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Current Updates on the Diagnosis and Management of Multiple Sclerosis for the General Neurologist

Baskaran AB, Grebenciucova E, Shoemaker T, Graham EL

Multiple sclerosis (MS) is an immune-driven disease that affects the central nervous system and is characterized by acute-on-chronic demyelination attacks. It is a major cause of global neurological disability, and...
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Sudden Death Associated With Possible Flare-Ups of Multiple Sclerosis After COVID-19 Vaccination and Infection: A Case Report and Literature Review

Jeon YH, Choi S, Park JH, Lee JK, Yeo NS, Lee S, Suh YL

We present an autopsy case of a 19-year-old man with a history of epilepsy whose unwitnessed sudden death occurred unexpectedly in the night. About 4 years before death, he was...
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Biomechanical changes of the common carotid artery and internal jugular vein in patients with multiple sclerosis

Rastegari K, Mokhtari-Dizaji M, Harirchian MH, Hashemi H, Ayoobi Yazdi N, Saberi H

Purpose: Investigations of the hemodynamic changes of the venous system in patients with multiple sclerosis (MS) have shown contradictory results. Herein, the biomechanical parameters of the internal jugular vein (IJV)...
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Autonomic dysfunction in multiple sclerosis and neuromyelitis optica spectrum disorder

Kwon S, Min JH

Autonomic dysfunction occurs frequently in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Patients with either condition may present with autonomic symptoms such as bladder, sexual, cardiovascular, thermoregulatory, and...
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Congestive myelopathy due to spinal dural arteriovenous fistula mimicking CNS demyelinating disease

Kim N, Kim H, Kim H, Park J

Spinal dural arteriovenous fistula (SDAVF) is known for its ambiguous and various clinical presentations. Among these presentations, congestive myelopathy is one of the most common, yet it is challenging to...
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Safety and Temporal Pattern of the Lymphocyte Count During Fingolimod Therapy in Patients With Multiple Sclerosis: Real-World Korean Experience

Huh SY, Kim SH, Kim KH, Kwon YN, Kim SM, Kim SW, Shin HY, Chung YH, Min JH, So J, Lim YM, Kim KK, Kim NH, Nam TS, Kang SY, Oh J, Oh Si, Sohn E, Kim HJ

Background and Purpose Fingolimod (FTY) inhibits lymphocyte egress from lymphoid organs to cause lymphopenia, but the clinical implications of FTY-induced lymphopenia are not fully understood. We aimed to determine the...
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Ontology for Symptomatic Treatment of Multiple Sclerosis

Esfahani MZ, Ahmadi M, Adibi I

Objectives: Symptomatic treatment is an essential component in the overall treatment of multiple sclerosis (MS). However, knowledge in this regard is confusing and scattered. Physicians also have challenges in choosing...
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Amino Acid Levels as Potential Biomarkers of Multiple Sclerosis in Elderly Patients: Preliminary Report

Rzepiński , Kośliński P, Gackowski M, Koba M, Maciejek Z

Background and Purpose Aging in multiple sclerosis is associated with both disease- and age-dependent neurodegeneration. Serum metabolomic profiling of amino acids seems to be a promising method for searching for...
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Autoantibodies in central nervous system and neuromuscular autoimmune disorders: A narrative review

Jeon MY, Seok JM, Fujihara K, Kim BJ

The discovery of novel autoantibodies in neurological disorders contributes to a better understanding of its pathogenesis, improves the accuracy of diagnosis, and leads to new treatment strategies. Advances in techniques...
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Choroidal Thickness in Multiple Sclerosis: An Optical Coherence Tomography Study

Masala A, Mola ID, Cellerino c M, Pera V, Vagge A, Uccelli A, Christian C, Traverso CE, Iester M

Background and Purpose To identify changes in the choroidal thickness (CT) in multiple sclerosis (MS) patients with and without optic neuritis (ON) using enhanced-depth-imaging optical coherence tomography (EDI-OCT). Methods This cross-sectional...
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Clinical and Radiological Features of Myelin Oligodendrocyte Glycoprotein-Associated Myelitis in Adults

