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Mouse Models of Gastric Carcinogenesis

Yu S, Yang M, Nam KT

  • KMID: 2372515
  • J Gastric Cancer.
  • 2014 Jun;14(2):67-86.
Gastric cancer is one of the most common cancers in the world. Animal models have been used to elucidate the details of the molecular mechanisms of various cancers. However, most...
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The Clinical Outcomes of Manual Continuous Curvilinear Capsulorhexis and Precision Pulse Capsulotomy

Ji M, Lee HJ, Ha A, Nam KT, Jeong J

Purpose: To compare the safety and consistency of manual capsulorhexis and precision pulse capsulotomy performed using pulsed energy during bilateral cataract surgery and to explore the differences in clinical outcomes. Methods:...
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Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

Lee K, Hwang H, Nam KT

  • KMID: 1774539
  • Gut Liver.
  • 2014 Mar;8(2):131-139.
Gastric cancer is the second most common cause of cancer-related death in the world. A growing body of evidence indicates that inflammation is closely associated with the initiation, progression, and...
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Evaluation of skin phototoxicity of transdermally administered pharmaceuticals in Sprague-Dawley rats

Youn NH, Kim EJ, Yi JS, Kim JH, Cho YJ, Nam KT, Park KS, Lee JK

Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test...
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The Prediction of Changes in Mean Corneal Refractive Power by Pterygium Size after Pterygium Surgery

Nam KT, Eom YS, Rhim JW, Kang SY, Kim HM, Song JS

PURPOSE: To assess the changes in mean corneal refractive power (DeltaK) following pterygium surgery and to predict DeltaK in cases of combined cataract and pterygium surgery. METHODS: Thirty-seven eyes of unilateral...
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Comparison of Methods Used to Prevent Fogging of a Non-contact Wide-field Viewing System during Vitrectomy

Seo M, Ha A, Lee HJ, Jeong J, Nam KT

Purpose: To compare the effectiveness of warm saline and anti-fog solution for preventing fogging of a non-contact wide-field viewing system during vitrectomy. Methods: Five liters of water at 36°C were placed...
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Analyses of Vessel Densities and Foveal Avascular Zones Using Four Optical Coherence Tomography Angiography Devices

Park SY, Nam KT, Yun C, Jang S

Purpose: To compare the vessel density (VD) and foveal avascular zone (FAZ) area using four different optical coherence tomography angiography (OCTA) images. Methods: This prospective study analyzed the OCTA images of...
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A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate

Kim M, Hur S, Kim KH, Cho Y, Kim K, Kim HR, Nam KT, Lim KM

Liver fibrosis is part of the wound healing process to help the liver recover from the injuries caused by various liver-damaging insults. However, liver fibrosis often progresses to life-threatening cirrhosis...
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Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis

Kim H, Jeong H, Cho Y, Lee J, Nam KT, Lee HW

Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of...
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SARS-CoV-2 Infection Induces HMGB1 Secretion Through Post-Translational Modification and PANoptosis

Kwak MS, Choi S, Kim J, Lee H, Park IH, Oh J, Mai DN, Cho NH, Nam KT, Shin JS

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces excessive pro-inflammatory cytokine release and cell death, leading to organ damage and mortality. High-mobility group box 1 (HMGB1) is one of the...
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Influence of Watching 3D Television on Refractive Error in Children with Exodeviation

Seo HJ, Kim SH, Suh YW, Choi YM, Yoo EJ, Han JY, Nam KT, Cho YA

PURPOSE: To investigate the effects of watching three-dimensional (3D) television (TV) on the angle of deviation and refractive error in children with exodeviation. METHODS: Twenty-three volunteers with exodeviation, aged 6 to...
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Rab25 Deficiency Perturbs Epidermal Differentiation and Skin Barrier Function in Mice

Jeong H, Lim KM, Goldenring JR, Nam KT

Rab25, a member of the Rab11 small GTPase family, is central to achieving cellular polarity in epithelial tissues. Rab25 is highly expressed in epithelial cells of various tissues including breast,...
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Sensitivity to tumor development by TALEN-mediated Trp53 mutant genes in the susceptible FVB/N mice and the resistance C57BL/6 mice

Yun WB, Kim JE, Lee ML, Choi JY, Park JJ, Song BR, Kang BC, Nam KT, Lee HW, Hwang DY

Background: This study was undertaken to compare the sensitivities of mice strains during tumor induction by transcription activator-like effector nucleases (TALEN)-mediated Trp53 mutant gene. Alterations of their tumorigenic phenotypes including...
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Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet

Kim BH, Won YS, Kim EY, Yoon M, Nam KT, Oh GT, Kim DY

  • KMID: 1089604
  • J Vet Sci.
  • 2003 Dec;4(3):239-244.
Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha(PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic...
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Establishment of particulate matterinduced lung injury model in mouse

Park SY, An KS, Lee B, Kang JH, Jung HJ, Kim MW, Ryu HY, Shim KS, Nam KT, Yoon YS, Oh SH

Background: Particulate matter (PM) is one of the principal causes of human respiratory disabilities resulting from air pollution. Animal models have been applied to discover preventive and therapeutic drugs for...
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Perceived Stress Levels and Associated Factors in Adult Patients with Primary Open-angle Glaucoma: A Prospective Survey Study

Ji M, Kim JS, Baek SU, Kim YK, Nam KT, Lee JY, Lee HJ, Jeong J, Ha A

Purpose: To investigate adult primary open-angle glaucoma (POAG) patients’ perceived stress levels and to examine the associations with their clinical characteristics. Methods: Sixty-seven POAG patients, excluding those meeting the exclusion criteria...
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Expression Levels of GABA-A Receptor Subunit Alpha 3, Gabra3 and Lipoprotein Lipase, Lpl Are Associated with the Susceptibility to Acetaminophen-Induced Hepatotoxicity

Kim M, Yun JW, Shin K, Cho Y, Yang M, Nam KT, Lim KM

Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts...
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H. pylori Infection and Gastric Carcinogenesis

Han SU, Cho YK, Chung JY, Park HJ, Kim YB, Nam KT, Kim DY, Joo HJ, Choi JH, Kim JH, Lee KM, Kim MW, Cho SW, Hahm KB

  • KMID: 2372165
  • J Korean Gastric Cancer Assoc.
  • 2002 Jun;2(2):73-80.
In spite the fact that H. pylori infection might be the causative organisms of acute and chronic gastritis, peptic ulcer diseases and the definition as the class I carcinogen by...
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Low-Dose Bisphenol A Increases Bile Duct Proliferation in Juvenile Rats: A Possible Evidence for Risk of Liver Cancer in the Exposed Population?

Jeong JS, Nam KT, Lee B, Pamungkas , Song D, Kim M, Yu WJ, Lee J, Jee S, Park YH, Lim KM

Increasing concern is being given to the association between risk of cancer and exposure to low-dose bisphenol A (BPA), especially in young-aged population. In this study, we investigated the effects...
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Enrichment of Short-Chain Ceramides and Free Fatty Acids in the Skin Epidermis, Liver, and Kidneys of db/db Mice, a Type 2 Diabetes Mellitus Model

Kim M, Jeong H, Lee B, Cho Y, Yoon WK, Cho A, Kwon G, Nam KT, Ha H, Lim KM

Patients with diabetes mellitus (DM) often suffer from diverse skin disorders, which might be attributable to skin barrier dysfunction. To explore the role of lipid alterations in the epidermis in...
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