- Resveratrol attenuates lipopolysaccharide-induced dysfunction of blood-brain barrier in endothelial cells via AMPK activation
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Hu M, Liu B
- KMID: 2371049
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):325-332.
- doi: 10.4196/kjpp.2016.20.4.325
Resveratrol, a phytoalexin, is reported to activate AMP-activated protein kinase (AMPK) in vascular cells. The blood-brain barrier (BBB), formed by specialized brain endothelial cells that are interconnected by tight junctions,... -
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- High Glucose and/or Free Fatty Acid Damage Vascular Endothelial Cells via Stimulating of NAD(P)H Oxidase-induced Superoxide Production from Neutrophils
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Kim SS, Kim SY, Lee SH, Kang YH, Kim IJ, Kim YK, Son SM
- KMID: 2298066
- Korean Diabetes J.
- 2009 Apr;33(2):94-104.
- doi: 10.4093/kdj.2009.33.2.94
BACKGROUND: Oxidative stress and inflammation are important factors in the pathogenesis of diabetes and contribute to the development of diabetic complications. To understand the mechanisms that cause vascular complications in... -
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- Expression of NAD(P)H Oxidase Subunits and Their Contribution to Cardiovascular Damage in Aldosterone/Salt-Induced Hypertensive Rat
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Park YM, Lim BH, Touyz RM, Park JB
- KMID: 1107531
- J Korean Med Sci.
- 2008 Dec;23(6):1039-1045.
- doi: 10.3346/jkms.2008.23.6.1039
NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this... -
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- The Role of Janus Kinase in Superoxide-mediated Proliferation of Diabetic Vascular Smooth Muscle Cells
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Lee JY, Park JY, Kim CD
- KMID: 1512915
- Korean J Physiol Pharmacol.
- 2007 Feb;11(1):31-36.
To elucidate a potential molecular link between diabetes and atherosclerosis, we investigated the role of Janus tyrosine kinase (JAK) for NAD(P)H oxidase-derived superoxide generation in the enhanced proliferative capacity of... -
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- High Glucose Modulates Vascular Smooth Muscle Cell Proliferation Through Activation of PKC-sigma-dependent NAD(P)H oxidase
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Kim BH, Lee CW, Park JL, Kang YH, Kim IJ, Kim YK, Son SM
- KMID: 2331790
- J Korean Diabetes Assoc.
- 2006 Nov;30(6):416-427.
BACKGROUND: Oxidative stress is thought to be one of the causative factors contributing to macrovascular complications in diabetes. However, the mechanisms of development and progression of diabetic vascular complications are... -
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- The Effect of High Glucose on the Proliferation and Migration of Vascular Smooth Muscle Cells
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Kim MK, Kang YH, Son SM, Kim IJ, Kim YK
- KMID: 2008168
- J Korean Diabetes Assoc.
- 2004 Oct;28(5):407-415.
BACKGROUND: Oxidative stress contributes to vascular diseases for patients with diabetes by promoting vascular smooth muscle cell (VSMC) proliferation, monocyte/macrophage infiltration, and vascular tone alteration. As the mechanism of development... -
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- Involvement of Vascular NAD(P)H Oxidase-derived Superoxide in Cerebral Vasospasm after Subarachnoid Hemorrhage in Rats
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Kim DE, Kim CD
- KMID: 1614853
- Korean J Physiol Pharmacol.
- 2002 Feb;6(1):15-20.
The role of vascular NAD(P)H oxidase in subarachnoid hemorrhage (SAH)-induced vasospasm in the basilar artery was examined in a rat model. Arterial vasospasm characterized by increased wall thickness and decreased... -
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- Mechanism of Impaired Endothelium-dependent Vasodilation in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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Chun KJ, Son SM, Kim IJ, Kim CD, Yoo SD, Kim YK
- KMID: 1569047
- J Korean Diabetes Assoc.
- 2002 Feb;26(1):46-56.
BACKGROUND: Impaired vascular endothelium-dependent relaxation and augmented contractile responses have been reported in several long-term animals hyperglycemia models and human diabetic patients. Since oxidative stress has been implicated as... -
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