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Galectin-3 Derived from HucMSC Exosomes Promoted Myocardial Fibroblast-to-Myofibroblast Differentiation Associated with β-catenin Upregulation

Guo Q, Zhao Y, Li J, Huang C, Wang H, Zhao X, Wang M, Zhu W

Background and Objectives: Galectin-3 promotes fibroblast-to-myofibroblast differentiation and facilitates injury repair. Previous studies have shown that exosomes derived from human umbilical cord mesenchymal stem cells (hucMSC-ex) promote the differentiation of...
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An Immunohistochemical and Polarizing Microscopic Study of the Tumor Microenvironment in Varying Grades of Oral Squamous Cell Carcinoma

Khalid A, Siddiqui S, Bordoloi B, Faizi N, Samadi F, Saeed N

BACKGROUND: Invasion of epithelial cells into the connective tissue brings about massive morphological and architectural changes in the underlying stroma. Myofibroblasts reorganize the stroma to facilitate the movement of tumor...
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A Case of Dermatomyofibroma on Inguinal Area in a Middle Aged Woman

Song SE, Hong SG, Jo SY, Heo EP, Ro KW

  • KMID: 2437060
  • Korean J Dermatol.
  • 2018 Dec;56(10):640-641.
No abstract available.
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Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression

Park H, An E, Lee AR

To evaluate whether Palmitoyl-pentapeptide (Pal-KTTKS), a lipidated subfragment of type 1 pro-collagen (residues 212–216), plays a role in fibroblast contractility, the effect of Pal-KTTKS on the expression of pro-fibrotic mediators...
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Experimental systems to study the origin of the myofibroblast in peritoneal fibrosis

Padwal M, Margetts P

Peritoneal fibrosis is one of the major complications occurring in long-term peritoneal dialysis patients as a result of injury. Peritoneal fibrosis is characterized by submesothelial thickening and fibrosis which is...
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Inhibition of Fibrotic Contraction by C-Phycocyanin through Modulation of Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression

An E, Park H, Lee AR

The effects of C-phycocyanin (C-pc), a phycobiliprotein, on the expression of pro-fibrotic mediators in hyper-tropic scarring such as connective tissue growth factor (CTGF) and α-smooth muscle actins (α-SMA) were investigated...
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The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration

Lua I, Asahina K

Mesothelial cells (MCs) cover the surface of visceral organs and the parietal walls of cavities, and they synthesize lubricating fluids to create a slippery surface that facilitates movement between organs...
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Inhibitory Effect of Delphinidin on Extracellular Matrix Production via the MAPK/NF-kappaB Pathway in Nasal Polyp-Derived Fibroblasts

Cho JS, Kang JH, Shin JM, Park IH, Lee HM

PURPOSE: Nasal polyps are associated with chronic inflammation of the mucous membranes in the nose and paranasal sinuses and involved in extracellular matrix (ECM) accumulation. Delphinidin promotes ECM degradation in...
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Role of Caffeic Acid on Collagen Production in Nasal Polyp-Derived Fibroblasts

Chung SW, Park IH, Hong SM, Cho JS, Moon JH, Kim TH, Lee HM

OBJECTIVES: Caffeic acids are known to have anti-oxidant, anti-inflammatory, immunomodulatory, and tissue reparative effects. The purposes of this study were to determine the effect of caffeic acid on transforming growth...
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The Role of Focal Adhesion Kinase in the TGF-beta-Induced Myofibroblast Transdifferentiation of Human Tenon's Fibroblasts

Hong S, Lee JB, Iizuka Y, Song YK, Seong GJ, Han SH

PURPOSE: To investigate the role of focal adhesion kinase (FAK) in transforming growth factor (TGF)-beta-induced myofibroblast transdifferentiation of human Tenon's fibroblasts. METHODS: Primary cultured human Tenon's fibroblasts were exposed to TGF-beta1...
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Plexiform Angiomyxoid Myofibroblastic Tumor of the Stomach: A Case Report

