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Identification of a conservative site in the African swine fever virus p54 protein and its preliminary application in a serological assay

Xu L, Cao C, Yang Z, Jia W

Background: ASF was first reported in Kenya in 1910 in 1921. In China, ASF spread to 31 provinces including Henan and Jiangsu within six months after it was first reported...
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Early Oxygen Requirement in Patients with Mild-to-Moderate COVID-19 Who Received Regdanvimab after DeltaVariant Outbreak

Lee CM, Park SW, Lee E

Background: Regdanvimab is a monoclonal antibody targeted against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and a treatment option for patients with mild-to moderate coronavirus disease 2019 (COVID-19). However, there...
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Real World Experience with Regdanvimab Treatment of Mild-toModerate Coronavirus Disease-19 in a COVID-19 Designated Hospital of Korea

Hong SI, Ryu BH, Hong KW, Bae IG, Cho OH

Background: Real-world clinical data concerning regdanvimab, a monoclonal antibody treatment for patients with mild-to-moderate coronavirus disease 2019 (COVID-19), are urgently needed. Here, we describe our experience with regdanvimab. Materials and Methods:...
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Effectiveness of Regdanvimab at Preventing the Need for Oxygen Therapy in Patients with Mild-to-Moderate COVID-19: A Retrospective Cohort Study

Choi SJ, Park SW, Lee E

Background: Monoclonal antibodies are a treatment option for patients with mild-tomoderate coronavirus disease (COVID-19). We investigated the effectiveness of regdanvimab, an anti-severe acute respiratory syndrome coronavirus-2 monoclonal antibody approved in...
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Korean Society of Infectious Diseases/National Evidence-based Healthcare Collaborating Agency Recommendations for Anti-SARSCoV-2 Monoclonal Antibody Treatment of Patients with COVID-19

Kim SB, Kim J, Huh K, Choi WS, Kim YJ, Joo EJ, Kim YJ, Yoon YK, Heo JY, Seo YB, Jeong SJ, Yu SY, Peck KR, Choi M, Yeom JS, Korean Society of Infectious Diseases (KSID)

Neutralizing antibodies targeted at the receptor-binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein have been developed and now under evaluation in clinical trials. The US Food...
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Effectiveness of Mavrilimumab in Viral Infections Including SARS-CoV-2 Infection - A Brief Review

Bhatt K, Garimella R, Taugir R, Mehta I, Jamal M, Vijayan R, Offor R, Nwankwo K, Arif U, Waheed K, Kumari P, Lathiya M, Michel G, Pandya N, Halpern J, Nasir H, Sanchez-Gonzalez MA

Hyperinflammation and cytokine storm has been noted as a poor prognostic factor in patients with severe pneumonia related to coronavirus disease 2019 (COVID-19). In COVID-19, pathogenic myeloid cell overactivation is...
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Monoclonal Antibody Therapies for Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

Kim W, Kim HJ

Considerable progress has been made in treatments for multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) over the last several decades. However, the present treatments do not show satisfactory...
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Major clinical research advances in gynecologic cancer in 2019

Kim M, Suh DH, Lee KH, Eom KY, Lee JY, Lee YY, Hansen HF, Mirza MR, Kim JW

In 2019, 12 topics were selected as the major research advances in gynecologic oncology. Herein, we first opted to introduce the significant clinical activity of pembrolizumab in women with advanced...
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Radioimmunotherapy (RIT) in Brain Tumors

Gholamrezanezhad A, Shooli H, Jokar N, Nemati R, Assadi M

Annually, the incidence of brain tumors has slightly increased and also the patient prognosis is still disappointing, especially for high-grade neoplasms. So, researchers seek methods to improve therapeutic index as...
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Early Experiences with Nivolumab in Patients with Metastatic Renal Cell Carcinoma and Failed Target Therapy

Lee JH, Kang M, Chung JH, Sung HH, Jeon HG, Jeong BC, Jeon SS, Lee HM, Park SH, Kim B, Kwon GY, Seo SI

