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The Interaction of Oxytocin and Social Support, Loneliness, and Cortisol Level in Major Depression

Tsai TY, Tseng HH, Chi MH, Chang HH, Wu CK, Yang YK, Chen PS

OBJECTIVE: Loneliness is a specific risk factor for depressive symptoms and suicidal behavior. The present study examined whether the serum oxytocin level would interact with social support and buffers loneliness...
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Outcomes of ‘one-day trial of vaginal delivery of twins’ at 36–37 weeks' gestation in Japan

Haruna Y, Suzuki S

OBJECTIVE: The lack of obstetricians in Japan has prevented the implementation of a 24–hour delivery monitoring system for high-risk deliveries such as twin vaginal delivery at many obstetric facilities. To...
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Learning and Oxytocin

Chung YI, Lee BD, Lee YM

Neuropeptide oxytocin serves as a neuromodulator in the brain and as a hormone in the body. Oxytocin as a hypothalamic hormone causes contractions during the second and third stages of...
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The relaxant effect of nicardipine on the isolated uterine smooth muscle of the pregnant rat

Kim DJ, Hwang MH, An TH, Jung KT

BACKGROUND: Nicardipine, a calcium channel blocker, is used to treat hypertension in pregnancy or preterm labor. The current study was conducted to investigate the relaxant effects of nicardipine on the...
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Intranasal Administration of Oxytocin Attenuates Stress Responses Following Chronic Complicated Stress in Rats

Yang Y, Yu H, Babygirija R, Shi B, Sun W, Zheng X, Zheng J

  • KMID: 2460490
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):611-622.
  • doi: 10.5056/jnm19065
BACKGROUND/AIMS: Gastrointestinal (GI) symptoms may develop when we fail to adapt to various stressors of our daily life. Central oxytocin (OXT) can counteract the biological actions of corticotropin-releasing factor (CRF),...
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Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line

Lim JS, Eom YW, Lee ES, Kwon HJ, Kwon JY, Choi J, Chung CH, Jo YS, Lee EJ

BACKGROUND: Oxytocin (OXT) has been reported to act as a growth regulator in various tumor cells. However, there is a paucity of data on the influence of OXT on cell...
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The Effect of Breastfeeding on Prevention of Maternal Hypertension: Systematic Review

Jeon H, Joo SH, Choi A, Han JY, Jeong ES, Shin HJ, Kim JY

PURPOSE: The purpose of this study is to clarify the relevance of breastfeeding and its preventive effect on maternal hypertension as well as to evaluate the theoretical mechanism behind of...
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Outcomes of Maternal and Newborn in Waterbirth; A Review of 3-Year Medical Records in a Natural Birth Center

Gang JH, Park HR

PURPOSE: This study aims to investigate the effects of waterbirth on the maternal delivery process and its safety on the newborn babies. METHODS: This study is a retrospective study, analyzing the...
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The Role of Intranasal Oxytocin in Anxiety and Depressive Disorders: A Systematic Review of Randomized Controlled Trials

De Cagna F, Fusar-Poli L, Damiani S, Rocchetti , Giovanna G, Mori A, Politi P, Brondino N

Several studies have demonstrated the neuromodulating function of oxytocin (OT) in response to anxiogenic stimuli as well as its potential role in the pathogenesis of depression. Consequently, intranasal OT (IN-OT)...
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No Association between Polymorphisms of Vitamin D and Oxytocin Receptor Genes and Autistic Spectrum Disorder in a Sample of Turkish Children

Bozdogan S, Kutuk MO, Tufan E, Altıntaş Z, Temel GO, Toros F

OBJECTIVE: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in social skills and communication with repetitive behaviors. Etiology is still unclear although it is thought to develop...
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The Relationship between Plasma Oxytocin Levels and Social Anxiety Symptoms

