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Novel nomogram-based integrated gonadotropin therapy individualization in in vitro fertilization/intracytoplasmic sperm injection: A modeling approach

Ebid AHIM, Motaleb SMA, Mostafa MI, Soliman MMA

Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the...
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Generation of cynomolgus monkey fetuses with intracytoplasmic sperm injection based on the MII-stage oocytes acquired by personalized superovulation protocol

Huang Z, Li Y, Jiang Q, Wang Y, Ma K, Li Q

Background: Mature oocytes at the metaphase II status (MII-stage oocytes) played an important role in assisted reproductive technology in non-human primates. Objectives: In order to improve the proportion of MII-stage oocytes...
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A survey on the awareness and knowledge about elective oocyte cryopreservation among unmarried women of reproductive age visiting a private fertility center

Hong YH, Park JW, Kim H, Kim SK, Choo CW, Jee BC, Suh CS, Kim SH

OBJECTIVE: The aim of this study was to investigate the level of awareness and knowledge regarding elective oocyte cryopreservation (OC) among unmarried women of reproductive age in Korea. METHODS: A survey...
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The association of follicular fluid volume with human oolemma stretchability during intracytoplasmic sperm injection

Inoue T, Yamashita , Tsujimoto , Yamamoto S, Taguchi S, Hirao K, Uemura M, Ikawa K, Miyazaki K

OBJECTIVE: Oocyte degeneration often occurs after intracytoplasmic sperm injection (ICSI), and the risk factor is low-quality oocytes. The follicular fluid (FF) provides a crucial microenvironment for oocyte development. We investigated...
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Acceptance of Oocytes Freezing for Fertility Preservation for Social Reasons Among Unmarried Korean Women

Cho HS, Kim HO

PURPOSE: To evaluate the awareness of unmarried Korean women about the relationship between fertility and age with respect to the need to consider oocyte freezing to preserve fertility in cases...
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Embryonic development after exposure of mouse oocyte to various amount of ovarian endometriotic fluid

Kim H, Jeong M, Kim SK, Jee BC

This study assesses the fertilization and blastocyst-forming rate in mice cumulus-oocyte complexes (COCs) after the exposure of human ovarian endometriotic fluid. Endometriotic fluid was obtained from a single patient by...
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Application of serum anti-Müllerian hormone levels in selecting patients with polycystic ovary syndrome for in vitro maturation treatment

Seok HH, Song H, Lyu SW, Kim YS, Lee DR, Lee WS, Yoon TK

OBJECTIVE: The purpose of this study was to identify useful clinical factors for the identification of patients with polycystic ovary syndrome (PCOS) who would benefit from in vitro maturation (IVM)...
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Nomogram to predict the number of oocytes retrieved in controlled ovarian stimulation

Moon KY, Kim H, Lee JY, Lee JR, Jee BC, Suh CS, Kim KC, Lee WD, Lim JH, Kim SH

OBJECTIVE: Ovarian reserve tests are commonly used to predict ovarian response in infertile patients undergoing ovarian stimulation. Although serum markers such as basal follicle-stimulating hormone (FSH) or random anti-Müllerian hormone...
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Vitrification, in vitro fertilization, and development of Atg7 deficient mouse oocytes

Bang S, Lee GK, Shin H, Suh CS, Lim HJ

OBJECTIVE: Autophagy contributes to the clearance and recycling of macromolecules and organelles in response to stress. We previously reported that vitrified mouse oocytes show acute increases in autophagy during warming....
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The potential role of granulosa cells in the maturation rate of immature human oocytes and embryo development: A co-culture study

Jahromi BN, Mosallanezhad Z, Matloob N, Davari M, Ghobadifar MA

OBJECTIVE: In order to increase the number of mature oocytes usable for intracytoplasmic sperm injection (ICSI), we aimed to investigate the effect of co-culturing granulosa cells (GCs) on human oocyte...
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Endoplasmic reticulum stress in periimplantation embryos

Michalak M, Gye MC

Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is...
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Fertilization and embryo quality of mature oocytes with specific morphological abnormalities

Yu EJ, Ahn H, Lee JM, Jee BC, Kim SH

OBJECTIVE: To investigate fertilization and embryo quality of dysmorphic mature oocytes with specific morphological abnormalities obtained from intracytoplasmic sperm injection (ICSI). METHODS: The fertilization rate (FR) and embryo quality were compared...
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Maternal effect genes: Findings and effects on mouse embryo development

Kim KH, Lee KA

Stored maternal factors in oocytes regulate oocyte differentiation into embryos during early embryonic development. Before zygotic gene activation (ZGA), these early embryos are mainly dependent on maternal factors for survival,...
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Activation of Lysophosphatidic Acid Receptor Is Coupled to Enhancement of Ca(2+)-Activated Potassium Channel Currents

Choi SH, Lee BH, Kim HJ, Hwang SH, Lee SM, Nah SY

The calcium-activated K+ (BKCa) channel is one of the potassium-selective ion channels that are present in the nervous and vascular systems. Ca2+ is the main regulator of BKCa channel activation....
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Inhibitory Effects of Ginsenoside Metabolites, Compound K and Protopanaxatriol, on GABAC Receptor-Mediated Ion Currents

Lee BH, Hwang SH, Choi SH, Kim HJ, Lee JH, Lee SM, Ahn YG, Nah SY

Ginsenosides, one of the active ingredients of Panax ginseng, show various pharmacological and physiological effects, and they are converted into compound K (CK) or protopanaxatriol (M4) by intestinal microorganisms. CK...
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Fertilization and pregnancy potential of immature oocytes from stimulated intracytoplasmic sperm injection cycles

Shin SB, Cho JW, Lee SH, Yang KM, Lim CK, Lee HS

OBJECTIVE: We evaluated the fertilization potential of immature oocytes obtained from controlled ovarian hyperstimulation cycles of patients undergoing ICSI. METHODS: We retrospectively analyzed 463 ICSI cycles containing at least one immature...
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Effect of propofol on oxidative stress-attenuated glutamate transporter EAAT4 activity

Ryu JH, Kim CS, Do SH, Park HS

  • KMID: 1741909
  • Anesth Pain Med.
  • 2011 Jul;6(3):225-230.
BACKGROUND: Propofol (2, 6-diisopropylphenol) has been known to have neuroprotective effects. Excitatory amino acid transporter 4 (EAAT4) is a glutamate transporter predominantly expressed in the cerebellar Purkinje cells, which is...
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Dynamic analysis of Ca2+ level during bovine oocytes maturation and early embryonic development

Liang SL, Zhao QJ, Li XC, Jin YP, Wang YP, Su XH, Guan WJ, Ma YH

Mammalian oocyte maturation and early embryo development processes are Ca(2+)-dependent. In this study, we used confocal microscopy to investigate the distribution pattern of Ca2+ and its dynamic changes in the...
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Cryopreservation of Oocytes and Embryos by Vitrification

Gupta MK, Lee HT

  • KMID: 1458325
  • Korean J Reprod Med.
  • 2010 Dec;37(4):267-291.
Life can be kept in suspended animation either before fertilization at oocyte stage or after fertilization at different stages of embryonic development for a variety of reasons. It not only...
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Amino acid residues involved in agonist binding and its linking to channel gating, proximal to transmembrane domain of 5-HT3A receptor for halothane modulation

Kim MK, Min KT, Koo BN

BACKGROUND: The 5-hydroxytryptamine type 3 (5-HT3) receptor is a member of the Cys-loop superfamily of ligand-gated ion channels (LGICs) and modulated by pharmacologic relevant concentrations of volatile anesthetics or n-alcohols...
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