Kim A, Bae YK, Shin HC, Choi JH

Plexiform angiomyxoid myofibroblastic tumor (PAMT) is a recently described mesenchymal tumor of the stomach. We report the first case of PAMT in Korea. A 52-yr-old man underwent esophagogastroduodenoscopy due to...
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Lung interstitial cells during alveolarization

Choi CW

Recent progress in neonatal medicine has enabled survival of many extremely low-birth-weight infants. Prenatal steroids, surfactants, and non-invasive ventilation have helped reduce the incidence of the classical form of bronchopulmonary...
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An Inflammatory Myofibroblastic Tumor that Originated from the Posterior Mediastinum

Song DS, Chung WS, Kim JH

  • KMID: 1987474
  • Korean J Thorac Cardiovasc Surg.
  • 2008 Feb;41(1):145-148.
An inflammatory myofibroblastic tumor (IMT) is a rare disease and can occur in nearly every site of the body. The usual intrathoracic sites where an IMT has been recorded are...
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Role of Reactive Oxygen Species in Transforming Growth Factor - beta1 - inuduced Fibronectin Secretion and alpha - Smooth Muscle Actin Expression in Human Lung Fibroblasts

Ha H, Yu MR, Uh ST, Park CS, Lee HB

BACKGROUND: The transforming growth factor-beta1 (TGF-beta1) plays a key role in lung fibrosis. However, the mole?cular mechanisms involved in TGF-beta1-induced lung fibrosis are unclear. TGF-beta1 is the key inducer of...
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Two Cases of Dupuytren's Contracture

Choi HJ, Park YM, Park CJ

  • KMID: 1355978
  • Korean J Dermatol.
  • 2004 Jul;42(7):932-935.
Dupuytren's contracture is characterized by the development of palmar fibrous nodules and bands over the fourth or fifth metacarpal head that may eventually cause contracture of the fingers. It has...
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The Metabolic and Morphological Effects of Transforming Growth Factor (TGF)-beta1 in Bovine Retinal Pigment Epithelial Cells

Lee JS, Lee JE, Park HJ, Oum BS

  • KMID: 2206654
  • J Korean Ophthalmol Soc.
  • 2003 Aug;44(8):1895-1902.
PURPOSE: To evaluate the effects of transforming growth factor (TGF)-beta1 on the cellular metabolic activity and morphological changes on retinal pigment epithelial cells that influence the development of proliferative vitreoretinopathy....
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A Case of Dermatomyofibroma in a 2-year-old Boy

Kim SH, Oh JJ, Lee JH, Lee ES

Dermatomyofibroma is a rare benign dermal tumor, mainly found in young women. Clinically it can be confused with keloid or dermatofibrosarcoma protuberans. Typical histopathologic features of dermatomyofibroma are sufficiently distinctive...
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Adhesion and Morphologic Change of Lens Epithelial Cell According to Materials of Intraocular Lens

Kim CK, Lee JA, Tchah HW

  • KMID: 2337086
  • J Korean Ophthalmol Soc.
  • 2003 Feb;44(2):445-453.
PURPOSE: We investigated the adhesion rate and morphologic change of lens epithelial cell (LEC) according to materials of intraocular lens (IOL). With the results, we estimated the appearance and characteristics...
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Change of alpha-SM Actin Expression Induced by the Antibody for TGF-beta in Fibroblast NIH3T3 Culture: The basic research for the inhibition of wound contracture

Lee BH, Kang HK, Kim JJ, Kim DK, Yoon DW

  • KMID: 1835259
  • J Korean Soc Coloproctol.
  • 2001 Jun;17(3):113-118.
PURPOSE: The purpose of this experiment is to measure the expression of TGF-beta and alpha-SM actin (smooth muscle actin) from fibroblast culture by the duration of culture days and to...
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A Case of Dermatomyofibroma

Jin SH, Kim HS, Lee SH

  • KMID: 1863726
  • Korean J Dermatol.
  • 2000 Mar;38(3):380-382.
Dermatomyofibroma is a recently described, benign acquired plaque-like cutaneous proliferation of fibroblast and myofibroblast. Clinically, it is located in or around the shoulder and measures from 1 to 2 cm in greatest...
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