- Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes
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Kim PC, Lee JS, Chung SS, Park KS
- KMID: 2542515
- Diabetes Metab J.
- 2023 May;47(3):382-393.
- doi: 10.4093/dmj.2022.0156
Background: Leptin is a 16-kDa fat-derived hormone with a primary role in controlling adipose tissue levels. Leptin increases fatty acid oxidation (FAO) acutely through adenosine monophosphate-activated protein kinase (AMPK) and... -
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- MR Template‑Based Individual Brain PET Volumes‑of‑Interest Generation Neither Using MR nor Using Spatial Normalization
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Seo S, Oh J, Chung J, Kim S, Kim J
- KMID: 2541616
- Nucl Med Mol Imaging.
- 2023 Apr;57(2):73-85.
- doi: 10.1007/s13139-022-00772-4
For more anatomically precise quantitation of mouse brain PET, spatial normalization (SN) of PET onto MR template and subsequent template volumes-of-interest (VOIs)-based analysis are commonly used. Although this leads to... -
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- Virtual Screening and Testing of GSK-3 Inhibitors Using Human SH-SY5Y Cells Expressing Tau Folding Reporter and Mouse Hippocampal Primary Culture under Tau Cytotoxicity
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Lin CH, Hsieh YS, Sun YC, Huang WH, Chen SL, Weng ZK, Lin TH, Wu YR, Chang KH, Huang HJ, Lee GC, Hsieh-Li HM, Lee-Chen GJ
- KMID: 2537589
- Biomol Ther.
- 2023 Jan;31(1):127-138.
- doi: 10.4062/biomolther.2022.035
Glycogen synthase kinase-3β (GSK-3β) is an important serine/threonine kinase that implicates in multiple cellular processes and links with the neurodegenerative diseases including Alzheimer’s disease (AD). In this study, structure-based virtual... -
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- Changes in Gut Microbiome upon Orchiectomy and Testosterone Administration in AOM/DSS-Induced Colon Cancer Mouse Model
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Song CH, Kim N, Nam RH, Choi SI, Jang JY, Lee HN
- KMID: 2538005
- Cancer Res Treat.
- 2023 Jan;55(1):196-218.
- doi: 10.4143/crt.2022.080
Purpose Sex hormones are known to affect the gut microbiota. Previously, we reported that endogenous and exogenous testosterone are associated with colorectal cancer (CRC) development and submucosal invasion. In the... -
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- Molecular and Immune Profiling of Syngeneic Mouse Models Predict Response to Immune Checkpoint Inhibitors in Gastric Cancer
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Lee D, Choi J, Oh HJ, Ham IH, Lee SH, Nomura S, Han SU, Hur H
- KMID: 2538002
- Cancer Res Treat.
- 2023 Jan;55(1):167-178.
- doi: 10.4143/crt.2022.094
Purpose Appropriate preclinical mouse models are needed to evaluate the response to immunotherapeutic agents. Immunocompetent mouse models have rarely been reported for gastric cancer. Thus, we investigated immunophenotypes and responses... -
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- Succinate Induces Liver Damage and Hepatic Fibrosis in a Mouse Model
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Le CT, Nguyen G, Dong HN, Park SY, Cho YK, Choi DH, Park WS, Lee Y, Lee JY, Cho EH
- KMID: 2536901
- Keimyung Med J.
- 2022 Dec;41(2):84-91.
- doi: 10.46308/kmj.2022.00143
Hepatic stellate cells (HSCs) play a key role in liver fibrosis. Succinate and succinate receptor (GPR91) signaling pathway are involved in the activation, proliferation, and migration of HSCs. We investigated... -
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- Anesthesia and analgesia for common research models of adult mice
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Ahmadi‑Noorbakhsh S, Abbasi M, Ghasemi M, Bayat G, Davoodian N, Sharif‑Paghaleh E, Poormoosavi S, Rafizadeh M, Maleki M, Shirzad‑Aski H, Jahromi H, Dadkhah M, Khalvati B, Safari T, Behmanesh M, Khoshnam S, Houshmand G, Talaei S
- KMID: 2537628
- Lab Anim Res.
