- EF-hand like Region in the N-terminus of Anoctamin 1 Modulates Channel Activity by Ca²⺠and Voltage
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Tak MH, Jang Y, Son WS, Yang YD, Oh U
- KMID: 2468883
- Exp Neurobiol.
- 2019 Dec;28(6):658-669.
- doi: 10.5607/en.2019.28.6.658
Anoctamin1 (ANO1) also known as TMEM16A is a transmembrane protein that functions as a Ca²⺠activated chloride channel. Recently, the structure determination of a fungal Nectria haematococca TMEM16 (nhTMEM16) scramblase... -
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- Englerin A-sensing charged residues for transient receptor potential canonical 5 channel activation
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Jeong S, Ko J, Kim M, Park KC, Park EY, Kim J, Baik Y, Wie J, Cho AE, Jeon JH, So I
- KMID: 2443607
- Korean J Physiol Pharmacol.
- 2019 May;23(3):191-201.
- doi: 10.4196/kjpp.2019.23.3.191
The transient receptor potential canonical (TRPC) 5 channel, known as a nonselective cation channel, has a crucial role in calcium influx. TRPC5 has been reported to be activated by muscarinic... -
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- Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea
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Byeon S, Kim Y, Lim SW, Cho JH, Park S, Lee J, Sun JM, Choi YL, Lee SH, Ahn JS, Park K, Ahn MJ
- KMID: 2464409
- Cancer Res Treat.
- 2019 Apr;51(2):623-631.
- doi: 10.4143/crt.2018.151
PURPOSE: Epidermal growth factor receptor (EGFR) exon 20 insertion mutations account for approximately 4% of all EGFR mutations. Given the rarity of this mutation, its clinical outcomes are not fully... -
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- Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing
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Park BM, Roh JI, Lee J, Lee HW
- KMID: 2459304
- Lab Anim Res.
- 2018 Dec;34(4):264-269.
- doi: 10.5625/lar.2018.34.4.264
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers.... -
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- Functional identification of protein phosphatase 1-binding consensus residues in NBCe1-B
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Lee KP, Kim HJ, Yang D
- KMID: 2398559
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):91-99.
- doi: 10.4196/kjpp.2018.22.1.91
Protein phosphatase 1 (PP1) is involved in various signal transduction mechanisms as an extensive regulator. The PP1 catalytic subunit (PP1c) recognizes and binds to PP1-binding consensus residues (FxxR/KxR/K) in NBCe1-B.... -
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- IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
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Zhang HF, Wu MX, Lin YQ, Xie SL, Huang TC, Liu PM, Nie RQ, Meng QQ, Luo NS, Chen YX, Wang JF
- KMID: 2396793
- Exp Mol Med.
- 2017 Nov;49(11):e388.
- doi: 10.1038/emm.2017.183
We evaluated the role of IL-10- in IL-33-mediated cholesterol reduction in macrophage-derived foam cells (MFCs) and the mechanism by which IL-33 upregulates IL-10. Serum IL-33 and IL-10 levels in coronary... -
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- Modulating the Voltage-sensitivity of a Genetically Encoded Voltage Indicator
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Jung A, Rajakumar , Yoon BJ, Baker BJ
- KMID: 2398429
- Exp Neurobiol.
- 2017 Oct;26(5):241-251.
- doi: 10.5607/en.2017.26.5.241
Saturation mutagenesis was performed on a single position in the voltage-sensing domain (VSD) of a genetically encoded voltage indicator (GEVI). The VSD consists of four transmembrane helixes designated S1-S4. The... -
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- Effect of the fourth nucleotide at the 3′ end of neuraminidase and matrix viral genomic RNA on the pathogenicity of influenza virus A/PR/8/34
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Lee CY, Kwon HJ, Nguyen TT, Kim I, Jang HK, Kim JH
- KMID: 2412555
- J Vet Sci.
- 2017 Aug;18(S1):307-313.
- doi: 10.4142/jvs.2017.18.S1.307
Twelve nucleotides located at the 3′ end of viral genomic RNA (vRNA) are conserved among influenza A viruses (IAV) and have a promoter function. Hoffmann's 8-plasmid reverse genetics vector system... -
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- Antimutagenic and Antioxidant Activities of Thai Rice Brans
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Insuan O, Chariyakornkul A, Rungrote Y, Wongpoomchai R
- KMID: 2400772
- J Cancer Prev.
- 2017 Jun;22(2):89-97.
- doi: 10.15430/JCP.2017.22.2.89
BACKGROUND: Rice bran is the outer layer of the rice grain, and contains high amounts of bioactive phytochemicals. Here, we investigated and compared chemopreventive properties of purple and white rice... -
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- Identification of Genes Related to Fungicide Resistance in Fusarium fujikuroi
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Choi Y, Jung B, Li T, Lee J
- KMID: 2385658
- Mycobiology.
- 2017 Jun;45(2):101-104.