Kim KH, Kim SH, Hyun JW, Kim HJ

Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have recently been established as a biomarker for MOG-antibody-associated disease (MOGAD), which is a distinct demyelinating disease of the central nervous system. Among the...
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Transanal Irrigation for Neurogenic Bowel Dysfunction in Multiple Sclerosis: A Retrospective Study

Teng M, Miget G, Moutounaïck M, Kervinio F, Charlanes A, Chesnel C, Breton FL, Amarenco G

  • KMID: 2528047
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):320-326.
  • doi: 10.5056/jnm19040
Background/Aims Sixty-eight percent of multiple sclerosis (MS) patients suffer from neurogenic bowel dysfunction (NBD). Transanal irrigation (TAI) is part of the therapeutic strategy. This retrospective study aims to assess the efficacy...
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Preliminary Analysis of Brain Footprints in Multiple Sclerosis Females With Detrusor Sphincter Dyssynergia: A Concurrent Urodynamic and Functional Magnetic Resonance Imaging Study

Tran K, Hubbard L, Karmonik C, Boone TB, Khavari R

Purpose: This study evaluates the grey and white brain matter characteristics in women with multiple sclerosis (MS) and detrusor sphincter dyssynergia (DSD). Grey matter is assessed via the functional connectivity...
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Atypical Multiple Sclerosis Presenting as Bilateral Optic Neuritis

Lee SY, Park MR

Purpose: We report a case of multiple sclerosis with bilateral optic neuritis that was atypical in terms of both the clinical signs and symptoms. Case summary: A 34-year-old female visited the...
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One-and-a-half Syndrome Associated with Multiple Sclerosis in a 14-year-old Girl

Lim YJ, Lee SJ

Purpose: To report the case of a 14-year-old female patient with one-and-a-half syndrome subsequently diagnosed with multiple sclerosis involving the pons. Case summary: A 14-year-old girl without any underlying disease presented...
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Therapeutic Aspects of Mesenchymal Stem Cell-Based Cell Therapy with a Focus on Human Amniotic Epithelial Cells in Multiple Sclerosis: A Mechanistic Review

ArefNezhad R, Motedayyen H, Mohammadi A

Multiple sclerosis (MS) is an inflammatory disease of central nervous system (CNS). The mmune system plays an important role in its pathogenesis. Current treatments are unable to cure patients and...
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Scales for Spinal Cord Disorders

Kim JA, Kim SM

Clinical scales are important tools for quantitatively evaluating impairments and disabilities related to diseases. Clinical scales are also used in many clinical studies to assess therapeutic effects. Spinal cord disorders...
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The Expanded Disability Status Scale Score and Demographic Indexes Are Correlated with the Severity of Cognitive Impairment in Multiple Sclerosis Patients

Sadigh-Eteghad S, Garravnd NA, Feizollahi M, Talebi M

Background and Purpose Cognitive impairment (CI) is a common symptom of multiple sclerosis (MS). Although demographic and clinical factors contribute to MS-dependent CI, previous findings have been inconsistent. This study...
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GRIM-19 Ameliorates Multiple Sclerosis in a Mouse Model of Experimental Autoimmune Encephalomyelitis with Reciprocal Regulation of IFNγ/Th1 and IL-17A/Th17 Cells

Moon J, Lee SH, Lee Sy, Ryu J, Jhun J, Choi J, Kim GN, Roh S, Park SH, Cho ML

The protein encoded by the Gene Associated with Retinoid-Interferon-Induced Mortality-19 (GRIM-19) is located in the mitochondrial inner membrane and is homologous to the NADH dehydrogenase 1-alpha subcomplex subunit 13 of...
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Paramagnetic Rims in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder: A Quantitative Susceptibility Mapping Study with 3-T MRI

Jang J, Nam Y, Choi Y, Shin NY, An JY, Ahn KJ, Kim Bs, Lee KS, Kim W

Background and Purpose: Iron retained by activated microglia and macrophages in multiple sclerosis (MS) lesions may serve as a marker of innate immune system activation. Among several magnetic resonance imaging...
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