- An Alternative Dendritic Cell-Induced Murine Model of Asthma Exhibiting a Robust Th2/Th17-Skewed Response
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Park SC, Kim H, Bak Y, Shim D, Kwon KW, Kim CH, Yoon JH, Shin SJ
- KMID: 2471235
- Allergy Asthma Immunol Res.
- 2020 May;12(3):537-555.
- doi: 10.4168/aair.2020.12.3.537
PURPOSE: Simple and reliable animal models of human diseases contribute to the understanding of disease pathogenesis as well as the development of therapeutic interventions. Although several murine models to mimic... -
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- Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model
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Khalmuratova R, Lee M, Park JW, Shin HW
- KMID: 2468464
- Allergy Asthma Immunol Res.
- 2020 Mar;12(2):306-321.
- doi: 10.4168/aair.2020.12.2.306
PURPOSE: Osteitis refers to the development of new bone formation and remodeling of bone in chronic rhinosinusitis (CRS) patients; it is typically associated with eosinophilia, nasal polyps (NPs), and recalcitrant... -
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- Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids
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Kim HJ, Lee SH, Hong SJ
- KMID: 2462578
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):137-148.
- doi: 10.4168/aair.2020.12.1.137
PURPOSE: Alterations in the intestinal microbiota in early life affects the development of atopic dermatitis (AD) in humans. This study aimed to further investigate the effects of gut dysbiosis in... -
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- Reversal of Olfactory Disturbance in Allergic Rhinitis Related to OMP Suppression by Intranasal Budesonide Treatment
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Jung AY, Kim YH
- KMID: 2462576
- Allergy Asthma Immunol Res.
- 2020 Jan;12(1):110-124.
- doi: 10.4168/aair.2020.12.1.110
PURPOSE: We evaluated the severity of olfactory disturbance (OD) in the murine model of allergic rhinitis (AR) and local allergic rhinitis (LAR) in mice. We also investigated the therapeutic effect... -
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- Four amino acids as serum biomarkers for anti-asthma effects in the ovalbumin-induced asthma mouse model treated with extract of Asparagus cochinchinensis
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Choi JY, Kim SH, Kim JE, Park JW, Kang MJ, Choi HJ, Bae SJ, Lee JH, Jung YS, Hwang DY
- KMID: 2470022
- Lab Anim Res.
- 2019 Dec;35(4):238-247.
- doi: 10.1186/s42826-019-0033-x
The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAW) effectively prevents inflammation and remodeling of airway in the ovalbumin (OVA)-induced asthma model. To characterize biomarkers that can... -
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- Respiratory syncytial virus increases eosinophil extracellular traps in a murine model of asthma
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Silveira J, Antunes GL, Gassen RB, Breda RV, Stein RT, Pitrez PM, da Cunha A
- KMID: 2461104
- Asia Pac Allergy.
- 2019 Oct;9(4):e32.
- doi: 10.5415/apallergy.2019.9.e32
BACKGROUND: Respiratory viral infections are the leading cause of asthma exacerbations. Eosinophil activation results in the formation of eosinophil extracellular traps (EETs), which release web-like structures of DNA and proteins... -
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- Activated Leukocyte Cell Adhesion Molecule Modulates Th2 Immune Response in Atopic Dermatitis
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Oh MS, Hong JY, Kim MN, Kwak EJ, Kim SY, Kim EG, Lee KE, Kim YS, Jee HM, Kim SH, Sol IS, Park CO, Kim KW, Sohn MH
- KMID: 2452758
- Allergy Asthma Immunol Res.
- 2019 Sep;11(5):677-690.
- doi: 10.4168/aair.2019.11.5.677
PURPOSE: Activated leukocyte cell adhesion molecule (ALCAM), a member of the immunoglobulin superfamily, is highly expressed on dendritic cells. ALCAM and its receptor CD6 are co-stimulatory molecules in the immunological... -
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- Magnolol exerts anti-asthmatic effects by regulating Janus kinase-signal transduction and activation of transcription and Notch signaling pathways and modulating Th1/Th2/Th17 cytokines in ovalbumin-sensitized asthmatic mice
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Huang Q, Han L, Lv R, Ling L
- KMID: 2450492
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):251-261.
- doi: 10.4196/kjpp.2019.23.4.251
Allergic asthma, is a common chronic inflammatory disease of the airway presenting with airway hyperresponsiveness and airway remodelling. T helper cells-derived cytokines are critically associated with asthma pathogenesis. Janus kinase-signal... -
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- Polymeric Nanoparticles Containing Both Antigen and Vitamin D₃ Induce Antigen-Specific Immune Suppression
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Jung HH, Kim SH, Moon JH, Jeong SU, Jang S, Park CS, Lee CK
- KMID: 2450204
- Immune Netw.
- 2019 Jun;19(3):e19.
- doi: 10.4110/in.2019.19.e19
The active form of vitamin D3, 1,25-dihydroxyvitamin D₃ (aVD₃), is known to exert beneficial effects in the treatment of autoimmune diseases because of its immunosuppressive effects. However, clinical application of... -
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- Antiallergic Effect of Hizikia fusiformis in an Ovalbumin-Induced Allergic Rhinitis Mouse Model
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Zhang YL, Shin HJ, Lee JH, Lee J
- KMID: 2447429
- Clin Exp Otorhinolaryngol.
- 2019 May;12(2):196-205.
