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Comparison of Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis

Hyun JW, Jang H, Yu J, Park NY, Kim SH, Huh SY, Kim W, Park MS, Oh J, Park KD, Kim HJ

BACKGROUND AND PURPOSE: To compare the characteristics of neuropathic pain in neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS). METHODS: From 2016 to 2018, 500 patients with NMOSD and MS...
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Neuropsychiatric Symptoms of Multiple Sclerosis: State of the Art

Silveira C, Guedes R, Maia D, Curral R, Coelho R

Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric manifestations have a high prevalence in MS patients and may worsen the illness progression and the patients’ quality of life...
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Exercise and Neuroinflammation in Health and Disease

Seo DY, Heo JW, Ko JR, Kwak HB

Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces...
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Isolated Trigeminal Neuralgia Presented Due to Cerebellopontine Angle Epidermoid Cyst

Yim SH, Yoon B, Lee JG, Kim YD, Na SJ

Trigeminal neuralgia (TN) is a paroxysmal shock like pain restricted to the innervations of the areas of one or more trigeminal branches. The pathogenesis of TN is uncertain and typically...
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The Effect of Repetitive Transcranial Magnetic Stimulation on Spasticity in Patients with Multiple Sclerosis

Şan AU, Yılmaz B, Kesikburun S

BACKGROUND AND PURPOSE: This randomized controlled study examined the effect of repetitive transcranial magnetic stimulation (rTMS) on spasticity in patients with multiple sclerosis (MS). METHODS: This study included 16 patients with...
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High Seroprevalence and Index of Anti-John-Cunningham Virus Antibodies in Korean Patients with Multiple Sclerosis

Kim SH, Kim Y, Jung JY, Park NY, Jang H, Hyun JW, Kim HJ

BACKGROUND AND PURPOSE: The anti-John-Cunningham virus (JCV)-antibody serostatus and index are used in the risk stratification of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS) patients treated with natalizumab. However,...
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Intrathecal Baclofen Dosage for Long-Term Treatment of Patients With Spasticity Due to Traumatic Spinal Cord Injuries or Multiple Sclerosis

Skoog B, Hedman B

OBJECTIVE: To investigate dosage changes in intrathecal baclofen during long-term treatment of patients with severe leg spasticity. METHODS: We performed a retrospective chart review of 49 patients treated with an intrathecal...
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Isolated Unilateral Sixth Nerve Palsy as the First Manifestation of Multiple Sclerosis

Park HY, Kim HJ

No abstract available.
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Isolated Unilateral Sixth Nerve Palsy as the First Manifestation of Multiple Sclerosis

Park HY, Kim HJ

No abstract available.
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Data-Driven Machine-Learning Quantifies Differences in the Voiding Initiation Network in Neurogenic Voiding Dysfunction in Women With Multiple Sclerosis

Karmonik C, Boone T, Khavari R

PURPOSE: To quantify the relative importance of brain regions responsible for reduced functional connectivity (FC) in their Voiding Initiation Network in female multiple sclerosis (MS) patients with neurogenic lower urinary...
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The Anti-Inflammatory Effect of Sulforaphane in Mice with Experimental Autoimmune Encephalomyelitis

Yoo IH, Kim MJ, Kim J, Sung JJ, Park ST, Ahn SW

BACKGROUND: Multiple sclerosis (MS) is an immune-associated inflammatory disorder of the central nervous system and results in serious disability. Although many disease-modifying therapy drugs have been developed, these drugs have...
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Therapeutic Outcome of Alemtuzumab in Korean Patients with Multiple Sclerosis: 2-Year Follow-Up

Hyun JW, Shin HJ, Jang H, Park NY, Kim SH, Kim HJ

BACKGROUND AND PURPOSE: Alemtuzumab has shown high efficacy in clinical trials that primarily involved Western multiple sclerosis (MS) patients. To evaluate the therapeutic outcome of alemtuzumab in Korean patients with...
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Primary central nervous system lymphoma with intramedullary spinal cord involvement mimicking inflammatory demyelinating disease

Kim H, Nam TS, Levy M, Lee KH, Kim J, Lee SJ

BACKGROUND: Spinal cord involvement of primary central nervous system lymphoma (PCNSL) is rare in a young immunocompetent patient and can be misdiagnosed as an inflammatory demyelinating disease (IDD) of the...
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Two Cases of Radiologically Isolated Syndrome: First Case Report in Korea

Im K, Sunwoo JS, Kwon KY, Lee KB, Ahn MY, Roh H

With increasing sensitivity, availability, and use of magnetic resonance imaging (MRI) in the past three decades, there is also an increase in incidental abnormal findings. The most common findings of...
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Duration of Treatment Effect of Extracorporeal Shock Wave on Spasticity and Subgroup-Analysis According to Number of Shocks and Application Site: A Meta-Analysis

Oh JH, Park HD, Han SH, Shim GY, Choi KY

OBJECTIVE: To investigate duration of the treatment effect of extracorporeal shockwave therapy (ESWT) on spasticity levels measured with Modified Ashworth Scale (MAS) regardless of the patient group (stroke, multiple sclerosis,...
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Neuroprotective Effects of 6-Shogaol and Its Metabolite, 6-Paradol, in a Mouse Model of Multiple Sclerosis

Sapkota A, Park SJ, Choi JW

Multiple sclerosis (MS) is an autoimmune disease characterized by progressive neuronal loss, neuroinflammation, axonal degeneration, and demyelination. Previous studies have reported that 6-shogaol, a major constituent of ginger (Zingiber officinale...
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Gene Expression Profile of Olfactory Transduction Signaling in an Animal Model of Human Multiple Sclerosis

Kim J, Ahn M, Choi Y, Ekanayake , Park CM, Moon C, Jung K, Tanaka A, Matsuda H, Shin T

Olfactory dysfunction occurs in multiple sclerosis in humans, as well as in an animal model of experimental autoimmune encephalomyelitis (EAE). The aim of this study was to analyze differentially expressed...
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Association of Optic Neuritis with Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis in Korea

Kim H, Park KA, Oh SY, Min JH, Kim BJ

PURPOSE: To describe the clinical characteristics and course of optic neuritis (ON) and its association with neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) in Korea. METHODS: In this retrospective...
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Quality of Life and Emotional Strain in Caregivers of Patients with Multiple Sclerosis

Petrikis P, Baldouma A, Katsanos A, Konitsiotis S, Giannopoulos S

BACKGROUND AND PURPOSE: This study aimed was to measure the quality of life, fatigue, stress, and depression in a consecutive sample of caregivers of multiple sclerosis (MS) patients. METHODS: We included...
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Real-World Effectiveness of Disease-Modifying Therapies in Korean Patients with Relapsing Multiple Sclerosis

Kim SH, Park MS, Kim W, Huh SY, Shin HJ, Hyun JW, Kim HJ

BACKGROUND AND PURPOSE: This study assessed the long-term outcomes of disease-modifying therapies (DMTs) in Korean multiple sclerosis (MS) patients treated in real-world clinical settings in Korea. METHODS: We retrospectively evaluated the...
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