- Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism
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Kim HL, Ha AW, Kim WK
- KMID: 2471878
- Nutr Res Pract.
- 2020 Apr;14(2):109-116.
- doi: 10.4162/nrp.2020.14.2.109
BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study... -
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- Aralia cordata Extract Activates NF-κB and MAPK Signaling Pathways and Induces Pro-inflammatory Changes in RAW264.7 Macrophages
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Seo DW, Cho YI, Yi YJ, Lee SM
- KMID: 2468022
- J Bacteriol Virol.
- 2019 Dec;49(4):153-161.
- doi: 10.4167/jbv.2019.49.4.153
Macrophages play essential roles in innate immune responses by producing various immune mediators. Therefore, modulating macrophage function is an attractive strategy to treat immune disorders. Aralia cordata var. continentalis (AC),... -
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- Optimization of Microenvironments Inducing Differentiation of Tonsil-Derived Mesenchymal Stem Cells into Endothelial Cell-Like Cells
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Oh SY, Choi DH, Jin YM, Yu Y, Kim HY, Kim G, Park YS, Jo I
- KMID: 2467055
- Tissue Eng Regen Med.
- 2019 Dec;16(6):631-643.
- doi: 10.1007/s13770-019-00221-y
BACKGROUND: Stem cell engineering is appealing consideration for regenerating damaged endothelial cells (ECs) because stem cells can differentiate into EC-like cells. In this study, we demonstrate that tonsil-derived mesenchymal stem... -
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- Telmisartan Inhibits Nitric Oxide Production and Vessel Relaxation via Protein Phosphatase 2A-mediated Endothelial NO Synthase-Ser¹¹â·â¹ Dephosphorylation
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Cho DH
- KMID: 2461172
- J Korean Med Sci.
- 2019 Nov;34(42):e266.
- doi: 10.3346/jkms.2019.34.e266
BACKGROUND: Apart from its blood pressure-lowering effect by blocking the renin-angiotensin-aldosterone system, telmisartan, an angiotensin II type 1 receptor blocker (ARB), exhibits various ancillary effects including cardiovascular protective effects in... -
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- Rhodanthpyrone A and B play an anti-inflammatory role by suppressing the nuclear factor-κB pathway in macrophages
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Kim KS, Han CY, Han YT, Bae EJ
- KMID: 2461042
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):493-499.
- doi: 10.4196/kjpp.2019.23.6.493
Macrophage-associated inflammation is crucial for the pathogenesis of diverse diseases including metabolic disorders. Rhodanthpyrone (Rho) is an active component of Gentiana rhodantha, which has been used in traditional Chinese medicine... -
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- Arg-Leu-Tyr-Glu Suppresses Retinal Endothelial Permeability and Choroidal Neovascularization by Inhibiting the VEGF Receptor 2 Signaling Pathway
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Park W, Baek YY, Kim J, Jo DH, Choi S, Kim JH, Kim T, Kim S, Park M, Kim JY, Won MH, Ha KS, Kim JH, Kwon YG, Kim YM
- KMID: 2456222
- Biomol Ther.
- 2019 Sep;27(5):474-483.
- doi: 10.4062/biomolther.2019.041
Vascular endothelial growth factor (VEGF) plays a pivotal role in pathologic ocular neovascularization and vascular leakage via activation of VEGF receptor 2 (VEGFR2). This study was undertaken to evaluate the... -
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- Docosahexaenoic acid reduces adenosine triphosphate-induced calcium influx via inhibition of store-operated calcium channels and enhances baseline endothelial nitric oxide synthase phosphorylation in human endothelial cells
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Vu TT, Dieterich , Vu TT, Deussen A
- KMID: 2455811
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):345-356.
- doi: 10.4196/kjpp.2019.23.5.345
Docosahexaenoic acid (DHA), an omega-3-fatty acid, modulates multiple cellular functions. In this study, we addressed the effects of DHA on human umbilical vein endothelial cell calcium transient and endothelial nitric... -
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- Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model
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Lee H, Yeom A, Kim KC, Hong YM
- KMID: 2455794
- Korean Circ J.
- 2019 Sep;49(9):866-876.
- doi: 10.4070/kcj.2019.0006
BACKGROUND AND OBJECTIVES: Elevated endothelin (ET)-1 level is strongly correlated with the pathogenesis of pulmonary arterial hypertension (PAH). Expression level of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 4 is increased... -
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- Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain
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Choi SR, Beitz AJ, Lee JH
- KMID: 2458549
- Exp Neurobiol.
- 2019 Aug;28(4):516-528.
- doi: 10.5607/en.2019.28.4.516
We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory... -
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- The Effect of Saccharin on the Gene Expression of NF-κB and Inflammatory Cytokines in LPS-Stimulated SW480 Colon Cancer Cells
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Choi H, Kim S, Kang H, Kim M, Kim W
- KMID: 2455070
- J Korean Diet Assoc.
- 2019 Aug;25(3):217-228.
- doi: 10.14373/JKDA.2019.25.3.217
There have been no published studies concerning the anti-inflammatory effects of corn silk on colon cancer cells. Thus, this study was conducted to investigate the effect of corn silk extract... -
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- Protective effect of Cordyceps militaris against hydrogen peroxide-induced oxidative stress in vitro
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He MT, Lee AY, Park CH, Cho EJ
- KMID: 2453105
- Nutr Res Pract.
