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Resveratrol attenuates lipopolysaccharide-induced dysfunction of blood-brain barrier in endothelial cells via AMPK activation

Hu M, Liu B

Resveratrol, a phytoalexin, is reported to activate AMP-activated protein kinase (AMPK) in vascular cells. The blood-brain barrier (BBB), formed by specialized brain endothelial cells that are interconnected by tight junctions,...
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High Glucose and/or Free Fatty Acid Damage Vascular Endothelial Cells via Stimulating of NAD(P)H Oxidase-induced Superoxide Production from Neutrophils

Kim SS, Kim SY, Lee SH, Kang YH, Kim IJ, Kim YK, Son SM

BACKGROUND: Oxidative stress and inflammation are important factors in the pathogenesis of diabetes and contribute to the development of diabetic complications. To understand the mechanisms that cause vascular complications in...
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Expression of NAD(P)H Oxidase Subunits and Their Contribution to Cardiovascular Damage in Aldosterone/Salt-Induced Hypertensive Rat

Park YM, Lim BH, Touyz RM, Park JB

NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this...
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The Role of Janus Kinase in Superoxide-mediated Proliferation of Diabetic Vascular Smooth Muscle Cells

Lee JY, Park JY, Kim CD

  • KMID: 1512915
  • Korean J Physiol Pharmacol.
  • 2007 Feb;11(1):31-36.
To elucidate a potential molecular link between diabetes and atherosclerosis, we investigated the role of Janus tyrosine kinase (JAK) for NAD(P)H oxidase-derived superoxide generation in the enhanced proliferative capacity of...
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High Glucose Modulates Vascular Smooth Muscle Cell Proliferation Through Activation of PKC-sigma-dependent NAD(P)H oxidase

Kim BH, Lee CW, Park JL, Kang YH, Kim IJ, Kim YK, Son SM

  • KMID: 2331790
  • J Korean Diabetes Assoc.
  • 2006 Nov;30(6):416-427.
BACKGROUND: Oxidative stress is thought to be one of the causative factors contributing to macrovascular complications in diabetes. However, the mechanisms of development and progression of diabetic vascular complications are...
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The Effect of High Glucose on the Proliferation and Migration of Vascular Smooth Muscle Cells

Kim MK, Kang YH, Son SM, Kim IJ, Kim YK

  • KMID: 2008168
  • J Korean Diabetes Assoc.
  • 2004 Oct;28(5):407-415.
BACKGROUND: Oxidative stress contributes to vascular diseases for patients with diabetes by promoting vascular smooth muscle cell (VSMC) proliferation, monocyte/macrophage infiltration, and vascular tone alteration. As the mechanism of development...
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Involvement of Vascular NAD(P)H Oxidase-derived Superoxide in Cerebral Vasospasm after Subarachnoid Hemorrhage in Rats

Kim DE, Kim CD

  • KMID: 1614853
  • Korean J Physiol Pharmacol.
  • 2002 Feb;6(1):15-20.
The role of vascular NAD(P)H oxidase in subarachnoid hemorrhage (SAH)-induced vasospasm in the basilar artery was examined in a rat model. Arterial vasospasm characterized by increased wall thickness and decreased...
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Mechanism of Impaired Endothelium-dependent Vasodilation in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

Chun KJ, Son SM, Kim IJ, Kim CD, Yoo SD, Kim YK

  • KMID: 1569047
  • J Korean Diabetes Assoc.
  • 2002 Feb;26(1):46-56.
BACKGROUND: Impaired vascular endothelium-dependent relaxation and augmented contractile responses have been reported in several long-term animals hyperglycemia models and human diabetic patients. Since oxidative stress has been implicated as...
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