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Prevalence of PALB2 Germline Mutations in Early-onset and Familial Breast/Ovarian Cancer Patients from Pakistan

Rashid MU, Khan FA, Muhammad N, Loya A, Hamann U

PURPOSE: Partner and localizer of BRCA2 (PALB2) is a breast cancer susceptibility gene that plays an important role in DNA repair. This is the first study assessing the prevalence of...
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Nuclear Medicine Theranostics: Perspective from Pakistan

Bashir H, Younis MN, Gul MR

Nuclear medicine has been offering diagnostic and therapeutic solution since the introduction of radioactive iodine for thyroid diseases since decades. However, the concept of theranostics has given a new found...
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Clinical Efficacy and Safety of Injectable Levetiracetam Versus Phenytoin as Second-Line Therapy in the Management of Generalized Convulsive Status Epilepticus in Children: An Open-Label Randomized Controlled Trial

Noureen N, Khan S, Khursheed , Iqbal I, Maryam M, Sharib SM, Maheshwary N

BACKGROUND AND PURPOSE: There is sparsity of quality evidence for the use of drugs after first-line benzodiazepines in convulsive status epilepticus in children. The aim of the study was to...
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A Retrospective Analysis on the Cystic Echinococcosis Cases Occured in Northeastern Punjab Province, Pakistan

Khan A, Zahoor S, Ahmed H, Malik U, Butt RA, Muzam MS, Kilinc SG, Noor N, Zahoor S, Afzal MS, Mansur H, Irum S, Simsek S

A retrospective study was performed to report the case occurrence of cystic echinococcosis (CE) in three hospitals of north-eastern region in Punjab Province, Pakistan. We reviewed retrospectively the clinical records...
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Areca Nut Chewing and the Risk of Re-hospitalization and Mortality Among Patients With Acute Coronary Syndrome in Pakistan

Karim MT, Inam S, Ashraf T, Shah N, Adil SO, Shafique K

OBJECTIVES: Areca nut is widely consumed in many parts of the world, especially in South and Southeast Asia, where cardiovascular disease (CVD) is also a huge burden. Among the forms...
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Clinicohematological parameters and outcomes in a cohort of chronic lymphocytic leukemia patients with Deletion 17p from Pakistan

Mahmood R, Khan SA, Altaf C, Malik HS, Khadim MT

BACKGROUND: Chronic lymphocytic leukemia (CLL) exhibits profound heterogeneity in its clinical course. Its clinicohematological and cytogenetic features play a significant role in determining the clinical course and in predicting the...
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One-stage Hip Reconstruction for Developmental Hip Dysplasia in Children over 8 Years of Age

Qadir I, Ahmad S, Zaman AU, Khan CM, Ahmad S, Aziz A

PURPOSE: This study was performed to assess the clinical and radiological outcomes following one-stage hip reconstruction, consisting of open reduction femoral shortening and pelvic osteotomy, for neglected developmental dislocation of...
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Outcome of 980 nm diode laser vaporization for benign prostatic hyperplasia: A prospective study

Mithani MH, Khalid SE, Khan SA, Sharif I, Awan AS, Mithani S, Majeed I

PURPOSE: To evaluate the initial experience and outcome of photo-selective vaporization of the prostate (PVP) for benign prostatic hyperplasia (BPH) in Pakistan with the use of a 980 nm diode...
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Differences in High Dose Antipsychotic Prescriptions in Patients with Schizophrenia in Asian Countries/Areas: Findings from the REAP-AP Study

Park YC, Yang SY, Chong MY, Kanba S, Sartorius , Shinfuku N, Tan CH, Park SC

The REAP-AP study recruited 3,746 patients with schizophrenia, in March and April 2016, from 71 centers in 15 Asian countries/territories namely Bangladesh, China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia,...
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A Novel Homozygous Variant of SETX Causes Ataxia with Oculomotor Apraxia Type 2