- 2022 Dec;38(4):271-286.
- doi: 10.1186/s42826-022-00150-3
Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles.... -
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- In vivo molecular imaging in preclinical research
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Kim SJ, Lee HY
- KMID: 2537624
- Lab Anim Res.
- 2022 Dec;38(4):256-261.
- doi: 10.1186/s42826-022-00142-3
In vivo molecular imaging is a research field in which molecular biology and advanced imaging techniques are combined for imaging molecular-level biochemical and physiological changes that occur in a living... -
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- Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests: a small scale study
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Aasland Hansen K, Hudecová A, Haugen F, Skjerve E, Ropstad E, Zimmer K
- KMID: 2537631
- Lab Anim Res.
- 2022 Dec;38(4):287-293.
- doi: 10.1186/s42826-022-00140-5
Background: All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two... -
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- Differential effects of various dietary proteins on dextran sulfate sodiuminduced colitis in mice
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Ahn E, Jeong H, Kim E
- KMID: 2536505
- Nutr Res Pract.
- 2022 Dec;16(6):700-715.
- doi: 10.4162/nrp.2022.16.6.700
BACKGROUND/OBJECTIVES: Chronic colitis is a risk factor for colorectal cancer (CRC) development in both animals and humans. Previously, we reported that a diet rich in protein (with casein as the... -
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- Functional and Immunofluorescence Evaluations of Vascular and Neural Integrities in Urinary Bladder of Streptozotocin-Induced Diabetic Mice
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Kwon MH, Choi MJ, Liu FY, Fridayana FR, Niloofar L, Yin GN, Ryu JK
- KMID: 2533656
- Int Neurourol J.
- 2022 Sep;26(3):201-209.
- doi: 10.5213/inj.2244152.076
Purpose: To assess functional and structural changes in vascular and neural structures associated with diabetic bladder dysfunction (DBD) in the bladders of streptozotocin (STZ)-induced diabetic mice. Methods: Eight-week-old C57BL/6 mice were... -
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- Ventilator-induced lung injury results in oxidative stress response and mitochondrial swelling in a mouse model
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Joelsson JP, Asbjarnarson A, Sigurdsson S, Kricker J, Valdimarsdottir B, Thorarinsdottir H, Starradottir E, Gudjonsson T, Ingthorsson S, Karason S
- KMID: 2534144
- Lab Anim Res.
- 2022 Sep;38(3):169-183.
- doi: 10.1186/s42826-022-00133-4
Background: Mechanical ventilation is a life-saving therapy for critically ill patients, providing rest to the respiratory muscles and facilitating gas exchange in the lungs. Ventilator-induced lung injury (VILI) is an... -
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- Humulus japonicus attenuates LPS-and scopolamine-induced cognitive impairment in mice
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Go J, Park HY, Lee DW, Maeng SY, Lee IB, Seo YJ, An JP, Oh WK, Lee CH, Kim KS
- KMID: 2534143
- Lab Anim Res.
- 2022 Sep;38(3):159-168.
- doi: 10.1186/s42826-022-00134-3
Background: Neuroinflammation plays an important role in cognitive decline and memory impairment in neurodegenerative disorders. Previously, we demonstrated that Humulus japonicus (HJ) has anti-inflammatory effects in rodent models of Alzheimer’s... -
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- Development of a High-Yield Isolation Protocol Optimized for the Retrieval of Active Muscle Satellite Cells from Mouse Skeletal Muscle Tissue
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Lee H, Han NR, Kim SJ, Yun JI, Lee ST
- KMID: 2532403
- Int J Stem Cells.
- 2022 Aug;15(3):283-290.
