- Dual-Blocking of PI3K and mTOR Improves Chemotherapeutic Effects on SW620 Human Colorectal Cancer Stem Cells by Inducing Differentiation
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Kim MJ, Koo JE, Han GY, Kim B, Lee YS, Ahn C, Kim CW
- KMID: 2363495
- J Korean Med Sci.
- 2016 Mar;31(3):360-370.
- doi: 10.3346/jkms.2016.31.3.360
Cancer stem cells (CSCs) have tumor initiation, self-renewal, metastasis and chemo-resistance properties in various tumors including colorectal cancer. Targeting of CSCs may be essential to prevent relapse of tumors after... -
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- Palonosetron versus granisetron in combination with aprepitant for the prevention of chemotherapy-induced nausea and vomiting in patients with gynecologic cancer
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Fujiwara S, Terai Y, Tsunetoh S, Sasaki H, Kanemura M, Ohmichi M
- KMID: 2345922
- J Gynecol Oncol.
- 2015 Oct;26(4):311-319.
- doi: 10.3802/jgo.2015.26.4.311
OBJECTIVE: There is no research regarding the appropriate antiemetic agents for female patients, especially those receiving moderately emetogenic chemotherapy (MEC). We evaluated the antiemetic efficacy of a combination of 5-HT3... -
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- Effects of the Addition of Mosapride to Gastroesophageal Reflux Disease Patients on Proton Pump Inhibitor: A Prospective Randomized, Double-blind Study
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Lim HC, Kim JH, Youn YH, Lee EH, Lee BK, Park H
- KMID: 2325770
- J Neurogastroenterol Motil.
- 2013 Oct;19(4):495-502.
BACKGROUND/AIMS: Proton pump inhibitors (PPIs) which are the most effective agents for the treatment of gastroesophageal reflux disease (GERD), have been known to delay gastric emptying. Mosapride has been used... -
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- A Case of Phendimetrazine Induced-Psychotic Disorder and Dependence
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Yun JA, Park WR, Yu JC, Choi KS
- KMID: 2343635
- J Korean Neuropsychiatr Assoc.
- 2013 Sep;52(5):402-405.
Phendimetrazine and related amphetamine-like compounds are used widely as appetite suppressants in Korea. We report on a patient who developed psychotic disorder and dependence while using phendimetrazine. A 25-year-old female... -
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- A Phase II Study to Evaluate the Efficacy of Ramosetron, Aprepitant, and Dexamethasone in Preventing Cisplatin-Induced Nausea and Vomiting in Chemotherapy-Naive Cancer Patients
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Jang G, Song HH, Park KU, Kim HS, Choi DR, Kwon JH, Kim HY, Han B, Kim JH, Jung JY, Kim HJ, Zang DY
- KMID: 2167624
- Cancer Res Treat.
- 2013 Sep;45(3):172-177.
PURPOSE: Combination therapy with aprepitant, serotonin receptor antagonist, and steroids improves the complete response rate of both acute and delayed chemotherapy-induced nausea and vomiting (CINV). However, it is not known... -
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- The Effects of Prucalopride on Postoperative Ileus in Guinea Pigs
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Park SJ, Choi EJ, Yoon YH, Park H
- KMID: 2158217
- Yonsei Med J.
- 2013 Jul;54(4):845-853.
- doi: 10.3349/ymj.2013.54.4.845
PURPOSE: Postoperative ileus (POI) is an impairment of coordinated gastrointestinal (GI) motility that develops as a consequence of abdominal surgery and is a major factor contributing to patient morbidity and... -
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- Behavioral Intervention and Anti-Obesity Drug Therapy
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Kim MK
- KMID: 2267840
- Korean J Med.
- 2013 May;84(5):624-628.
Obesity is associated with a reduction in life expectancy and an increase in mortality from cardiovascular diseases, cancer, and other causes. The U.S. Preventive Service Task Force (USPSTF) recommends screening... -
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- Long-Term Anticoagulation in the Extreme Elderly with the Newer Antithrombotics: Safe or Sorry?
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Chiong JR, Cheung RJ
- KMID: 2224916
- Korean Circ J.
- 2013 May;43(5):287-292.
- doi: 10.4070/kcj.2013.43.5.287
BACKGROUND AND OBJECTIVES: The prevalence of atrial fibrillation (AF) doubles in the extreme elderly and is higher than in the rest of the population. Warfarin therapy to prevent thromboembolic events... -
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- Onychomycosis Caused by Chaetomium globosum
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Kim DM, Lee MH, Suh MK, Ha GY, Kim H, Choi JS
- KMID: 2171796
- Ann Dermatol.
- 2013 May;25(2):232-236.
- doi: 10.5021/ad.2013.25.2.232
Onychomycosis is usually caused by dermatophytes, but some nondermatophytic molds and yeasts are also associated with invasion of nails. The genus Chaetomium is a dematiaceous nondermatophytic mold found in soil... -
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- Insulin Like Growth Factor Binding Protein-5 Regulates Excessive Vascular Smooth Muscle Cell Proliferation in Spontaneously Hypertensive Rats via ERK 1/2 Phosphorylation
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Lee DH, Kim JE, Kang YJ
- KMID: 1429387
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):157-162.
- doi: 10.4196/kjpp.2013.17.2.157
Insulin-like growth factor binding proteins (IGFBPs) are important components of insulin growth factor (IGF) signaling pathways. One of the binding proteins, IGFBP-5, enhances the actions of IGF-1, which include the... -
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- Functional activity of the cannabinoid 1 receptor is not affected by opioid antagonists in the rat brain
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Lee H
- KMID: 1767337
- Korean J Anesthesiol.
