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Induced Intermediate Mesoderm Combined with Decellularized Kidney Scaffolds for Functional Engineering Kidney

Zhang J, Li K, Kong F, Sun C, Zhang D, Yu X, Wang X, Li X, Liu T, Shao G, Guan Y, Zhao S

BACKGROUND: Chronic kidney disease is a severe threat to human health with no ideal treatment strategy. Mature mammalian kidneys have a fixed number of nephrons, and regeneration is difficult once...
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Proximal renal tubular acidosis with and without Fanconi syndrome

Kashoor I, Batlle D

Proximal renal tubular acidosis (RTA) is caused by a defect in bicarbonate (HCO₃⁻) reabsorption in the kidney proximal convoluted tubule. It usually manifests as normal anion-gap metabolic acidosis due to...
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Effects of Prenatal Growth Status on Subsequent Childhood Renal Function Related to High Blood Pressure

Park B, Lee JW, Kim HS, Park EA, Cho SJ, Park H

BACKGROUND: Hypertension is one of the major causes of chronic diseases. The effect on high blood pressure (BP) with fetal growth restriction is now well-established. Recent studies suggest that a...
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Extracellular vesicles in renal physiology and clinical applications for renal disease

Kwon SH

Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules....
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Immune mechanisms in the different phases of acute tubular necrosis

Kundert F, Platen L, Iwakura T, Zhao Z, Marschner , Anders HJ

Acute kidney injury is a clinical syndrome that can be caused by numerous diseases including acute tubular necrosis (ATN). ATN evolves in several phases, all of which are accompanied by...
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Predicting trifecta outcomes after robot-assisted nephron-sparing surgery: Beyond the nephrometry score

Sharma AP, Mavuduru R, Bora GS, Devana SK, Singh SK, Mandal AK

PURPOSE: RENAL nephrometry score (RNS) was devised for deciding the approach for renal tumors. It is increasingly used in predicting perioperative outcomes with variable results. The actual difficulty encountered during...
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Renal intercalated cells and blood pressure regulation

Wall SM

Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate...
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Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys

Awazu M

Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)...
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A Case of Secondary FSGS due to Chronic Chloride Diarrhea

Kim BK, Lee HS, Yim HE, Cheong HI, Yoo KH

Congenital chloride diarrhea (CLD) is a rare autosomal recessive disease that is difficult to diagnose. CLD requires early treatment to correct electrolyte imbalance and alkalosis and to prevent severe dehydration....
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Effect of Diet and Water Intake on Aquaporin 2 Function

Kim JM, Kim TH, Wang T

Appropriate control of diet and water intake is important for maintaining normal blood pressure, fluid and electrolyte homeostasis in the body. It is relatively understood that the amount of sodium...
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RNA sequencing of the nephron transcriptome: a technical note

Lee JW

To understand the functions of the kidney, the transcriptome of each part of the nephron needs to be profiled using a highly sensitive and unbiased tool. RNA sequencing (RNA-seq) has...
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Impact of Graft Kidney Volume and Weight on Graft Function in Living Donor Kidney Transplantation

Eo SH, Lee SH, Won JH, Oh CK

BACKGROUND: Low functional nephron mass and graft kidney-recipient body size mismatch can lead to poor graft function. To examine the impact of the ratios of the surrogates to recipient body...
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Risk factors and long-term outcomes of delayed graft function in deceased donor renal transplantation

Seo CH, Ju JI, Kim MH, Jun KW, Ahn SH, Hwang JK, Kim SD, Park SC, Choi BS, Kim JI, Yang CW, Kim YS, Moon IS

PURPOSE: The purpose of this study was to analyze the risk factors for delayed graft function (DGF) and determine its impact on the outcomes of deceased donor (DD) kidney transplantation...
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'Lemonade Legs': Why do Some Patients Get Profound Hypomagnesaemia on Proton-Pump Inhibitors?

Atkinson N, Reynolds D, Travis SP

Proton pump inhibitors (PPIs) are widely used though an association with hypomagnesaemia and hypocalcaemia has only been described since 2006. Patients typically present after years of stable dosing with musculoskeletal,...
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Metabolic Effects of Growth Hormones in Children

Rhie YJ

  • KMID: 2271160
  • Korean J Obes.
  • 2015 Jun;24(2):87-91.
Ever since recombinant human growth hormones (GH) were produced in the 1980s, many studies on their metabolic effects have been performed. GH has been shown to have a diabetogenic action...
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When morphogenetic proteins encounter special extracellular matrix and cell-cell connections at the interface of the renal stem/progenitor cell niche

Minuth WW, Denk L

Reciprocal exchange of morphogenetic proteins between epithelial and mesenchymal cells in a stem/progenitor cell niche results in formation of a nephron. To maintain diffusion of morphogenetic proteins, it is assumed...
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Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension

Moon JY

The activation of renin-angiotensin-aldosterine system(RAAS) is one of the main pathogenesis of hypertension. All the components of RAAS are present in the kidneys at higher concentrations compared to plasma levels,...
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Pseudohypoaldosteronism Type 1

Cheong HI

Pseudohypoaldosteronism (PHA), a rare syndrome of systemic or renal mineralocorticoid resistance, is clinically characterized by hyperkalemia, metabolic acidosis, and elevated plasma aldosterone levels with either renal salt wasting or hypertension....
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Molecular regulation of kidney development

Chai OH, Song CH, Park SK, Kim W, Cho ES

Genetically engineered mice have provided much information about gene function in the field of developmental biology. Recently, conditional gene targeting using the Cre/loxP system has been developed to control the...
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The Role of Proximal Nephron in Cyclophosphamide-Induced Water Retention: Preliminary Data

Kim S, Jo CH, Park JS, Han HJ, Kim GH

Cyclophosphamide is clinically useful in treating malignancy and rheumatologic disease, but has limitations in that it induces hyponatremia. The mechanisms by which cyclophosphamide induces water retention in the kidney have...
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