- doi: 10.15283/ijsc21179
Background and Objectives: Difficulties often encountered in separating and purifying active muscle satellite cells (MSCs) from skeletal muscle tissues have limited the supply of cells for muscle therapy and artificial... -
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- Behavioral Deficits in Adolescent Mice after Sub-Chronic Administration of NMDA during Early Stage of Postnatal Development
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Adil KJ, Remonde CG, Gonzales EL, Boo KJ, Kwon KJ, Kim DH, Kim HJ, Cheong JH, Shin CY, Jeon SJ
- KMID: 2530996
- Biomol Ther.
- 2022 Jul;30(4):320-327.
- doi: 10.4062/biomolther.2021.194
Neurodevelopmental disorders are complex conditions that pose difficulty in the modulation of proper motor, sensory and cognitive function due to dysregulated neuronal development. Previous studies have reported that an imbalance... -
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- Generation of Astrocyte-Specific MAOB Conditional Knockout Mouse with Minimal Tonic GABA Inhibition
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Lee JM, Sa M, An H, Kim JMJ, Kwon J, Yoon BE, Lee CJ
- KMID: 2531119
- Exp Neurobiol.
- 2022 Jun;31(3):158-172.
- doi: 10.5607/en22016
Monoamine oxidase B (MAOB) is a key enzyme for GABA production in astrocytes in several brain regions. To date, the role of astrocytic MAOB has been studied in MAOB null... -
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- Sestrin2 Regulates Beneficial β3-Adrenergic Receptor-Mediated Effects Observed in Inguinal White Adipose Tissue and Soleus Muscle
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Park MJ, Kim JW, Roh E, Choi KM, Baik SH, Hwang HJ, Yoo HJ
- KMID: 2531399
- Endocrinol Metab.
- 2022 Jun;37(3):552-557.
- doi: 10.3803/EnM.2022.1421
Sestrin2, a well-known adenosine monophosphate-activated protein kinase (AMPK) regulator, plays a protective role against metabolic stress. The β3-adrenergic receptor (β3AR) induces fat browning and inhibits muscle atrophy in an AMPK-dependent... -
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- Isolation of High Purity Mouse Mesenchymal Stem Cells through Depleting Macrophages Using Liposomal Clodronate
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Song JH, Kim JW, Lee MN, Oh SH, Piao X, Wang Z, Kwon SH, Kim OS, Koh JT
- KMID: 2530148
- Tissue Eng Regen Med.
- 2022 Jun;19(3):565-575.
- doi: 10.1007/s13770-021-00412-6
BACKGROUND: The use of mouse bone marrow mesenchymal stem cells (mBMSCs) represents a promising strategy for performing preclinical studies in the field of cell-based regenerative medicine; however, mBMSCs obtained via... -
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- Evaluation of host and bacterial gene modulation during Lawsonia intracellularis infection in immunocompetent C57BL/6 mouse model
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Kirthika P, Park S, Jawalagatti V, Lee JH
- KMID: 2530435
- J Vet Sci.
- 2022 May;23(3):e41.
- doi: 10.4142/jvs.21274
Background: Proliferative enteritis caused by Lawsonia intracellularis undermines the economic stability of the swine industry worldwide. The development of cost-effective animal models to study the pathophysiology of the disease will... -
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- Molecular Characteristics and Potent Immunomodulatory Activity of Fasciola hepatica Cystatin
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Zhang K, Liu Y, Zhang G, Wang X, Li Z, Shang Y, Ning C, Ji C, Cai X, Xia X, Qiao J, Meng Q
- KMID: 2529674
- Korean J Parasitol.
- 2022 Apr;60(2):117-126.
- doi: 10.3347/kjp.2022.60.2.117
Cystatin, a cysteine protease inhibitor found in many parasites, plays important roles in immune evasion. This study analyzed the molecular characteristics of a cystatin from Fasciola hepatica (FhCystatin) and expressed... -
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