- Solanum lycopersicum (tomato) ethanol extract elicits anti-inflammatory effects via the nuclear factor kappa B pathway and rescues mice from septic shock
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Saba E, Oh MJ, Kwak D, Roh SS, Kwon HW, Kim SD, Rhee MH
- KMID: 2386850
- Korean J Vet Res.
- 2017 Jun;57(2):97-104.
- doi: 10.14405/kjvr.2017.57.2.97
Solanum lycopersicum, commonly known as tomato, is widely used in raw, cooked, or liquid forms because it contains nutritional compounds that are beneficial for human health, including carotenoids, lycopene, ascorbic... -
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- Attenuated Nuclear Factor Kappa B Activity by E7 Protein of Human Papillomavirus Type 2 in Human Epidermal Keratinocytes
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Ryu YH, Han JH, Lee JH, Choi SY, Park YM
- KMID: 2378546
- Ann Dermatol.
- 2017 Jun;29(3):367-370.
- doi: 10.5021/ad.2017.29.3.367
No abstract available. -
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- Sinensetin Inhibits Interleukin-6 in Human Mast Cell - 1 Via Signal Transducers and Activators of the Transcription 3 (STAT3) and Nuclear Factor Kappa B (NF-κB) Pathways
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Chae HS, Kim YM, Chin YW
- KMID: 2376491
- Nat Prod Sci.
- 2017 Mar;23(1):1-4.
- doi: 10.20307/nps.2017.23.1.1
Sinensetin, a pentamethoxyflavone, is known to exert various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, its effects on the human mast cell - 1 (HMC-1) mediated inflammatory mechanism... -
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- Role of 5´-AMP-Activated Protein Kinase Activators in Regulating Nuclear Factor Kappa B Signaling
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Lee T
- KMID: 2365708
- Int Neurourol J.
- 2016 Sep;20(3):171-171.
- doi: 10.5213/inj.1620edi006
No abstract available. -
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- Lobaric Acid Inhibits VCAM-1 Expression in TNF-alpha-Stimulated Vascular Smooth Muscle Cells via Modulation of NF-kappaB and MAPK Signaling Pathways
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Kwon IS, Yim JH, Lee HK, Pyo S
- KMID: 2170537
- Biomol Ther.
- 2016 Jan;24(1):25-32.
- doi: 10.4062/biomolther.2015.084
Lichens have been known to possess multiple biological activities, including anti-proliferative and anti-inflammatory activities. Vascular cell adhesion molecule-1 (VCAM-1) may play a role in the development of atherosclerosis. Hence, VCAM-1... -
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- (E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone displays suppression of inflammatory responses via inhibition of Src, Syk, and NF-kappaB
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Kim Y, Jeong EJ, Han Lee IS, Kim MY, Cho JY
- KMID: 2150478
- Korean J Physiol Pharmacol.
- 2016 Jan;20(1):91-99.
- doi: 10.4196/kjpp.2016.20.1.91
(E)-3-(3-methoxyphenyl)-1-(2-pyrrolyl)-2-propenone (MPP) is an aldol condensation product resulting from pyrrole-2-carbaldehyde and m- and p- substituted acetophenones. However, its biological activity has not yet been evaluated. Since it has been reported... -
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- Viridicatol from Marine-derived Fungal Strain Penicillium sp. SF-5295 Exerts Anti-inflammatory Effects through Inhibiting NF-kappaB Signaling Pathway on Lipopolysaccharide-induced RAW264.7 and BV2 Cells
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Ko W, Sohn JH, Kim YC, Oh H
- KMID: 2312903
- Nat Prod Sci.
- 2015 Dec;21(4):240-247.
- doi: 10.20307/nps.2015.21.4.240
Viridicatol (1) has previously been isolated from the extract of the marine-derived fungus Penicillium sp. SF-5295. In the course of further biological evaluation of this quinolone alkaloid, anti-inflammatory effect of... -
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- Withaferin A Inhibits Helicobacter pylori-induced Production of IL-1beta in Dendritic Cells by Regulating NF-kappaB and NLRP3 Inflammasome Activation
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Kim JE, Lee JY, Kang MJ, Jeong YJ, Choi JA, Oh SM, Lee KB, Park JH
- KMID: 2132701
- Immune Netw.
- 2015 Dec;15(6):269-277.
- doi: 10.4110/in.2015.15.6.269
Helicobacter pylori infection is associated with chronic gastritis, peptic ulcer, and gastric cancer. There is evidence that IL-1beta is associated with the development of gastric cancer. Therefore, downregulation of H.... -
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- Acetylshikonin Inhibits Human Pancreatic PANC-1 Cancer Cell Proliferation by Suppressing the NF-kappaB Activity
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Cho SC, Choi BY
- KMID: 2380291
- Biomol Ther.
- 2015 Sep;23(5):428-433.
- doi: 10.4062/biomolther.2015.102
Acetylshikonin, a natural naphthoquinone derivative compound, has been used for treatment of inflammation and cancer. In the present study, we have investigated whether acetylshikonin could regulate the NF-kappaB signaling pathway,... -
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- Anti-inflammatory Activity of Fucoidan with Blocking NF-kappaB and STAT1 in Human Keratinocytes Cells
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Ryu MJ, Chung HS
- KMID: 2312897
- Nat Prod Sci.
- 2015 Sep;21(3):205-209.
