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Response to: “Long-term Outcomes of In Situ Fusion for Treating Dysplastic Spondylolisthesis”

Inage K, Orita S, Yamauchi K, Suzuki M, Sakuma Y, Kubota G, Oikawa Y, Sainoh T, Sato J, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Takahashi , Ohtori S

No abstract available.
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Improvements in Intractable Lumbar and LowerExtremity Symptoms after Systemic Administration of Tocilizumab, an Anti-interleukin-6 Receptor Antibody

Sainoh T, Sainoh T, Orita S, Orita S, Miyagi M, Miyagi M, Suzuki-Narita M, Suzuki-Narita M, Sakuma Y, Sakuma Y, Oikawa Y, Oikawa Y, Kubota G, Kubota G, Sato J, Sato J, Shiga Y, Shiga Y, Fujimoto K, Fujimoto K, Eguchi Y, Eguchi Y, Koda M, Koda M, Aoki Y, Aoki Y, Akazawa T, Akazawa T, Furuya T, Furuya T, Nakamura J, Nakamura J, Takahashi H, Takahashi H, Maki S, Maki S, Inoue M, Inoue M, Kinoshita H, Kinoshita H, Norimoto M, Norimoto M, Sato T, Sato T, Sato M, Sato M, Suzuki M, Suzuki M, Enomoto K, Enomoto K, Takaoka H, Takaoka H, Mizuki N, Mizuki N, Hozumi T, Hozumi T, Tsuchiya R, Tsuchiya R, Kim G, Kim G, Otagiri T, Otagiri T, Mukaihata T, Mukaihata T, Hishiya T, Hishiya T, Ohtori S, Ohtori S, Inage K, Inage K

Study Design: Prospective cohort study (open-label, single-arm, and non-blinded). Purpose: This study aims to determine the effects of systemic administration of tocilizumab, an anti-interleukin-6 (IL-6) receptor antibody on refractory low back...
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Evaluating Spinal Canal Lesions Using Apparent Diffusion Coefficient Maps with Diffusion-Weighted Imaging

Kanamoto H, Norimoto M, Eguchi Y, Oikawa Y, Orita S, Inage K, Abe K, Inoue M, Kinoshita H, Umimura T, Matsumoto K, Masuda Y, Furuya T, Koda M, Aoki Y, Watanabe A, Takahashi K, Ohtori S

Study Design: Observational study. Purpose: To evaluate healthy volunteers and patients with spinal canal lesions using apparent diffusion coefficient (ADC) maps with diffusion-weighted imaging. Overview of Literature: Decompression surgery for lumbar spinal...
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Up-Regulation of Pain Behavior and Glial Activity in the Spinal Cord after Compression and Application of Nucleus Pulposus onto the Sciatic Nerve in Rats

Norimoto M, Sakuma Y, Suzuki M, Orita S, Yamauchi K, Inoue G, Aoki Y, Ishikawa T, Miyagi M, Kamoda H, Kubota G, Oikawa Y, Inage K, Sainoh T, Sato J, Nakamura J, Toyone T, Takahashi , Ohtori S

STUDY DESIGN: Experimental animal study. PURPOSE: To evaluate pain-related behavior and changes in glial activity in the spinal dorsal horn after combined sciatic nerve compression and nucleus pulposus (NP) application in...
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Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction

Kinoshita , Orita S, Inage K, Fujimoto K, Shiga Y, Abe K, Inoue M, Norimoto M, Umimura T, Ishii T, Yonemoto T, Kamoda H, Tsukanishi T, Suzuki M, Hirosawa N, Akazawa T, Ohtori S

Study Design: Controlled laboratory study. Purpose: This study aimed to evaluate the in vitro pharmacological activity of growth factors (GFs) in freeze-dried platelet-rich plasma (FD-PRP) after storage for 4 weeks. Overview of...
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Correlation Between Walking Ability and Monthly Care Costs in Elderly Patients After Surgical Treatments for Hip Fractures

Abe K, Inage K, Yamashita , Yamashita , Yamamaoka , Norimoto M, Nakata Y, Mitsuka T, Suseki K, Orita S, Fujimoto K, Shiga Y, Kanamoto H, Inoue M, Kinoshita , Umimura T, Eguchi Y, Furuya T, Takahashi , Ohtori S

OBJECTIVE: To validate the relationship between residual walking ability and monthly care cost as well as long-term care insurance (LTCI) certification level in elderly patients after surgical treatment for hip...
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Time-Course Changes in Bone Metabolism Markers and Density in Patients with Osteoporosis Treated with Romosozumab: A Multicenter Retrospective Study

Inage K, Orita S, Eguchi Y, Shiga Y, Koda M, Aoki Y, Kotani T, Akazawa T, Furuya T, Nakamura J, Takahashi H, Suzuki-Narita M, Maki S, Hagiwara S, Inoue M, Norimoto M, Kinoshita H, Sato T, Sato M, Enomoto K, Takaoka H, Mizuki N, Hozumi T, Tsuchiya R, Kim G, Otagiri T, Mukaihata T, Hishiya T, Ohtori S

Purpose: In this multicenter retrospective observational study, we examined the early effects of romosozumab in patients with severe osteoporosis in terms of time-course changes in bone metabolism marker, improvement in...
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Diffusion Tensor Imaging of the Spinal Canal in Quantitative Assessment of Patients with Lumbar Spinal Canal Stenosis