Tariq H, Imran R, Naz S

BACKGROUND AND PURPOSE: Autosomal recessive cerebellar ataxias constitute a highly heterogeneous group of neurodegenerative disorders. This study was carried out to determine the clinical and genetic causes of ataxia in...
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Translation, Adaptation and Cross Language Validation of Tinnitus Handicap Inventory in Urdu

Aqeel M, Ahmed A

BACKGROUND AND OBJECTIVES: Tinnitus is characterized as a perception of numerous auditory sounds in absence of external stimulus. Tinnitus can have a considerable consequence on a person’s quality of life,...
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Mid-upper-arm circumference as a screening measure for identifying children with elevated body mass index: a study for Pakistan

Asif M, Aslam M, Altaf S

PURPOSE: Mid-upper-arm circumference (MUAC) is considered an alternative screening method for obesity. The aims of this investigation were to examine the ability of MUAC to correctly identify children with elevated...
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Stroke Epidemiology in South, East, and South-East Asia: A Review

Venketasubramanian N, Yoon BW, Pandian J, Navarro JC

Asia, which holds 60% of the world’s population, comprises some developing countries which are in economic transition. This paper reviews the epidemiology of stroke in South, East and South-East Asia....
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Genome-Wide Supported Risk Variants in MIR137, CACNA1C, CSMD1, DRD2, and GRM3 Contribute to Schizophrenia Susceptibility in Pakistani Population

Fatima A, Farooq M, Abdullah U, Tariq M, Mustafa T, Iqbal M, Tommerup N, Mahmood Baig S

OBJECTIVE: Schizophrenia is a chronic neuropsychiatric disease afflicting around 1.1% of the population worldwide. Recently, MIR137, CACNA1C, CSMD1, DRD2, and GRM3 have been reported as the most robustly emerging candidates...
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Fall Detection System for the Elderly Based on the Classification of Shimmer Sensor Prototype Data

Ahmed M, Mehmood N, Nadeem A, Mehmood A, Rizwan K

OBJECTIVES: Falling in the elderly is considered a major cause of death. In recent years, ambient and wireless sensor platforms have been extensively used in developed countries for the detection...
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Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer

Riaz R, Masood N, Benish A

BACKGROUND/AIMS: Colorectal cancer has long been considered disease of the West, typically occurring in old age; however, the incidence is rising in Asia. The pattern of disease is quite different...
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Evaluation of the Causes of Erectile Dysfunction in Patients Undergoing Penile Doppler Ultrasonography in Pakistan

Khanzada U, Khan SA, Hussain M, Adel H, Masood K, Adil SO, Manohar M

PURPOSE: In patients with erectile dysfunction, it is important to differentiate psychogenic from organic causes. Penile Doppler ultrasonography is a relatively inexpensive and minimally invasive tool for this purpose. This...
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Dengue Virus Serotypes Circulating in Khyber Pakhtunkhwa Province, Pakistan, 2013-2015

Suleman M, Faryal R, Alam MM, Sharif S, Shaukat S, Aamir UB, Khurshid A, Angez M, Umair M, Sufian MM, Arshad Y, Zaidi SS

From 2013 to 2015, the National Institute of Health, Pakistan, received 1,270 blood samples of suspected dengue cases reported from inpatient and outpatient departments of various hospitals in Khyber Pakhtunkhwa...
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Strengths, weaknesses, opportunities, and threats analysis of integrating the World Health Organization patient safety curriculum into undergraduate medical education in Pakistan: a qualitative case study

Misbah S, Mahboob U

PURPOSE: The purpose of this study was to conduct a strengths, weaknesses, opportunities, and threats (SWOT) analysis of integrating the World Health Organization (WHO) patient safety curriculum into undergraduate medical...
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Seroprevalence and Spatial Distribution of Toxoplasmosis in Sheep and Goats in North-Eastern Region of Pakistan

Ahmed H, Malik A, Mustafa I, Arshad M, Khan MR, Afzal S, Ali S, Hashmi MM, Simsek S

Toxoplasmosis is a protozoan disease that is caused by Toxoplasma gondii in livestock and humans. Due to its medical and veterinary importance, it is essential to study the seroprevalence of...
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