PURPOSE: The efficacy of nivolumab in metastatic renal cell carcinoma (mRCC) has been proven. However, the nivolumab experience in Korean patients with mRCC is still poorly reported. We report initial...
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Measurement of Tumor Pressure and Strategies of Imaging Tumor Pressure for Radioimmunotherapy

Kim HG, Yu AR, Lee JJ, Lee YJ, Lim SM, Kim JS

Tumor interstitial pressure is a fundamental feature of cancer biology. Elevation in tumor pressure affects the efficacy of cancer treatment and results in the heterogenous intratumoral distribution of drugs and...
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Development and Clinical Evaluation of a Rapid Diagnostic Test for Yellow Fever Non-Structural Protein 1

Kim YH, Kim TY, Park JS, Park JS, Lee J, Moon J, Chong CK, Junior IN, Ferry FR, Ahn HJ, Bhatt L, Nam HW

A rapid diagnostic test (RDT) kit was developed to detect non-structural protein 1 (NS1) of yellow fever virus (YFV) using monoclonal antibody. NS1 protein was purified from the cultured YFV...
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Radioimmunotherapy in Head and Neck Cancer

Choi IJ

Radioimmunotherapy (RIT) is a therapy that takes advantage of the “cross-fire” effect of emitted radiation by radionuclides conjugated to tumor-directed monoclonal antibodies (mAb) (including those fragments) or peptides. While RIT...
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Novel strategies in immunotherapy for allergic diseases

Rajakulendran M, Tham EH, Soh JY, Van Bever

Conventional immunotherapy (IT) for optimal control of respiratory and food allergies has been fraught with concerns of efficacy, safety, and tolerability. The development of adjuvants to conventional IT has potentially...
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Development of a Rapid Diagnostic Test Kit to Detect IgG/IgM Antibody against Zika Virus Using Monoclonal Antibodies to the Envelope and Non-structural Protein 1 of the Virus

Kim YH, Lee J, Kim YE, Chong CK, Pinchemel , Reisdörfer F, Coelho JB, Dias RF, Bae PK, Gusmão ZP, Ahn HJ, Nam HW

We developed a Rapid Diagnostic Test (RDT) kit for detecting IgG/IgM antibodies against Zika virus (ZIKV) using monoclonal antibodies to the envelope (E) and non-structural protein 1 (NS1) of ZIKV....
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Development of Monoclonal Antibodies for Diagnosis of Plasmodium vivax

Linh NT, Park H, Lee J, Liu DX, Seo GE, Sohn HJ, Han JH, Han ET, Shin HJ, Yeo SJ

Plasmodium lactate dehydrogenase (pLDH) is a strong target antigen for the determination of infection with Plasmodium species specifically. However, a more effective antibody is needed because of the low sensitivity...
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ELISA for Quantitative Determination of Hepatitis B Virus Surface Antigen

Kim SH

Several studies have reported a good correlation between levels of serum hepatitis B virus surface antigen (HBsAg) and covalently closed circular DNA (cccDNA) before and after antiviral therapy. As a...
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Levels of common salivary protein 1 in healthy subjects and periodontal patients

Heo SM, Lee S, Wang H, Jeong JH, Oh SW

PURPOSE: Human saliva, as a vital part of the immune defense system, contains a number of distinct proteins and peptides. Recently human common salivary protein 1 (CSP1) has been identified...
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Development of Lateral Flow Immunoassay for Antigen Detection in Human Angiostrongylus cantonensis Infection

Chen MX, Chen JX, Chen SH, Huang DN, Ai L, Zhang RL

Angiostrongyliasis is difficult to be diagnosed for the reason that no ideal method can be used. Serologic tests require specific equipment and are not always available in poverty-stricken zone and...
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Combination Radioimmunotherapy Approaches and Quantification of Immuno-PET

Kim JS

Monoclonal antibodies (mAbs), which play a prominent role in cancer therapy, can interact with specific antigens on cancer cells, thereby enhancing the patient's immune response via various mechanisms, or mAbs...
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