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Anti-microbial and Anti-inflammatory Activity of New 4-methoxy-3-(methoxymethyl) Phenol and (E)-N′-(5-bromo-2-methoxybenzylidene)-4-methoxy Benzohydrazide Isolated from Calotropis gigantean white

Manivannan R, Shopna R

  • Nat Prod Sci.
  • 2017 Mar;23(1):69-74.
  • doi: 10.20307/nps.2017.23.1.69
A new phenol and hydrazide derivatives were obtained for the first time from the C. giganteawhite by silica gel column chromatography. The structure of the isolated compounds was identified by...
Anti-obesity Effect of Steamed Soybean and Fermented Steamed Soybean in High-fat Diet-induced Obese ICR Mice

Seo HR, Lee AY, Cho KM, Cho EJ, Kim HY

  • Nat Prod Sci.
  • 2017 Mar;23(1):61-68.
  • doi: 10.20307/nps.2017.23.1.61
This study was performed to investigate the ameliorating effects of steamed soybeans (SS) and fermented SS (FSS) on lipid metabolism in high-fat diet-induced obese mice. ICR mice were divided into...
Ethanol Extract of Perillae Herba Enhances Pentobarbital-Induced Sleep and Non-Rapid Eye Movement (NREM) Sleep through GABA(A)-ergic Systems

Kwon YO, Ha TW, Oh KW

  • Nat Prod Sci.
  • 2017 Mar;23(1):53-60.
  • doi: 10.20307/nps.2017.23.1.53
Perillae Herba has been traditionally used for the sedation in the oriental countries. Therefore, this study was conducted to determine whether Perillae Herba ethanol extract (PHEE) enhances pentobarbital-induced sleeping behaviors...
Comprehensive Evaluation of the Anti-Helicobacter pylori Activity of Scutellariae Radix

Lee BW, Park IH, Yim D, Choi SS

  • Nat Prod Sci.
  • 2017 Mar;23(1):46-52.
  • doi: 10.20307/nps.2017.23.1.46
The aim of this study was to evaluate the anti-Helicobacter pylori activity of fractions and major aglycon compounds (baicalein, chrysin, oroxylin A, wogonin) of Scutellariae Radix. Minimum inhibitory concentration (MIC)...
Protection Against Electroshock- and Pentylenetetrazol-induced Seizures by the Water Extract of Rehmannia glutinous can be Mediated through GABA Receptor-chloride Channel Complexes

Kim M, Kim HJ, Kim SM, De la Peña JB, Dela Peña IJ, Botanas CJ, Woo T, Lee YS, Ryu JH, Cheong JH

  • Nat Prod Sci.
  • 2017 Mar;23(1):40-45.
  • doi: 10.20307/nps.2017.23.1.40
Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs...
Inhibitory Effect of D-chiro-inositol on Both Growth and Recurrence of Breast Tumor from MDA-MB-231 Cancer Cells

Kim YS, Park JS, Kim M, Hwang BY, Lee CK, Song S

  • Nat Prod Sci.
  • 2017 Mar;23(1):35-39.
  • doi: 10.20307/nps.2017.23.1.35
D-chiro-inositol (DCI) is a secondary messenger in insulin signal transduction. It is produced in vivo from myo-inositol via action of epimerase. In this study, we evaluated antitumor activity of DCI...
Effects of Homogentisic Acid and Natural Products Derived from Pinellia ternata on Secretion, Production and Gene Expression of MUC5AC Mucin from Cultured Airway Epithelial Cells

Lee HJ, Lee CJ

  • Nat Prod Sci.
  • 2017 Mar;23(1):29-34.
  • doi: 10.20307/nps.2017.23.1.29
In this study, we investigated whether adenosine, adenine, uridine and homogentisic acid derived from Pinellia ternata affect the secretion, production and gene expression of MUC5AC mucin from airway epithelial cells....
Diarylbutane-type Lignans from Myristica fragrans (Nutmeg) show the Cytotoxicity against Breast Cancer Cells through Activation of AMP-activated Protein Kinase

Le TV, Nguyen PH, Choi HS, Yang JL, Kang KW, Ahn SG, Oh WK

  • Nat Prod Sci.
  • 2017 Mar;23(1):21-28.
  • doi: 10.20307/nps.2017.23.1.21
In our program to search for new AMP-activated protein kinase (AMPK) activators from plants that exert potential anticancer property, we found that an EtOAc extract of Myristica fragrans (nutmeg) activated...
Chemical Constituents of Fermented Noni (Morinda citrifolia) Juice Exudates and Their Biological Activity

Youn UJ, Chang LC

  • Nat Prod Sci.
  • 2017 Mar;23(1):16-20.
  • doi: 10.20307/nps.2017.23.1.16
In a continuing study of the fermented noni (Morinda citrifolia) juice exudates, five compounds, heptanyl 2-O-β-D-xylofuranosyl-(1 → 6)-β-D-glucopyranoside (1), n-butyl β-D-glucopyranoside (2), (1S)-(3-ethenyl-phenyl)-1,2-ethanediol (3), (2S)-2-hydroxybutanedioic acid (4), and daucosterol (5)...
Optimization of Extraction Conditions for Active Compounds of Herbal Medicinal Formula, DF, by Response Surface Methodology

Jeong B, Choi SY, Jang HS, Yoo G, Kim SH, Kim JH, Kwon YS, Roh JS, Yoon Y, Shin SS, Yang H

  • Nat Prod Sci.
  • 2017 Mar;23(1):9-15.
  • doi: 10.20307/nps.2017.23.1.9
DF formula is comprised of three traditional herbs, Ephedra intermedia, Rheum palmatum and Lithospermum erythrorhizon, and locally used for treating of the metabolic diseases, such as obesity and diabetes in...
Antimicrobial Activity of Methyl Gallate isolated from the Leaves of Glochidion superbum Against Hospital Isolates of Methicillin Resistant Staphylococcus aureus

Ahmed MD, Taher M, Maimusa AH, Rezali MF, Mahmud MI

  • Nat Prod Sci.
  • 2017 Mar;23(1):5-8.
  • doi: 10.20307/nps.2017.23.1.5
An antimicrobial compound has been isolated from the leaves of Glochidion superbum. The compound was determined as methyl 3, 4, 5-trihydroxybenzoate (methyl gallate), based on ultraviolet (UV), infrared (IR), nuclear...
Sinensetin Inhibits Interleukin-6 in Human Mast Cell - 1 Via Signal Transducers and Activators of the Transcription 3 (STAT3) and Nuclear Factor Kappa B (NF-κB) Pathways

Chae HS, Kim YM, Chin YW

  • Nat Prod Sci.
  • 2017 Mar;23(1):1-4.
  • doi: 10.20307/nps.2017.23.1.1
Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism...

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