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Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation

Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW

Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after...
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Palonosetron versus granisetron in combination with aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with gynecologic cancer

Fujiwara S, Terai Y, Tsunetoh S, Sasaki H, Kanemura M, Ohmichi M

OBJECTIVE: There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC). We evaluated the antiemetic efficacy of a combination of 5-HT3...
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Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study

Lim HC, Kim JH, Youn YH, Lee EH, Lee BK, Park H

  • KMID: 2325770
  • J Neurogastroenterol Motil.
  • 2013 Oct;19(4):495-502.
BACKGROUND/AIMS: Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used...
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A Case of Phendimetrazine Induced-Psychotic Disorder and Dependence

Yun JA, Park WR, Yu JC, Choi KS

  • KMID: 2343635
  • J Korean Neuropsychiatr Assoc.
  • 2013 Sep;52(5):402-405.
Phendimetrazine and related amphetamine-like compounds are used widely as appetite suppressants in Korea. We report on a patient who developed psychotic disorder and dependence while using phendimetrazine. A 25-year-old female...
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A Phase II Study to Evaluate the Efficacy of Ramosetron, Aprepitant, and Dexamethasone in Preventing Cisplatin-Induced Nausea and Vomiting in Chemotherapy-Naive Cancer Patients

Jang G, Song HH, Park KU, Kim HS, Choi DR, Kwon JH, Kim HY, Han B, Kim JH, Jung JY, Kim HJ, Zang DY

  • KMID: 2167624
  • Cancer Res Treat.
  • 2013 Sep;45(3):172-177.
PURPOSE: Combination therapy with aprepitant, serotonin receptor antagonist, and steroids improves the complete response rate of both acute and delayed chemotherapy-induced nausea and vomiting (CINV). However, it is not known...
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The Effects of Prucalopride on Postoperative Ileus in Guinea Pigs

Park SJ, Choi EJ, Yoon YH, Park H

PURPOSE: Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and...
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Behavioral Intervention and Anti-Obesity Drug Therapy

Kim MK

  • KMID: 2267840
  • Korean J Med.
  • 2013 May;84(5):624-628.
Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes. The U.S. Preventive Service Task Force (USPSTF) recommends screening...
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Long-Term Anticoagulation in the Extreme Elderly with the Newer Antithrombotics: Safe or Sorry?

Chiong JR, Cheung RJ

BACKGROUND AND OBJECTIVES: The prevalence of atrial fibrillation (AF) doubles in the extreme elderly and is higher than in the rest of the population. Warfarin therapy to prevent thromboembolic events...
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Onychomycosis Caused by Chaetomium globosum

Kim DM, Lee MH, Suh MK, Ha GY, Kim H, Choi JS

Onychomycosis is usually caused by dermatophytes, but some nondermatophytic molds and yeasts are also associated with invasion of nails. The genus Chaetomium is a dematiaceous nondermatophytic mold found in soil...
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Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation

Lee DH, Kim JE, Kang YJ

Insulin-like growth factor binding proteins (IGFBPs) are important components of insulin growth factor (IGF) signaling pathways. One of the binding proteins, IGFBP-5, enhances the actions of IGF-1, which include the...
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Functional activity of the cannabinoid 1 receptor is not affected by opioid antagonists in the rat brain

Lee H

BACKGROUND: WIN55212-2 is a synthetic cannabinoid agonist and selective to cannabinoid 1 (CB1) receptors, which are distributed mainly in the central nervous system. Opioid receptors and CB1 receptors have several...
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Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting

Lim CS, Ko YK, Kim YH, Park SI, Kim JK, Kim MJ, Kim HJ

BACKGROUND: 5-HT3 receptor antagonist, dexamethasone and droperidol were used for the prevention of postoperative nausea and vomiting (PONV). Recently, neurokinin-1 (NK1) antagonist has been used for PONV. We evaluated the...
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New oral anticoagulants

Oh S

The most important and widely-prescribed drug for anticoagulation is a vitamin K antagonist such as warfarin although it has several limitations in clinical use. New oral anticoagulants (NOACs) have been...
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Focused Update on Primary Stroke Prevention in Patients with Atrial Fibrillation in Korean Clinical Practice Guidelines for Stroke

Park JM, Hong KS, Han SW, Kim HY, Cho YJ, Kang K, Yu KH, Rha JH, Heo JH, Kwon SU, Oh CW, Bae HJ, Lee BC, Yoon BW, Koo J

  • KMID: 2288694
  • Korean J Stroke.
  • 2012 Dec;14(3):106-115.
Pivotal clinical trials testing the efficacy of new antithrombotics for the prevention of stroke and systemic embolism in patients with atrial fibrillation have been published since the release of the...
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Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1beta in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages

Won K, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K

TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to...
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Drug Therapy for Obesity

Kim KS, Park SW

  • KMID: 2270999
  • Korean J Obes.
  • 2012 Dec;21(4):197-202.
Obesity is associated with a substantial increase in metabolic disorders and various cancers. As weight loss achieved with lifestyle intervention is modest, there is a need for drug treatment. Orlistat, phentermine,...
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Comparison of Hematologic Changes between Rivaroxaban and Aspirin for Venous Thromboembolism Prophylaxis after Total Knee Arthroplasty

Song MH, Kim BH, Ahn SJ, Yoo SH, Kim YJ

PURPOSE: To compare the hematologic changes and the rates of transfusion of patients using rivaroxaban or aspirin for venous thromboembolism prophylaxis after a total knee arthroplasty. MATERIALS AND METHODS: Among patients...
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Fingernail Onychomycosis Due to Aspergillus niger

Kim DM, Suh MK, Ha GY, Sohng SH

Onychomycosis is usually caused by dermatophytes, but some species of nondermatophytic molds and yeasts are also associated with nail invasion. Aspergillus niger is a nondermatophytic mold which exists as an...
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The effect of aprepitant for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic surgery with intravenous patient controlled analgesia using fentanyl: aprepitant plus ramosetron vs ramosetron alone

Lee SJ, Lee SM, Kim SI, Ok SY, Kim SH, Park SY, Kim MG

BACKGROUND: The purpose of this study was to evaluate the effect of an aprepitant, neurokinin-1(NK1) receptor antagonist, for reducing postoperative nausea and vomiting (PONV) for up to 24 hours in...
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Effects of 5-HT4 selective receptor agonist, mosapride citrate on electrocardiogram in dogs

Chae JS, Ahn JO, Coh YR, Park CW, Youn HY

  • KMID: 1435829
  • Korean J Vet Res.
  • 2012 Sep;52(3):163-167.
Mosapride stimulated dietary motility was introduced because of the arrhythmogenic effect of cisapride. Cisapride, 5-HT receptor agonist, induces prolongation of QT interval. Additionally, this condition can raise the possibility of...
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