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Clinical Variables Correlated with Numbers of Intra-arterial Nimodipine Infusion in Patients with Medically Refractory Cerebral Vasospasm

Kim SY, Kim KH, Cho JH, Kim YD

OBJECTIVE: The objective of this study was to find out the clinical variables correlated with repeated intra-arterial (IA) nimodipine infusions in patients with medically refractory cerebral vasospasm (CV) following subarachnoid...
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Effects of Nimodipine on Dose-Response Curves of Vecuronium, Rocuronium, and Atracurium Using Phrenic Nerve-Diaphragm Preparations of Rats

Cho IH, Kim YJ, Baik HJ, Kim JH

BACKGROUND: Interactions between nimodipine, a calcium channel blocker, used perioperatively for the treatment of subarachnoid hemorrhage, and vecuronium, rocuronium, and atracurium were studied with phrenic nerve-hemidiaphragm preparations of rats. METHODS:...
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Intra-arterial Nimodipine for the Treatment of Symptomatic Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage : Preliminary Report Clinical Research

Lee JW, Kim KH, Ahn SK

  • KMID: 2256588
  • Korean J Cerebrovasc Surg.
  • 2005 Sep;7(3):218-223.
OBJECTIVE: We evaluated the efficacy of intra-arterial nimodipine, a calcium-channel blocker acting mainly on cerebral vessels, in patients with symptomatic cerebral vasospasm following subarachnoid hemorrhage. METHODS: Clinical records of...
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The Effect of Nimodipine on Single High Dose Irradiation-Induced Apoptosis in the Rat Spinal Cord

Lee CI, Chung YG, Kim HK, Kim CY, Cho TH

  • KMID: 2339712
  • J Korean Neurosurg Soc.
  • 2003 Nov;34(5):450-455.
OBJECTIVE: Radiation injury includes radiation necrosis and apoptosis. Though some of its mechanism in brain are reported, those in spinal cord are not determined yet. The purpose of this study...
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The Effects of Nimodipine on Irradiation-Induced Apoptosis in the Rat Spinal Cord

Kim SH, Cho TH, Lim DJ, Park JY, Chung YG, Suh JK

  • KMID: 2339695
  • J Korean Neurosurg Soc.
  • 2003 Jun;33(6):576-581.
OBJECTIVE: Radiation therapy is an effective adjunctive therapy in the management of brain and spinal cord tumors. The damage to normal tissue, however, has been often the dose-limiting factor in...
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The Preventive Effect of Nimodipine on the Cisplatin Induced Neuropathy

Kim CH, Choi HC, Roh GH

  • KMID: 2178721
  • J Korean Acad Rehabil Med.
  • 2003 Feb;27(1):90-95.
OBJECTIVE: Cisplatin has effectiveness in the treatment of solid tumor by active cytotoxic action, but with significant side effects such as peripheral neuropathy. To investigate the prevention of neuropathy, nimodipine...
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Effect of Saponin, Allopurinol and Nimodipine on Noise Induced Treshold Changes of ABRs in Guinea Pigs

Park YH, Min IK, Nam BH, Park CI

  • KMID: 2275945
  • Korean J Otolaryngol-Head Neck Surg.
  • 2002 Aug;45(8):760-764.
BACKGROUND AND OBJECTIVES: Several studies have demonstrated that noise exposure may result in cochlear damage. The purpose of this study was to evaluate the effect of red Korean ginseng saponin...
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Nimodipine as a potential pharmacological tool for characterizing R-type calcium currents

Oh SB

  • KMID: 1607140
  • Korean J Physiol Pharmacol.
  • 2001 Dec;5(6):511-519.
Nimopidine, one of dihydropyridine derivatives, has been widely used to pharmacologically identify L-type Ca currents. In this study, it was tested if nimodipine is a selective blocker for L-type Ca...
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Therapeutic Effect of Nimodipine in Neonatal Rat Model of Cerebral Hypoxia-Ischemia

Hong IH, Kim HM

  • KMID: 2207695
  • J Korean Pediatr Soc.
  • 1999 Nov;42(11):1552-1558.
PURPOSE: Recent studies suggest that nimodipine, a potent calcium-channel blocker, may improve neurological outcome after experimental hypoxia-ischemic brain injury. This study was conducted to evaluate the therapeutic effect of nimodipine...
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Effects of Nimodipine Treatment on Aneurysmal Subarachnoid Hemorrhage

Lee SY, Choi CH

  • KMID: 2018999
  • J Korean Neurosurg Soc.
  • 1997 Apr;26(4):555-562.
Nimodipine, a potent, central active, calcium channel blocker, is known to relieve vasospasm, increase cerebral blood flow(CBF) and affect positively on clinical outcome in patients with subarachnoid hemorrhage. Experimentally, the...
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The Effect of Nimodipine and 21-aminosteroid(U74389G) on Cerebral Infarction and Cerebral Blood Flow during the Continuous and Repeated Interruptions of the Focal Cerebral Blood Flow in Cats