- 2019 Aug;13(4):279-285.
- doi: 10.4162/nrp.2019.13.4.279
BACKGROUND/OBJECTIVES: Excessive production of reactive oxygen species (ROS) such as hydroxyl (·OH), nitric oxide (NO), and hydrogen peroxide (H2O2) is reported to induce oxidative stress. ROS generated by oxidative stress... -
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- Adipose Tissue-Derived Stem Cell Therapy for Cavernous Nerve Injury-Induced Erectile Dysfunction in the Rat Model: A Systematic Review and Meta-Analysis Using Methodological Quality Assessment
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Park HJ, Jeong H, Park YH, Yim HW, Ha US, Hong SH, Kim SW, Kim NJ, Lee JY
- KMID: 2465892
- Int J Stem Cells.
- 2019 Jul;12(2):206-217.
- doi: 10.15283/ijsc18122
BACKGROUND AND OBJECTIVES: Few studies were evaluated the effect of blindness on outcome in animal models, though a potential effect of blinding has been reported in clinical trials. We evaluated... -
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- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis
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Yoo IH, Kim MJ, Kim J, Sung JJ, Park ST, Ahn SW
- KMID: 2452635
- J Korean Med Sci.
- 2019 Jul;34(28):e197.
- doi: 10.3346/jkms.2019.34.e197
BACKGROUND: Multiple sclerosis (MS) is an immune-associated inflammatory disorder of the central nervous system and results in serious disability. Although many disease-modifying therapy drugs have been developed, these drugs have... -
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- Synergistic effects of extracorporeal shockwave therapy and modified Ojayeonjonghwan on erectile dysfunction in an animal model of diabetes
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Jeong HC, Bae WJ, Zhu GQ, Jeon SH, Choi SW, Kim SJ, Cho HJ, Hong SH, Lee JY, Hwang SY, Kim SW
- KMID: 2450546
- Investig Clin Urol.
- 2019 Jul;60(4):285-294.
- doi: 10.4111/icu.2019.60.4.285
PURPOSE: We investigated the synergy effect of extracorporeal shock wave therapy (ESWT) with modified Ojayeonjonghwan (Korean herbal formula, KH-204) in an animal model of diabetes mellitus (DM)-induced erectile dysfunction (ED). MATERIALS... -
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- Combination Effect of Titrated Extract of Centella asiatica and Astaxanthin in a Mouse Model of Phthalic Anhydride-Induced Atopic Dermatitis
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Park JH, Yeo IJ, Jang JS, Kim KC, Park MH, Lee HP, Han SB, Hong JT
- KMID: 2448757
- Allergy Asthma Immunol Res.
- 2019 Jul;11(4):548-559.
- doi: 10.4168/aair.2019.11.4.548
PURPOSE: In our previous study, we demonstrated that both titrated extract of Centella asiatica (TECA) and astaxanthin (AST) have anti-inflammatory effects in a 5% phthalic anhydride (PA) mouse model of... -
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- Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis
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Zhong X, Surh YJ, Do SG, Shin E, Shim KS, Lee CK, Na HK
- KMID: 2454672
- J Cancer Prev.
- 2019 Jun;24(2):129-138.
- doi: 10.15430/JCP.2019.24.2.129
BACKGROUND: Baicalein is a bioactive flavone that is originally extracted from the root of Scutellaria baicalensis Georgi. This plant has long served as Chinese herbal medicine in the management of... -
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- Anti-inflammatory effect of aged black garlic on 12-O-tetradecanoylphorbol-13-acetate-induced dermatitis in mice
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You BR, Yoo JM, Baek SY, Kim MR
- KMID: 2453282
- Nutr Res Pract.
- 2019 Jun;13(3):189-195.
- doi: 10.4162/nrp.2019.13.3.189
BACKGROUND/OBJECTIVES: Although aged black garlic has various biological activities such as anti-allergy, anti-inflammation and neuroprotection, effect of aged black garlic on chemically contact dermatitis is unclarified. MATERIALS/METHODS: To evaluate anti-dermatitic activity... -
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- Effect of Garcinia mangostana L. and propolis extracts on the inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats
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Sung SJ, Kang KM, Lee KH, Yoo SY, Kook JK, Lee DS, Yu SJ
- KMID: 2452748
- Int J Oral Biol.
- 2019 Jun;44(2):55-61.
- doi: 10.11620/IJOB.2019.44.2.55
The purpose of this study was to evaluate the effect of mangosteen extract complex (MEC; Garcinia mangostana L. and propolis extracts) on the inhibition of inflammation and prevention of alveolar... -
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- Analgesic Effect of Toll-like Receptor 4 Antagonistic Peptide 2 on Mechanical Allodynia Induced with Spinal Nerve Ligation in Rats
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Yin Y, Park H, Lee SY, Lee WH, Song HJ, Kim J, Kim DW, Hong J
- KMID: 2451071
- Exp Neurobiol.
- 2019 Jun;28(3):352-361.
- doi: 10.5607/en.2019.28.3.352
Neuroinflammation is one of the key mechanisms of neuropathic pain, which is primarily mediated by the Toll-like receptor 4 (TLR4) signaling pathways in microglia. Therefore, TLR4 may be a reasonable... -
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