct;41(7):594-601.
Panax ginseng C.A. Meyer (Panax ginseng) has been used for several thousand years to prolong longevity in Asian countries. Ginsenosides are the most active components isolated from ginseng and belong...
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Radioprotective effects of an acidic polysaccharide of Panax ginseng on bone marrow cells

Kim HJ, Kim MH, Byon YY, Park JW, Jee Y, Joo HG

An acidic polysaccharide of Panax ginseng (APG), so called ginsan is known to have important immunomodulatory activities. It was recently reported that APG has radioprotective effects in mice but the...
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Double-blind, Placebo-controlled, Multi-center Study for Therapeutic Effects of Mountain Panax Ginseng C.A. Meyer Extract in Men with Erectile Dysfunction: a Preliminary Report

Kim HS, Woo SH, Jo S, Hahn EJ, Youn NY, Lee HL

  • KMID: 2298608
  • Korean J Androl.
  • 2006 Aug;24(2):84-88.
PURPOSE: We investigated the effect of 100-year-old mountain ginseng(Panax ginseng C.A. Meyer, PG-CAM) extract on patients with erectile dysfunction(ED). MATERIALS AND METHODS: A total of 35 patients with ED(23 patients...
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