Park HS, Joo JY, Kim SH, Lee KC

  • KMID: 1955232
  • J Korean Neurosurg Soc.
  • 1997 Mar;26(3):335-346.
Temporary interruption of cerebral blood flow is an effective maneuver to prevent and/or to control excessive bleeding during cerebrovascular procedures. Despite the benefits of temporary arterial occlusion, there is still...
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Controlled Study of Nimodipine in Patients with Aneurysmal Subarachnoid Hemorrhage:Effect on the Short-Term Outcome and Safety Assessment

Paek SH, Oh CW, Han DH

  • KMID: 1671273
  • J Korean Neurosurg Soc.
  • 1996 Dec;25(12):2472-2477.
From January 1996 to September 1996, we enrolled 30 patients with a clinical status over Hunt and Hess grade IV, presenting within 5 days after spontaneous subarachnoid hemorrhage to determine...
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The Effects of Intravenous Administration of Nimodipine on Cerebral Pial Vessels Following the Injection of Autogenous Hemolytic Blood into Cisterna Magna in Rabbits

Cha SH, Jang BJ

  • KMID: 1954578
  • J Korean Neurosurg Soc.
  • 1995 Mar;24(3):278-289.
The reactions of cerebral pial vessels following the injection of normal saline(0.05cc, at 37 degrees C, pH7.4) and autogenous hemolytic blood(0.05cc, 0.1cc 0.2cc) into the cisterna magna of rabbits were...
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Outcome of Nimodipine Treatment on the Surgical Cases of Aneurysmal Subarachnoid Hemorrhage

Lee SH, Han DH

  • KMID: 2044426
  • J Korean Neurosurg Soc.
  • 1994 Nov;23(11):1299-1309.
In order to elucidate the clinical effectiveness of nimodipine treatment, we analyzed 322 consecutive patients with the aneurysmal subarachnoid hemorrhage operated between September, 1987 and December, 1991. The nimodipine treatment...
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Effect of Nimodipine on Incomplete Global Cerebral Ischemia-Reperfusion with prior Hyperglycemia: in vivo 31P Magnetic Resonance Spectroscopic Study in Cats

Park PH, Lee YM, Choi JM

In vivo 31P magnetic resonance spectroscopy (MRS) was used to evaluate the effect of nimodipine on changes of [H] (pH) and the ratio of [PCr]/[Pi] in cats subjected to an...
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The Effect of Nimodipine, Indeced Hypertension, and Combined Nimodipine Therapies with Induced Hypertension on Experimental Cerebral Infarction

Seo YH, Kim IH, Lee JC, Son EI, Kim DW, Yim MB

  • KMID: 1954666
  • J Korean Neurosurg Soc.
  • 1994 Jun;23(6):607-614.
The treatment with nimodipine is recommended as an effective therapy for the delayed ischemic neurological deficits(DIND) caused by cerebral vasospasm following aneurysmal subarachnoid hemorrhage. The induced hypertension is also widely...
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The Effects of Nimodipine and Intracisternal Urokinase on the Content of Leukotrience C4 in the Brain Tissue after Experimental Subarachnoid Hemorrhage in Rats

Lee SH, Yim MB, Kim SY, Lee JC, Son EI, Kim DW, Kim IH, Lee IK

  • KMID: 1954696
  • J Korean Neurosurg Soc.
  • 1994 Apr;23(4):365-374.
To find out whether early lysis of subarachnoid blood clot with intracisternal urokinase as well as intraperitoneal nimodipine prevents or decrease the breakdown of arachidonic acid(AA) of the brain after...
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Measurement of Regional Tissue Water and Ionic Concentrations During the Evolution of Infraction and the Therapeutic Value of Nimodipine in Rat Middle Cerebral Artery Occlusion Model of Ischemia

Chung YS, Kim HJ, Jung HW, Cho BK, Choi KS, Han DH

  • KMID: 2068010
  • J Korean Neurosurg Soc.
  • 1994 Jan;23(1):12-27.
The evolution of infarction in the rat middle cerebral artery(MCA) occlusion model was examined by atomic absorption spectrometric measurements of Na, K and Ca concentrations in brain tissue sample. At...
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Experimental Study of the Effect of Nimodipine on CSF Formation

Song JH, Park YK, Chung HS, Suh JK, Lee HK, Lee KC, Chu CW

  • KMID: 2067979
  • J Korean Neurosurg Soc.
  • 1993 Sep;22(9):947-952.
The author has performed an experimental study in order to investigate the effect of nimodipine on the production of CSF in 12 cats. The cats were divided into 2 groups,...
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Effects of Intravenous Administration of Nimodipine on Cerebral Pial Vessels after Experimental Subarachnoid Hemorrhage in Rabbits

Hwang SG, Lee YW

  • KMID: 2067974
  • J Korean Neurosurg Soc.
  • 1993 Jul;22(7):834-844.
No abstract available.
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