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New Onset Obsessive Compulsive Disorder Following High Frequency Repetitive Transcranial Magnetic Stimulation over Left Dorsolateral Prefrontal Cortex for Treatment of Negative Symptoms in a Patient with Schizophrenia

Garg H, Kumar S, Singh S, Kumar N, Verma R

Obsessive-compulsive symptoms and/or obsessive-compulsive disorders (OCD) are frequently comorbid with schizophrenia, though the exact clinical and etiological relationship between them is poorly understood. Here we describe a case that, to...
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Comparative Study of Clinical Features between Early- and Late-Onset Schizophrenia in South Korea

Ko MA, Lee SK, Lee JS

OBJECTIVES: Late-onset schizophrenia (LOS, age at first onset ≥40 years) is characterized by including predominance of women, better premorbid social adjustment and lower severity of positive/negative symptoms. However, few studies...
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Is the Prevalence of the Deficit Syndrome in Schizophrenia Higher than Estimated? Results of a Meta-Analysis

López-Díaz A, Lara I, Lahera G

The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of deficit syndrome (DS). Until date, it is...
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Validation of the Korean Version of the Clinical Assessment Interview for Negative Symptoms

Jang SK, Park SC, Choi KH, Yi JS, Park JK, Lee JS, Lee SH

OBJECTIVE: Clinical Assessment Interview for Negative Symptoms (CAINS) has recently been developed to improve measurement of negative symptoms in schizophrenia. We performed a multi-center study to validate the Korean version...
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Efficacy and Safety of Bitopertin in Patients with Schizophrenia and Predominant Negative Symptoms: Subgroup Analysis of Japanese Patients from the Global Randomized Phase 2 Trial

Hirayasu Y, Sato SI, Shuto N, Nakano M, Higuchi T

OBJECTIVE: The aim of the present study was to perform a subgroup analysis of data from a phase II global, multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and...
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Validation of the Korean-Version of the Clinical Assessment Interview for Negative Symptoms of Schizophrenia (CAINS)

Jung SI, Woo J, Kim YT, Kwak SG

The Clinical Assessment Interview for Negative Symptoms (CAINS) was developed to overcome the limitations of existing instruments and reflect the current view of negative symptoms. The aim of the present...
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The Pharmacogenetics of Symptom Response to Antipsychotic Drugs

Reynolds G

  • KMID: 2316154
  • Psychiatry Investig.
  • 2012 Mar;9(1):1-7.
Antipsychotic drugs are limited in their efficacy by the relatively poor response of negative and cognitive symptoms of schizophrenia as well as by the substantial variability in response between patients....
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The Characteristics of Associative Learning of Reward Approach and Loss Aversion in Schizophrenia

Park S, Kim SH, Park IH, Kim JH, Kim JJ, Koo MS, Song J

OBJECTIVES: Schizophrenia patients have deficits of prediction and learning related to dopaminergic dysfunction. It is hypothesized that there would be different characteristics in associative learning of reward approach and loss...
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Associated Factors of Quality of Life in First-Episode Schizophrenia Patients

Song YY, Kim KR, Park JY, Lee SY, Kang JI, Lee E, An SK, Kwon JS

  • KMID: 2316085
  • Psychiatry Investig.
  • 2011 Sep;8(3):201-206.
OBJECTIVE: Improving quality of life is an important goal in the treatment of schizophrenia. In previous research, quality of life has been reported to be compromised in patients with schizophrenia....
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Bone Density in Chronic Schizophrenia with Long-Term Antipsychotic Treatment: Preliminary Study

Lee TY, Chung MY, Chung HK, Choi JH, Kim TY, So HS

  • KMID: 2315915
  • Psychiatry Investig.
  • 2010 Dec;7(4):278-284.
OBJECTIVE: Decreased bone mineral density has been found in the chronic schizophrenic patients who have been given a long-term administration of antipsychotics. Hyperprolactinemia from the antipsychotics and the negative symptom...
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Serum S100B Protein in Medication-Free Schizophrenic Patients

Jin SN, Park DB, Kim HR, Baek HT

  • KMID: 2299979
  • Korean J Biol Psychiatry.
  • 2007 Aug;14(3):177-183.
OBJECTIVES: Previous studies have suggested that S100B protein play an important role in the pathogenesis and progress of schizophrenia. In the present study, we evaluate the serum levels of S100B...
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Differences of the Neurocognitive Function in the Specific Symptom Subgroups of Schizophrenia