- doi: 10.21053/ceo.2019.00094
OBJECTIVES: The extract of Hizikia fusiformis is known to exhibit anticancer, antiatopic and antioxidant activities. We aimed to investigate the extract of H. fusiformis on allergic rhinitis inflammation in a... -
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- Intranasal Treatment With 1, 25-Dihydroxyvitamin D3 Alleviates Allergic Rhinitis Symptoms in a Mouse Model
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Cho SW, Zhang YL, Ko YK, Shin JM, Lee JH, Rhee CS, Kim DY
- KMID: 2431858
- Allergy Asthma Immunol Res.
- 2019 Mar;11(2):267-279.
- doi: 10.4168/aair.2019.11.2.267
PURPOSE: Vitamin D is a potent immunomodulator. However, its role in the pathogenesis of allergic rhinitis is unclear. METHODS: The aim of this study was to evaluate the antiallergic effect of... -
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- A Fusion Protein of Derp2 Allergen and Flagellin Suppresses Experimental Allergic Asthma
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Tan W, Zheng JH, Duong TM, Koh YI, Lee SE, Rhee JH
- KMID: 2431857
- Allergy Asthma Immunol Res.
- 2019 Mar;11(2):254-266.
- doi: 10.4168/aair.2019.11.2.254
PURPOSE: The house dust mite (HDM) is one of the most important sources of indoor allergens and a significant cause of allergic rhinitis and allergic asthma. Our previous studies demonstrated... -
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- Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma
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Kang JY, Kim IK, Hur J, Kim SC, Lee SY, Kwon SS, Kim YK
- KMID: 2441732
- Tuberc Respir Dis.
- 2019 Jan;82(1):71-80.
- doi: 10.4046/trd.2018.0049
BACKGROUND: Efficacy and safety of tiotropium bromide, a muscarinic receptor antagonist, in treatment of asthma have been reported. However, its effect on airway remodeling in chronic asthma of the elderly... -
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- Suppressive Effect of 4-Hydroxy-2-(4-Hydroxyphenethyl) Isoindoline-1,3-Dione on Ovalbumin-Induced Allergic Asthma
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Huang J, Su M, Lee BK, Kim MJ, Jung JH, Im DS
- KMID: 2427506
- Biomol Ther.
- 2018 Nov;26(6):539-545.
- doi: 10.4062/biomolther.2018.006
4-Hydroxy-2-(4-hydroxyphenethyl)isoindoline-1,3-dione (PD1) is a synthetic phthalimide derivative of a marine compound. PD1 has peroxisome proliferator-activated receptor (PPAR) γ agonistic and anti-inflammatory effects. This study aimed to investigate the effect of... -
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- Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model
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Liang L, Hur J, Kang JY, Rhee CK, Kim YK, Lee SY
- KMID: 2426406
- Korean J Intern Med.
- 2018 Nov;33(6):1210-1223.
- doi: 10.3904/kjim.2017.207
BACKGROUND/AIMS: The co-occurrence of obesity aggravates asthma symptoms. Diet-induced obesity increases helper T cell (TH) 17 cell differentiation in adipose tissue and the spleen. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pravastatin... -
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- Dose dependence and durability of the therapeutic effects of Asparagus cochinchinensis fermented extract in an ovalbumin-challenged asthma model
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Choi JY, Park JW, Kim JE, Park JJ, Lee MR, Song BR, Kang MJ, Hwang DY
- KMID: 2420822
- Lab Anim Res.
- 2018 Sep;34(3):101-110.
- doi: 10.5625/lar.2018.34.3.101
The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAfW) significantly suppressed the inflammatory response induced by lipopolysaccharide (LPS) treatment in RAW264.7 cells. To investigate the dose dependence... -
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- Influence of rutin on the effects of neonatal cigarette smoke exposure-induced exacerbated MMP-9 expression, Th17 cytokines and NF-κB/iNOS-mediated inflammatory responses in asthmatic mice model
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Liu LL, Zhang Y, Zhang XF, Li FH
- KMID: 2418998
- Korean J Physiol Pharmacol.
- 2018 Sep;22(5):481-491.
- doi: 10.4196/kjpp.2018.22.5.481
Allergic asthma is one of the most enduring diseases of the airway. The T-helper cells and regulatory T-cells are critically involved in inflammatory responses, mucus hypersecretion, airway remodelling and in... -
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- TRPV1 Blocking Alleviates Airway Inflammation and Remodeling in a Chronic Asthma Murine Model
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Choi JY, Lee HY, Hur J, Kim KH, Kang JY, Rhee CK, Lee SY
- KMID: 2409056
- Allergy Asthma Immunol Res.
- 2018 May;10(3):216-224.
- doi: 10.4168/aair.2018.10.3.216
PURPOSE: Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. There is emerging interest in the involvement of the transient receptor potential vanilloid 1... -
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- Effects of Macrolide and Corticosteroid in Neutrophilic Asthma Mouse Model
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An TJ, Rhee CK, Kim JH, Lee YR, Chon JY, Park CK, Yoon HK
- KMID: 2420594
- Tuberc Respir Dis.
- 2018 Jan;81(1):80-87.
- doi: 10.4046/trd.2017.0108
BACKGROUND: Asthma is a disease of chronic airway inflammation with heterogeneous features. Neutrophilic asthma is corticosteroid-insensitive asthma related to absence or suppression of TH2 process and increased TH1 and/or TH17... -
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- Inhibitory effects of 2,6-di-tert-butyl-4-hydroxymethylphenol on asthmatic responses to ovalbumin challenge in conscious guinea pigs
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Jeong SY, Lee JY
- KMID: 2398558
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):81-89.
- doi: 10.4196/kjpp.2018.22.1.81
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining... -
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