Norimoto M, Eguchi Y, Kanamoto H, Oikawa Y, Matsumoto K, Masuda Y, Furuya T, Orita S, Inage K, Maki S, Shiga Y, Kinoshita H, Abe K, Inoue M, Umimura T, Sato T, Sato M, Suzuki M, Enomoto K, Ohtori S

Study Design Retrospective observational study. Purpose Lumbar spinal stenosis (LSS) has traditionally been evaluated morphologically, there is a paucity of literature on quantitative assessment of LSS. The purpose of this study was to...
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Elevated Levels of Serum Pentosidine Are Associated with Dropped Head Syndrome in Older Women

Eguchi Y, Toyoguchi , Inage K, Orita S, Yamauchi K, Suzuki M, Kanamoto H, Abe K, Norimoto M, Umimura T, Koda M, Furuya T, Aoki Y, Takahashi , Ohtori S

STUDY DESIGN: A retrospective observational study was performed. PURPOSE: We investigated the prevalence of sarcopenia in dropped head syndrome (DHS), and the relationship between biochemical markers, including major advanced glycation end...
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Long-Term Outcomes of In Situ Fusion for Treating Dysplastic Spondylolisthesis

Inage K, Orita S, Yamauchi K, Suzuki M, Sakuma Y, Kubota G, Oikawa Y, Sainoh T, Sato J, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Takahashi , Ohtori S

STUDY DESIGN: Retrospective, observational, single-center study. PURPOSE: To investigate the long-term outcomes of in situ fusion procedures for treating dysplastic spondylolisthesis. OVERVIEW OF LITERATURE: In situ fusion performed in patients with dysplastic...
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Usefulness of Simultaneous Magnetic Resonance Neurography and Apparent T2 Mapping for the Diagnosis of Cervical Radiculopathy

Enomoto K, Eguchi Y, Sato T, Norimoto M, Inoue M, Watanabe A, Sakai T, Yoneyama M, Aoki Y, Orita S, Narita M, Inage K, Shiga Y, Umimura T, Sato M, Suzuki M, Takaoka H, Mizuki N, Kim G, Hozumi T, Hirosawa N, Furuya T, Maki S, Nakamura J, Hagiwara S, Koda M, Akazawa T, Takahashi H, Takahashi K, Ohtori S

Study Design: Retrospective observational study. Purpose: We investigated the correlation between T2 relaxation times and clinical symptoms in patients with cervical radiculopathy caused by cervical disk herniation. Overview of Literature: There are...
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Correlation among Inflammatory Cytokine Expression Levels, Degree of Disk Degeneration, and Predominant Clinical Symptoms in Patients with Degenerated Intervertebral Discs

Sainoh T, Inage K, Orita S, Koda M, Furuya T, Yamauchi K, Suzuki M, Sakuma Y, Kubota G, Oikawa Y, Sato J, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Takahashi , Ohtori S

STUDY DESIGN: Observational study. PURPOSE: To assess the correlation among inflammatory cytokine expression levels, degree of intervertebral disk (IVD) degeneration, and predominant clinical symptoms observed in degenerative disk disease (DDD). OVERVIEW OF...
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Use of Bioelectrical Impedance Analysis for the Measurement of Appendicular Skeletal Muscle Mass/Whole Fat Mass and Its Relevance in Assessing Osteoporosis among Patients with Low Back Pain: A Comparative Analysis Using Dual X-ray Absorptiometry

Fujimoto K, Inage K, Eguchi Y, Orita S, Suzuki M, Kubota G, Sainoh T, Sato J, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Koda M, Furuya T, Akazawa T, Toyoguchi , Terakado A, Takahashi , Ohtori S

STUDY DESIGN: Cross-sectional observational study. PURPOSE: To compare measurements of appendicular skeletal muscle mass (ASMM) and whole fat mass (WFM) obtained using dualenergy X-ray absorptiometry (DXA) and bioelectrical impedance analysis (BIA)...
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Influence of Skeletal Muscle Mass and Spinal Alignment on Surgical Outcomes for Lumbar Spinal Stenosis

Eguchi Y, Suzuki M, Yamanaka H, Tamai H, Kobayashi , Orita S, Yamauchi K, Suzuki M, Inage K, Fujimoto K, Kanamoto H, Abe K, Norimoto M, Umimura T, Aoki Y, Koda M, Furuya T, Toyone T, Ozawa T, Takahashi , Ohtori S

STUDY DESIGN: Retrospective observational study. PURPOSE: We considered the relationship between spinal alignment and skeletal muscle mass on clinical outcomes following a surgery for lumbar spinal stenosis (LSS). OVERVIEW OF LITERATURE: There...
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Inhibiting Vascular Endothelial Growth Factor in Injured Intervertebral Discs Attenuates Pain-Related Neuropeptide Expression in Dorsal Root Ganglia in Rats

Sato J, Inage K, Miyagi M, Sakuma Y, Yamauchi K, Koda M, Furuya T, Nakamura J, Suzuki M, Kubota G, Oikawa Y, Sainoh T, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Inoue M, Kinoshita , Norimoto M, Umimura T, Takahashi , Ohtori S, Orita S

STUDY DESIGN: An experimental animal study. PURPOSE: To evaluate effects of anti-vascular endothelial growth factor (VEGF) on the content and distribution of the calcitonin gene-related peptide (CGRP) in the dorsal ganglia...
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