- doi: 10.5941/MYCO.2017.45.2.101
We identified two genes related to fungicide resistance in Fusarium fujikuroi through random mutagenesis. Targeted gene deletions showed that survival factor 1 deletion resulted in higher sensitivity to fungicides, while... -
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- Safety and immunogenicity of recombinant rabies virus (ERAGS) in mice and raccoon dogs
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Yang DK, Kim HH, Choi SS, Kim JT, Lee KB, Lee SH, Cho IS
- KMID: 2421563
- Clin Exp Vaccine Res.
- 2016 Jul;5(2):159-168.
- doi: 10.7774/cevr.2016.5.2.159
PURPOSE: The development of a genetically modified live rabies vaccine applicable to wild raccoon dogs is necessary for the eradication of rabies in Korea. Thus, we constructed a recombinant rabies... -
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- Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association
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Park PW, Ahn JY, Yang D
- KMID: 2371061
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):433-440.
- doi: 10.4196/kjpp.2016.20.4.433
Inositol-1,4,5-triphosphate [IP3] receptors binding protein released with IP3 (IRBIT) was previously reported as an activator of NBCe1-B. Recent studies have characterized IRBIT homologue S-Adenosylhomocysteine hydrolase-like 2 (AHCYL2). AHCYL2 is highly... -
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- Roles of RUNX1 and PU.1 in CCR3 Transcription
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Kong SK, Kim BS, Hwang SM, Lee HH, Chung IY
- KMID: 2299791
- Immune Netw.
- 2016 Jun;16(3):176-182.
- doi: 10.4110/in.2016.16.3.176
CCR3 is a chemokine receptor that mediates the accumulation of allergic inflammatory cells, including eosinophils and Th2 cells, at inflamed sites. The regulatory sequence of the CCR3 gene, contains two... -
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- Genome Editing Using Engineered Nucleases
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Shin JH, Kim H
- KMID: 2162812
- J Korean Orthop Res Soc.
- 2015 Dec;18(2):60-73.
- doi: 10.0000/jkors.2015.18.2.60
Genome editing is a useful research tool essentially applicable to gene therapy in the field of biotechnology, pharmaceutics and medicine. Scientists have developed three types of programmable nucleases for genome... -
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- Transcriptional mutagenesis by 8-oxodG in alpha-synuclein aggregation and the pathogenesis of Parkinson's disease
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Basu S, Je G, Kim YS
- KMID: 2155433
- Exp Mol Med.
- 2015 Aug;47(8):e179.
- doi: 10.1038/emm.2015.54
Parkinson's disease (PD) is an age-related progressive neurodegenerative disease associated with selective loss of dopaminergic neurons. The characteristic hallmark of the disease is intracytoplasmic proteinacious inclusion bodies called Lewy bodies,... -
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- Hypoparathyroidism, sensorineural deafness, and renal dysgenesis syndrome with a GATA3 mutation
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Shim YS, Choi W, Hwang IT, Yang S
- KMID: 1789533
- Ann Pediatr Endocrinol Metab.
- 2015 Mar;20(1):59-63.
- doi: 10.6065/apem.2015.20.1.59
Hypoparathyroidism, sensorineural deafness, and renal dysgenesis syndrome is an autosomal dominant disease caused by mutations in the GATA3 gene on chromosome 10p15. We identified a patient diagnosed with hypoparathyroidism who... -
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- Genome Architecture and Its Roles in Human Copy Number Variation
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Chen L, Zhou W, Zhang L, Zhang F
- KMID: 2391488
- Genomics Inform.
- 2014 Dec;12(4):136-144.
- doi: 10.5808/GI.2014.12.4.136
Besides single-nucleotide variants in the human genome, large-scale genomic variants, such as copy number variations (CNVs), are being increasingly discovered as a genetic source of human diversity and the pathogenic... -
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- An antibody reactive to the Gly63-Lys68 epitope of NT-proBNP exhibits O-glycosylation-independent binding
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Lee Y, Kim H, Chung J
- KMID: 2155379
- Exp Mol Med.
- 2014 Sep;46(9):e114.
- doi: 10.1038/emm.2014.57
The N-terminal fragment of prohormone brain natriuretic peptide (NT-proBNP) is a commonly used biomarker for the diagnosis of congestive heart failure, although its biological function is not well known. NT-proBNP... -
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- Neuropathic Pain Model of Peripheral Neuropathies Mediated by Mutations of Glycyl-tRNA Synthetase
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Lee SJ, Seo AJ, Park BS, Jo HW, Huh Y
- KMID: 2129611
- J Korean Med Sci.
- 2014 Aug;29(8):1138-1144.
- doi: 10.3346/jkms.2014.29.8.1138
Charcot-Marie-Tooth disease (CMT) is the most common inherited motor and sensory neuropathy. Previous studies have found that, according to CMT patients, neuropathic pain is an occasional symptom of CMT. However,... -
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- Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11
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Choi S, Han S, Lee H, Chun YJ, Kim D
- KMID: 2170668
- Biomol Ther.
- 2013 Nov;21(6):487-492.
Cytochrome P450 4A11 (CYP4A11) is a fatty acid hydroxylase enzyme expressed in human liver. It catalyzes not only the hydroxylation of saturated and unsaturated fatty acids, but the conversion of... -
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