Kim CK, Kim SS, Kim MJ

  • KMID: 2196860
  • J Korean Neuropsychiatr Assoc.
  • 2003 Jan;42(1):69-78.
OBJECTIVES: This study investigated the validity of positive-negative dichotomy model by comparing the differences of neurocognitive function in the specific symptom subgroups of schizophrenia. METHODS: Factor analysis was performed on 14...
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Relationships between Nailfold Plexus Visibility, and Clinical Variables and Neuropsychological Functions in Schizolphrenic Patients

Kang DY, Jang HR

  • KMID: 2202796
  • J Korean Soc Biol Psychiatry.
  • 2002 Jul;9(1):50-61.
OBJECTIVES: High nailfold plexus visibility can reflect central nervous system defects as an etiologic factor of schizophrenia indirectly. Previous studies suggest that this visibility is particularly related to the negative...
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PANSS and Cognition Change in D-Cycloserine Compination Treatment of Schizophrenia

Yoon BM, Lee SG, Joe SH, Jeong IK, Kim SH

  • KMID: 2037064
  • Korean J Psychopharmacol.
  • 2002 Dec;13(4):289-296.
OBJECTIVE: Recently, there are many reports that glutamate receptors have close relationships with a pathophysiology of schizophrenia. The purpose of this study was to assess the effects of D-cycloserine, which...
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Effects of Acute and Chronic Treatment of Olanzapine and Risperidone on the Extracellular Dopamine Concentrations of the Prefrontal Cortex in Rats

Moon SK, Chung YC, Eun HB, Hwang IK, Park TW

  • KMID: 2340641
  • J Korean Neuropsychiatr Assoc.
  • 2002 Jan;41(1):61-68.
OBJECT: It is reported that the effect of antipsychotics on the extracellular dopamine levels in the prefrontal cortex is related to the their effect on the negative symptoms. Therefore, we...
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Relationships between Nailfold Plexus Visibility and Clinical Variables in Adult Schizophrenics

Kang DY, Chang HY, Kang SS

  • KMID: 2334599
  • J Korean Soc Biol Psychiatry.
  • 1999 Jul;6(1):111-118.
OBJECTIVES: There have been several evidences that the central nervous system defect is one of the etiologic factors in schizophrenia and high nailfold plexus visibility can reflect indirectly. These are...
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A Clinical Significance of the Subjective Experiences of Negative Symptoms in the Patients with Schizophrenia

Kim JW, Kim CH, Koo MS, Sohn SH, Park JC, Choi MJ, Lee EC, Yoon DJ, Lee HS

  • KMID: 2340268
  • J Korean Neuropsychiatr Assoc.
  • 1999 Jan;38(1):128-138.
OBJECTIVE: Since the evaluation of negative symptoms has depended on the clinician's objective observation, the patients' subjective experience of negative symptoms has been neglected. However, in fact, a lot...
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Efforts and Therapeutic Factors of Short-term Token Economy for Negative Symptoms of Schizophrenic In-patients

Ahn JS, Lee YD, Bang HS, Park JE, Shin JH

  • KMID: 2340089
  • J Korean Neuropsychiatr Assoc.
  • 1997 Sep;36(5):794-803.
OBJECTIVE: The negative symptoms of schizophrenia usually are not responsive to drug therapy to persist and make schizophrenics more difficult in their rehabilitation. The authors investigated the therapeutic effect of...
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Relationships among Plasma Homovanillic Acid, 5-hydroxyindoleacetic Acid Concentrations and the Psychopathology of Schizophrenic Patients

Kim YK, Park SG, Kim L, Lee MS

  • KMID: 1944950
  • J Korean Soc Biol Psychiatry.
  • 1997 Jun;4(1):95-101.
The recent hypothesis about the pathophysiology of schizophrenia has been centered mainly on two theories, i.e. dopamine hypothesis and serotonin hypothesis. We investigate the correlations between plasma metabolite concentrations and...
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Effects of Mianserin on Negative Symptoms of Chronic Schizophrenia

Jeon YW, Bahk WM, Kim KS, Seo SW, Lee CT, Lew TY

  • KMID: 2340038
  • J Korean Neuropsychiatr Assoc.
  • 1997 Mar;36(2):259-266.
This study was designed to examine the mianserin effects on the negative symptoms of chronic schizophrenia. The chronic schizophrenics(N= 14) diagnosed by DSM-III-R, who were treated at the Catholic University...
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