- 2013 Mar;64(3):257-261.
- doi: 10.4097/kjae.2013.64.3.257
BACKGROUND: WIN55212-2 is a synthetic cannabinoid agonist and selective to cannabinoid 1 (CB1) receptors, which are distributed mainly in the central nervous system. Opioid receptors and CB1 receptors have several... -
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- Efficacy of the oral neurokinin-1 receptor antagonist aprepitant administered with ondansetron for the prevention of postoperative nausea and vomiting
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Lim CS, Ko YK, Kim YH, Park SI, Kim JK, Kim MJ, Kim HJ
- KMID: 1767329
- Korean J Anesthesiol.
- 2013 Mar;64(3):212-217.
- doi: 10.4097/kjae.2013.64.3.212
BACKGROUND: 5-HT3 receptor antagonist, dexamethasone and droperidol were used for the prevention of postoperative nausea and vomiting (PONV). Recently, neurokinin-1 (NK1) antagonist has been used for PONV. We evaluated the... -
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- New oral anticoagulants
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Oh S
- KMID: 2192901
- J Korean Med Assoc.
- 2013 Jan;56(1):57-61.
- doi: 10.5124/jkma.2013.56.1.57
The most important and widely-prescribed drug for anticoagulation is a vitamin K antagonist such as warfarin although it has several limitations in clinical use. New oral anticoagulants (NOACs) have been... -
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- Focused Update on Primary Stroke Prevention in Patients with Atrial Fibrillation in Korean Clinical Practice Guidelines for Stroke
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Park JM, Hong KS, Han SW, Kim HY, Cho YJ, Kang K, Yu KH, Rha JH, Heo JH, Kwon SU, Oh CW, Bae HJ, Lee BC, Yoon BW, Koo J
- KMID: 2288694
- Korean J Stroke.
- 2012 Dec;14(3):106-115.
Pivotal clinical trials testing the efficacy of new antithrombotics for the prevention of stroke and systemic embolism in patients with atrial fibrillation have been published since the release of the... -
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- Multiple Signaling Molecules are Involved in Expression of CCL2 and IL-1beta in Response to FSL-1, a Toll-Like Receptor 6 Agonist, in Macrophages
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Won K, Kim SM, Lee SA, Rhim BY, Eo SK, Kim K
- KMID: 2285454
- Korean J Physiol Pharmacol.
- 2012 Dec;16(6):447-453.
- doi: 10.4196/kjpp.2012.16.6.447
TLR6 forms a heterodimer with TLR2 and TLR4. While proinflammatory roles of TLR2 and TLR4 are well documented, the role of TLR6 in inflammation is poorly understood. In order to... -
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- Drug Therapy for Obesity
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Kim KS, Park SW
- KMID: 2270999
- Korean J Obes.
- 2012 Dec;21(4):197-202.
Obesity is associated with a substantial increase in metabolic disorders and various cancers. As weight loss achieved with lifestyle intervention is modest, there is a need for drug treatment. Orlistat, phentermine,... -
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- Comparison of Hematologic Changes between Rivaroxaban and Aspirin for Venous Thromboembolism Prophylaxis after Total Knee Arthroplasty
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Song MH, Kim BH, Ahn SJ, Yoo SH, Kim YJ
- KMID: 2185303
- J Korean Orthop Assoc.
- 2012 Dec;47(6):410-415.
- doi: 10.4055/jkoa.2012.47.6.410
PURPOSE: To compare the hematologic changes and the rates of transfusion of patients using rivaroxaban or aspirin for venous thromboembolism prophylaxis after a total knee arthroplasty. MATERIALS AND METHODS: Among patients... -
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- Fingernail Onychomycosis Due to Aspergillus niger
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Kim DM, Suh MK, Ha GY, Sohng SH
- KMID: 2266043
- Ann Dermatol.
- 2012 Nov;24(4):459-463.
- doi: 10.5021/ad.2012.24.4.459
Onychomycosis is usually caused by dermatophytes, but some species of nondermatophytic molds and yeasts are also associated with nail invasion. Aspergillus niger is a nondermatophytic mold which exists as an... -
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- The effect of aprepitant for the prevention of postoperative nausea and vomiting in patients undergoing gynecologic surgery with intravenous patient controlled analgesia using fentanyl: aprepitant plus ramosetron vs ramosetron alone
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Lee SJ, Lee SM, Kim SI, Ok SY, Kim SH, Park SY, Kim MG
- KMID: 2236271
- Korean J Anesthesiol.
- 2012 Sep;63(3):221-226.
- doi: 10.4097/kjae.2012.63.3.221
BACKGROUND: The purpose of this study was to evaluate the effect of an aprepitant, neurokinin-1(NK1) receptor antagonist, for reducing postoperative nausea and vomiting (PONV) for up to 24 hours in... -
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- Effects of 5-HT4 selective receptor agonist, mosapride citrate on electrocardiogram in dogs
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Chae JS, Ahn JO, Coh YR, Park CW, Youn HY
- KMID: 1435829
- Korean J Vet Res.
- 2012 Sep;52(3):163-167.
Mosapride stimulated dietary motility was introduced because of the arrhythmogenic effect of cisapride. Cisapride, 5-HT receptor agonist, induces prolongation of QT interval. Additionally, this condition can raise the possibility of... -
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