- doi: 10.0000/nps.2015.21.3.205
Fucoidan, a sulfated polysaccharide is found in several types of edible brown algae. It has shown numerous biological activities; however, the molecular mechanisms on the activity against atopic dermatitis have... -
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- Differential Regulation of NF-kappaB Signaling during Human Cytomegalovirus Infection
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Kwon KM, Ahn JH
- KMID: 2149217
- J Bacteriol Virol.
- 2015 Jun;45(2):159-164.
- doi: 10.4167/jbv.2015.45.2.159
NF-kappaB transcription factors are key regulators of immune and stress responses, apoptosis, and differentiation. Human cytomegalovirus (HCMV) activates or represses NF-kappaB signaling at different times during infection. An initial increase... -
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- Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-kappaB Pathway
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Kim EJ, Lee MY, Jeon YJ
- KMID: 1791421
- Korean J Physiol Pharmacol.
- 2015 May;19(3):211-218.
- doi: 10.4196/kjpp.2015.19.3.211
The present study showed that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibited lipopolysaccharide (LPS)-induced morphological changes in the mouse RAW264.7 macrophage cell line. We also showed... -
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- Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-kappaB Pathways
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Kim SH, Lee IC, Ko JW, Moon C, Kim SH, Shin IS, Seo YW, Kim HC, Kim JC
- KMID: 2380352
- Biomol Ther.
- 2015 Mar;23(2):180-188.
- doi: 10.4062/biomolther.2014.126
This study investigated the possible effects and molecular mechanisms of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) in rats. Inflammation response was assessed by histopathology and serum cytokines... -
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- Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-kappaB
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Prasad RG, Choi YH, Kim GY
- KMID: 2380343
- Biomol Ther.
- 2015 Mar;23(2):110-118.
- doi: 10.4062/biomolther.2015.006
According to the expansion of lifespan, neuronal disorder based on inflammation has been social problem. Therefore, we isolated shikonin from Lithospermum erythrorhizon and evaluated anti-inflammatory effects of shikonin in lipopolysaccharide... -
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- Foeniculum vulgare Mill. Protects against Lipopolysaccharide-induced Acute Lung Injury in Mice through ERK-dependent NF-kB Activation
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Lee HS, Kang P, Kim KY, Seol GH
- KMID: 2285571
- Korean J Physiol Pharmacol.
- 2015 Mar;19(2):183-189.
- doi: 10.4196/kjpp.2015.19.2.183
Foeniculum vulgare Mill. (fennel) is used to flavor food, in cosmetics, as an antioxidant, and to treat microbial, diabetic and common inflammation. No study to date, however, has assessed the... -
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- Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-kappaB Signaling
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Shao HJ, Lou Z, Jeong JB, Kim KJ, Lee J, Lee SH
- KMID: 2380361
- Biomol Ther.
- 2015 Jan;23(1):39-44.
- doi: 10.4062/biomolther.2014.088
Tolfenamic acid (TA) is a traditional non-steroid anti-inflammatory drug (NSAID) and has been broadly used for the treatment of migraines. Nuclear factor kappa B (NF-kappaB) is a sequence-specific transcription factor... -
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- Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-kappaB Pathways in Nasal Fibroblasts
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Park IH, Um JY, Cho JS, Lee SH, Lee SH, Lee HM
- KMID: 2260180
- Allergy Asthma Immunol Res.
- 2014 Nov;6(6):567-572.
- doi: 10.4168/aair.2014.6.6.567
PURPOSE: Based on the close relationship between histamine and interleukin 6 (IL-6), we hypothesized that histamine may regulate the production of cytokines, such as IL-6, during allergic inflammation. Here, we... -
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- Methanol Extract of Croton Pycnanthus Benth. Inhibits Osteoclast Differentiation by Suppressing the MAPK and NF-kappaB Signaling Pathways
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Lee J, Kim HH
- KMID: 2170055
- J Bone Metab.
- 2014 Nov;21(4):269-275.
- doi: 10.11005/jbm.2014.21.4.269
BACKGROUND: Osteoclasts are differentiated from monocytes/macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL). Croton pycnanthus Benth. (CPB) is a herbal plant that belongs to... -
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- Anti-inflammatory effects of Rubus coreanus Miquel through inhibition of NF-kappaB and MAP Kinase
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Lee JE, Cho SM, Park E, Lee SM, Kim Y, Auh JH, Choi HK, Lim S, Lee SC, Kim JH
- KMID: 2313770
- Nutr Res Pract.
- 2014 Oct;8(5):501-508.
- doi: 10.4162/nrp.2014.8.5.501
BACKGROUND/OBJECTIVES: Rubus Coreanus Miquel (RCM), used as a traditional Korean medicine, reduces chronic inflammatory diseases such as cancer and rheumatoid arthritis. However, its mechanism has not been elucidated. In this... -
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- Protective Effects of the Nuclear Factor Kappa B Inhibitor Pyrrolidine Dithiocarbamate on Experimental Testicular Torsion and Detorsion Injury
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Kabay S, Ozden H, Guven G, Burukoglu , Ustuner MC, Topal F, Gunes HV, Ustuner D, Ozbayer C
- KMID: 2285526
- Korean J Physiol Pharmacol.
- 2014 Aug;18(4):321-326.
- doi: 10.4196/kjpp.2014.18.4.321
Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B... -
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