Oh KS, Kim EJ, Ha JW, Woo HY, Kwon MJ, Shin DW, Shin YC, Lim SW

OBJECTIVE: The pathophysiology of social anxiety disorder (SAD) is not yet well understood, but previous research has suggested that oxytocin is associated with social behavior and may play a role...
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Effects of Intranasal Oxytocin on Emotion Recognition in Korean Male: A Dose-Response Study

Shin NY, Park HY, Jung WH, Kwon JS

OBJECTIVE: Research has shown that intranasal oxytocin affects social cognition and behavior; however, its effects vary based on social context, individual characteristics and dose. The present study aimed to determine...
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Oxytocin produces thermal analgesia via vasopressin-1a receptor by modulating TRPV1 and potassium conductance in the dorsal root ganglion neurons

Han RT, Kim HB, Kim YB, Choi K, Park GY, Lee PR, Lee J, Kim HY, Park CK, Kang Y, Oh SB, Na HS

Recent studies have provided several lines of evidence that peripheral administration of oxytocin induces analgesia in human and rodents. However, the exact underlying mechanism of analgesia still remains elusive. In...
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Effects of corticotropin-releasing hormone on the expression of adenosine triphosphate-sensitive potassium channels (Kir6.1/SUR2B) in human term pregnant myometrium

Kim JY, Wu WH, Jun JH, Sohn J, Seo YS

OBJECTIVE: Corticotropin-releasing hormone (CRH) is a crucial regulator of human pregnancy and parturition. Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels are important for regulating myometrial quiescence during pregnancy. We investigated regulatory...
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Does anaesthesia in mothers during delivery affect bilirubin levels in their neonates?

El-Kabbany ZA, Toaima NN, Toaima TN, EL-Din MY

PURPOSE: This study aimed to assess whether different anesthetic techniques and oxytocin use applied during delivery affect transcutaneous bilirubin levels during the first 24 hours in neonates. METHODS: A total of...
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Efficacy of oxytocin antagonist infusion in improving in vitro fertilization outcomes on the day of embryo transfer: A meta-analysis

Kim SK, Han EJ, Kim SM, Lee JR, Jee BC, Suh CS, Kim SH

OBJECTIVE: Uterine contraction induced by the embryo transfer (ET) process has an adverse effect on embryo implantation. The aim of this study was to determine the effect of oxytocin antagonist...
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Myometrial relaxation of mice via expression of two pore domain acid sensitive K⁺ (TASK-2) channels

Kyeong KS, Hong SH, Kim YC, Cho W, Myung SC, Lee MY, You RY, Kim CH, Kwon SY, Suzuki H, Park YJ, Jeong EH, Kim HS, Kim H, Lim SW, Xu WX, Lee SJ, Ji IW

Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing K⁺ channels (TASK-2) might be...
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Clinical Consideration of Treatment to Ablate Uterine Fibroids with Magnetic Resonance Imaging-guided High Intensity Focused Ultrasound (MRgFUS): Sonalleve

Jeong JH, Hong GP, Kim YR, Ha JE, Lee KS

OBJECTIVES: Magnetic resonance imaging (MRI)-guided high intensity focused ultrasound surgery (MRgFUS) is a newly emerging non-invasive technique for the treatment of uterine fibroids. The purpose of this study is to...
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Aggression and Neurotransmitters

Yu SY, Choi Y, Kim S, Jeong HS, Ma J, Kim YH, Moon S, Kang I, Jeong E, Suh CW, Shin KS, Kim JE

Aggression and aggressive behaviors, often explained as harmful social interaction with the intention of hurting or inflicting damage upon another, have been considered as an adaptive mechanism from the evolutionary...
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Kisspeptin Regulation of Neuronal Activity throughout the Central Nervous System

Liu X, Herbison A

Kisspeptin signaling at the gonadotropin-releasing hormone (GnRH) neuron is now relatively well characterized and established as being critical for the neural control of fertility. However, kisspeptin fibers and the kisspeptin...
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